Clinical trials: Rupture, Spontaneous
Bacterial Vaginosis, Fetal Membranes, Premature Rupture
Perinatal Infections in Pakistan
There are large differences in health outcomes related to pregnancy and birth between developed and developing countries. This study will investigate how infections, medical history, health care behavior and psychosocial issues…
- Conditions
- Bacterial Vaginosis, Fetal Membranes, Premature Rupture, Chorioamnionitis, Pregnancy
- Trial name
- NCT00070746
- Where
- Pakistan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Rupture, Spontaneous, Rupture Liver
Management of Spontaneous Ruptured Hepatocellular Carcinoma
To investigate the best treatment for hepatocellular carcinoma rupture
- Conditions
- Rupture, Spontaneous, Rupture Liver, Hepatocellular Carcinoma
- Trial name
- NCT03516890
- Testing
- Partial hepatectomy
- Volunteers
- 216 people
- Sponsor
- Huazhong University of Science and Technology
Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature
Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA
This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after…
- Conditions
- Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature, Rupture of Membranes; Premature, Affecting Fetus, Preterm Birth
- Trial name
- NCT04047849
- Testing
- Antibiotics, oral Azithromycin and oral Amoxicillin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Woman's
Abortion, Second Trimester, PPROM
Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
When time allows, administration of mifepristone prior to second trimester induction of labor decreases total labor time. However, in the setting of many pregnancy complications, decreasing time from diagnosis of nonviable…
- Conditions
- Abortion, Second Trimester, PPROM, Rupture, Spontaneous, Fetal Demise
- Trial name
- MIST (NCT05322252)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Preterm Labor, Preterm Birth
The FLIP-1 Study: Vaginal Lactobacillus Supplementation in Women at High Risk of Preterm Birth
Preterm birth (PTB) is the primary cause of infant death worldwide. It has been shown that a vaginal microbiota deplete in Lactobacillus species is a risk factor for preterm labour.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Premature Rupture of Membrane, Cervical Incompetence
- Trial name
- NCT03992534
- Testing
- LACTIN-V
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Preterm Birth
Glycoproteomic Analysis of Urine in Women Undergoing Spontaneous Preterm Delivery
When babies are premature, or born before they are fully developed, they face many different medical problems, some of which are quite devastating, such as cerebral palsy, mental retardation, blindness, deafness, severe…
- Trial name
- NCT01348230
- Testing
- Urine samples
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Perineal Tear, Episiotomy Extended by Laceration
Pushing and Manual Perineal Protection Techniques
Perineal trauma during vaginal delivery is very common, especially in countries with a high prevalence of episiotomy. Perineal traumas can range from tears limited to the skin, subcutaneous and vaginal mucosa to severe tears…
- Conditions
- Perineal Tear, Episiotomy Extended by Laceration, Labor Complication
- Trial name
- NCT04823598
- Testing
- Coached pushing and Finnish manual perineal protection, Uncoached pushing and Hands-poised perineal protection
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Istinye University
Perineal Tear
Low Power Laser for Spontaneous Perineal Laceration
Scenario: spontaneous perineal laceration is an injury to the tissue in the perineum region, which can occur during vaginal delivery.
- Trial name
- LASER (NCT04914182)
- Testing
- LASER, CONTROL
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Rupture, Spontaneous, Rupture Liver
A Comparison Between Child-Pugh and Albumin-Bilirubin Scores
To compare Child-Pugh and Albumin-Bilirubin scores in patients with spontaneous rupture of hepatocellular carcinoma
- Conditions
- Rupture, Spontaneous, Rupture Liver, Hepatocellular Carcinoma, Hepatic Impairment
- Trial name
- NCT03534843
- Testing
- Liver resection, Transcatheter arterial embolization
- Volunteers
- 230 people
- Sponsor
- Huazhong University of Science and Technology
Rupture of Membranes; Premature, Distress; Fetal, Complicating Delivery
PeRinatal Outcomes With ACTive Versus Expectant Management of Women With Pre-labor Rupture Of Membranes
Term pre-labor rupture of membranes (PROM) occurs in about 12% of pregnancies and the time between PROM and delivery increases the risk of maternal/fetal infections.
- Conditions
- Rupture of Membranes; Premature, Distress; Fetal, Complicating Delivery, Delayed Delivery After Spontaneous or Unspecified Rupture of Membranes, Maternal Sepsis
- Trial name
- PROACT PROM (NCT05958953)
- Testing
- Induction of Labor IoL
- Where
- Italy
- Volunteers
- 1,400 people
- Sponsor
- University of Modena and Reggio Emilia
Acute Coronary Syndrome, Myocardial Infarction
Exploring the MEchanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and computationaL Fluid Dynamic
The EMERALD trial is a multinational, multicenter study. The patients presented with AMI/definite evidence of plaque rupture and had underwent coronary CT angiography from 1 month to 2 year prior to the event will be…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Plaque, Atherosclerotic, Rupture, Spontaneous
- Trial name
- EMERALD (NCT02374775)
- Where
- 2 sites in South Korea
- Volunteers
- 77 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma, Transcatheter Arterial Chemoembolization
TACE Combined With Lenvatinib and PD-1 Inhibitor for Ruptured Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) with spontaneous rupture is a potentially fatal complication and usually has poor prognosis. In most conditions, the tumors could not be radically moved.
