Clinical trials: S-ketamine
Laparoscopic Cholecystectomy, Optic Nerve Sheath Diameter Measurement
Effects of Bolus Versus Infusion Ketamine During Laparoscopic Cholecystectomy
This prospective, randomized, controlled study evaluated the effects of different ketamine administration strategies in adult patients undergoing elective laparoscopic cholecystectomy under general anesthesia.
- Conditions
- Laparoscopic Cholecystectomy, Optic Nerve Sheath Diameter Measurement, Ketamine, Postoperative Pain
- Trial name
- ketamine (NCT07900854)
- Testing
- ketamine bolus, ketamin infusion, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Propofol, Ketamine
Propofol-Ketamine Versus Sevoflurane for Laryngeal Mask Anesthesia in Pediatric Cardiac Catheterization
Children undergoing cardiac catheterization will be given anesthesia using either a combination of propofol and ketamine or sevoflurane gas. The time taken to fall asleep will be recorded.
- Conditions
- Propofol, Ketamine, General Anesthetic Drug Adverse Reaction
- Trial name
- NCT07907796
- Testing
- Ketamine-Propofol, Sevoflurane
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Rawalpindi Institute of Cardiology
Critically Ill, Intubation Complication
Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients
The aim of this retrospective cohort study is to compare the safety and efficacy of induction agents for tracheal intubation in critically ill adult patients.
- Conditions
- Critically Ill, Intubation Complication, Oxygenation, Airway Management
- Trial name
- NCT07222007
- Testing
- induction type for intubation in ICU
- Where
- United States
- Volunteers
- 806 people
- Sponsor
- Zeliha Alicikus
Suicide, Depressive Disorder, Treatment-Resistant
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
Background: Major depressive disorder (MDD) is a serious mental illness that can put people at risk of self-harm and death. Many drugs are used to treat MDD, but it can take a long time for them to be effective.
- Conditions
- Suicide, Depressive Disorder, Treatment-Resistant, Ketamine, Molecular Mechanisms of Pharmacological Action
- Trial name
- NCT06511908
- Testing
- (2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Mental Health (NIMH)
Behavioral Symptoms, Suicide
Natural History of Depression, Bipolar Disorder and Suicide Risk
Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments.
- Conditions
- Behavioral Symptoms, Suicide, Self-Injurious Behavior, Sensory System Agents
- Trial name
- NCT06462196
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Mental Health (NIMH)
Ketamine, Cognitive
Intraoperative Ketamine Versus Lidocaine Infusion on Postoperative Cognitive Dysfunction in Patients Undergoing Hip Surgery
This study aims to compare effects of ketamine versus lidocaine on postoperative cognitive dysfunction in geriatric patient undergoing hip surgery.
- Conditions
- Ketamine, Cognitive, Dysfunction, Hip Surgeries
- Trial name
- NCT07838909
- Testing
- Group Ketamine, Group Lidocaine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Depression - Major Depressive Disorder, Treatment-resistant Depression (TRD)
Biomarker-Guided Antidepressant Selection
Depression is one of the leading causes of disability worldwide. Common treatments like antidepressant medications and talk therapy work well for some people, but many others do not improve, even after trying multiple treatments.
- Conditions
- Depression - Major Depressive Disorder, Treatment-resistant Depression (TRD), rTMS, Ketamine
- Trial name
- BioSelect (NCT07680140)
- Testing
- TMS, Ketamine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Weill Medical College of Cornell University
Ketamine, Refractory Cancer Pain
Continuous IntraVenous Infusion of Ketamine in Terminally Ill Cancer Patients
To establish the role of ketamine in hospitalized terminally ill cancer patients with refractory cancer pain, using continuous intravenous infusion of ketamine
- Trial name
- CIVIK (NCT03362073)
- Testing
- Ketamine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Pusan National University Yangsan Hospital
Suicide Prevention, Ketamine
Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE)
The SAVE study will test whether a single esketamine infusion or a single Crisis Response Planning session, each added to enhanced treatment as usual, reduces future suicide-related events compared with enhanced treatment as…
- Conditions
- Suicide Prevention, Ketamine, Crisis Response Plan
- Trial name
- SAVE (NCT07120477)
- Testing
- Intravenous Esketamine, Crisis Response Planning (CRP), Enhanced Treatment as Usual (eTAU)
- Where
- Brazil
- Volunteers
- 478 people
- Sponsor
- University of Sao Paulo
Chronic Pain, Ketamine
Outcomes Registry After Ketamine Infusions for Chronic Pain: A Longitudinal Evaluation
Ketamine is an anesthetic drug that is sometimes used to relieve chronic pain. The goal of this observational study is to learn about how patients respond to ketamine infusions for chronic pain.
