Clinical trials: Risk of Fracture
Acromegaly, Osteoporosis Risk
Bone MicroArchitecture in Acromegaly
The investigators will conduct a cross-sectional study of bone density, bone microarchitecture, vertebral fractures and trabecular bone score in 25 patients with acromegaly treated with Pegvisomant, the growth hormone (GH)…
- Trial name
- NCT03225040
- Testing
- Pegvisomant
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Columbia University
Osteoporosis Diagnosis, Bone Health
REMS vs DXA for Osteoporosis Diagnosis and Fracture Risk Prediction
This prospective, observational, comparative diagnostic study will evaluate the performance of Radiofrequency Echographic Multi Spectrometry (REMS) for the diagnosis of osteoporosis and prediction of fragility fracture risk in a…
- Conditions
- Osteoporosis Diagnosis, Bone Health, Fracture
- Trial name
- NCT07876882
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- BoneVue Diagnostics
Ankle Fracture
Brace Versus Casting in Pediatric Low Risk Ankle Fractures
Acute ankle fractures are common in children. Most of these are stable and have a low risk of problems in the future. Even though these fractures are benign, these injuries are often casted for a fixed time period, which is…
- Trial name
- NCT00132964
- Testing
- Below knee walking cast, Removable ankle brace
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- The Hospital for Sick Children
Acromegaly
Acromegaly: Balance, Falls and Fracture Risk
The goal of this observational, cross-sectional study is to study bone quality, joint quality and fall risk in acromegalic patients, compared with healthy controls.
- Trial name
- NCT05752825
- Testing
- HR-pQCT, DXA scan, Bone microindentation
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Christian Alexander H Rosendal
Fractures in Children, Apophysitis
Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football
A total genotype risk score was generated based on the findings of previous research for non-contact injury, non-contact muscle injury, tendon injury, ligament injury, fracture injury and apophysitis injury.
- Conditions
- Fractures in Children, Apophysitis, Muscle Strain, Ligament Injury
- Trial name
- NCT05220969
- Testing
- Total Genotype Risk Score
- Where
- 2 sites in United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Osteoporotic Fractures
Study of the Key Techniques of Prevention and Treatment of Osteoporotic Refracture
This project anchors osteoporotic fractures, conduct registration and follow-up studies, and conduct prospective treatment studies.
- Trial name
- NCT05866029
- Testing
- Denosumab, Teriparatide
- Where
- 58 sites in China
- Volunteers
- 2,478 people
- Sponsor
- Peking Union Medical College Hospital
HIV Infection, Alcohol Consumption
Boston ARCH 4F Intervention to Reduce Fall Risk in People With HIV and Alcohol Use
This study is being conducted to assess the acceptability and feasibility of a randomized trial of a 10 week virtual intervention to reduce fall risk in people with HIV who consume alcohol.
- Conditions
- HIV Infection, Alcohol Consumption, Falls, Accidental, Falls
- Trial name
- NCT04804579
- Testing
- Fall Prevention Intervention
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Boston University
DVT
Bedside Ultrasound by Anesthesiologists for Screening Deep Venous Thrombosis
The study is designed as a prospective comparative study. All patients will receive prophylactic anticoagulation according to routine hospital protocol after surgery.
- Trial name
- NCT03443310
- Testing
- Ultrasound assessment of DVT
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University Health Network, Toronto
Post Operative Surgical Site Infection
Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High Energy Fracture Surgery
The OXYGEN Study is a double blinded prospective randomized controlled trial that will compare the proportion of surgical site infections within 6 months in patients treated with Supplemental Perioperative Oxygen compared to…
- Trial name
- OXYGEN (NCT01798810)
- Testing
- Supplemental Perioperative Oxygen
- Where
- 2 sites in United States
- Volunteers
- 1,171 people
- Sponsor
- Major Extremity Trauma Research Consortium
Osteoporosis, Bone Loss, Age Related
Osteoporosis Choice Decision Aid for Use of Bisphosphonates in Postmenopausal Women
To develop a decision aid to support the decision to use (or not use) bisphosphonates in postmenopausal women at risk for osteoporotic fractures, and to assess the impact of the decision aid on start and six month adherence to…
- Conditions
- Osteoporosis, Bone Loss, Age Related, Postmenopausal Bone Loss, Postmenopausal Osteoporosis
- Trial name
- NCT00578981
- Testing
- Osteoporosis Choice Decision Aid
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
All-cause Mortality
ADL and CONUT for Predicting 1-year Mortality Risk in Older Adults After Hip Fracture
Hip fracture has a serious impact on the quality of life and even the survival of older adults. The multidisciplinary management of hip fracture has been shown to be effective in improving patient outcome and cost-effective in…
- Trial name
- NCT05814172
- Testing
- no intervention
- Where
- China
- Volunteers
- 303 people
- Sponsor
- Beijing Tongren Hospital
Atypical Femur Fracture
Personalizing Osteoporosis Care: Clinical & Genetic Risk Factors for AFFs
The overall objective of this project is to identify clinical and genetic risk factors for Atypical Femur Fractures (AFFs) in Anti-resorptive therapy (ART) users by conducting a case control study of 330 cases of AFFs and 660…
- Trial name
- NCT04110795
- Testing
- No Intervention
- Where
- 3 sites in Canada
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Pain, Hip Fractures
Comparison Effects of Two Regional Anesthetic Technique on Pain During High Risk Hip Fracture Surgery
In this study, our is to compare effect of lumbosacral plexus and sacral plexus + suprainguinal fascia iliaca plane block on perioperative pain via analgesia nociceptive index monitor on high-risk patients undergoing hip fracture…
- Conditions
- Pain, Hip Fractures, Perioperative Analgesia
- Trial name
- NCT05862922
- Testing
- Analgesia Nosiception İndex Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Spinal Cord Injury
The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and…
- Trial name
- IBSCI (NCT05319522)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pain, Postoperative, Liposomal Bupivacaine
Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain
The supraclavicular brachial plexus block (BPB) is a frequently used anaesthetic method for upper limb surgeries, including distal radial fracture surgery.
- Conditions
- Pain, Postoperative, Liposomal Bupivacaine, Dexamethasone, Supraclavicular Brachial Plexus Block
- Trial name
- NCT07665762
- Testing
- 10ml 0.5% plain bupivacaine with 10ml 1.33% liposomal bupivacaine, 19ml 0.5% plain bupivacaine with 1ml (4mg) dexamethasone
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Menopausal Symptoms, Physical Activity and Sedentary Behavior
Prevalence of Menopause-associated Symptoms Throughout the Menopausal Transition in Women Aged 40 to 70 Residing in Spain and Its Relationship With Physical Activity - MdH Study
The goal of this observational study is to learn about menopause-related symptoms in women aged 40 to 70 years who live in Spain.
- Trial name
- NCT07596069
- Testing
- Reproductive stage, Physical Activity Level
- Where
- 2 sites in Spain
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Cuerpos Serranos S.L.
Hip Fracture
Population-based Registry Study on Primary Hip Fracture Surgery
This study aims to describe primary hip fracture surgeries and to identify patient-related and perioperative risk factors affecting outcomes.
- Trial name
- NCT06773884
- Testing
- "Observational Analysis of Primary Hip Fracture Surgery Outcomes"
- Where
- Sweden
- Volunteers
- 90,000 people
- Sponsor
- Region Örebro County
Osteoporosis, Fractures in the Elderly
Fractures in the Elderly Population of El Salvador at Hospital Zacamil: Exploring Knowledge, Causes, Risk Factors, and Outcomes
As the population's life expectancy increases, fractures among the elderly in El Salvador are also increasing. There is currently limited data specific to the incidence and cause of fractures in the elderly within developing…
- Trial name
- NCT00625599
- Testing
- Osteoporosis Prevention Information
- Where
- 2 sites in El Salvador
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Ankle Fractures
Factors Influencing the Risk of Surgical Site Infections and Wound Complications in Operatively Treated Ankle Fractures in the Elderly
This study is to analyse risk factors for wound complications or surgical site infections and to analyse whether risk factors for wound complications or surgical site infections are also factors for other complications.
- Trial name
- NCT04379791
- Testing
- Data collection from routine medical records
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Distal Radius Fracture, Osteoporosis
Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk
The objective of this study is to determine whether a new minimally invasive method for in vivo measurement of cortical bone tissue properties can identify those who are at risk for fragility fractures of the hip and radius.
- Conditions
- Distal Radius Fracture, Osteoporosis, Hip Fractures
- Trial name
- NCT03076034
- Testing
- Reference Point Indentation
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center