- Conditions
- Hepatocellular Carcinoma, Transcatheter Arterial Chemoembolization, Anti-PD1 Antibody, Lenvatinib
- Trial name
- NCT06740370
- Testing
- TACE, Lenvatinib, PD-1 Inhibitors
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Sun Yat-sen University
Rupture, Spontaneous
A New Prognostic Scoring System for Spontaneous Ruptured Hepatocellular
Develop a new scoring system for HCC patients with tumor rupture.
- Trial name
- NCT03504358
- Testing
- Liver resection
- Volunteers
- 129 people
- Sponsor
- Huazhong University of Science and Technology
Preterm Birth, Preterm Premature Rupture of Membrane
Cerclage After Full Dilatation Caesarean Section
CRAFT-OBS: Observational Study; To evaluate subsequent pregnancy risk of preterm birth in women with a history of previous caesarean in established labour.
- Conditions
- Preterm Birth, Preterm Premature Rupture of Membrane, Preterm Spontaneous Labor With Preterm Delivery
- Trial name
- CRAFT (NCT04110704)
- Testing
- Insertion of transvaginal cerclage
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
PROM (Pregnancy), Induced; Birth
Effects of Acupuncture in Spontaneous Rapture of Membranes: Applicability and Effectiveness
The aim of the study is to investigate the effects of acupuncture in women presenting with spontaneous rapture of membranes (PROM) at term and negative swab for Streptococcus Agalactie to promote a spontaneous onset of labour and…
- Conditions
- PROM (Pregnancy), Induced; Birth, Acupuncture, Labour
- Trial name
- NCT06623175
- Testing
- Acupuncture needles
- Where
- Italy
- Volunteers
- 131 people
- Sponsor
- Prof. Fabio Facchinetti
Preterm Premature Rupture of Membrane
The Value of Amniopatch in Preterm Premature Rupture of Membranes
A randomized controlled trial that involved 100 women diagnosed with PPROM between 24 and 34 weeks of gestational age. Participants were randomized equally into 2 groups.
- Trial name
- NCT03473210
- Testing
- Antibiotics, Corticosteroid, Amniopatch
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Anterior Cruciate Ligament Injuries, Ligament; Rupture, Knee, Spontaneous
Functional Outcome Comparison of Implant-Free Bone-Patellar Tendon Autograft in Arthroscopic ACL Reconstruction
The use of implants for conventional anterior cruciate ligament (ACL) graft fixation has been associated with several problems including graft injury, implant osteolysis, implant migration and soft tissue irritation.
- Conditions
- Anterior Cruciate Ligament Injuries, Ligament; Rupture, Knee, Spontaneous, Tendon Graft; Complication, Mechanical
- Trial name
- NCT04123834
- Testing
- Patella tendon & bone block autograft + press-fit femoral technique, Arthroscopic ACL reconstruction, Hamstring tendon autograft + implant fixation
- Volunteers
- 32 people
- Sponsor
- Universitas Indonesia
Subarachnoid Hemorrhage
Searching a Dysfunction of Corticotropic & Thyrotropin Axis During the Acute Phase of a Subarachnoid Hemorrhage Secondary to Spontaneous Rupture of Cerebral Aneurysm
Searching a dysfunction of corticotropic and thyrotropin axis during the acute phase ( ≤48h ) of a subarachnoid hemorrhage secondary to spontaneous rupture of cerebral aneurysm.
- Trial name
- HSA (NCT03655509)
- Testing
- Dynamic test ACTH stimulation
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Rennes University Hospital
Labor Onset and Length Abnormalities
Misoprostol Versus Oxytocin for Induction of Labour in Parturients With Spontaneous Rupture of Fetal Membranes at Term
Intravenous oxytocin titration has a prime position as a choice agent for induction of labour following term PROM as it has been shown to be efficacious for such purpose.
- Trial name
- NCT06343480
- Testing
- Labour Induction
- Where
- 2 sites in Nigeria
- Volunteers
- 120 people
- Sponsor
- Federal Teaching Hospital Abakaliki
Patients With Spontaneous Rupture of the Fetal Membranes
Kinetics of Inflammation Markers in Maternal Plasma: Study of the Correlation With the Diagnosis of Chorioamnionitis in Women Hospitalized for Spontaneous Rupture of the Fetal Membranes
The principal aim of this study is to help obstetricians to diagnose chorioamniotic infection early, in cases of premature rupture of the fetal membranes before 34 WA, by proposing earlier and more specific markers of infection…
- Trial name
- NCT01903759
- Testing
- Blood samples
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Centre Hospitalier Universitaire Dijon