Clinical trials: Rocuronium, open to volunteers
Airway Management, Supraglottic Airway Device Insertion
Effect of Neuromuscular Blocking Agent Use on Video Laryngeal Mask Airway Insertion
This study aims to investigate whether the administration of a neuromuscular blocking agent (rocuronium) improves the anatomical positioning of a third-generation video laryngeal mask airway (video LMA) in adult patients…
- Conditions
- Airway Management, Supraglottic Airway Device Insertion, Laryngeal Mask Airways, Anesthesia, General
- Trial name
- NCT07894029
- Testing
- Rocuronium, Standard Anesthesia Induction (Propofol and Remifentanil)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Hacettepe University
Obesity
Comparison of Acceleromyography and Electromyography in Obese Patients Undergoing General Anesthesia
The goal of this prospective observational study is to compare two different methods of monitoring muscle relaxation during anesthesia - acceleromyography (AMG) and electromyography (EMG) - in people with obesity who are having…
- Trial name
- OBAEG (NCT07283354)
- Testing
- Neuromuscular monitoring with electromyography (EMG), Neuromuscular monitoring with acceleromyography (AMG)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Padova
Postoperative Residual Curarization, Neuromuscular Block Prolonged
Postoperative Residual Neuromuscular Block and Passive Smoke Exposure in Pediatric Dental Patients
Postoperative residual neuromuscular block (PRNB) may persist despite apparent clinical recovery from neuromuscular blockade and may increase the risk of postoperative respiratory complications.
- Trial name
- NCT07831434
- Testing
- Passive Smoke Exposure
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Istanbul University - Cerrahpasa
Post Operative Pulmonary Complications, Neuromuscular Blockade
Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease
The purpose of the study is to determine which combination of neuromuscular blocking agent and reversal agent is safer to use during anesthesia for patients with chronic kidney disease.
- Conditions
- Post Operative Pulmonary Complications, Neuromuscular Blockade, General Anesthesia
- Trial name
- NCT07203287
- Testing
- Rocuronium, Cisatracurium, Sugammadex
- Where
- United States
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Neuromuscular Blockade
Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation and Bolus Maintenance in Adults
The study will enroll adult patients scheduled for elective surgery requiring general anesthesia. Participants will be randomly assigned to receive either HRS-9190 for Injection or Rocuronium.
- Trial name
- NCT07746726
- Testing
- HRS-9190, Rocuronium
- Where
- 2 sites in China
- Volunteers
- 320 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Anesthesia
Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine
The purpose of this study is to assess and compare conditions for tracheal intubation obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg succinylcholine.
- Trial name
- NCT06029049
- Testing
- Modified Time Principle Induction (MTPI) with rocuronium, RSI succinylcholine
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- The University of Texas Health Science Center, Houston
Tracheal Intubation, Video Laryngoscopy
Remifentanil Versus Rocuronium for Optimizing Video Laryngoscopy-assisted Tracheal Intubation
Globally, we are approaching 1 million surgical procedures each day. Tracheal intubation is the mainstay of securing the patient's airway and breathing during general anaesthesia.
- Conditions
- Tracheal Intubation, Video Laryngoscopy, Remifentanil, Rocuronium
- Trial name
- ROCVIDEO (NCT06564857)
- Testing
- Remifentanil, Rocuronium
- Where
- 2 sites in Denmark
- Volunteers
- 2,684 people
- Sponsor
- Nordsjaellands Hospital
Neuromuscular Block, Residual, Pain
Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults
This randomized controlled trial aims to compare the effects of intravenous methylprednisolone and dexamethasone on the reversal time of rocuronium by sugammadex in adult patients undergoing elective septoplasty or rhinoplasty.
- Conditions
- Neuromuscular Block, Residual, Pain, Postoperative Nausea
- Trial name
- NCT07187037
- Testing
- Methylprednisolone (MP), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Reversing Vecuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery, Reversing Rocuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery
A Dose-Finding Study of Amogammadex Sodium for Reversing Vecuronium and Rocuronium-Induced Neuromuscular Blockade
Background context: Amogammadex sodium has completed Phase I-III clinical studies in China for reversal of rocuronium-induced blockade. No clinical studies have yet been conducted for vecuronium-induced blockade.
- Trial name
- NCT07595393
- Testing
- Rocuronium (0.6mg/kg), vecuronium bromide (0.1mg/kg)
- Volunteers
- 64 people
- Sponsor
- Amckaus PTY LTD.
Kidney Failure, Acute, Myopathy; Drugs
The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)
The study aims to improve the safety of the electroporation ablation (PFA) procedure by using muscle relaxants to reduce skeletal muscle damage during the procedure.
