Clinical trials: Roux-en-Y Anastomosis
Obesity
5 and 7-year Follow-up of the YOMEGA Trial Cohort
Over the last 40 years, the Roux-en-Y Gastric Bypass (RYGB) has been the gold standard in the surgical management of morbid obesity. and is a validated bariatric procedure in France.
- Trial name
- YOMEGA 5-7y (NCT05549271)
- Testing
- Laparoscopic Mini-gastric bypass, Laparoscopic Roux-en-Y Gastric ByPass (RYGBP)
- Where
- 9 sites in France
- Volunteers
- 248 people
- Sponsor
- Hospices Civils de Lyon
Clinically Severe Obesity, Metabolic Complications After Jejunoileal Bypass
Laparoscopic Revision of Jejunoileal Bypass to Gastric Bypass
This study objectives are the following. To describe the updated clinical presentation, indications, and multidisciplinary medical management of patients with a failed and/or complicated jejunoileal bypass (JIB).
- Conditions
- Clinically Severe Obesity, Metabolic Complications After Jejunoileal Bypass, Nutritional Complications After Jejunoileal Bypass, Obesity Recidivism
- Trial name
- JIB-to-RYGB (NCT01040533)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Francisco
Bariatric Surgery
MINI Bypass Versus Roux-en-Y Bypass: Differences in HOrmonal Secretions at 2 Years of Surgery
Gastric bypass with omega loop technic (OLGB) seems to be as effective as gastric bypass roux-en-Y (RYGB the reference) for the management of obesity and type 2 diabetes, but with less early surgical complications and more…
- Trial name
- MINIBHO (NCT03482895)
- Testing
- Blood sampling, Feces sampling
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
GERD
A Prospective Blinded Randomized Study Comparing Laparoscopic Sleeve Gastrectomy and Laparoscopic Roux-en-y Gastric Bypass and Their Effect on Gastro-Esophageal Reflux Disease Using 24 Horus pH Monitoring
Obesity has become a significant health problem in Canada. It is known to be a risk factor for many diseases, including Gastro-Esophageal Reflux Disease (GERD).
- Trial name
- GERD (NCT02142998)
- Testing
- 24 pH monitoring, Esophageal Manometry:
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Bariatric Surgery
Fat Absorption and Metabolism After Roux-en-Y Gastric Bypass
Using intravenous and oral administration of stable isotope tracers, we will investigate the importance of altered fat absorption and altered whole body fat metabolism for the reduced postprandial systemic TAG concentrations in…
- Trial name
- FAT-BAR (NCT04859816)
- Testing
- Metabolic test, DXA-scan, MRS
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity
Brain Activation in Response to Appetitive Cues Pre- and Post- Bariatric Surgery
Utilizing fMRI, this study will examine changes in BOLD signal as a proxy measure of brain activation in response to highly palatable (high energy density [kcal/g]), less palatable and non-food stimuli in severely obese women…
- Trial name
- NCT01590914
- Testing
- Fed Condition, Fasted Condition
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- New York Obesity and Nutrition Research Center
Gastric Bypass
Mini Gastric Bypass vs Roux enY Gastric Bypass
The primary aim of this research project is to assess the safety and efficacy of the MGB operation in the UK
- Trial name
- MGB vs RYGB (NCT03673969)
- Testing
- Gastric bypass
- Where
- United Kingdom
- Sponsor
- Doncaster And Bassetlaw Hospitals NHS Foundation Trust
Roux-en-Y Gastric Bypass, Obesity
Assessing the Safety and Performance of the easyEndoTM Universal Linear Cutting Stapler in Laparoscopic Gastric Bypass Surgery
The purpose of this observational registry is to evaluate the safety and performance of the easyEndoTM Universal Linear Cutting Stapler and reloads from Ezisurg Medical used in laparoscopic RYGB surgery to create anastomoses.
- Trial name
- NCT03968757
- Testing
- easyEndoTM Universal Linear Cutting Stapler and reloads (Ezisurg Medical)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Duomed
Morbid Obesity
Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy
The sleeve gastrectomy that has been utilized as a first-stage bariatric procedure to reduce surgical risk in high-risk patients by induction of weight loss is now gaining popularity as a standalone procedure for the treatment of…
- Trial name
- NCT00667706
- Testing
- laparoscopic operation Sleeve Gastrectomy, laparoscopic operation Roux-en-Y Gastric bypass
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Effect of Revisional Surgery for Failed Gastric Banding
Revisional Versus Primary Roux-en-Y Gastric Bypass: a Case Matched Analysis
This study compared revisional malabsorptive laparoscopic very very long limb gastric bypass (VVLL RYGB) with primary VVLL RYGB and tested the hypothesis that one staged revisional laparoscopic VVLL RYGB is a safe and effective…
- Trial name
- NCT01771744
- Volunteers
- 96 people
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
Binge Eating, Depression and Anxiety Outcomes After Sleeve Gastrectomy Versus Gastric Bypass: A Cohort Study
The goal of this clinical trial is to learn if the type of weight-loss surgery (sleeve gastrectomy or gastric bypass) affects binge eating, depression, and anxiety in adults with severe obesity.
