Clinical trials: Root Canal
Apical Lesion
The Effect of Injectable Platelet Rich Fibrin on Apical Lesion Healing
In recent years, the use of autologously obtained blood products that stimulate cell proliferation, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), has become increasingly widespread.
- Trial name
- NCT07876427
- Testing
- i-PRF, root canal treatment and intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hande Has Elçi
Osteoarthritis, Total Knee Replacement
Adductor Canal Block
The investigators aim to investigate whether the addition of a surgeon-administered adductor canal blockade to a multimodal periarticular injection cocktail provides additional pain relief for patients undergoing total knee…
- Trial name
- NCT04513145
- Testing
- Ropivacaine injection, Saline Injection, Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- OrthoCarolina Research Institute, Inc.
Blood Contamination of Root Canal During Endodontic Therapy
A New Approach for Controlling Hemostasis During Canal Treatment: a Pilot Study
Blood contamination, such as apical microleakage, of root canal during preparation can be a major problem in endodontics. The purpose of this investigation was to evaluate the hemostatic properties of sulfonic/sulfuric acid…
- Trial name
- NCT03060486
- Testing
- HYBENX®
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Dr Riccardo Pace
Endodontically Treated Teeth, Postoperative Pain
Different Endodontic Treatment Techniques in Postoperative Symptoms, Apical Repair, Longevity of Rehabilitations, and Oral Health-related Quality of Life
Objective: The objective of this study will be to evaluate the effectiveness of different endodontic treatment techniques in postoperative symptoms, apical repair, longevity of rehabilitations, and oral health-related quality of…
- Conditions
- Endodontically Treated Teeth, Postoperative Pain, Edema, Photochemotherapy
- Trial name
- NCT03704857
- Testing
- Foraminal Enlargement / Irrigating solutions / Filling materials, Photobiomodulation, Passive ultrasonic irrigation
- Where
- Brazil
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Post Operative Pain After Root Canal Therapy
Postoperative Pain Comparison of Two Root Canal Sealers in Irreversible Pulpitis
This study, approved by the Institutional Ethics Review Committee, AFID (Annex "A"), will involve 62 eligible patients from the Operative Dentistry Department, Armed Forces Institute of Dentistry.
- Trial name
- NCT06975761
- Testing
- Resin Based sealer, ZnO eugenol based sealers
- Where
- Pakistan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Bacterial Count Reduction in Oval Canal After Rotary Instrumentation With Different Systems, Post-operative Pain After Rotary Instrumentation of Oval Canal With Different Systems
Postoperative Pain and Bacterial Reduction in Oval Canals After Instrumentation With Different Noval Rotary Files Systems
Postoperative pain after endodontic treatment can affect a patient's quality of life. It is reported that debris extrusion after the instrumentation technique can influence postoperative pain.
- Trial name
- NCT07019792
- Testing
- Protaper ultimate, Truanatomy file system, Hyflex EDM
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Postoperative Pain, Root Canal
Gutta-percha Solvent on Postoperative Pain After Root Canal Retreatment
The process of non-surgical retreatment includes removing the previous root canal filling materials, disinfecting and sealing the root canal system to prevent re-infection.
- Conditions
- Postoperative Pain, Root Canal, Retreatment
- Trial name
- NCT04326998
- Testing
- solvent, non-solvent
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Osteoarthritis, Knee
Perineural Steroids for Peripheral Nerve Blocks
This study will look at the efficacy of dexamethasone for prolongation of peripheral nerve blocks.
- Trial name
- NCT02462148
- Testing
- Dexamethasone, Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Dental Pulp Diseases
Survival of Root Canal Treated Teeth Restored With Ceramic Onlays
Advances in digital dentistry coupled with increased demand for aesthetic restorations have led to developments in CAD CAM( Computer Aided Design and Computer Aided manufacturing)systems for manufacturing tooth restorations.
- Trial name
- NCT03378778
- Testing
- Root canal treatment
- Where
- United Kingdom
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- King's College London
Apical Periodontitis, Pulp Disease, Dental
In-Vivo Diagnostic Accuracy and Repeatability of Root ZX3 for Working-Length Determination in Single-Rooted Teeth: Agreement With CBCT and Microscopic Validation
This study evaluated the accuracy and repeatability of the Root ZX3 electronic apex locator for working-length determination in 77 single-rooted permanent teeth.
