Clinical trials: Rupture
Rotator Cuff Injuries, Shoulder Pain
ASHCOM Shoulder System and Its Related Instruments
The objectives of this study are to confirm safety, performance and clinical benefits of the ASHCOM Shoulder System and its related instruments by analysis of standard scoring systems, radiographs and adverse event records.
- Conditions
- Rotator Cuff Injuries, Shoulder Pain, Arthropathy; Traumatic, Arthroplasty Complications
- Trial name
- NCT04258605
- Testing
- ASHCOM Shoulder System
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Zimmer Biomet
Seasonal Allergic Rhinitis
A Phase III Efficacy Study of the Symptomatic Treatment of Seasonal Allergic Rhinitis With Bilastine
The objective of the study was to determine the efficacy and tolerability of 20 mg of Bilastine, compared to Desloratadine and placebo for the treatment of Seasonal Allergic Rhinitis.
- Trial name
- NCT01108783
- Testing
- Bilastine, Desloratadine
- Volunteers
- 720 people
- Sponsor
- Faes Farma, S.A.
Pregnancy, Childbirth
Comparison of the Flexibility of the Perineum in Primiparous Women Using the Medical Device Emagina During 90 Days of Their Pregnancy Compared to Those Having a Standard Pregnancy Follow-up
The goal of this clinical investigation is to learn if training with Emagina device can improve flexibility of the perineum during childbirth with the help of a balloon that inflates in the genital area according to a…
- Trial name
- PeriFlex (NCT06542744)
- Testing
- Training with the Emagina device at home until birth, No intervention
- Where
- 15 sites in France
- Volunteers
- 88 people
- Sponsor
- Mumming
Tear Film Characteristics
Clinical Evaluation of An Approved Contact Lens
This is an 8-visit, bilateral, dispensing clinical study to evaluate the change in tear fluid pH and tear film osmolarity in an FDA-cleared contact lens in new contact lens users over a 14-day period.
- Trial name
- NCT02760810
- Testing
- Marketed Contact Lens
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Childbirth
A Clinical Phase II Study of the Materna Device to Shorten Delivery Time During Childbirth
This feasibility study is a prospective, non-randomized, single arm study to evaluate safety and prevention of maternal pelvic soft-tissue damage using the Materna Medical Device.
- Trial name
- NCT06698185
- Testing
- Materna Prep Device
- Where
- United States
- Sponsor
- Materna Medical
Aortic Dissection
Zenith® Dissection Clinical Trial
The Zenith® Dissection Clinical Trial is a clinical trial approved by US FDA to study the safety and effectiveness of the Zenith® Dissection Endovascular System in the treatment of acute, complicate Type B aortic dissection.
- Trial name
- NCT01568320
- Testing
- Endovascular Treatment (Zenith)
- Where
- 24 sites in United States, Japan
- Volunteers
- 73 people
- Sponsor
- Cook Research Incorporated
Dry Eye Syndromes, Dry Eye Disease (DED)
Clinical Investigation Between the Topical Administration of a Tear Substitute With Ancillary Medicinal Substance and Hyaluronic Acid 0.3% (FBV_01) vs Hyaluronic Acid 0.3% in Subjects in the Treatment From Moderate to Severe DED
The goal of this clinical investigation plan is to evaluate the performance, tolerability, safety, and compliance of an ophthalmic solution containing an ancillary medicinal substance and hyaluronic acid 0.3% (FBV_01) compared…
- Trial name
- NCT07412860
- Testing
- FBV_01, HYLO-VISION® SafeDrop® Gel
- Where
- 2 sites in Italy
- Volunteers
- 74 people
- Sponsor
- FB Vision S.p.A
Dry Eye Disease
Evaluation of the Tolerability and Efficacy of CWT-f-002 Lubricant Eye Drops
The primary objective is to evaluate the tolerability and efficacy of CWT-f-002 lubricant eye drops in the treatment of the signs and symptoms of dry eye disease.
- Trial name
- NCT05660681
- Testing
- glycerin 0.7%/PEG 400 0.3%, polyethylene glycol 400 0.4%/propylene glycol 0.3%
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Calm Water Therapeutics LLC
Intra-amniotic Infection, Preterm Birth
Biomarkers of Intra-amniotic Infection in Women With Preterm Premature Ruptured Amniotic Membranes
The purpose of this study is to investigate the expression of protein biomarkers in cervical vaginal fluid in women with preterm premature rupture of membranes (PPROM)
- Trial name
- PPROM (NCT00701350)
- Where
- 4 sites in United States
- Volunteers
- 79 people
- Sponsor
- ProteoGenix, Inc.
Dry Eye
Evaluating a Device for Blocking the Tear Duct
Participants will receive a tear duct plug to see if their eye comfort improves.
- Trial name
- NCT05748951
- Testing
- Canalicular occlusion device
- Where
- Mexico
- Volunteers
- 33 people
- Sponsor
- AesculaTech, Inc.
Dry Eye Syndrome
SYSTANE® BALANCE Symptoms (OSDI) & Inflammatory Biomarkers
The purpose of this study is to evaluate the ability of SYSTANE® BALANCE and SYSTANE® Gel to improve comfort in subjects with dry eyes.
- Trial name
- NCT01733732
- Testing
- SYSTANE® BALANCE Lubricant Eye Drops, SYSTANE® Gel
- Volunteers
- 54 people
- Sponsor
- Alcon Research
Dry Eye
Efficacy of Systane Balance to Stabilize the Tear Film in Dry Eye Subjects
Evaluation of the optical effects of Systane Ultra
- Trial name
- NCT01086774
- Testing
- Systane Ultra Lubricant Eye Drops
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Achilles Tendon Tear
Acute Achilles Repair With or Without OrthADAPT Augmentation
The purpose of this study is to assess the clinical performance of the OrthADAPT Bioimplant in patients with acute mid-substance Achilles tendon tears requiring surgical repair.
- Trial name
- NCT00962143
- Testing
- Achilles repair with OrthADAPT augmentation, Achilles repair without OrthADAPT Augmentation
- Where
- United States
- Sponsor
- Baxter Healthcare Corporation
Dry Eye Disease
Influence of Perfluorohexyloctane (NovaTears) on Tear Film Thickness in Patients With Mild to Moderate Dry Eye Disease
Patients with mild to moderate dry eye disease will be randomized to receive either NovaTears® or Hydrabak® eye drops as control.
- Trial name
- NCT03048526
- Testing
- NovaTears®, Hydrabak®
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Novaliq GmbH
Rotator Cuff Tear
Prospective Study for Safety and Efficacy of InSpace™ in Rotator Cuff Tear Subjects
Title: One-arm, international, multi-center with competitive recruitment, prospective study to assess the safety and efficacy of OrthoSpace's InSpace™ in rotator cuff tear subjects scheduled for surgery of the rotator cuff - A…
- Trial name
- NCT00916994
- Testing
- SpaceGuard Balloon
- Where
- Israel
- Volunteers
- 58 people
- Sponsor
- OrthoSpace Ltd.
Rotator Cuff Tears (RCTs)
SINEFIX-2022 Pilot Phase
Shoulder pain is one of the most commonly reported musculoskeletal complaints, which negatively affects upper limb use, night rest, daily life activities, work, sports performance and autonomy.
- Trial name
- NCT05721560
- Testing
- Rotator cuff repair with the SINEFIX
- Where
- Germany
- Volunteers
- 9 people
- Sponsor
- BAAT Medical Products B.V.
Partial Thickness Rotator Cuff Tear
A Longitudinal, Multi-Center Safety Study of Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial-Thickness Rotator Cuff Tears
This is a longitudinal follow-up study of the RC-002 study, in which up to 246 subjects assigned to two randomization arms will be enrolled: an adipose-derived regenerative cell (ADRC) injection arm (ADRC treatment arm) and the…
- Trial name
- NCT05400798
- Testing
- Adipose Derived Regenerative Cells, Corticosteroid
- Where
- 11 sites in United States
- Volunteers
- 246 people
- Sponsor
- InGeneron, Inc.
Myopia, Hyperopia
Subjective Comparison of Pre-Lens Tear Film Stability With Daily Disposable Contact Lenses
The purpose of this study was to compare three CE-marked daily disposable contact lenses for tear film stability as measured by pre-lens non-invasive keratograph break up time (PL NIK-BUT).
- Conditions
- Myopia, Hyperopia, Refractive Error
- Trial name
- NCT01839318
- Testing
- Nelfilcon A contact lenses, Omafilcon A contact lenses, Etafilcon A contact lenses
- Volunteers
- 30 people
- Sponsor
- Alcon Research
Dry Eye Disease
A Study Designed to Evaluate Tear Production
The purpose of this study is to evaluate tear production following acute administration of AR-15512 ophthalmic solution 0.003% (0.003% AR-15512) in subjects with dry eye disease (DED).
- Trial name
- NCT06544707
- Testing
- 0.003% AR-15512 ophthalmic solution
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Alcon Research
Preterm Labor, Preterm Birth
MIRACLE of LIFE Study
The goal of this observational study is to develop and validate cell-free RNA-based biomarkers for predicting a variety of adverse pregnancy outcomes in a pregnant person population. The main question it aims to answer are: 1.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane
- Trial name
- MoL (NCT06074601)
- Testing
- Mirvie Predictive Test for Adverse Pregnancy Outcomes
- Where
- 10 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Mirvie