- Conditions
- Kidney Failure, Acute, Myopathy; Drugs, Heart Arrhythmia, Succinylcholine Sensitivity
- Trial name
- NCT06707532
- Testing
- Propofol, Rocuronium
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Emergencies, Out-of-hospital Setting
Optimisation Strategy for Emergency Tracheal Intubation
This study has to objective to assess, in adults' patients needing tracheal intubation because of vital distress, the effect of a combined strategy to reduce intubation-related morbidity.
- Conditions
- Emergencies, Out-of-hospital Setting, Tracheal Intubation
- Trial name
- OSETIM (NCT05539391)
- Testing
- Data patient, Physical examination, Rapid sequence intubation (RSI) : Rocuronium /Bag-mask ventilation /GEB
- Where
- 22 sites in France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Bordeaux
Neuromuscular Blocking Agents, Residual Neuromuscular Block
Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis
The use of intravenous muscle relaxants during anaesthesia can significantly facilitate endotracheal intubation and reduce the chance of possible airway complications during intubation.
- Conditions
- Neuromuscular Blocking Agents, Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
- Trial name
- NCT07080528
- Testing
- Sevofluorane, Propofol
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Tamas Vegh, MD
Muscle Relaxation
Effect of Magnesium Sulphate Pretreatment in Pediatric Abdominal Surgery
In this study, the investigators will compare the effect of magnesium sulphate pretreatment on the onset and duration of intense and deep neuromuscular Block of rocuronium versus Cis-Atracurium and on the period of no response to…
- Trial name
- MgSO4/MR (NCT05736744)
- Testing
- MgSO4, Cis-Atracurium
- Where
- 2 sites in Egypt
- Volunteers
- 58 people
- Sponsor
- Assiut University
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Surgery, Neuromuscular Blockade
TetraGraph to Evaluate Onset and Recovery Times of Rocuronium
In most clinical instances, direct laryngoscopy and endotracheal intubation is performed after a set time (generally 60 seconds) following the administration of a neuromuscular (NM) blocking agent, rocuronium.
- Trial name
- NCT07435792
- Testing
- TetraGraph
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Nationwide Children's Hospital
Spine Surgery, Intraoperative Neurophysiological Monitoring
Low-Dose Rocuronium Maintenance During Spine Surgery With Intraoperative Neurophysiological Monitoring
This randomized controlled trial will compare two strategies for rocuronium use during general anesthesia for spine surgery with intraoperative neurophysiological monitoring.
- Conditions
- Spine Surgery, Intraoperative Neurophysiological Monitoring, Neuromuscular Blockade
- Trial name
- ROC-IONM (NCT07627750)
- Testing
- Low-Dose Rocuronium Maintenance, Rocuronium
- Where
- Vietnam
- Volunteers
- 62 people
- Sponsor
- Bach Mai Hospital
Infant, Premature, Intubation, Intratracheal
Fentanyl and Rocuronium for Tracheal Intubation in Newborns
Tracheal intubation is a common and critical procedure in neonatal intensive care units (NICU). Despite its clinical importance, first-attempt success rates remain low (approximately 50%), and adverse events - including oxygen…
- Conditions
- Infant, Premature, Intubation, Intratracheal, Respiratory Distress Syndrome, Newborn, Apnea of Prematurity
- Trial name
- NEORIN (NCT07650552)
- Testing
- Rocuronium Bromide 10 MG/ML, Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation.
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- UEA - Universidade Do Estado Do Amazonas
Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade
Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade
In operating procedure with general anesthesia muscle relaxant is usually used to increase success rate of the operation and to give better outcome.
- Conditions
- Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade, Recovery Time
- Trial name
- NCT06794450
- Testing
- Sugammadex 1 mg/kg, Neostigmine + Atropine
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Padjadjaran
Awareness, Mechanical Ventilation
The ED-AWARENESS-2 Trial
The investigators will screen all mechanically ventilated ED patients for study eligibility and will enroll all consecutive patients satisfying inclusion and exclusion criteria.
- Conditions
- Awareness, Mechanical Ventilation, Intubation Complication, PTSD
- Trial name
- ED-AWARENES II (NCT05534243)
- Testing
- Standard neuromuscular blocker practices, Education
- Where
- 4 sites in United States
- Volunteers
- 3,212 people
- Sponsor
- Washington University School of Medicine
Airway Management, Endotracheal Intubation
REMIfentanil (2 vs. 4 mcg/kg) Facilitated Intubation Without Neuromuscular Blockade Versus Succinylcholine and Rocuronium With Sugammadex for Endotracheal Intubation in Spine Surgery Requiring Motor Evoked Potential Monitoring
The purpose of this research is to compare four commonly used anesthesia medication strategies for placing a breathing tube in patients undergoing spine surgery that requires motor evoked potential (MEP) monitoring.
- Trial name
- REMI-MEP (NCT07835295)
- Testing
- Low-Dose Remifentanil, High-Dose Remifentanil, Succinylcholine
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- Mayo Clinic