- Conditions
- Apical Periodontitis, Pulp Disease, Dental, Device Reliability, Device Performance
- Trial name
- NCT07689838
- Testing
- Root ZX3 Electronic Apex Locator
- Where
- Saudi Arabia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Hypertensive Anal Canal
Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy
Idiopathic hypertensive anal canal is a fact and already exists presented by anal pain aggravated by defecation. It can be managed safely by closed lateral sphincterotomy but chemical sphincterotomy had a minor role in its…
- Trial name
- NCT00927849
- Testing
- lateral internal sphincterotomy (LIS), Glycerin trinitrate (GTN), botulinum toxin injection (BTX A)
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pain After Total Knee Arthroplasty, Pain, Postoperative
Comparison of BiFeS + ACB and IPACK + ACB Block Combinations for Postoperative Pain After Total Knee Arthroplasty
This prospective observational study will compare the postoperative analgesic efficacy of two multimodal regional anesthesia combinations routinely used after total knee arthroplasty (TKA) performed under spinal anesthesia.
- Conditions
- Pain After Total Knee Arthroplasty, Pain, Postoperative, Arthroplasty, Replacement, Knee
- Trial name
- NCT07231692
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Root Canal Infection, Periapical Diseases
Calcium Silicate Sealer-based Obturation in Root Canal Retreatment
This study will evaluate the outcome of calcium silicate sealer-based obturations in root canal retreatment.
- Trial name
- NCT05714384
- Testing
- CeraSeal (Calcium Silicate-based Root Canal Sealer)
- Where
- Kuwait
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Kuwait
ACL Injury
Continuous Vs Single Shot Block After ACL
The investigators will be randomizing patients to either receive an adductor canal block in the operating room postoperatively as single shot of 20-30cc bupivacaine or to have a catheter inserted into the adductor canal which…
- Trial name
- NCT04101682
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Undescended Testis, Inguinal; Testicle
Value of Inguinal Exploration for Impalpable Testes
To determine the percentage of children with impalpable testis who benefit from inguinal exploration after laparoscopic identification of cord structures entering the inguinal canal.
- Trial name
- NCT06187844
- Testing
- Inguinal exploration, Laparoscopy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji
Ambient air temperatures in Fiji are increasing due to climate change. Solutions are needed to build heat resilience in communities and adapt.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- NCT07592117
- Testing
- Cool roof
- Where
- Fiji
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Pain, Postoperative
Pain Intensity After Root Canal Instrumentation
Assess the pain intensity in a two visit treatment of molars with irreversible pulpitis after instrumentation with two rotary systems Mpro and Hyflex files.
- Trial name
- NCT04216940
- Testing
- mechanical preparation of root canal system
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Asthma
Assessing the Efficacy of CREWS01 to Decrease Usage of Rescue Inhalers in Moderate to Severe Asthmatic Adults
This is a double-blind, randomized, placebo-controlled, proof of concept, study in adults with poorly controlled moderate to severe asthma.
- Trial name
- CREWS01 (NCT02153541)
- Testing
- Antipyrine-benzocaine otic solution, Glycerin with Oxyquinoline Sulfate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Global United Pharmaceutical Corporation
Root Canal Therapy
Novel Collagen Scaffold vs Conventional Scaffold in Regeneration of Human Dental Pulp Tissue
The purpose of this investigation is to assess the use of a novel scaffold (an FDA-approved collagen-hydroxyapatite material called Syn-Oss) for regeneration of pulp tissues versus the use of a traditional scaffold (blood clot).
- Trial name
- NCT03613090
- Testing
- Collagen-hydroxyapatite scaffold (Syn-Oss), Collagen Scaffold (Colla-Plug)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Postoperative Pain, Recovery
COMPARISON OF THE EFFECT OF DISTAL ADDUCTOR CANAL BLOCK COMBINED WITH GENICULAR NERVE BLOCK OR PERIARTICULAR INJECTION ON POSTOPERATIVE QOR-15 IN TOTAL KNEE ARTHROPLASTIES
Objective: This study compares the effects of genicular nerve block (GNB) and periarticular injection (PAI), added to distal adductor canal block (ACB), on postoperative recovery quality (QoR-15), morphine use, and pain scores…
- Trial name
- NCT07077720
- Testing
- genicular nerve block, periarticular injection, Addukctor canal block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University