Clinical trials: Rupture of Membranes; Premature
Fetal Growth Restriction (FGR), Preterm Birth
Enhancing Prediction of Adverse Pregnancy Outcomes in Africa Through Partnerships and Innovation
Pregnancy complications such as pre-eclampsia (high blood pressure during pregnancy), poor fetal growth, unexplained stillbirth, and spontaneous preterm birth are major causes of illness and death for mothers and babies in…
- Conditions
- Fetal Growth Restriction (FGR), Preterm Birth, Still Births, Abruptio Placentae
- Trial name
- EPAPOA (NCT07844876)
- Where
- 2 sites in Uganda
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Makerere University
Induction of Labor
Safety and Efficacy of Dinoprostone (Propess) in the Women With Premature Rupture of Membrane or Gestational Age <38
Dinoprostone(propess) is commonly used for induction of labor in the pregnant women who has intact membrane after 38weeks of gestational age.
- Trial name
- NCT01916291
- Testing
- Propess insertion group
- Where
- 2 sites in South Korea
- Volunteers
- 189 people
- Sponsor
- Seoul National University Hospital
Premature Rupture of Fetal Membranes
Oxytocin vs. Prostaglandin for Induction of Labor in Primiparas With Prelabor Rupture of Membrane and Low Bishop
The purpose of the study is to compare between oxytocin to prostaglandin (PGE2), regarding time from induction of labor (IOL) to delivery among primiparas at term with prelabor rupture of membrane (PROM) and an unfavorable cervix.
- Trial name
- NCT02801227
- Testing
- Oxytocin, Prostaglandin E2
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Preterm Premature Rupture of the Membranes
Antibiotics Study in Preterm Premature Rupture of the Membranes
The purpose of this study is to compare the efficacy on maternal infection, chorioamnionitis and neonatal morbidity and mortality, and to review the evidence and provide recommendations on the use of antibiotics in PPROM.
- Trial name
- PPROM (NCT01401179)
- Testing
- cefazolin, erythromycin, clarithromycin
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Samsung Medical Center
Preterm Premature Rupture of Membrane
The Psychological Experience of Pathological Pregnancy. Study of the Case of Premature Rupture of Membranes and Evaluation of the Impact of Hypnosis Support
This research investigates the impact of a hypnosis-based intervention in alleviating state anxiety in Preterm Premature Rupture of Membranes (PPROM).
- Trial name
- HYPNOPROM (NCT05353153)
- Testing
- hypnosis, standart care
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Lille
Pregnancy Complications
Diamine Oxidase and Adverse Pregnancy Outcomes
In normal pregnancies, blood histamine concentration remains within normal values; however, the serum histaminolytic activity is increased.
- Trial name
- NCT06281366
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Preterm Membrane Rupture, Neonatal Sepsis
Comparison of the Effectiveness of Two Different Antibiotic Regimens of the Treatment of Pregnant Women With Preterm Rupture of Membranes
There is no consensus around the world on the treatment of preterm rupture of membranes, which is one of the important causes of early neonatal sepsis and one of the common causes of prematurity.
- Trial name
- NCT04528251
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Maternal Infection During Pregnancy (Diagnosis), Neonatal Infection
Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic Prophylaxis
The primary aim of this study is to determine if antibiotics combined with immediate induction can significantly reduce the rate of maternal and neonatal infection compared with immediate induction alone in women presenting with…
- Trial name
- NCT02985086
- Testing
- Cefoxitin, oxytocin/misoprostol
- Where
- 2 sites in Portugal
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Hospital de Santa Maria, Portugal
Preterm Premature Rupture of Membranes
The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes
To study the association between maternal serum vitamin C concentration in women with preterm premature rupture of membranes (PPROM) and women without PPROM.
- Trial name
- NCT02635451
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
PPROM
Pro-omega-3, Reduction of Inflammation and Modulation of Prematurity
The aim of the project is to decrease the inflammatory status of pregnant women with preterm premature rupture of membranes to delay the initiation of labour that would inevitably lead to premature delivery.
- Trial name
- Pro-MEGA (NCT03739463)
- Testing
- MAG-DHA, Oleic acid
- Volunteers
- 70 people
- Sponsor
- Université de Sherbrooke
Fetal Membranes, Premature Rupture
Perinatal Outcome After Premature Rupture of Membranes
Premature rupture of membranes is an important cause of neonatal morbidity and mortality, mainly because of the complications associated with this pathology (oligohydramnios, cord compression or prolapse, infection).
