Clinical trials: Roux-en-Y
Bariatric Surgery
Incretin Hormone Antagonism After Bariatric Surgery
Using the glucagon-like peptide-1 (GLP-1) antagonist exendin(9-39) and the glucose-dependent insulinotropic peptide (GIP) antagonist GIP(3-30), the purpose of this study is to clarify the importance of endogenous GLP-1 and GIP…
- Trial name
- INCA-BAR (NCT03950245)
- Testing
- GLP-1 antagonism, GIP antagonism, GLP-1 and GIP antagonism
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Atrial Fibrillation, Obesity and Obesity-related Medical Conditions
Metabolic Surgery for Atrial Fibrillation Elimination
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is estimated that between 3 and 6 million Americans are currently living with AF, while 12 million people in the United States will have AF in 2030.
- Trial name
- METSAFE (NCT07027969)
- Testing
- Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ali Aminian
Bariatric Surgery, Alcohol Consumption
Effect of Moderate Alcohol Consumption to Cognitive Functioning After Roux-en Y Gastric Bypass
Objectives: Alcohol metabolism is changed in gastric bypass patients, leading to faster resorption and higher alcohol peak concentrations in blood.
- Conditions
- Bariatric Surgery, Alcohol Consumption, Cognitive Function
- Trial name
- NCT02380950
- Testing
- 250 ml alcohol consumption
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- eSwiss Medical & Surgical Center
Type 2 Diabetes Mellitus, Obesity
Silastic Ring Gastric Bypass Versus Sleeve Gastrectomy for Type 2 Diabetes Mellitus in Obese Patients
Type 2 diabetes (T2DM) and obesity are becoming increasingly common in New Zealand (NZ) and worldwide. Both are associated with a risk of early mortality (death).
- Trial name
- NCT01486680
- Testing
- Laparoscopic Silastic Ring Roux-en-Y Gastric Bypass, Laparoscopic Sleeve gastrectomy
- Where
- 2 sites in New Zealand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- North Shore Hospital, New Zealand
Bariatric Surgery Candidate
Video-Assisted Presentation Before Bariatric Surgery Enhanced Understanding of Informed Consent Content
This study evaluates the addition of video presentation on conventional informed consent. Participants divided two randomly, one group read only conventional informed consent, the other video presentation was watched after…
- Trial name
- NCT03653962
- Testing
- video assisted group, non-video group
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Inonu University
Hypoglycemia
Mechanisms of Post-Bariatric Hypoglycemia
Post-bariatric hypoglycemia (PBH) is an increasingly recognized syndrome that is incompletely understood. The purpose of this study is to increase our level of understanding by investigating mechanisms contributing to this…
- Trial name
- NCT04428866
- Testing
- Continuous Glucose Monitoring, activity monitor, Mixed meal tolerance test
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Meal, Obesity, Morbid
Microstructural Analysis of Ingestive Behavior After Roux-en-Y Gastric Bypass - Pilot
The ability to assess ingestion in fine detail over the time course of a liquid meal allows for comparison of early and late meal features of drinking and may help dissociate manipulations (surgical, neural, pharmacological…
- Conditions
- Meal, Obesity, Morbid, Food Deprivation, Bariatric Surgery
- Trial name
- NCT03747445
- Testing
- Roux-en-Y gastric bypass
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marco Bueter
Obesity
Exendin-9,39 and Satiety After Bariatric Surgery
The overall aim of the application is to determine the contribution of the elevated incretin hormone concentrations seen after certain types of bariatric surgery to the regulation of food intake and satiety.
- Trial name
- NCT02779075
- Testing
- Saline, Exendin-9,39
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Anastomotic Stricture, Morbid Obesity
Study of Proton Pump Inhibitors (PPI) to Prevent Strictures After Gastric Bypass Surgery
The purpose of this study is to determine whether suppressing acid production by administration of daily proton pump inhibitors in the early post-operative period will reduce the gastrojejunal anastomosis stricture rate in…
- Trial name
- NCT00361985
- Testing
- Esomeprazole
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Obesity, Vitamin D Deficiency
Efficacy of Vitamin D Supplementation in Bariatric Surgery Patients
As the use of bariatric surgery for treatment of extreme obesity adults continues to rise, clinicians must be aware of pre-existing nutritional deficiencies in overweight and obese patients.
- Trial name
- NCT01385098
- Testing
- Vitamin D3 and Calcium
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Vadim Sherman, MD
Bariatric Surgery (Gastric Bypass)
Can Postprandial Reactive Hypoglycaemia be Reduced in Patients After Roux-en-Y Gastric Bypass With a Low Carbohydrate Diet?
Roux-en-Y gastric bypass (RYGB) accelerates nutrient delivery to the small intestine causing higher peak blood glucose concentration early after meal intake.
- Trial name
- NCT02665715
- Testing
- Low carbohydrate meals, Standard carbohydrate meals
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Amirsalar Samkani
Type 2 Diabetes, Obesity
The Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity in Type 2 Diabetes
Gastric bypass surgery induces remission of diabetes within days after surgery, before significant weight loss. The aim of the study is to examine whether improved insulin sensitivity of muscle and liver contributes to the…
- Trial name
- NCT01202526
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity, Morbid
Effect of Biliopancreatic Diversion on Glucose Homeostasis
Biliopancreatic diversion (BPD) surgery results in greater resolution of type 2 diabetes than all other bariatric surgical procedures, and it is hypothesized that this procedure has specific beneficial effects on glucose…
- Trial name
- BPD-Mingrone (NCT03111953)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Biliopancreatic Diversion Surgery
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Roux En Y Gastric Bypass
Safety and Efficacy Study of Duet TRS
The objectives of this clinical trial are the overall performance and safety of the ENDO GIA Staplers with ENDO GIA SULUs with Duet TRS TM.
- Trial name
- NCT00950872
- Testing
- Duet TRS
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Bariatric Surgery Candidate, Pain, Postoperative
The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery
This study is prospective, randomized trial in which the efficacy of liposomal bupivacaine (Exparel®) is compared to standard bupivacaine local surgical site injection in reducing total IV and oral morphine equivalents required…
- Trial name
- Exparel (NCT03196505)
- Testing
- Exparel 266 MG Per 20 ML Injection, Bupivacaine
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity
Endostapler Gastric Bypass Study
The goal of this prospective, post-market study is to evaluate safety and efficacy of the AEON™ Endostapler when used in laparoscopic Roux-en-Y gastric bypass surgery.
- Trial name
- NCT04712526
- Testing
- AEON Endostapler
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lexington Medical Inc.
Bariatric Surgery Candidate
Change in Reward System Activation and Gut Microbiota Following RYGB and Sleeve Gastrectomy for Weight Loss vs. Control-Heads Up Ancillary
Bariatric surgery is considered an effective long-term intervention for the treatment of obesity and associated complications. While bariatric surgery has been shown to result in a large sustained weight loss, the degree of…
- Trial name
- NCT02735564
- Testing
- Bariatric Surgery
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center