Clinical trials: Risk
Myelodysplastic Syndrome (MDS)
LBH589 Alone or in Combination With Erythropoietin Stimulating Agents (ESA) in Patients With Low or Int-1 Risk Myelodysplastic Syndromes (MDS)
This study assessed the efficacy and safety of LBH589 as single agent and in combination with ESA in red blood cell transfusion-dependent Low and Int-1 MDS patients being either refractory to ESA or with a low probability of…
- Trial name
- GEPARD (NCT01034657)
- Testing
- LBH589, Epoetin Alfa
- Where
- 12 sites in Germany
- Volunteers
- 34 people
- Sponsor
- Novartis Pharmaceuticals
Endometrial Cancer
Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Endometrial Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00005583
- Testing
- cisplatin, doxorubicin hydrochloride, epirubicin hydrochloride
- Where
- 23 sites in Belgium, France and 9 more
- Volunteers
- 400 people
- Sponsor
- Nordic Society of Gynaecological Oncology - Clinical Trials Unit
Heart Failure
FIND HF Risk-guided Screening for Heart Failure - Pilot Study
The goal of this clinical trial is to learn if the FIND HF algorithm detection rates of heart failure during testing are higher amongst participants identified as high FIND-HF risk compared to those identified as low risk in a…
- Trial name
- FIND HF (NCT07367841)
- Testing
- FIND HF algorithm
- Where
- United Kingdom
- Volunteers
- 475 people
- Sponsor
- University of Leeds
Dermatology/Skin - Other, Health Behavior
Project Options - The ABC Method
The present study explores the ability of dermatologists to influence patients' behavior using a novel and brief (3 minute) behavioral intervention in the context of naturally occurring patient interactions and shows promise for…
- Conditions
- Dermatology/Skin - Other, Health Behavior, Sunburn
- Trial name
- NCT03489356
- Testing
- Addressing Behavior Change (ABC)
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Penn State University
Peptic Ulcer Disease
Study Comparing Esomeprazole and ASA Combined Together as One Capsule Versus These Medications Taken Separately
The purpose of this study is to investigate whether a fixed dose combination (FDC) capsule of esomeprazole 20 mg and acetylsalicylic acid (ASA) 81 mg has equivalent therapeutic efficacy compared to each of 2 free combinations of…
- Trial name
- NCT01015729
- Testing
- Esomeprazole/ASA Fixed Combination, Esomeprazole, ASA
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Contrast-Induced Nephropathy
Theophylline, N-acetylcysteine, and Theophylline Plus N-acetylcysteine in Preventing Contrast-induced Nephropathy
The aim of this study is to determine the efficacy of Theophylline, N-Acetylcysteine and, and Theophylline plus N-acetylcysteine in the prevention of contrast-induced nephropathy.
- Trial name
- NCT02088502
- Testing
- N-acetylcysteine, Theophylline, 0.9% sodium chloride
- Where
- Iran
- Volunteers
- 96 people
- Sponsor
- Isfahan University of Medical Sciences
Precancerous Condition
Risk Factors for Barrett's Esophagus in Patients With BE, Gastroesophageal Reflux, or Gastrointestinal Bleeding
RATIONALE: A study that evaluates DNA changes and other disease-related health information in patients with Barrett's esophagus, gastroesophageal reflux, or gastrointestinal bleeding may help doctors learn more about the risk…
- Trial name
- NCT00445653
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Massachusetts General Hospital
Hypertension, Diabetes Mellitus
Community Based Multiple Risk Factors Intervention Strategy
Randomized controlled trial of CORFIS Programme. The study objectives are as follows: 1. To determine the efficacy of a community based multiple risk factors interventional strategy (CORFIS) for a treatment period of 6 months in…
- Conditions
- Hypertension, Diabetes Mellitus, Hyperlipidemia
- Trial name
- CORFIS (NCT00490672)
- Testing
- No Active Intervention., Community Based Multiple Risk Factor Intervention Strategies
- Where
- 78 sites in Malaysia
- Volunteers
- 770 people
- Sponsor
- Ministry of Health, Malaysia
Metabolic Syndrome
The Effect of Dietary Fat Modification on Risk Factors Associated With the Metabolic Syndrome
The LIPGENE Human Dietary Intervention Study, multi-centre, trans -European, single-blinded, randomised, controlled trial with two principal aims.