- Trial name
- NCT01538030
- Where
- Panama
- Volunteers
- 80 people
- Sponsor
- Saint Thomas Hospital, Panama
Oligohydramnios
Amnioinfusion Initiative
The aim of this study is to compare perinatal survival in patients presenting with early spontaneous PPROM and persistent oligohydramnios, managed either conservatively or with serial amnioinfusions.
- Trial name
- NCT00787163
- Testing
- amnioinfusion
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- Università degli Studi di Brescia
Prelabor Rupture of Membranes
Induction of Labor in Pregnant Women With Prelabor Rupture of Membranes - Oxytocin or Misoprostol
The aim of study is to compare the efficacy and safety of oral misoprostol versus oxytocin in induction of labor in pregnant women with prelabor rupture of membranes at term.
- Trial name
- NCT05215873
- Testing
- Misoprostol, Syntocinon
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams Maternity Hospital
PPROM, Preterm
Preterm Rupture of Membranes Optimising Antibiotics Trial
The goal of this clinical trial is to learn which antibiotic regimen works best to prevent infection in pregnant women whose waters break early (preterm, pre-labour rupture of membranes, or PPROM) and assess the health outcomes…
- Trial name
- PROMOAT (NCT06906757)
- Testing
- Erythromycin 250mg and Amoxicillin 500mg
- Volunteers
- 3,900 people
- Sponsor
- University of Melbourne
Preterm Premature Rupture of the Membranes, Physical Activity
A Comparison of Bed Rest Versus Moderate Activity in Preterm Premature Rupture of Membranes (PPROM)
Bed rest has been a commonly prescribed intervention for high risk pregnancies, despite the lack of data to support its benefits, and increasing evidence pointing to potential harms.
- Trial name
- PACT (NCT02327637)
- Testing
- Moderate Activity
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Diego
Premature Rupture of Membrane
Preterm Premature Rupture of Fetal Membranes: Cervical Ultrasound and Biological Markers to Diagnose Prematurity (RECHOBIOL)
Our main hypothesis is to consider that the detection of biomarkers on admission combined with the length of the cervix would improve the prediction of the latency period in case of preterm premature rupture of membranes (pPROM).
- Trial name
- RECHOBIOL (NCT04237142)
- Testing
- Vaginal secretions collection, Blood sample
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Clermont-Ferrand
Premature Rupture of Membranes at Term
Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term
The purpose of this study is to determine whether induction of labor with vaginal misoprostol application will result in fewer cesarean deliveries than vaginal PGE2 gel application in women with premature rupture of membranes at…
- Trial name
- NCT00355303
- Testing
- Misoprostol, PGE2 gel
- Where
- India
- Volunteers
- 932 people
- Sponsor
- Nilratan Sircar Medical College
Previous; Cesarean Section, Cicatricial, Complicating Pregnancy or Childbirth, Affecting Fetus or Newborn, Prelabor Rupture of Membranes
Balloon Induction of Labor in PROM for TOLAC
A prospective randomized controlled trial to evaluate the safety and efficacy of labor induction with a double balloon catheter (Atad Ripener Device) in women desiring TOLAC (trial of labor after cesarean) with PROM (pre labor…
- Trial name
- BILROM-TOLAC (NCT03399266)
- Testing
- Double Balloon catheter for induction of labor
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Maternal; Chorioamnionitis, Affecting Fetus, Early-Onset Sepses, Neonatal
A Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis Calculator
This study will review practices in relation to chorioamnionitis (CAM) before and after to the implementation of the Neonatal Early-Onset Sepsis (EOS) Risk Calculator to determine the effect in the nursery at Banner - University…
- Trial name
- NCT04513691
- Testing
- EOS Calculator
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Pediatrix
Preterm Premature Rupture of Membrane
Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes
The aim of the study is to assess the efficacy of 17-hydroxyprogesterone caproate (17P) therapy on the latency period in pregnant women with Preterm premature rupture of membranes.
- Trial name
- NCT04807543
- Testing
- 17-hydroxyprogesterone caproate, Castor Oil
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University