- Trial name
- ORACLE (NCT07648771)
- Testing
- Ketamine (Ketalar)
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Stanford University
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial
This investigator-initiated, randomized, controlled, single-blind, superiority trial aims to assess the efficacy and safety of esketamine combined with dexmedetomidine for the management of agitation or delirium in intensive care…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy
- Trial name
- SEED-NIRS (NCT07377981)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 356 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease
Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults
The purpose of this research is to see if ketamine is effective and safe in treating children and young adults with sickle cell disease experiencing sickle cell related pain.
- Conditions
- Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease, Ketamine Infusion, Pain Management
- Trial name
- NCT07369024
- Testing
- Sub-dissociative Ketamine Infusion
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Mohsen Saidinejad
Ketamine, Anesthesia
Use of S+Ketamine During Target-Controlled Intravenous Anaesthesia After Abdominal Hysterectomy
The investigators want to investigate the effect of low dose S+ ketamine compared to placebo on cumulative morphine consumption at 24 hours in 90 women undergoing open abdominal hysterectomy with remifentanil-propofol target…
- Conditions
- Ketamine, Anesthesia, Morphine, Hysterectomy
- Trial name
- NCT03231683
- Testing
- Esketamine, Saline, Remifentanil
- Where
- Singapore
- Volunteers
- 90 people
- Sponsor
- KK Women's and Children's Hospital
Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction
Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass
This study compares ketamine/fentanyl versus ketamine/lidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better…
- Conditions
- Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction, Induction Anesthesia, Coronary Bypass Graft Surgery
- Trial name
- NCT07248202
- Testing
- Fentanyl (IV), lidocaine
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Ketamine, Oculocardiac Reflex
Two Intravenous Doses of Ketamine in Reducing the Oculocardiac Reflex in Adult Patients Undergoing Ophthalmic Surgery
This study aims to evaluate whether a lower dose of ketamine (0.5 mg/kg IV) may be as effective as a higher dose (0.75 mg/kg IV) in reducing oculocardiac reflex (OCR) incidence in adult patients undergoing ophthalmic surgery.
- Conditions
- Ketamine, Oculocardiac Reflex, Ophthalmic Surgery
- Trial name
- NCT07708740
- Testing
- 0.5 mg/kg intravenous ketamine, 0.75 mg/kg intravenous ketamine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Infusion of Ketamine in Severe Borderline Personality Disorder, Borderline Personality Disorder (BPD)
Ketamine Infusion for Symptomatic Improvement in Severe Borderline Personality Disorder
The main objective of this pilot study is to evaluate at D9 the evolution of BPD symptoms' intensity(scale BSL-23) in severe BPD patients, after two Ketamine infusions (0.5mg/kg at H0 and H24).
- Trial name
- BorderKET (NCT07099534)
- Testing
- IV Ketamine (0.5 mg/kg) Infusion - Two Doses Administered 24 Hours Apart for Severe Borderline Personality Disorder
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Toulouse
Ketamine-Induced Brain Activity Changes, Psychotic-like Symptoms
Effects of TAK-063 on Preventing Ketamine-Induced Brain Activity Changes as Well as Psychotic-Like Symptoms in Healthy Male Adults
The purpose of this study is to determine whether ketamine-induced brain activity changes are modulated by TAK-063 administration using neuroimaging battery tests.
- Trial name
- NCT01892189
- Testing
- Ketamine, TAK-063
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Takeda
IV Ketamine With Spinal Block
Effect of Intravenous Ketamine Combined With Spinal Anesthesia on Sensory Block Duration Compared to Spinal Anesthesia Alone in Lower Limb Surgeries in Geriatrics.
Effect of Intravenous Ketamine combined with Spinal Anesthesia on Sensory Block Duration compared to Spinal Anesthesia alone in Lower Limb surgeries in geriatrics:
- Trial name
- NCT07520487
- Testing
- Patients will receive 0.2 mg/kg IV of ketamine diluted to 5 ml followed by infusion 0.1 mg/kg/hr as a 20 ml solution, Patients will receive 5 ml of saline followed by infusion 0.1 ml/kg/hr as a 20 ml solution as a control group
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Cairo University
Severe Depression, Moderate Depression
Nebulized Ketamine for the Treatment of Major Depressive Disorder
This is a double-blind active placebo controlled clinical trial for individuals with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.
- Conditions
- Severe Depression, Moderate Depression, Ketamine, Midazolam
- Trial name
- NCT06752759
- Testing
- nebulized ketamine, nebulized midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Theresa Jacob, PhD, MPH
Treatment Resistant Depression, Major Depressive Disorder
Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression
The purpose of this study is to assess the effects of simultaneous administration of oral aspirin and oral ketamine as a therapeutic for those with Treatment Resistant Depression.
- Conditions
- Treatment Resistant Depression, Major Depressive Disorder, Analgesia, Ketamine
- Trial name
- NCT05615948
- Testing
- VTS-K
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Theresa Jacob, PhD, MPH