- Trial name
- NCT00429195
- Testing
- Dietary Fatty Acid Modification
- Where
- Ireland
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Adverse Maternal and Neonatal Outcomes
Risk Factors for Pregnancy-induced Hypertension in Pregnant Patients Undergoing Cesarean Section
After Institutional Review Board approval, we performed a retrospective cohort study among all women presenting for pregnancy-induced hypertension under Cesarean section in Renji Hospital Affiliated to Shanghai Jiaotong…
- Trial name
- NCT04808375
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- RenJi Hospital
Spinal Cord Injuries, Obesity
Spinal Cord Injury Model Systems (SCIMS) - Education Module
The purpose of this study is to find out if receiving education regarding increased risks of cardiometabolic disease helps subjects understand these risks and how these risks participants' health.
- Conditions
- Spinal Cord Injuries, Obesity, Cardiometabolic Syndrome
- Trial name
- NCT06003686
- Testing
- PVA Consumer Guide, WebMD
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Miami
Tuberculosis
Assessing the Ability of the T-SPOT®.TB Test (IQ)
The primary objective of this clinical research study is to demonstrate performance of the normalized TB specific lymphocyte response (NTBSLR) in identifying patients with active TB disease.
- Trial name
- IQ (NCT03973970)
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Oxford Immunotec
Continuous Lactate Measurements, Cardiosurgery
Lactate in High-risk Cardiac Surgery
The major combined interventions are between challenging and high-risk aspects of current cardiosurgical practice. The results of operation may be hampered by unexpected anatomic and technical features influencing the surgical…
- Trial name
- CLM-CARD (NCT02568969)
- Testing
- Eirus continuous lactate monitor
- Where
- Russia
- Volunteers
- 21 people
- Sponsor
- Northern State Medical University
Cardiovascular Diseases (CVD), Cardiovascular Diseases Risk
Cardiovascular Health and Nursing Interventions in 6th Grade Middle School Children
Interventions that can improve cardiovascular health behaviors in children are of critical importance for reducing the burden of cardiovascular disease in the future.
- Conditions
- Cardiovascular Diseases (CVD), Cardiovascular Diseases Risk, Health Behavior, School Health Services
- Trial name
- NCT06812156
- Testing
- Cardiovascular Health Education
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara University
Clear Cell Renal Cell Carcinoma
Study of Neoadjuvant Nivolumab in Patients With Non-metastatic Stage II-IV Clear Cell Renal Cell Carcinoma
This study will evaluate the use of nivolumab before surgery in patients with high-risk clear cell renal cell carcinoma who are eligible for nephrectomy.
- Trial name
- NCT02575222
- Testing
- Nivolumab
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pediatric Cardiac Surgery, Transfusion
Is Redo Pediatric Cardiac Surgery a Risk Factor for Transfusion?
In pediatric cardiac surgery, transfusion requirements are associated with age, development status, pathology, type of surgical intervention and extracorporeal bypass.
- Trial name
- NCT04456751
- Testing
- Redo op
- Where
- Belgium
- Volunteers
- 2,439 people
- Sponsor
- Brugmann University Hospital
Vesicoureteral Reflux
Bacterial and Host Genetic Risk Factors in Acute Pyelonephritis
No single host or pathogen trait identified by previous research can be correlated with all cases of childhood acute pyelonephritis or APN (i.e., kidney/upper urinary tract infections) and APN-associated renal scarring (the…
- Trial name
- NCT01137929
- Sponsor
- Hans Pohl
Metabolic Syndrome, Abdominal Obesity
Copenhagen Obesity Risk Assessment Study
The aim of the present study is to assess the effect of a high intake of industrially produced trans fatty acids for 16 weeks on abdominal obesity and risk markers of type 2 diabetes and heart disease in healthy, moderately…
- Conditions
- Metabolic Syndrome, Abdominal Obesity, Heart Disease, Type 2 Diabetes
- Trial name
- COBRA (NCT00655902)
- Testing
- Trans fat (soy bean oil), Control fat (sunflower oil)
- Where
- Denmark
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Aging, Alzheimer Disease
Tennessee Alzheimer's Project
The primary objective of the Vanderbilt Alzheimer's Disease Research Center (VADRC) is to provide local and national researchers with access to a well-characterized and diverse clinical cohort, including participant referrals…
- Conditions
- Aging, Alzheimer Disease, Biomarker, Cognitive Dysfunction
- Trial name
- TAP (NCT05372172)
- Testing
- none, observational study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Medicare Patients, High Risk of Hospitalizations
Comprehensive Care Physician: Integrated Inpatient and Outpatient Care for Patients at High Risk of Hospitalization
The investigators propose an innovative new model of care in which patients identified to be at high risk of hospitalization are offered care by a physician who will direct their care both in the hospital and in clinic but is…
- Trial name
- CCP (NCT01929005)
- Testing
- Comprehensive Care
- Where
- United States
- Volunteers
- 2,008 people
- Sponsor
- University of Chicago