Clinical trials: Root Canal
Hearing Loss
Clinical Study of Released Unitron RIC and BTE Hearing Aid Models
The present study will confirm the clinical benefit of 2 different released hearing aid models for speech understanding (in noise).
- Trial name
- NCT05197803
- Testing
- Hearing aid
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sonova AG
Root Canal Treatment, Post Operative Pain
A First in Human Study to Compare Feasibility of Inertial Cavitation Irrigation to SNI in Root Canal Treatment.
The study design is a single-center 2-arm randomized controlled clinical trial. 10 subjects (teeth) requiring a root canal treatment will be enrolled in 2 groups (5 in each group).
- Trial name
- NCT05374434
- Testing
- Conventional irrigation, Inertial cavitation
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Lumendo AG
Postoperative Pain
Adductor Canal Mid-thigh and Adductor Canal Distal Thigh: Is Cutaneous Sensory Blockade Similar Among Block Techniques?
This is a randomized noninferiority interventional study to determine the equivalence of two adductor canal block (ACB) methods: mid-thigh and distal thigh in patients undergoing medial foot, medial ankle, or medial leg surgery.
- Trial name
- NCT02788019
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Knee Osteoarthritis, Arthroplasty Complications
Pre vs Post Block in Total Knee Arthroplasty (TKA)
The purpose of this project is to determine if a change in patient reported pain, nausea and vomiting after total knee arthroplasty can be observed with the substitution of a post operative adductor canal block for a preoperative…
- Conditions
- Knee Osteoarthritis, Arthroplasty Complications, Postoperative Pain
- Trial name
- NCT05974501
- Testing
- Dexamethasone, Acetaminophen, Lyrica
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Miami
Pain, Postoperative, Total Knee Arthroplasty (TKA)
Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty
Recently, several articles have suggested or reported that Adductor Canal Blocks (ACBs) offer adequate or equal analgesia and may promote better performance in early rehabilitation following Total Knee Arthroplasty (TKA) when…
- Trial name
- FemVsACB (NCT02453321)
- Testing
- Continuous Femoral Nerve Block, Nerve Block, Continuous Adductor Canal, Continuous Sciatic Nerve Block
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Kevin King, DO
Hearing Loss
Evaluation of Open-canal Behind-the-Ear Hearing Aids and Traditional In-the-ear Hearing Aids.
This study is being conducted to evaluate the benefits of in-the-ear vs. open-fit behind-the-ear hearing aids. We want to learn more about which patients prefer each type, so we can make better choices about which type of hearing…
- Trial name
- NCT00727909
- Testing
- Hearing Aid Treatments
- Where
- 3 sites in United States
- Volunteers
- 290 people
- Sponsor
- US Department of Veterans Affairs
Lumbar Spinal Stenosis
Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis
This is a single-center, randomized, prospective, double-blind clinical study to assess the clinical application and outcomes with MILD® devices versus epidural steroid injection in patients with symptomatic moderate to severe…
- Trial name
- NCT00995371
- Testing
- MILD® (Minimally Invasive Lumbar Decompression), Epidural Steroid Injection
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Coastal Orthopedics & Sports Medicine
Knee Arthropathy
Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)
A comparison of two pain control methods - the combination of Adductor Canal Block (ACB)/Periarticular Injection (PAI)/Infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (IPACK)…
- Trial name
- IPACK (NCT03094663)
- Testing
- Bupivacaine with epinephrine, Methylprednisolone, Cefazolin
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Hospital for Special Surgery, New York
Tooth, Nonvital
Effect of Passive Ultrasonic Irrigation on the Reduction of Bacteria and Endotoxins in Root Canals
The purpose of this clinical study was to compare the effectiveness of passive ultrasonic irrigation with that of traditional syringe irrigation on the removal of bacteria and endotoxin (lipopolysaccharide [LPS]) from root canals.
- Trial name
- NCT02917642
- Testing
- Ultrasonic Irrigation, Non-Ultrasonic Irrigation
- Volunteers
- 66 people
- Sponsor
- University of Sao Paulo
Endodontic Disease, Post Operative Pain
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.
- Conditions
- Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
- Trial name
- NCT05338671
- Testing
- Local anesthetic
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Washington
Complications; Arthroplasty, Knee Injuries
Ultrasound-guided Adductor Canal Block for Total Knee Replacement
Total knee arthroplasty is associated with intense early postoperative pain. Fast track recovery programs including early therapy protocols and early hospital discharge are being implemented at various hospitals.
