Clinical trials: Roux-en-Y
Gastric Bypass
Mechanistic Investigation Of Intestinal Cytochrome p450 3A4 Following Roux-en-Y Surgery And Its Effect on Plasma Concentrations of Buspirone
This study is to compare intestinal Cytochrome P450 3A4 (CYP3A4) activity in 9-18 month post weight loss surgery Roux-en-Y Gastric Bypass (RYGB) versus control subjects who have not had a weight loss surgery and are of similar…
- Trial name
- NCT02483598
- Testing
- Buspirone, Buspirone and Grapefruit Juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Obesity, Morbid, Weight Gain
DIStal gastriC Bypass OUtcome in Revision SurgEry After Roux-en-y Gastric Bypass
This study is designed as a prospective multicenter randomized controlled clinical trial comparing two surgical techniques of distal gastric bypass (DGB) in revisional surgery following failed Roux-en-Y gastric bypass.
- Trial name
- DISCOURSE (NCT04894838)
- Testing
- Distal gastric bypass
- Where
- 8 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Bariatric Surgery Candidate
Pilot Study for Zoledronic Acid to Prevent Bone Loss After Bariatric Surgery
This study evaluates whether zoledronic acid can prevent the high bone turnover that occurs after Roux-en-Y Gastric Bypass (RYGB) and sleeve gastrectomy (SG) surgery.
- Trial name
- NCT03424239
- Testing
- Zoledronic Acid, Calcium citrate + vitamin D, Vitamin D3
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Hemorrhage, Bleeding
Peroperative Administration of Tranexamic Acid in Roux-en-Y Gastric Bypass and One-anastomosis Gastric Bypass
The incidence of bleeding after metabolic surgery seems to increase. The administration of a drug (tranexamic acid) that can reduce bleeding could possibly also reduce bleeding after metabolic surgery.
- Trial name
- PATRY (NCT05464394)
- Testing
- Tranexamic Acid Injection [Cyklokapron], Sodium chloride 0.9%
- Volunteers
- 1,524 people
- Sponsor
- Franciscus Gasthuis
Obesity, Bariatric Surgery
Does Participation in a Pre-Operative Physical Activity Program Improve Patient Outcomes and Quality of Life?
The primary objective of the study is to determine whether participation in a pre-bariatric surgery physical activity and behavior modification/education program (ENCOURAGEING START) that is tailored to the unique needs of obese…
- Conditions
- Obesity, Bariatric Surgery, Roux-En-Y Gastric Bypass, Exercise
- Trial name
- NCT03049696
- Testing
- ENCOURAGEING START
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
Obesity, Type 2 Diabetes
Weight Loss-Independent Metabolic Effects of Roux-En-Y Gastric Bypass in Diabetes
For this purpose, we will compare the effects of targeted 16-18% (with a range of 16-25%) weight loss induced by Roux-en-Y Gastric bypass (RYGB) surgery with the same weight loss induced by a low-calorie diet (LCD) on liver and…
- Trial name
- RBD-T2D (NCT02207777)
- Testing
- Roux-en-Y gastric bypass surgery, Low-calorie diet
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Washington University School of Medicine
NASH - Nonalcoholic Steatohepatitis, Bariatric Surgery Candidate
Gut Permeability and Bariatric-metabolic Surgery
Increased intestinal permeability and dysbiosis have been causally associated with NAFLD and NASH progression. However, to date, there are no systematic studies, on the effect of bariatric-metabolic surgery on intestinal…
- Conditions
- NASH - Nonalcoholic Steatohepatitis, Bariatric Surgery Candidate, Intestinal Permeability
- Trial name
- NCT05257200
- Where
- Austria
- Volunteers
- 125 people
- Sponsor
- Medical University of Vienna
Obesity
Binge Eating, Depression and Anxiety Outcomes After Sleeve Gastrectomy Versus Gastric Bypass: A Cohort Study
The goal of this clinical trial is to learn if the type of weight-loss surgery (sleeve gastrectomy or gastric bypass) affects binge eating, depression, and anxiety in adults with severe obesity.
- Trial name
- NCT07600411
- Testing
- Laparoscopic Sleeve Gastrectomy, Gastric Bypass
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Stomach Neoplasms
Laparoscopic Proximal Gastrectomy With Double-flap Technique Versus Laparoscopic Total Gastrectomy With Roux-en-Y Reconstruction for Proximal Early Gastric Cancer
Proximal early gastric cancer can choose radical total gastrectomy or proximal gastrectomy. But if use simple esophagogastric anastomosis for proximal gastrectomy, the incidence of postoperative reflux esophagitis is up to 62%…
- Trial name
- NCT05890339
- Testing
- Laparoscopic Proximal Gastrectomy With Double-flap Technique, Laparoscopic Total Gastrectomy With Roux-en-Y Reconstruction
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Contraception
Pharmacokinetics of Drospirenone Only Pills: A Pre- and Post-Bariatric Surgery Study
The purpose of this study is to investigate whether bariatric surgery affects Drospirenone only pills absorption
- Trial name
- NCT06345560
- Testing
- Drospirenone
- Where
- Thailand
- Volunteers
- 16 people
- Sponsor
- Chulalongkorn University
Obesity
Changes in Body Composition Following Bariatric Surgery
Obesity is an important public health issue worldwide. In the United States, the percentage of overweight and obese adults increased from 47 and 15%, respectively, to 69 and 36% in the last 40 years.
- Trial name
- NCT02148068
- Testing
- Bariatric Surgery
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Peter Nau
Post Bariatric Hypoglycemia
Avexitide for Treatment of Post-Bariatric Hypoglycemia
AVX-001 (LUCIDITY) is a Phase 3 study to evaluate avexitide compared to placebo in participants with post bariatric hypoglycemia (PBH) related to Roux-en-Y gastric bypass (RYGB).
- Trial name
- LUCIDITY (NCT06747468)
- Testing
- Avexitide
- Where
- 21 sites in United States
- Volunteers
- 75 people
- Sponsor
- Amylyx Pharmaceuticals Inc.
Obesity, Severe, Diabetes Mellitus, Type 2
Roux-en-Y Gastric Bypass (RYGB) Versus Omega-Loop Gastric Bypass (OLGB) Safety and Efficacy Short-term Study
The aim of this study is to compare the relative clinical outcomes between two variants of gastric bypass [Roux-en-Y Gastric Bypass (RYGB) or Omega-Loop Gastric Bypass (OLGB)] in metabolic surgery candidates with Body Mass Index…
- Trial name
- ROSESS (NCT02290418)
- Testing
- Roux-en-Y Gastric Bypass, Omega-Loop Gastric Bypass
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Nemocnice Břeclav, p.o.
Small Intestine Length Measurement
Digital 3D Reconstruction Predicts Small Bowel Length
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing annually worldwide, and the prevalence of diabetes has reached 11.6% in China.
- Trial name
- DTDRPSBL-BS (NCT05338567)
- Testing
- Small intestine length measurement method
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Gastric Cancer, Stomach Cancer
A Study Comparing Billroth II With Roux-en-Y Reconstruction for Gastric Cancer
Both Billroth II and Roux en Y are acceptable techniques of reconstruction after subtotal gastrectomy, however the debate one which is better remains unanswered.
- Conditions
- Gastric Cancer, Stomach Cancer, Gastrectomy
- Trial name
- SCAR (NCT01257711)
- Testing
- Roux-en-Y or Billroth II
- Where
- 4 sites in Hong Kong, Singapore
- Volunteers
- 96 people
- Sponsor
- National Healthcare Group, Singapore
Obesity
Phenotypical Approach of the Drug Metabolizing Hormones Activity Before and After Roux-en Y-Gastric Bypass
The activity of drug-metabolizing enzymes and transporters evolutes after Roux-en-Y gastric Bypass. Primary aim : To study the intra individual evolution of phenotypical markers of different drug metabolizing enzymes and one…
- Trial name
- SODA (NCT01443039)
- Testing
- phenotypical approach
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Morbid Obesity
Levothyroxine (L-T4) Absorption After Bariatric Surgery
Intestinal absorption of levothyroxine (LT4) tablets depends on its dissolution in gastric acid secretion, which is reduced after bariatric interventions.
- Trial name
- RYS (NCT01189344)
- Testing
- Levothyroxine
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Obesity, Protein-energy; Imbalance
Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity
The purpose of the study is to determine the effect of three weight loss surgeries compared to a low calorie diet with regard to energy expenditure, body composition, insulin sensitivity, and the response of gastrointestinal…
- Conditions
- Obesity, Protein-energy; Imbalance, Insulin Sensitivity, Gastrointestinal Complication
- Trial name
- BARIA (NCT00936130)
- Testing
- Laparoscopic Roux-en-Y gastric bypass, Laparoscopic gastric banding, Laparoscopic sleeve gastrectomy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Pennington Biomedical Research Center
Morbid Obesity
Effect of Long Biliopancreatic Limb RYGB on Weight Loss and Comorbidities
Morbid obesity is an increasing medical problem in the western countries. It's related to comorbidities as diabetes mellitus, hypertension, OSAS, arthrosis and hypercholesterolemia.
- Trial name
- Elegance (NCT01686997)
- Testing
- Roux-en-Y Gastric Bypass
- Where
- Netherlands
- Volunteers
- 280 people
- Sponsor
- Rijnstate Hospital
Laparoscopic Sleeve Gastrectomy, Sleeve Gastrectomy
A Retrospective Multicenter Comparison of Laparoscopic and Robotic-Assisted Roux-en-Y Gastrectomy
The prevalence of obesity has tripled in the last 50 years with presently about 1.7 billion of the world population aged 18 years and over either overweight or obese.1 In the US alone, 35% of the population is obese.2 Although…
- Trial name
- NCT05224791
- Testing
- Roux-en-Y Gastric Bypass, Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Methodist Health System