Clinical trials: Risk of Fracture
Osteoporosis, Postmenopausal Osteoporosis
AGE Burden and Response to Antiresorptive Therapy in Osteoporosis
Osteoporosis is a common condition that increases the risk of bone fractures. Although antiresorptive treatments such as bisphosphonates and denosumab are effective in increasing bone mineral density, some patients continue to…
- Trial name
- NCT07329543
- Volunteers
- 240 people
- Sponsor
- Bursa City Hospital
Hip Fractures (ICD-10 72.01-72.2)
Risk Early Warning Management for Postoperative Hip Fracture Rehabilitation and Delirium Prevention in Elderly Patients
This clinical study aims to evaluate the effectiveness of a perioperative risk early warning management strategy in patients undergoing surgical treatment for hip fractures.
- Trial name
- NCT06966947
- Testing
- Risk Early Warning Management, Standard Perioperative Care
- Where
- China
- Volunteers
- 284 people
- Sponsor
- People's Hospital Affiliated to Hubei University of Medicine
Intertrochanteric Fractures
Blocks for Intertrochanteric Fracture Repair Surgery
This single-center open label study compares the outcomes of surgical repair of intratrochanteric fracture under general anesthetic or peripheral nerve blocks.
- Trial name
- NCT04470115
- Testing
- General anesthesia, Regional anesthesia- femoral and lateral femoral cutaneous nerve blocks
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Military Institute od Medicine National Research Institute
Osteoporosis
Real-World Evidence of Adherence to Denosumab Therapy and Fracture Risk Associated With Drug Withdrawal: A Cross-sectional Study
In the light of current literature data, it is not recommended to discontinue Denosumab therapy without initiating another antiresorptive therapy.
- Trial name
- NCT06414616
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people
- Sponsor
- Trakya University
Breast Cancer, Metastatic Breast Cancer (MBC)
A Study of Romosozumab in People With Breast Cancer and Osteoporosis
The researchers are doing this study to see if romosozumab is effective at helping with bone formation in people with metastatic breast cancer (MBC) that has spread to the bones. All participants will have osteoporosis.
- Trial name
- NCT07776613
- Testing
- Romosozumab
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hip Fractures, Rehabilitation
Cross-sectoral Rehabilitation of Older High-risk Patients With Hip Fracture
The goal of this observational study is to learn about and monitor the cross-sectoral rehabilitation process in older high-risk patients treated for at fragility fracture of the hip.
- Conditions
- Hip Fractures, Rehabilitation, Recovery of Function
- Trial name
- NCT06304584
- Where
- Denmark
- Volunteers
- 53 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Bone Fractures Multiple
Wound Perfusion in High Risk Surgical Incisions
This is a prospective cohort pilot study. The primary purpose is to report the perfusion status of the surgical field in at risk surgical incisions.
- Trial name
- NCT04233307
- Testing
- Telethermographic images
- Volunteers
- 100 people
- Sponsor
- Florida Orthopaedic Institute
Proximal Femur Fracture
Postoperative Pain Relieve for Patients Undergoing Surgical Treatment of Femoral Fracture
The aim of the study is to investigate postoperative pain relief for patients undergoing surgical treatment of proximal femoral fracture using intrathecal administration of morphine.
- Trial name
- NCT05920642
- Testing
- Intrathecal morphine administration, Parenteral administration of analgesics
- Where
- Czechia
- Volunteers
- 82 people
- Sponsor
- University Hospital Ostrava
Shoulder Dystocia,, Brachial Plexus Injury
New Prophylactic Maneuver: the "Pushing" Maneuver, Aiming to Reduce the Risk for Shoulder Dystocia
Shoulder dystocia is a major obstetric emergency defined as a delivery requiring maneuver in addition to downward traction on the fetal head for delivery of the shoulders.
- Conditions
- Shoulder Dystocia,, Brachial Plexus Injury, Asphyxia,, Hematoma,
- Trial name
- CONTRADYS (NCT01297439)
- Testing
- suctioning of fetal nose and mouth during delivery, Pushing maneuver
- Where
- France
- Volunteers
- 1,538 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoporosis
Secondary Prevention of Osteoporosis
The purpose of this study is to develop and implement an evidence based protocol for the secondary prevention of osteoporotic fractures and falls, and to determine how compliance with this intervention improves muscle strength…
- Trial name
- NCT00421343
- Testing
- alendronate with cholecalciferol, calcium carbonate with cholecalciferol, Falls prevention measures
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Hebrew SeniorLife
Cardiovascular Diseases, Fracture
Prevalence and Risk Factors for Common Diseases
By using national databases in Sweden the aim of the present project is to: 1. Investigate if the incidence of our most common diseases, such as fracture and cardiovascular disease, has changed from 1970-2017 2.