- Trial name
- NCT02100579
- Testing
- Bupivacaine, Preservative free normal saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Anal Cancer, Rectal Cancer
A Phase 2 Study of Axalimogene Filolisbac (ADXS11-001) in Participants With Carcinoma of the Anorectal Canal
This is a single arm Phase 2 study. Stage 1 and 2 of the study are monotherapy evaluations of ADXS11-001 in 31 and 24 participants, respectively with persistent/recurrent, loco-regional or metastatic squamous cell carcinoma…
- Trial name
- NCT02399813
- Testing
- Axalimogene filolisbac
- Where
- 10 sites in United States
- Volunteers
- 36 people
- Sponsor
- Advaxis, Inc.
Carcinoma of the Anal Canal
Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma
This research study is a Pilot Study. Pilot studies are conducted to see if it is practical to do this type of research ona larger scale in the future.
- Trial name
- NCT01858025
- Testing
- Pencil Beam scanning Radiation, 5-fluorouracil, Mitomycin-C
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Orthopedic Disorders, Injury of Anterior Cruciate Ligament
Injection Pressure & Adductor Canal Block
This is a prospective, randomized, single-blinded human clinical trial that will examine how injection pressure influences the spread of a given volume of injectate in the adductor canal, during adductor canal nerve block.
- Trial name
- NCT02563990
- Testing
- High Pressure Injection, Low Pressure Injection
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Miami
Squamous Cell Carcinoma of Anal Canal
A Study of INCMGA00012 in Squamous Carcinoma of the Anal Canal Following Platinum-Based Chemotherapy (POD1UM-202)
The purpose of this study is to assess the efficacy of INCMGA00012 in participants with locally advanced or metastatic squamous carcinoma of the anal canal (SCAC) who have progressed after platinum-based chemotherapy.
- Trial name
- NCT03597295
- Testing
- Retifanlimab
- Where
- 46 sites in United States, Belgium and 7 more
- Volunteers
- 94 people
- Sponsor
- Incyte Corporation
Anterior Cruciate Ligament Injury
A Novel Analgesia Technique for ACL Reconstruction
A comparison of two anesthetic techniques-- the Adductor Canal Block (ACB) and the Adductor Canal Block with Infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (ACB/IPACK)-- in…
- Trial name
- NCT03292926
- Testing
- Bupivacaine, Ultrasound, Dexamethasone
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Hospital for Special Surgery, New York
Post-operative Pain, Quadriceps Muscle Strength
Ultrasound Guided Adductor Canal Versus Femoral Nerve Blocks for Anterior Cruciate Ligament Reconstruction in Pediatrics
Both Ultrasound guided Adductor Canal Block ( ACB) and Femoral Nerve Block (FNB) has been used to provide postoperative analgesia for knee surgeries.
- Trial name
- NCT03053401
- Testing
- Adductor Canal Block, Femoral Nerve Block, Ultrasound
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Akron Children's Hospital
Pain Management
Can Single-Injection Adductor Canal Blocks Improve PostOp Pain Relief in Patients Undergoing Total Knee Arthroplasty?
The purpose of the study is to determine the effect of a single injection adductor canal block (ACB) on pain scores within 24 hours post total knee arthroplasty (TKA).
- Trial name
- NCT02276495
- Testing
- ACB Control - 20 ml saline injection for ACB, ACB Study - 20 ml 0.5% Ropivacaine for Adductor Canal Block, Local infiltration - 100 mLs of a solution containing: Ropivacaine + Epinephrine + Ketorolac + Clonidine + 0.9% Normal saline
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, Irvine
Symptomatic Irreversible Pulpitis, Apical Periodontitis
Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator
Patients with painful molars will be randomly assigned to 2 different groups: GentleWave and EndoActivator. The root canals will be completed using identical protocols except in the mode of delivery and activation of irrigation…
- Trial name
- NCT04552132
- Testing
- Multisonic vs Sonic activation of irrigants
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- St. Louis University
ACL Surgery
Optimal Location of Nerve Block to Minimize Perioperative Opioid Administration in ACL Surgery: Comparing True Adductor Canal to Proximal Block
This is a prospective, randomized, single blinded trial involving human subjects. The goal of this study is to determine an optimal location (proximal or distal) for the nerve block and whether it will make a difference in how…
- Trial name
- NCT03401450
- Testing
- ACB within true AC with bupivacaine 0.5% 20cc, ACB proximal to true AC with bupivacaine 0.5% 20cc
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- NYU Langone Health