Clinical trials: Roux-en-Y Anastomosis
Malignant Gastric Outlet Obstruction
Roux-en-Y Gastric Bypass Versus Loop Gastrojejunostomy for Malignant Gastric Outlet Obstruction
This study is intended to investigate whether roux-en-y bypass surgery is superior to conventional loop gastrojejunostomy for Malignant gastric outlet obstruction in terms of tolerance to solid food intake.
- Trial name
- NCT05986890
- Testing
- Roux-en-Y Bypass, gastrojejunostomy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Corewell Health West
Obesity
Gut Microbiota Post Roux-en-Y Gastric Bypass Surgery
The purpose of this study is to investigate mechanisms responsible for weight change in patients who have undergone weight loss surgery.
- Trial name
- NCT02654496
- Testing
- Meal challenge
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Morbid Obesity
Changes in Incretines, Gut Hormones and Bile Acids After Roux-en-Y Gastric Bypass
Obesity is an increasing world wide problem. Moreover, the increase in patients who are considered morbidly obese is even higher (Sturm et al, Healt Aff 2004).
- Trial name
- NCT03384303
- Testing
- Standardized meal test
- Volunteers
- 10 people
- Sponsor
- Rijnstate Hospital
Laparoscopic Roux-en-y Gastric Bypass
The BlackBox Study
This is a hypothesis generating pilot study to compare the impact of 2D versus 3D visualization on surgical performance, as measured by the OR BlackBox platform, during laparoscopic bariatric surgery.
- Trial name
- NCT03252470
- Testing
- Laparoscopic Roux-en-y Gastric Bypass Surgery
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Olympus Corporation of the Americas
Hypoglycemia
Mechanisms of Post-Bariatric Hypoglycemia
Post-bariatric hypoglycemia (PBH) is an increasingly recognized syndrome that is incompletely understood. The purpose of this study is to increase our level of understanding by investigating mechanisms contributing to this…
- Trial name
- NCT04428866
- Testing
- Continuous Glucose Monitoring, activity monitor, Mixed meal tolerance test
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Gastric Cancer, Nutrition Disorders
Functional Jejunal Interposition Improve Nutritional Status After Total Gastrectomy
The purpose of this study is to find out whether the nutritional status of patients undergoing Functional Jejunal Interposition is better than those with Roux-en-Y After Total Gastrectomy for Gastric Cancer.
- Trial name
- FJINS (NCT01996059)
- Testing
- Functional Jejunal Interposition, Roux-en-Y
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Sun Yat-sen University
Diabetes Mellitus, Obesity
Single Loop DJB Sleeve Gastrectomy for Poorly Controlled T2DM
Type 2 diabetes mellitus (T2DM) is a chronic progressive illness affecting a substantial percentage of the general population. While pharmacotherapy remains the mainstay of treatment, around 60% of patients cannot achieve the…
- Conditions
- Diabetes Mellitus, Obesity, Bariatric Surgery Candidate, Weight Loss
- Trial name
- NCT03125369
- Testing
- Sleeve gastrectomy + duodeno-jejunal bypass, Roux-Y gastric bypass
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Obesity
Postprandial Nutrient Homeostasis Before and After Weight Loss Induced by Low-calorie Diet or RYGB
The purpose of this study is to compare the metabolic responses to low-carbohydrate and standard-carbohydrate meals in African Americans and non-Hispanic White adults with obesity and the effect of weight loss induced by…
- Trial name
- FGB (NCT03091725)
- Testing
- Roux-en-Y gastric bypass surgery, Low-calorie diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity
Minimally Invasive Trocar Placement in Obesity Surgery
During surgery for obesity, minimally invasive endoscopy can be performed and can assist the surgeon in determining surgical incision sites.
- Trial name
- NCT00610025
- Testing
- Transgastric access to the abdomen
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Jeffrey Hazey
Biliary Obstruction, Choledochal Cyst
Isolated Vascularized Gastric Tube Biliary Enteric Drainage: A Paediatric Case Series Experience.
This was a retrospective case series experience of paediatric patients who had an Isolated vascularized gastric tube biliary enteric drainage procedure for biliary obstruction over the past five years.
- Trial name
- NCT04319302
- Testing
- Isolated Vascularized Gastric Tube (IVGT) graft
- Where
- South Africa
- Volunteers
- 8 people
- Sponsor
- University of KwaZulu
Obesity
Mechanisms Underlying Predictors of Success From Obesity Surgery
The goal of this project is to identify predictors of success in the treatment of obesity after bariatric surgery. The specific aims of this proposal are to: 1.
