Clinical trials: Ruptured Aneurysm
Preventive Medicine, Multi Organ Failure
Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Prevention of Multi-Organ Failure on Patients After Open Surgery for a RAAA
A study to assess effectiveness and safety of a drug FP-1201-lyo (Recombinant Human Interferon Beta-1a) in the Prevention of Multi-Organ Failure on patients after Open Surgery for a Ruptured Abdominal Aortic Aneurysm
- Trial name
- INFORAAA (NCT03119701)
- Testing
- Interferon Beta-1A
- Where
- 9 sites in Estonia, Finland and 1 more
- Volunteers
- 40 people
- Sponsor
- Faron Pharmaceuticals Ltd
Intracranial Aneurysms, Unruptured Intracranial Aneurysm
ANEURYSM@RISK: Automatic Intracranial Aneurysm Quantification and Feature Learning Modelling to Optimize Intracranial Aneurysm Rupture Prediction
ANEURYSM@RISK is an observational study aiming to develop and validate an artificial intelligence (AI)-based prediction model for the growth and rupture of intracranial aneurysms (IAs).
- Conditions
- Intracranial Aneurysms, Unruptured Intracranial Aneurysm, Subarachnoid Hemorrhage (SAH) From Ruptured Aneurysm
- Trial name
- NCT07111975
- Where
- Netherlands
- Volunteers
- 3,800 people
- Sponsor
- UMC Utrecht
Intracranial Sacciform Aneurysm
Evaluation of Intestinal Microbiota Implication in Ruptured Intracranial Aneurysm
The physiopathology of intracranial aneurysm from initiation to ruptured is incompletely understood but included inflammation. The microbiota is known to interact with brain and can promote inflammation.
- Trial name
- AneBiote (NCT05914636)
- Testing
- analysis of foecal microbiota
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Social Determinant of Health, Intracranial Aneurysms
Risk Analysis of Intracranial Aneurysm Rupture Through Social Determinants of Health
Intracranial aneurysms (IA) are arterial malformations affecting about 3% of the overall population. Rupture is the most severe complication, as it is associated with nearly 30% of death or severe disability.
- Conditions
- Social Determinant of Health, Intracranial Aneurysms, Subarachnoid Hemorrhage, Treatment Outcomes
- Trial name
- ARAMISS (NCT06866210)
- Where
- France
- Volunteers
- 1,800 people
- Sponsor
- Nantes University Hospital
Aortic Rupture
In Vivo Evaluation of Growth and Risk of Rupture of Dilated Ascending Aorta Using 4D Cardiac Magnetic Resonance
Ascending aorta aneurysmal disease is common and can be complicated by dissection or rupture. There is substantial variation in individual aneurysm progression: established risk factors for an accelerated aneurysm growth rate…
- Trial name
- NCT03172390
- Testing
- 4D Cardiac Magnetic Resonance
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Subarachnoid Hemorrhage, Aneurysmal
Mild Hypothermia During Intracranial Aneurysm Clipping
The purpose of this study is to determine whether mild hypothermia causes reduction of vasoconstriction in microcirculation after clipping of aneurysms, and affects the blood flow in small diameter arteries at operating site…
- Trial name
- NCT02544256
- Testing
- Mild hypothermia
- Where
- Czechia
- Sponsor
- University Hospital Hradec Kralove
Subarachnoid Hemorrhage
Impact of Ultra-Early Intracranial Aneurysm Treatment in SAH
This is the first prospective study in Hong Kong that recruit patients with poor neurological status after intracranial aneurysm rupture in all seven public neurosurgical services in Hong Kong.
- Trial name
- UEAT (NCT03894202)
- Where
- China
- Volunteers
- 293 people
- Sponsor
- Chinese University of Hong Kong
Aorta Aneurysm, Aorta Dissection
Spanish Percutaneous Aortic INtervention REGISTRY (SPAIN REGISTRY)
Multicentre prospective registry including consecutive patients undergoing Percutaneous Endovascular Aneurysm Repair (PEVAR), Percutaneous Endovascular Thoracic Aneurysm Repair (PTEVAR) or Transcatheter Aortic Valve Implantation…
- Conditions
- Aorta Aneurysm, Aorta Dissection, Aorta Stenosis, Aortic Coarctation
- Trial name
- SPAIN (NCT04307888)
- Testing
- Perclose Proglide (Abbott)
- Volunteers
- 600 people
- Sponsor
- Sociedad Espanola de Angiologia y Cirugia Vascular
Ruptured Aneurysm
Ruptured Aneurysms Treated With Hydrogel Coils
To determine safety and occlusion rates when second-generation hydrogel coils are used in the treatment of ruptured intracranial aneurysms.
- Trial name
- RAGE (NCT03252314)
- Testing
- Second-generation hydrogel coils
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Microvention-Terumo, Inc.
Subarachnoid Hemorrhage, Intracranial Aneurysm
Swiss Study on Subarachnoid Hemorrhage
This registry was created to assess management parameters of patients treated for aneurysmal subarachnoid hemorrhage in Switzerland.
