Clinical trials: Roux-en-Y
Morbid Obesity, Postoperative Complications
Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic One Anastomosis Gastric Bypass
This study try to identify differences in cost, length of operation and results between two different bariatric surgical techniques, the laparoscopic Roux-en-Y gastric bypass and the Single anastomosis laparoscopic gastric…
- Conditions
- Morbid Obesity, Postoperative Complications, Weight Loss
- Trial name
- OAGB-vs-LRYGB (NCT02779322)
- Testing
- Minigastric bypass, Gastric bypass
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Puerta de Hierro University Hospital
Obesity, Morbid, Anastomosis
Regain Rate According to gj Anastomosis Size in Gastric Bypass
Obesity has become an important medical and social problem in western countries today. Roux-en-Y gastric bypass (LRYGB) is the most commonly performed surgery for the treatment of morbid obesity in the United States.
- Conditions
- Obesity, Morbid, Anastomosis, Roux-en-y Anastomosis Site
- Trial name
- NCT05655975
- Testing
- upper gi endoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Acid Reflux Esophagitis, Non-acid Reflux Esophagitis
Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy
Somatostatine induces a dose-dependent reduction of postprandial plasma cholecystokinin (CCK) secretion with a concomitant inhibition of postprandial gallbladder contraction, abolishing almost completely bile salts output from…
- Trial name
- NCT02054637
- Testing
- Lanreotide
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Obesity, Morbid
Effect of Biliopancreatic Diversion on Glucose Homeostasis
Biliopancreatic diversion (BPD) surgery results in greater resolution of type 2 diabetes than all other bariatric surgical procedures, and it is hypothesized that this procedure has specific beneficial effects on glucose…
- Trial name
- BPD-Mingrone (NCT03111953)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Biliopancreatic Diversion Surgery
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Contraception
Drospirenone Only Pills and Cervical Mucus Changes: A Pre- and Post-Bariatric Surgery Study
The purpose of this study is to study the effect of Drospirenone on cervical mucus change by modified Insler score, pre-bariatric surgery and post-bariatric surgery
- Trial name
- NCT06345586
- Testing
- Drospirenone
- Where
- Thailand
- Volunteers
- 16 people
- Sponsor
- Chulalongkorn University
Bariatric Surgery Candidate, Protein Deficiency
Effect of Protein Supplementation on Fat Free Mass Preservation After Bariatric Surgery
This double blind randomized placebo controlled trial investigates the effect of protein supplementation on fat free mass loss in patients who underwent a Roux-en-Y gastric bypass.
- Conditions
- Bariatric Surgery Candidate, Protein Deficiency, Muscle Loss
- Trial name
- PROMISE (NCT05570474)
- Testing
- Protein drink supplementation
- Where
- Netherlands
- Volunteers
- 266 people
- Sponsor
- Maasstad Hospital
Complications of Diabetes Mellitus
Clinical Study on Metabolic Surgery Compared to the Best Clinical Treatment in Patients With Type 2 Diabetes Mellitus
This is a prospective, open, randomized study involving 100 patients with microvascular complications of type 2 diabetes mellitus and obesity, who will undergo gastric bypass (Roux-en-Y gastric bypass ARM A) or receive best…
- Trial name
- MOMS (NCT01821508)
- Testing
- Clinical Treatment, Roux-En-Y gastric bypass surgery
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Alemão Oswaldo Cruz
Type 2 Diabetes, Obesity
The Effect of Roux-en-Y Gastric Bypass on Mitochondrial Function in Type 2 Diabetes
Roux-en-Y gastric bypass (RYGB) surgery induces resolution of type 2 diabetes, often within days after surgery and before significant weight loss.
- Trial name
- NCT01468116
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity
5 and 7-year Follow-up of the YOMEGA Trial Cohort
Over the last 40 years, the Roux-en-Y Gastric Bypass (RYGB) has been the gold standard in the surgical management of morbid obesity. and is a validated bariatric procedure in France.
- Trial name
- YOMEGA 5-7y (NCT05549271)
- Testing
- Laparoscopic Mini-gastric bypass, Laparoscopic Roux-en-Y Gastric ByPass (RYGBP)
- Where
- 9 sites in France
- Volunteers
- 248 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Morbid, Gastroesophageal Reflux (GERD)
AJYR+GV vs RYGB for GERD
This study focuses on gastroesophageal reflux disease (GERD), a condition in which stomach acid flows back into the esophagus (the tube that carries food from the mouth to the stomach), causing heartburn and other symptoms.
- Trial name
- NCT07768202
- Testing
- sleeve gastrectomy with Roux-en-Y antrojejunal anastomosis, AJYR+SG, Roux-en-Y gastric bypass, RYGB
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Victor Dib Institute
Revisional Bariatric Surgery
Comparing Revisional Laparoscopic Roux-en-Y Gastric Bypass Versus Ringed Revisional Roux-en-Y Gastric Bypass After Laparoscopic Sleeve Gastrectomy
Obesity remains a major global health challenge, with rising prevalence and significant metabolic, cardiovascular, and gastrointestinal comorbidities.
- Trial name
- NCT07436013
- Testing
- Standard revisional RYGB, Revisional Banded RYGB
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Morbid Obesity
Clinical and Economic Outcomes in Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass Surgery
Study objectives: 1. generate local clinical, health-related quality-of-life and health economic data to evaluate the benefits of two types of minimally invasive weight-loss surgery 2.
- Trial name
- OPTIMIZE (NCT01754194)
- Testing
- Gastric Sleeve Resection, Roux-en-Y Gastric Bypass
- Where
- 18 sites in Germany
- Volunteers
- 293 people
- Sponsor
- Medtronic - MITG
Obesity, Morbid
Outpatient Bariatric Surgery
This study first presents the organizational path and the health interventions included in the care episode for outpatient bariatric surgery, as compared to the health interventions usually performed in the care episode for…
- Trial name
- Bariatric Ambu (NCT04423575)
- Testing
- Outpatient health care pathway
- Where
- France
- Volunteers
- 60 people
- Sponsor
- IHU Strasbourg
Laparoscopic-Roux-en-Y Gastric Bypass, Obesity
Gastric Bypass With Different Lengths of the Bilipancreatic Limb
Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) has been the most performed bariatric surgical intervention until a few years ago, due to its good results in terms of weight loss and remission of comorbidities such as hypertension…
- Conditions
- Laparoscopic-Roux-en-Y Gastric Bypass, Obesity, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- BPG-1 (NCT05334173)
- Testing
- Roux-en-Y Gastric Bypass (RYGB) measuring the lengh of the common limb
- Where
- 3 sites in Spain
- Volunteers
- 94 people
- Sponsor
- Hospital Universitario de Fuenlabrada
Roux-en-y Anastomosis Site, Marginal Ulcer
Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment
The objective of the study is to investigate the treatment of marginal ulcers with Low Thermal plasma in an endoscopic setting. By a treatment of the ulcerated areas with argon plasma with low power settings (~ 1 W) we…
- Conditions
- Roux-en-y Anastomosis Site, Marginal Ulcer, Marginal Ulcer (Peptic) or Erosion, Ulcer
- Trial name
- AMULET (NCT06543316)
- Testing
- Low Thermal Plasma (LTP) Treatment, Standard of Care Ulcer Treatment (typically PPI Administration)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Type II Diabetes Mellitus, Obesity
Metabolomics of Roux-en-Y Gastric Bypass (RYGB) With Gastrostomy
This study is an investigation of the "metabolomics of RYGB with gastrostomy."
- Trial name
- NCT00887302
- Testing
- Gastric Band, Gastric Sleeve, Gastrostomy Tube
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- East Carolina University
Pancreatic Cancer
Benefit of Roux-en-Y (R-Y) Reconstruction After Pancreaticoduodenectomy
One of the most common complications of pancreaticoduodenectomy (PD) is delayed gastric emptying (DGE), otherwise known as "gastroparesis," which is not fatal but results in prolonged hospital stay and increased hospital costs.
- Trial name
- NCT00906802
- Testing
- R-Y reconstruction
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Kochi University
Obesity, Metabolic Syndrome
The Predictive Role of Preoperative Pentraxin-3 (PTX3) in Metabolic and Inflammatory Outcomes After Roux-en-Y Gastric Bypass
This study evaluated the prognostic value of preoperative pentraxin-3 (PTX3) levels in predicting weight loss, inflammatory resolution (CRP, IL-6), and metabolic improvements (HOMA-IR) following Roux-en-Y gastric bypass in…
- Conditions
- Obesity, Metabolic Syndrome, Insulin Resistance, Inflammation
- Trial name
- PTX3-BYPASS (NCT07241741)
- Testing
- Biomarker Stratification by PTX3
- Volunteers
- 23 people
- Sponsor
- Istanbul University
Roux en Y Gastric Bypass
A Comparison of Sustained and Extended Release Bupropion Following Bariatric Surgery
This study is being conducted to evaluate how the body absorbs and processes the sustained release (SR) and extended release (XL) medication bupropion (Wellbutrin®).
- Trial name
- NCT02173886
- Testing
- Bupropion SR and XL
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Choledocholithiasis, Bile Duct Neoplasms
Mechanistic Loop Resolution Strategy for Short-type Single Balloon Enteroscopy
Endoscopic retrograde cholangiopancreatography (ERCP) is the current standard technique for the treatment of pancreatobiliary disease. However, ERCP in patients with a surgically altered anatomy (SAA) remains a challenge.
- Conditions
- Choledocholithiasis, Bile Duct Neoplasms, Biliary Tract Diseases, Roux-en-Y Anastomosis
- Trial name
- NCT04847167
- Testing
- Single balloon enteroscopy assisted ERCP using a mechanistic loop resolution strategy group
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Ajou University School of Medicine