- Conditions
- Cardiovascular Diseases, Fracture, Cancer
- Trial name
- NCT04091035
- Testing
- To describe the incidence of disease and evaluate risk factors
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Anna Nordström
Idiopathic Parkinson's Disease
Volumetric Bone Mineral Density and it's Relationship With Osteoporotic Fractures in Parkinson's Disease
Idiopathic Parkinson's disease (IPD) is the second most frequent neurodegenerative disease. Its association with osteroporosis and fragility fracture is now clearly demonstrated, but the determinants of this osteoporosis are yet…
- Trial name
- DOPPA (NCT03095690)
- Testing
- High resolution peripheral scanner (HRpQCT).
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Osteoporosis, Postmenopausal
Efficacy and Safety of MW031 in PMO Subjects
This study is a multicenter, randomized, double-blinded, placebo-controlled Phase III clinical study to evaluate the clinical efficacy and safety of MW031 in Chinese postmenopausal osteoporotic subjects with increased bone…
- Trial name
- NCT05215977
- Testing
- MW031
- Where
- China
- Volunteers
- 448 people
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Vertebral Metastases, Vertebral Fracture
A Multicenter Prospective Observational Study on Vertebral Fracture Risk Stratification in Patients With Vertebral Metastases
Vertebral fracture is a common clinically significant skeletal related event in cancer patients. Stratification of patients diagnosed with one or more vertebral metastases according to the risk of pathological fracture is an…
- Trial name
- Valid-METASTRA (NCT06910618)
- Where
- 4 sites in Germany, Hungary and 2 more
- Volunteers
- 300 people
- Sponsor
- Buda Health Center
Multiple Myeloma
The Feasibility and Effects of Exercise on Patients Suffering From Multiple Myeloma
Multiple myeloma is the second most common haematological cancer with a cancer incidence of around 500 new cases in Austria per year .
- Trial name
- NCT04300335
- Testing
- Individual Exercise, Group Exercise
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Hip Fractures
Non Invasive Cardiac Output Monitoring to Guide Goal Directed Fluid Therapy in High Risk Patients Undergoing Urgent Surgical Repair of Proximal Femoral Fractures
Improving or maximising cardiac output in the perioperative setting through the use of goal directed fluid therapy has been shown to reduce complications and length of hospital stay in patients undergoing major abdominal surgery.
- Trial name
- ClearNOF (NCT02382185)
- Testing
- Fluid optimisation, Optimisation of blood pressure, Application of clearsight monitor
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- York Teaching Hospitals NHS Foundation Trust
Osteoporosis
Risk-stratified Osteoporosis Strategy Evaluation Study (ROSE)
The Risk-stratified Osteoporosis Strategy Evaluation Study (ROSE) is a randomised population-based study, including 20,904 Danish women aged 65-80 years, investigating the effectiveness of a two-step screening programme for…
- Trial name
- ROSE (NCT01388244)
- Testing
- Screening, Control
- Where
- Denmark
- Volunteers
- 35,000 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Delirium
With the Development of Research, New Algorithms and Technologies Have Emerged, One of Which is Machine Learning. Machine Learning Can Extract Key Factors From Vast Amounts of Data, Identify Underlying Patterns, and Predict Future Trends. In Recent Years, Machine Learning Has Been Widely Used in
The aim of this study is to construct a predictive model for postoperative delirium in elderly patients with hip fractures. The main question it answers is to construct a risk prediction model for hip fractures in the elderly…
- Trial name
- POD (NCT07121309)
- Where
- China
- Volunteers
- 901 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Soochow University
Postmenopausal Women With Osteoporosis
To Evaluate the Efficacy and Safety of Abaloparatide Injection (QLG2128) in the Treatment of Postmenopausal Women With Osteoporosis and at High Risk of Fracture
The purpose of this study is to evaluate the efficacy and safety of QLG2128 in the treatment of postmenopausal women with osteoporosis and at high risk of fracture.
- Trial name
- NCT06898060
- Testing
- QLG2128, Teriparatide Injection
- Volunteers
- 282 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Rheumatoid Arthritis (RA), Anticholinergic Adverse Reaction
Anticholinergic Burden and Osteoporosis in Rheumatoid Arthritis
Background: Rheumatoid arthritis (RA) is a chronic, progressive, inflammatory rheumatological disease. Use of corticosteroids for more than 3 months in RA treatment is considered an important risk factor in terms of developing…
- Conditions
- Rheumatoid Arthritis (RA), Anticholinergic Adverse Reaction, Fractures, Bone
- Trial name
- NCT06812481
- Testing
- Anticholinergic load was calculated using anticholinergic cognitive load (ACB)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Balikesir University