- Trial name
- Swiss-SOS (NCT03245866)
- Testing
- Observational/ no intervention
- Where
- 9 sites in Switzerland
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Geneva
Aneurysm, Ruptured, Coiling Therapy
The Neuroprotective Effect of Remote Ischemic Conditioning in Ruptured Aneurysm Coiling Therapy
The overall incidence of DWI positive for thromboembolic events following endovascular treatment of intracranial aneurysms is proximately 50%.
- Trial name
- NEAT-2 (NCT03561311)
- Testing
- remote ischemic conditioning
- Where
- 5 sites in China
- Volunteers
- 210 people
- Sponsor
- Capital Medical University
Subarachnoid Hemorrhage of Aneurysmal Cause
Observational Study on Mortality and Outcome of Patients Hospitalized for Subarachnoid Hemorrhage of Aneurysmal Origin in Martinique Between 2013 and 2021
The aim of our study is to analyze mortality and sequelae of subarachnoid hemorrhage of aneurysmal origin in hospitalized patients in Martinique. Predictive factors of poor prognosis will also be analyzed.
- Trial name
- HSA Rankin (NCT06525012)
- Testing
- Usual patient care for patients hospitalized for subarachnoid hemorrhage of aneurysmal origin
- Where
- Martinique
- Volunteers
- 122 people
- Sponsor
- University Hospital Center of Martinique
Intracranial Aneurysm, Brain Aneurysm
The RISE Trial: A Randomized Trial on Intra-Saccular Endobridge Devices
Intracranial bifurcation aneurysms are commonly repaired with surgical and with endovascular techniques. Wide-necked bifurcation aneurysms (WNBA) are a difficult subset of aneurysms to successfully repair endovascularly, and a…
- Conditions
- Intracranial Aneurysm, Brain Aneurysm, Unruptured Cerebral Aneurysm, Ruptured Cerebral Aneurysm
- Trial name
- RISE (NCT03936647)
- Testing
- surgical clipping, simple coiling, high-porosity stenting with/ without coiling, intra-arterial flow diversion with/ without coiling, WEB embolization device
- Where
- 4 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety Study of Carotid Body Neurostimulation to Treat Cerebral Vasospasm
The purpose of this study is to evaluate the safety and performance of the Delta system in the treatment of cerebral vasospasm post aneurysmal subarachnoid hemorrhage (aSAH) patients.
- Trial name
- NCT02129413
- Testing
- Delta system
- Where
- 7 sites in Czechia, Germany and 1 more
- Volunteers
- 23 people
- Sponsor
- Samson NeuroSciences
Ruptured Cerebral Aneurysm, Subarachnoid Hemorrhage (SAH)
Barrow Ruptured Aneurysm Trial
With evolving endovascular technologies there is a growing debate centered on the relative safety and efficacy of the currently accepted alternatives for the treatment of ruptured cerebral aneurysms in the face of acute…
- Trial name
- BRAT (NCT01593267)
- Testing
- coil embolization, clip occlusion
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Ruptured Cerebral Aneurysm, Unruptured Cerebral Aneurysm
Microsurgical Clipping and Endovascular Embolization Comparative Prospective Randomized Trial
Despite the active development of surgical methods of treatment (endovascular embolization and microsurgical clipping) of cerebral aneurysms, determining the indications and method of surgical treatment of cerebral aneurysms…
- Trial name
- MONICA (NCT04548856)
- Testing
- Microsurgical clipping, Endovascular embolization
- Volunteers
- 4 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Aneurysmal Subarachnoid Hemorrhage
Cerebral Hemodynamic Optimization by Milrinone to Prevent Delayed Cerebral Ischemia
The present study is a randomized, multi-center, double-blind, prospective study that tests the efficacy of intravenous milrinone to optimize cerebral hemodynamic and prevent delayed cerebral ischemia (DCI) during the high-risk…
- Trial name
- OPTIMIL (NCT04282629)
- Testing
- Milrinone Injection
- Where
- 5 sites in France
- Volunteers
- 234 people
- Sponsor
- University Hospital, Toulouse
Ruptured Aorta-iliac Aneurysms
Ruptured Aorta-iliac Aneurysms: Endo vs. Surgery
The aim of this multicenter randomized trial is to compare the endovascular repair versus conventional repair for ruptured aorta-iliac aneurysms observed on CT scan in stable patients with suitable anatomy.
- Trial name
- ECAR (NCT00577616)
- Testing
- Endovascular repair
- Where
- France
- Volunteers
- 107 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aneurysmal Subarachnoid Hemorrhage
Early Versus Ultra Early Surgical Treatment of Ruptured Intracranial Aneurysms
The goal of this clinical trial is to determine the most effective timing for clipping in adults with ruptured intracranial aneurysms.
- Trial name
- NCT06457347
- Testing
- Ultra early (<24 hours) ruptured aneurysm clipping, Early (24-72 hours) ruptured aneurysm clipping
- Volunteers
- 100 people
- Sponsor
- Revaz Dzhindzhikhadze
Unruptured Intracranial Aneurysm, Hypertension
China Antihypertensive Trial for Intracranial Aneurysm
The goal of this randomized controlled trial is to evaluate the benefits and safety of controlled hypotension in Chinese patients with unruptured intracranial aneurysms(UIA).
- Trial name
- ChATIA-1 (NCT05941377)
- Testing
- blood pressure lowering
- Where
- China
- Volunteers
- 577 people
- Sponsor
- Beijing Tiantan Hospital