Clinical trials: Root Canal Therapy
Pain, Postoperative, Root Canal Infection
Effectiveness of GentleWave System in Endodontic Treatment
This study aims to evaluate the efficacy of the GentleWave® System compared to conventional methods in reducing postoperative pain in patients with necrotic pulp or requiring endodontic retreatment.
- Conditions
- Pain, Postoperative, Root Canal Infection, Endodontically Treated Teeth
- Trial name
- NCT06518304
- Testing
- GentleWave, Conventional Protocol
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Pain, Postoperative Pain Pathologic Processes Postoperative Complications Signs and Symptoms
Comparative Evaluation of Post Endodontic Pain Following Root Canal Treatment With Two Rotary System: Neolix & Waveone
Today, dentists tend to use rotary systems. Despite the increasing diversity of these systems as well as a few studies on the prevalence of pain after root canal treatment by rotary systems, And in particular, comparing the…
- Trial name
- NCT02768311
- Testing
- neolix rotary system (continuous rotation system), waveone rotary system (reciprocating system), hand files k-files
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Zahedan University of Medical Sciences
Stage IV Esophageal Adenocarcinoma, Stage IV Esophageal Squamous Cell Carcinoma
Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers
This phase II trial studies how well radiation therapy works for the treatment of gastrointestinal cancer that are spreading to other places in the body (metastatic).
- Conditions
- Stage IV Esophageal Adenocarcinoma, Stage IV Esophageal Squamous Cell Carcinoma, Stage IV Gastric Cancer, Stage IV Adenocarcinoma of the Gastroesophageal Junction
- Trial name
- NCT04221893
- Testing
- Radiation Therapy (RT)
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Francisco
Tarlov Cysts
Case Report of Nerve Root Sleeve Reinforcement and Reconstruction and Sacral Canal Plasty for the Treatment of Sacral Canal
A retrospective study of the changes in the VAS scores and imaging examinations after the reconstruction and reinforcement of nerve root sleeves and caudal angioplasty for the treatment of sacral cysts from August 2017 to January…
- Trial name
- NCT04960462
- Testing
- nerve root sleeve reinforcement
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking University Third Hospital
Periradicular Disease
Comparing the Antibacterial Effect of 810 nm Diode Laser and Photodynamic Therapy
The aim of this study was to compare the Antibacterial Efficacy of Diode Laser 810nm and Photodynamic therapy in reducing bacterial microflora in endodontic retreatment of teeth with periradicular lesion.
- Trial name
- NCT02555488
- Testing
- diode laser, Methylene blue
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Teeth With Root Canal Treatment
Post-endodontic Access Cavity Cleaning Techniques
Aim This study aims to evaluate the effectiveness of different post-endodontic access cavity cleaning techniques (PACCTs) in removing residual epoxy resin-based root canal sealer from the pulp chamber floor following root canal…
- Trial name
- NCT06937424
- Testing
- Dry cotton pellet group, Ethanol-saturated cotton pellet 7 seconds group, Ethanol-saturated cotton pellet visibly clean group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Marmara University
Acute Pulpitis
The Effect of Premedication With Curcumin on Post-endodontic Pain
Will premedication with Curcumin in single endodontic treatment in patients having acute pulpitis in mandibular molars affect post- operative pain? This the present study hopes to bring an evidence based decision on the…
- Trial name
- NCT04012424
- Testing
- curcumin group:Curcumin is an ancient coloring spice . Interestingly, it has various pharmacological activities including analgesic, anti-inf, 400mg starch
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Necrosis
Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar
This randomized clinical study evaluates the antibacterial effectiveness and postoperative pain following root canal irrigation using the Triton irrigation protocol in necrotic mandibular molars.
- Trial name
- NCT07435883
- Testing
- triton irrigation protocol, conventional irrigation group
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- sara hosny mostafa
Apical Periodontitis, Postoperative Pain
Effect of Diode Laser on Post-operative Pain After Endodontic Treatment in Teeth With Apical Periodontitis
Aim: This study aims to assess the effect of root canal disinfection with a 980 µm diode laser following chemomechanical root canal preparation on the severity of pain after root canal treatment (RCT).
- Trial name
- NCT04486196
- Testing
- Medency Primo Diode Laser Device (Medency, Vicenza, Italy), 2.5% NaOCl, %17 EDTA, Distilled water, 30-gauge, side-opening needle (Canal Clean, Biodent, South Korea),
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biruni University
Irreversible Pulpitis, Root Canal Treatment
Simultaneous Working Length Detection Methods
Precise knowledge of the apical construction, which determines the end of the area for canal preparation and filling, is essential for the success of root canal treatment and the management of postoperative pain.