- Trial name
- NCT02697253
- Testing
- Exendin 9-39 and Sitagliptin
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Weight Loss
RYGB AL 150cm BPL 100cm vs RYGB AL 100cc BPL 150cm
A Roux-en-Y gastric bypass will be performed in all the cases. Patients will be randomized according the limb lengths: Group 1: Alimentary limb (AL) 150cm and biliopancreatic limb (BPL) 100cm Group 2: AL 100cm and BPL 150cm…
- Trial name
- NCT03838276
- Testing
- AL 150 BPL100, AL 100 BPL 150
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Elche
Hypoglycemia
CREON for the Treatment of Post-RYGB Hypoglycemia
Hypoglycemia is an increasingly recognized complication of Roux-en-Y gastric bypass (RYGB) that is poorly understood and difficult to treat.
- Trial name
- NCT02733848
- Testing
- Creon, Diet
- Volunteers
- 5 people
- Sponsor
- East Carolina University
Obesity
Roux-en-Y Gastric Bypass: Clinical Trial
The present study aims to describe the results of a modified gastric bypass surgery to ensure endoscopic access to the excluded remaining stomach, as well as to monitor the clinical conditions of comorbidities and the patient's…
- Trial name
- ERAPT (NCT04649619)
- Testing
- GASTRIC BYPASS MODIFIED IN ROUX-EN-Y AS A THERAPEUTIC OPTION IN PATIENTS WITH INDICATION OF BARIATRIC AND / OR METABOLIC SURGERY
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Paulo Reis Esselin de Melo
Obesity, Insulin Resistance
Ghrelin and Insulin Resistance
Ghrelin, a hormone produced in the stomach that stimulates hunger and food intake, declines immediately after weight loss surgery. Some studies suggest that ghrelin may worsen an individual's ability to respond to insulin.
- Conditions
- Obesity, Insulin Resistance, Normal Weight,Healthy Controls
- Trial name
- NCT00884494
- Testing
- Ghrelin infusion to assess effects on insulin sensitivity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Bariatric Surgery, Gastric Bypass
Study to Examine the Effect of Gastric Bypass Surgery on Venlafaxine ER Blood Levels
The purpose of the study is to determine whether a significant and predictable change in bioavailability of extended-release venlafaxine occurs following Roux-en-Y gastric bypass.
- Conditions
- Bariatric Surgery, Gastric Bypass, Roux-en-Y Gastric Bypass
- Trial name
- NCT01867255
- Testing
- venlafaxine ER (extended-release) 75 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
GERD, Obesity
Long Term Outcomes of Bariatric Patients Treated With Surgery or Endoscopy
GERD is common in the obese population. Bariatric procedures are the mainstay of therapy for these patients. Bariatric procedures can be surgical (Roux-en-Y gastric bypass and Vertical sleeve gastrectomy) or endoscopic…
- Trial name
- ROSE (NCT03705416)
- Testing
- Endoscopy, Surgery
- Where
- 6 sites in United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Morbid Obesity
Banded Versus Non-banded Roux-en-Y Gastric Bypass
This is a prospective randomized Study comparing Weight loss, Esophageal Motility and Reflux in lap. Gastric Bypass vs. lap. Banded-Gastric Bypass using the A.M.I. Soft Gastric Bypass Band (B-Band.
- Trial name
- NCT01078181
- Testing
- gastric bypass
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Obesity, Obesity, Morbid
Endoscopic Metabolic and Bariatric Therapies
This is a prospective collection of data from adult patients who have had an endoscopic metabolic and bariatric endoscopy procedure (EMBT) for primary or revision surgical procedures for obesity.
- Conditions
- Obesity, Obesity, Morbid, Obesity Associated Disorder, Bariatric Surgery Candidate
- Trial name
- EMBTs (NCT05725967)
- Testing
- Primary Obesity Endoscopic Procedures, Endoscopic Revision of Bariatric Surgical Procedures, Bariatric Surgery Procedures
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Type 2 Diabetes, Obesity
Changes in Glucose Metabolism After Roux-en-Y Gastric Bypass
Besides causing weight loss Roux-en-Y gastric bypass (RYGB) has profound effect on glucose metabolism leading to remission of type 2 diabetes early after surgery. However the mechanisms for this improvement remain uncertain.
- Trial name
- NCT01993511
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital