Clinical trials: Rs-fMRI
Painful Diabetic Neuropathy
Functional Magnetic Resonance Imaging of Brain Activity in Patients With Painful Diabetic Neuropathy
Patients with painful diabetic neuropathy (PDN) often combine with anxiety and depression. However, the pathogenesis of PDN is unclear, especially the mechanism associated with central nervous system.
- Trial name
- NCT03700502
- Testing
- resting-state functional Magnetic Resonance Imaging
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Hypnosis
Functional Magnetic Resonance Imaging (MRI) of Hypnosis and Mindfulness Meditation
Hypnotic trance and mindfulness meditation have both been shown to have benefits for physical health. The current study seeks to determine if there are distinct patterns of brain activity that correlate with hypnotic trance…
- Trial name
- NCT01135810
- Testing
- Hypnosis, Meditation
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Stanford University
Epilepsy
RESting-state Functional MRI for Prediction of Post-surgical Prognosis In Pediatric Drug-Resistant Epilepsy
Resting-state functional MRI (r-fMRI) has emerged in recent years to analyze resting networks. It allows, without active participation of the patients, to identify and analyze the different functional brain networks.
- Trial name
- RESPIRE (NCT04451278)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Primary Progressive Aphasia
Transmagnetic Stimulation Pilot in Primary Progressive Aphasia
Frontotemporal degeneration (FTD) is a non-Alzheimer's dementia that is the 2nd most common cause of dementia in the United States.
- Trial name
- TMS in PPA (NCT05860647)
- Testing
- Intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- HealthPartners Institute
Depression
(GluEsk) Glutamate and Esketamine
Esketamine is the S-enantiomer of racemic ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist. Esketamine and other antidepressant NMDA receptor antagonists are hypothesised to act by producing a rapid increase in brain…
- Trial name
- GluEsk (NCT06432322)
- Testing
- Esketamine nasal spray
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pleasure
RS-fMRI to Nutrient Shakes
Resting state functional magnetic resonance imaging (rsfMRl) of the brain is used to measure pleasantness after consumption of four different milkshakes with added sugars or sweeteners.
- Trial name
- NCT02745730
- Testing
- Glucose, Fructose, Sucralose
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Electroconvulsive Therapy, Major Depressive Disorder
Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy
To compare the efficacy and tolerability of Electroconvulsive Therapy (ECT) and Magnetic Seizure Therapy (MST) in patients with major depressive disorder (MDD).
- Conditions
- Electroconvulsive Therapy, Major Depressive Disorder, Magnetic Seizure Therapy
- Trial name
- NCT07473648
- Testing
- Electroconvulsive Therapy, Magnetic Seizure Therapy
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Anhui Medical University
Therapeutic Mechanism of Antidepressants for Refractory FD
MRI Study of Antidepressants in the Treatment of Refractory Functional Dyspepsia
In this study, diffusion tensor imaging（DTI）technique was used to evaluate the brain microstructures and connective white matter microstructures in patients with refractory FD, resting fMRI was used to evaluate the functional…
- Trial name
- NCT03973567
- Testing
- selective serotonin reuptake inhibitor (SSRI) or serotonin noradrenaline reuptake inhibitor (SNRI) antidepressants, conventional therapy
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Multiple Sclerosis
Allocentric Memory in MS and Resting State Functional MRI
The goals of this study are to 1. Investigate the sensitivity of allocentric visual memory when compared to more established measures of cognition in identifying cognitive difficulties among MS subjects when compared to controls.
- Trial name
- NCT02118298
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Cognitive Decline, Cardiovascular Diseases
Cardiovascular Disease Cohort
The Cardiovascular Disease Cohort study is a prospective cohort study among cardiovascular disease patients enrolled in the Affiliated Hospital of Hangzhou Normal University.
- Trial name
- NCT05309824
- Where
- China
- Sponsor
- Westlake University
Cerebral Small Vessel Disease, Vascular Cognitive Impairment
Personalized Intermittent Theta Burst Stimulation for Cognitive Impairment Related to Cerebral Small Vessel Disease
This study will evaluate whether personalized intermittent theta burst stimulation (iTBS), a form of noninvasive transcranial magnetic stimulation, can safely improve cognitive function in people with cognitive impairment related…
- Trial name
- NCT07891650
- Testing
- Active Personalized Intermittent Theta Burst Stimulation
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Xuanwu Hospital, Beijing
Disorder of Consciousness, Minimally Conscious State
Simultaneously PET/MRI in Prolonged DOC Patients
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, FDG-PET, Rs-fMRI
- Trial name
- NCT04164680
- Testing
- Multimodal Neuroimaging
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Encephalopathy, Hypoxic-Ischemic
PEDI-REAVASC Resonance Imaging of Infants With Hypoxic Ischemic Encephalopathy After Hypothermia Treatment.
This study is a prospective, observational, single-center study to assess the correlation between rs-fMRI measures and clinical measures of standard MRI, NIRS, EEG and clinical scores.
- Trial name
- PEDI-REAVASC (NCT06370624)
- Testing
- MRI-scan
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Brain Mass, Glioma
Resting-State Functional MRI in Glioma Patients Before and After Surgery
This clinical trial studies how well resting-state functional magnetic resonance imaging (MRI) and cerebrovascular reactivity (CVR) MRI performed before and after surgery works in measuring the effects on language in patients…
- Trial name
- NCT03964909
- Testing
- Functional Magnetic Resonance Imaging, Magnetic Resonance Imaging, Resting State Functional Connectivity Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- M.D. Anderson Cancer Center
Dementia
Apolipoprotein E Gene and Functional MRI
1. Apolipoprotein E gene (ApoE) is the most important genetic factor for Alzheimer disease (AD) and an important genetic factor for outcome of brain injury situations. 2.
- Trial name
- fMRI (NCT01287819)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Mild Cognitive Impairment (Vascular), Mild Cognitive Disorder (Vascular)
Symptomatic Treatment of Vascular Cognitive Impairment
Single center threeway double blind cross over trial investigating the pharmacological responsivity in patients with VCI using a challenge aimed at the monoaminergic and cholinergic neuronal systems
- Conditions
- Mild Cognitive Impairment (Vascular), Mild Cognitive Disorder (Vascular), Vascular Dementia
- Trial name
- STREAM-VCI (NCT02098824)
- Testing
- Galantamine, Methylphenidate
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Amsterdam UMC, location VUmc
Depression
The Study About Mechanism of Transcranial Magnetic Stimulation Treatment of Depression Using Medical Imaging
Depression is the most common psychiatric condition and a important public health concern in society. But medications for depression don't work as well as people expected and cause serious side-effects.
- Trial name
- NCT03500029
- Testing
- Transcranial magnetic stimulation (TMS), antidepressants
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Fibromyalgia
Effect of tDCS in Intrinsic Functional Brain Connectivity Assessed by Functional Magnetic Resonance in Fibromyalgia
Considering the central component of fibromyalgia (FM), the focus of research on current therapeutic approaches has been techniques that may modify the dysfunctional neuroplasticity process, such as transcranial direct current…
- Trial name
- NCT03841227
- Testing
- Active-tDCS
- Where
- 2 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Urinary Urgency Incontinence
Examining Bladder Control Using Mindful Based Approach
Urgency Incontinence (where the bladder muscles contract suddenly, causing an immediate urge to urinate that is difficult to prevent) is commonly experienced in patients with overactive bladder.
- Trial name
- NCT01843543
- Testing
- Mindfulness Based Stress Reduction Course
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Caffeine, Flavonoids
Effects of a Cocoa Shot on the Human Brain
The Hershey Company is interested in investigating the effects of various chocolate beverages on brain physiology and cognitive function.
- Trial name
- NCT01924481
- Testing
- High Caffeine, Low caffeine, High theobromine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences