Clinical trials: Roux-en-y Gastric Bypass
Liver Diseases
Hepatic Effects of Gastric Bypass Surgery
Liver disease in the morbidly obese is thought to occur due to the long-term presence of fat deposits in the liver, resulting in inflammation and scarring of the liver over time, which reduces liver function.
- Trial name
- NCT00701376
- Testing
- liver biopsy
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- The Cleveland Clinic
Type 2 Diabetes
Mechanisms of Diabetes Relapse After Bariatric Surgery
The objective of this study is to investigate the different mechanisms by which Gastric Bypass (GBP), laparoscopic adjustable gastric banding (LAGB) and vertical sleeve gastrectomy (VSG) affect glucose control.
- Trial name
- LAF26 (NCT01516320)
- Testing
- Roux-en-Y Gastric Bypass, Laparoscopic adjustable gastric banding, Vertical Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Blandine Laferrere
Diabetes Mellitus, Type 2
Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus With Body Mass Index (BMI) < 35
The aim of this study is to evaluate the effect of Roux-en-y gastric bypass (RYGB) in controlling diabetes in subjects with mild obesity (BMI 26-35).
- Trial name
- NCT00999050
- Testing
- Gastric bypass for diabetic patients <35 BMI
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Gastric Bypass, Body Weight
Pharmacokinetic Evaluation of Moxifloxacin Administered Intravenously and Orally in Healthy Volunteers Who Have Had a Gastric Bypass
Roux-and-Y gastric bypass is one of the most common forms of bariatric surgery; due to a reduction in size of the stomach and intestine, the available surface area for the absorption of oral drugs is strongly decreased.
- Trial name
- DRUG10_MOXI (NCT01130922)
- Testing
- moxifloxacin per IV, moxifloxacin per os
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Ghent
Morbid Obesity
Gastric Volumetry by Gastric Tomodensitometry With Gas
The Gastric bypass (GBP) is actually one of the most performed bariatric procedures worldwide. Short term results report 67% of mean Excess Weight Loss (EWL) at 2 years, and 58% EWL at 5 years.
- Trial name
- VOLUSCAN (NCT01963637)
- Testing
- gastric tomodensitometry with gas at 3 months and 12 months
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Hospices Civils de Lyon
Type 2 Diabetes, Obesity
Intestinal Remodeling And Reprogramming of Glucose Metabolism Following Laparoscopic Roux-en-Y Gastric Bypass
The purpose of this study is to investigate small intestinal remodeling and reprogramming of glucose metabolism in patients with Type 2 Diabetes Mellitus (T2DM) who undergo laparoscopic Roux-en-Y Gastric Bypass (RYGB).
- Trial name
- NCT02288351
- Testing
- Mix Nutrient Meal, labs, Biopsy
- Sponsor
- Duke University
Gastric Bypass Surgery
The Effects of Probiotic Supplementation on the Results of Gastric Bypass Surgery
In this study, patients undergoing the bariatric surgery will be assigned to take either probiotic capsules or placebos from 1 month before surgery to 3 months after the surgery.
- Trial name
- NCT02708589
- Testing
- probiotic
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- National Nutrition and Food Technology Institute
Morbid Obesity, Type2diabetes
Comorbidities Resolution After MGB Surgery and Change in Body Composition
This observational study aims to learn about the correlation between the improving comorbidities associated with obesity after MGB (Mini-Gastric Bypass) surgery and changes in body composition in morbidly obese patients.
- Conditions
- Morbid Obesity, Type2diabetes, Sleep Apnea, Hypothyroidism
- Trial name
- MOGAMBO (NCT06015620)
- Testing
- Mini gastric bypass surgery
- Where
- India
- Volunteers
- 35 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Obesity, Morbid, Gastric Bypass
Effects of Gastric Bypass Surgery and Calcium Metabolism and the Skeleton
Obesity is a chronic illness of staggering proportions. Because weight loss through diet and exercise is difficult to attain and maintain, there has been escalating interest in bariatric surgery, including Roux-en-Y gastric…
- Trial name
- NCT01330914
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Severe Obesity
Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass
The purpose of this study is to examine the effects of bile acid and bile acids sequestrants on GLP-1 Secretion, during a meal, in patients after Roux-en-Y gastric bypass.
- Trial name
- NCT02876484
- Testing
- Colesevelam, Chenodeoxycholic Acid, Water
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Hvidovre University Hospital
Dumping Syndrome
Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity
The postprandial dumping syndrome is a frequent consequence of Roux-en-Y Gastric ByPass due to the rapid emptying of the stomach remnant in to the intestinal lumen.
- Trial name
- IRCO (NCT02891330)
- Testing
- Dietary and nutritional recommendations conducted by a nurse
- Where
- 4 sites in France
- Volunteers
- 135 people
- Sponsor
- University Hospital, Lille
Post Bariatricsurgery, Hypoglycemia
Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery
RYGB (roux-en-y gastric bypass) has been reported to reverse type 2 diabetes (T2DM) immediately after surgery before any significant weight loss.
- Trial name
- NCT00992901
- Testing
- Exendin-(9-39), Atropine, GLP-1 and GIP
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Morbid Obesity, Inactivity
Effect of Physical Activity on Weight Loss and Cardiovascular Risk Factors After Gastric Bypass
The aim of this study is to increase our knowledge about the effect of physical activity in patients who have undergone gastric bypass surgery. The study will provide novel information in two areas.
- Trial name
- NCT01690728
- Testing
- Physical Activity
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Morbid Obesity
Banded Versus Non-banded Roux-en-y Gastric Bypass
A Roux-en-Y Gastric Bypass (RYGB) is on the long term not always successful in every patient because weight regain can occur. An intervention to prevent weight regain in the future is to place a silicone band (non-adjustable)…
- Trial name
- Bandolera (NCT02545647)
- Testing
- BRYGB
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Rijnstate Hospital
Morbid Obesity, Weight Loss
Efficacy of a Mobile Application to Help in Weight Loss Before Bariatric Surgery
The present randomized clinical trial aims to prove the safety and efficacy of an interactive mobile application (Care4Today®) to obtain sufficient weight loss and empower patients with morbid obesity before being submitted to a…
- Trial name
- VAMOS (NCT05598840)
- Testing
- Care4Today APP: multimodal digital prehabilitation programme for candidates undergoing bariatric surgery., Very low calory diet
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Hospital Universitari de Bellvitge
Weight Loss
RYGB AL 150cm BPL 100cm vs RYGB AL 100cc BPL 150cm
A Roux-en-Y gastric bypass will be performed in all the cases. Patients will be randomized according the limb lengths: Group 1: Alimentary limb (AL) 150cm and biliopancreatic limb (BPL) 100cm Group 2: AL 100cm and BPL 150cm…
- Trial name
- NCT03838276
- Testing
- AL 150 BPL100, AL 100 BPL 150
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Elche
Obesity, Metabolic Disease
Conventional Vs Tailored Limb Lengths in Laparoscopic Roux-en Y Gastric Bypass Surgery
The study aims to investigate whether tailoring limb lengths based on the 1/3rd and 2/3rd concept improves clinical outcomes in Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) surgery compared to conventional limb lengths.
- Conditions
- Obesity, Metabolic Disease, Bariatric Surgery Candidate, Metabolic Surgery
- Trial name
- TAILO-R-YGB (NCT06756789)
- Testing
- Laparoscopic Roux-en Y Gastric bypass (RYGB)- Conventional approach, Laparoscopic Roux-en Y Gastric bypass (RYGB)- Tailored approach
- Where
- India
- Volunteers
- 40 people
- Sponsor
- GEM Hospital & Research Center
Obesity, Morbid
Suboptimal Weight Loss After Gastric Bypass Surgery
Bariatric surgery is the only long-term established treatment for morbid obesity. However, some patients experience suboptimal weight loss after surgery and/or experience a significant weight regain.
- Trial name
- NCT01829906
- Testing
- Multidisciplinary outpatient programme, Inpatient lifestyle programme
- Where
- Norway
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Obesity
Comparison of Body Composition Changes With Weight Loss Interventions
This study is being done to compare the effects of a newer class of weight loss medications to weight loss surgery on the body's muscle, metabolism, and side effects over time.
- Trial name
- REFORM (NCT07115069)
- Testing
- GLP-1 receptor agonist, Gastric Bypass Surgery (laparoscopic), Gastric Bypass Surgery (robotic)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Protein-energy; Imbalance
Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity
The purpose of the study is to determine the effect of three weight loss surgeries compared to a low calorie diet with regard to energy expenditure, body composition, insulin sensitivity, and the response of gastrointestinal…
- Conditions
- Obesity, Protein-energy; Imbalance, Insulin Sensitivity, Gastrointestinal Complication
- Trial name
- BARIA (NCT00936130)
- Testing
- Laparoscopic Roux-en-Y gastric bypass, Laparoscopic gastric banding, Laparoscopic sleeve gastrectomy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Pennington Biomedical Research Center