- Trial name
- NCT06507982
- Testing
- EWL, SWL, RWL
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Postoperative Pain
Postoperative Pain After the Use of Different Root Canal Sealers
This study evaluated the postoperative pain after the endodontic treatment using AH Plus, Endoseal MTA and EndoSequence BC sealers in root canal obturation.
- Trial name
- NCT03919318
- Testing
- Root Canal Filling Sealers
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- TC Erciyes University
Dental Pulp Necrosis, Pulpitis
Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols
Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure…
- Trial name
- NCT07546773
- Testing
- Ultrasonic Irrigation Activation, Laser-Activated Irrigation, Mechanical Irrigation Activation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Suez Canal University
Hypoplastic Left Heart Syndrome, Atrioventricular Canal
Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle
Patients under the age of 5, with a diagnosis of hypoplastic left heart syndrome (HLHS), unbalanced atrioventricular canal (uAVC), or borderline left heart who are undergoing staged LV recruitment following bidirectional Glenn…
- Trial name
- NCT03079401
- Testing
- MPC; rexlemestrocel-L
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Boston Children's Hospital
Diabetes Mellitus, Postoperative Pain After Endodontic Treatment
Postoperative Pain After Single vs Multiple-Visit Root Canal Treatment in Diabetic Patients
A short description of the clinical study, including a brief statement of the clinical study's hypothesis, written in language intended for the lay public.
- Trial name
- RCT-DM-Pain (NCT07271511)
- Testing
- Single-Visit Root Canal Therapy, Multiple-Visit Root Canal Therapy
- Volunteers
- 200 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Cancer of the Cervix, Vulvar Cancer
Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
This study expands on protocol (NCT01908504"PET adaptive RT") designed to evaluate the utility of adaptive PET-CT planning for radiation therapy (RT).
- Conditions
- Cancer of the Cervix, Vulvar Cancer, Esophageal Cancer, Anal Canal Cancer
- Trial name
- NCT03403465
- Testing
- FDG PET scan
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Asymptomatic Vital Mandibular Molar Teeth
The Effect of Two Different Root Canal Sealers on Postobturation Pain and Clinical and Radiographical Outcome After Two-year Follow-up
Post-obturation pain evaluation(Part 1): One hundred asymptomatic mandibular molar teeth with vital pulp were randomly assigned into two groups according to the sealer used MTA Fillapex (Angelus Odontologica Industries SA…
- Trial name
- NCT05266599
- Testing
- MTA Fillapex root canal sealer, AH Plus root canal sealer
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ege University
Post Operative Pain, Root Canal Therapy
Effect of Sonic Activation of Irrigant on Post Operative Pain After Root Canal Treatment
Fifty-eight patients aged 18-60 years, diagnosed with symptomatic or asymptomatic apical periodontitis will be randomly allocated into two groups: Group A (EndoActivator) and Group B (conventional syringe irrigation).
- Trial name
- NCT07062419
- Testing
- endoactivator
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry
Obstructive Sleep Apnea, Postoperative Pain
Effect of Sleep Apnea on Pain After Dental Treatment
This observational study aims to investigate the effects of sleep quality and systemic health status on pain levels following endodontic treatment in adult patients.
- Conditions
- Obstructive Sleep Apnea, Postoperative Pain, Hypertension Complicated With Type 2 Diabetes
- Trial name
- OSA-EndoPain (NCT07581964)
- Testing
- Standard Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Harran University
Pulp Necrosis
This Study Compares Two Different Ways of Cleaning and Shaping Root Canals During Root-canal Treatment: the Step-down Technique and the Step-back Technique. Iu Want to Find Out Which Method Causes Less Pain After the Procedure. Patients Will be Randomly Placed Into One of the Two Groups, Treated Wit
This randomized clinical trial aims to compare the step-back and step-down root canal preparation techniques in patients with pulp necrosis. The study will evaluate which technique results in less postoperative pain.
- Trial name
- NCT07290192
- Testing
- Step down technique
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi
Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma
Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer
This phase III trial investigates how well nivolumab after combined modality therapy works in treating patients with high risk stage II-IIIB anal cancer.
- Conditions
- Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma, Anal Margin Squamous Cell Carcinoma, Stage IIB Anal Cancer AJCC v8
- Trial name
- NCT03233711
- Testing
- Biopsy Procedure, Biospecimen Collection, Colonoscopy
- Where
- 896 sites in United States, Canada
- Volunteers
- 344 people
- Sponsor
- National Cancer Institute (NCI)