Clinical trials: Roux-en-Y
Obesity, Bypass Complications
Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Mini Gastric Bypass
Several retrospective studies have shown same efficiency in regard to weight loss, with a lower rate of complications for the laparoscopic mini gastric bypass (LMGB) compared to Roux-en-Y gastric bypass (LRYGB).
- Trial name
- MGB (NCT02601092)
- Testing
- Mini Gastric Bypass, Roux-en-Y Gastric Bypass
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Spital Limmattal Schlieren
Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis
Metabolic Flux Analysis in Metabolic Dysfunction-Associated Steatotic Liver Disease
This prospective, single-center pilot study will evaluate metabolic flux dysregulation in adults with obesity and suspected or confirmed metabolic dysfunction-associated steatotic liver disease (MASLD) who are scheduled for…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis, Obesity, Bariatric Surgery
- Trial name
- MASLD (NCT07760909)
- Testing
- Bariatric surgery, Stable isotope tracer infusion, MRI/MRE
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Morbid, Weight Regain After Bariatric Surgery
Weight Loss and Comorbidity Outcomes After Revisional Bariatric Surgery
Some people who have had weight-loss (bariatric) surgery do not lose enough weight, regain much of the weight they lost, see obesity-related diseases such as diabetes or high blood pressure return, or develop complications of the…
- Conditions
- Obesity, Morbid, Weight Regain After Bariatric Surgery, Insufficient Weight Loss After Bariatric Surgery, Complication of Bariatric Surgery
- Trial name
- NCT07880691
- Testing
- Revisional bariatric surgery
- Volunteers
- 96 people
- Sponsor
- Kasr El Aini Hospital
Obesity, Morbid
Glycemic Variability After SASI Versus Roux-en-Y Gastric Bypass
The GLUBARI trial is a prospective, randomized, single-center clinical study comparing two bariatric surgical procedures in adults with morbid obesity: Single Anastomosis Sleeve Ileal Bypass (SASI) and Roux-en-Y Gastric Bypass…
- Trial name
- GLUBARI (NCT07872397)
- Testing
- Single Anastomosis Sleeve Ileal Bypass, Roux-en-Y Gastric Bypass
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Morbid Obesity
A Longitudinal Study on Short-term Effects of Gastric Bypass on Glucose Homeostasis in Obesity
The purpose of this study is to quantify the relative contribution of improved insulin sensitivity and improved insulin secretion to the glycaemic effect of bariatric surgery.
- Trial name
- NCT01063127
- Testing
- Study on insulin sensitivity after diet or bariatric surgery, gastric bypass
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Catholic University of the Sacred Heart
Obesity, Morbid
Single-anastomosis Duodeno Ileal Bypass (SADI) Versus Roux-en-Y Gastric Bypass
Obesity is a major public health problem worldwide. Bariatric surgery has proved to be the most effective treatment of morbid obesity in terms of weight reduction and remission of co-morbid conditions during long-term follow-up.
- Trial name
- SADISLEEVE (NCT03610256)
- Testing
- SADI-S, RYGB
- Where
- 22 sites in France
- Volunteers
- 382 people
- Sponsor
- Hospices Civils de Lyon
Bariatric Surgery Candidate
Pharmacokinetics and Pharmacodynamics of Edoxaban Before and After Bariatric Surgery
The study will be conducted at a single site in the Canada, Quebec. Participants will be recruited from the bariatric surgery clinic and will be required to be either, waiting for sleeve gastrectomy surgery (n=12, restrictive…
- Trial name
- EXPOSE (NCT06326138)
- Testing
- Edoxaban Pharmacokinetics and Pharmacodynamics
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Obesity
Effects of Gastric Bypass Surgery on Bile Acid Homeostasis
The purpose of this study is to determine whether the bile acid circulation is changed after gastric bypass surgery. Further, to account for how the changed anatomy of the gut influences how the bile acid and food is mixed in the…
- Trial name
- NCT03475849
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obese Patients, Obese Patients With Bariatric Surgery
Bariatric Surgery and Gut Microbiota Changes Over Time
The goal of this observational study is to learn how bariatric surgery affects gut bacteria and gut-related metabolic products over time in adults with obesity.
- Conditions
- Obese Patients, Obese Patients With Bariatric Surgery, Gut Microbiota, Healthy Participants
- Trial name
- RYGB-MICROGUT (NCT07381140)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Bariatric Surgery Candidate, Kidney Stone
GI Oxalate Absorption
This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week.
- Trial name
- NCT05356000
- Testing
- Special low-oxalate diet followed by all-day visit to University of Chicago research clinic
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Chicago
Morbid Obesity
Bioavailability of Paracetamol, Amoxicillin and Talinolol Before, Immediately and One Year After Gastric Bypass Operation
The purpose of this study is to evaluate pharmacokinetics of paracetamol, amoxicillin and talinolol in morbid adipose subjects before as well as shortly after and about one year after proximal Roux-en-Y Gastric Bypass (RYGB) and…
- Trial name
- NCT02514941
- Testing
- paracetamol, amoxicillin, talinolol
- Where
- 2 sites in Germany
- Volunteers
- 12 people
- Sponsor
- University Medicine Greifswald
Gastric Cancer, Distal Gastrectomy
Billroth-II Modified Versus Roux-en-Y After Distal Gastrectomy for Gastric Cancer
There are Billroth-I, Billroth-II, Billroth-II with Braun, and Roux-en-Y reconstruction after distal gastrectomy. Hypothesis: Billroth-II modified method is non-inferior to Roux-en-Y method in terms of reducing reflux esophagitis…
- Trial name
- NCT05344339
- Testing
- Distal gastrectomy
- Where
- Vietnam
- Volunteers
- 320 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Clinically Severe Obesity, Gastroesophageal Reflux Disease
Gastric Bypass After Previous Anti-reflux Surgery
The goal of this study is to describe the clinical presentation, indications, and operative treatment as well as assess the morbidity, mortality, and overall performance of revisional Roux-en-Y gastric bypass (RYGB) after either…
- Trial name
- RYGBafterARS (NCT01041105)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Obesity, Morbid, Type 2 Diabetes Mellitus
The Effects of the Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Mini Gastric Bypass on the Remission of Type II Diabetes Mellitus
It is estimated that there will be 439-552 million people with type 2 diabetes mellitus (T2DM) globally in 2030. Type 2 Diabetes Mellitus is present in one quarter of patients at the bariatric outpatient clinic.
- Trial name
- DIABAR (NCT03330756)
- Testing
- laparoscopic Roux-en-Y gastric bypass, laparoscopic Mini gastric bypass
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Slotervaart Hospital
Obesity
Exendin-9,39 and Satiety After Bariatric Surgery
The overall aim of the application is to determine the contribution of the elevated incretin hormone concentrations seen after certain types of bariatric surgery to the regulation of food intake and satiety.
- Trial name
- NCT02779075
- Testing
- Saline, Exendin-9,39
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastrectomy
Comparison of Billroth-I and Roux-en-Y Reconstruction After Distal Subtotal Gastrectomy
The purpose of this trial is to compare the degree of reflux, operative outcomes and quality of life between Roux en Y and Billroth-I reconstructions after distal subtotal gastrectomy for gastric cancer
- Trial name
- NCT01142271
- Testing
- Billroth-I, Roux en Y
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Ajou University School of Medicine
Morbid Obesity
Respiratory Quotient in Post Roux-en-Y Gastric Bypass Patients
Through the values of respiratory quotient (RQ) it is possible to estimate the utilization of energy substrates by the body, or if there is a higher or lower fat oxidation.
- Trial name
- RQ (NCT01396460)
- Testing
- breakfast (a chicken sandwich with juice)
- Where
- Brazil
- Volunteers
- 69 people
- Sponsor
- Gastrocirurgia, Brazil
Obesity, Morbid, Surgery
Sleeve Versus Bypass in Older Patients: a Randomized Controlled Trial
The aim of the study is to compare two different bariatric procedures performed in patients with 65 years or more: gastric bypass and sleeve gastrectomy.
- Conditions
- Obesity, Morbid, Surgery, Elderly
- Trial name
- BaSE (NCT03339791)
- Testing
- Sleeve Gastrectomy, Gastric Bypass
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo General Hospital
Morbid Obesity
Long-term Adverse Effects After Bariatric Surgery on Bone Density
The goal of this trial is to examine long-term effects of laparoscopic gastric bypass (LRYGB) and sleeve gastrectomy (LSG) on bone mineral density, fracture risk, and body composition ≥ 5 years post-surgery.
- Trial name
- FUB-A (NCT03410459)
- Testing
- DEXA (= Dual-energy x-ray absorptiometry)
- Where
- Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
MGB/OAGB Versus RYGB After Failed Sleeve
Sleeve Gastrectomy is the most performed bariatric procedure worldwide. But a growing number of data documents that some patients have to be surgical revised due to weight regain or gastro-esophageal reflux disease.
- Trial name
- NCT03526783
- Testing
- Roux en Y gastric bypass, Mini/One anastomosis gastric bypass
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Sana Klinikum Offenbach