- Trial name
- NCT07600411
- Testing
- Laparoscopic Sleeve Gastrectomy, Gastric Bypass
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Weight Loss
RYGB AL 150cm BPL 100cm vs RYGB AL 100cc BPL 150cm
A Roux-en-Y gastric bypass will be performed in all the cases. Patients will be randomized according the limb lengths: Group 1: Alimentary limb (AL) 150cm and biliopancreatic limb (BPL) 100cm Group 2: AL 100cm and BPL 150cm…
- Trial name
- NCT03838276
- Testing
- AL 150 BPL100, AL 100 BPL 150
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Elche
Pancreatic Cancer, Pancreatic Cystic Lesions
Trial Assessing Roux-en-Y Anastomosis of the Pancreatic Stump to Prevent Pancreatic Fistula Following Distal Pancreatectomy
The objective is to clarify Roux-en-Y anastomosis of the pancreatic stump decreases pancreatic fistula following distal pancreatectomy, compared with stapling closure of the pancreatic stump.
- Conditions
- Pancreatic Cancer, Pancreatic Cystic Lesions, Chronic Pancreatitis, Pancreatic Neuroendocrine Tumors
- Trial name
- NCT01384617
- Testing
- Stapling closure of the pancreatic stump, Roux-en-Y anastomosis of the pancreatic stump
- Where
- Japan
- Volunteers
- 136 people
- Sponsor
- Wakayama Medical University
Post-bariatric Hypoglycemia
An Expanded Access Protocol to Provide Avexitide in Patients With Post-Bariatric Hypoglycemia
The Expanded Access Program will provide access to avexitide for people with post-bariatric hypoglycemia (PBH) following Roux-en-Y gastric bypass (RYGB) who meet the eligibility criteria for this program.
- Trial name
- NCT07582874
- Testing
- Avexitide
- Where
- 4 sites in United States
- Sponsor
- Amylyx Pharmaceuticals Inc.
Pancreatic Cancer
A Comparative Clinical Research on Single Roux-en-Y and Traditional Roux-en-Y of Pancreaticojejunostomy-choledochojejunostomy For Treatment of Obstruction of Pancreatic Duct and Bile Duct
This study is being done to learn more about how different surgery procedures bring back the quality of life.After removing the small intestine at least 20cm in patients with pancreatic cancer, Some patients develop problems…
- Trial name
- NCT01926717
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chengyi Sun
Obesity
Metabolic Factors of Outcomes From Gastric Bypass Surgery
The objective of this study is to determine whether the metabolic, endocrine and energetic response to short term caloric restriction are factors in weight loss in subjects having gastric bypass (GB) surgery.
- Trial name
- Cassini (NCT01347840)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ethicon Endo-Surgery
Gastric Tumor
Impact of Roux-En-Y Pouch Reconstruction Compared With Conventional Roux-En-Y Reconstruction on Quality of Life in Patients Undergoing Total Gastrectomy
The purpose of this study is to find out more about differences of the quality of life in patients undergoing Roux-En-Y pouch reconstruction and conventional Roux-En-Y reconstruction.
- Trial name
- GCQOL02 (NCT01697943)
- Testing
- Roux-En-Y Pouch Reconstruction or Conventional Roux-En-Y Reconstruction
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fudan University
Morbid Obesity
Single Anastomosis Duodeno-Ileal Bypass vs Standard Duodenal Switch as a Second Step After Sleeve Gastrectomy in the Super-Morbid Obese Patient
Single-Anastomosis Duodeno-Ileal bypass with a 250 cm common/alimentary loop is a modification of standard duodenal switch in which a Roux-en-Y duodeno-ileal anastomosis is performed at 250 cm from the cecum and a 60 cm to 100 cm…
- Trial name
- SADI vs CD (NCT01685177)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital San Carlos, Madrid
Gastric Bypass
Prospective Trial Using Gastric Stapling Line Reinforcement With Seamguard in Roux-en-Y Gastric Bypass
Study objectives : Primary endpoint is to a assess the change in blood loss (originating from stapling the stomach) with the use of Seamguard reinforcement Secondary endpoint is to evaluate the difference in leak rate Methods …
- Trial name
- NCT01015157
- Testing
- Roux-en-Y laparoscopic gastric bypass for morbid obesity
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Clinique de l'Anjou
Type 2 Diabetes Mellitus
The Contribution of Incretin Hormones to the Amelioration of Glucose Metabolism After Roux-en-Y Gastric Bypass
The study is being undertaken to understand how a gastric bypass can affect a subject's diabetes even prior to their losing significant amounts of weight.
- Trial name
- NCT01843855
- Testing
- Exendin 9,39
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Adrian Vella