Clinical trials: S-ketamine
The Effect of S-ketamine on Pharmacokinetics of Morphine, Hydromorphone, and Buprenorphine
KetaMoHydBup: Pharmacokinetic Interaction of S-ketamine, Morphine, Hydromorphone and Buprenorphine
S-ketamine is often administered as a part of multimodal analgesia to reduce postoperative pain and postoperative opioid consumption.
- Trial name
- KetaMoHydBup (NCT05571176)
- Testing
- S-ketamine
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Elina Brinck
Postoperative Pain, Adults
Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in adults in perioperative settings.
- Conditions
- Postoperative Pain, Adults, Anesthesia
- Trial name
- NCT04837170
- Testing
- Conventional therapy + S (+)-Ketamine, Conventional therapy
- Volunteers
- 12,000 people
- Sponsor
- Chinese PLA General Hospital
Depression, Anxiety
Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery
A Dual-Center, Randomized, Controlled, Blinded, Prospective Study on the Effects of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery
- Conditions
- Depression, Anxiety, S-ketamine, Breast Cancer
- Trial name
- NCT07367542
- Testing
- Esketamine 0.3mg/kg, Normal Saline
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Cognitive Dysfunction
Effects of Thoracic Paravertebral Block Combined With S-ketamine on Postoperative Pain and Cognitive Function After Thoracoscopic Surgery
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block combined with intraoperative infusion of s-ketamine on postoperative acute pain and cognitive function in patients with thoracoscopic surgery
- Trial name
- NCT05341375
- Testing
- Thoracic paravertebral block, Esketamine, Measurement of cognitive function
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Hemorrhoids, Pain
Effect of Perioperative i.v. Low-dose S(+) Ketamine
The purpose of this study is to determine whether the use of perioperative intravenous S (+) ketamine reduces the amount and degree of postoperative pain.
- Trial name
- NCT00354029
- Testing
- S (+) Ketamine
- Where
- Norway
- Volunteers
- 83 people
- Sponsor
- Asker & Baerum Hospital
Postoperative Hyperalgesia
Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery
Postoperative hyperalgesia (POH) is a paradoxical clinical state of increased sensation of pain or increased sensitivity to non-painful stimuli at the site of surgery or at a surrounding area that was not directly injured.
- Trial name
- NCT05016128
- Testing
- S-ketamine, saline
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pain, Postoperative
Inhaled Nebulised S(+)-Ketamine for Postoperative Analgesia
Ketamine has been administrated via the intravenous, intramuscular, subcutaneous, rectal, oral, transdermal, intranasal, sublingual, transmucosal, epidural, intrathecal, and intra-articular routes.
- Trial name
- NCT02397356
- Testing
- Ketamine first AB
- Where
- Finland
- Sponsor
- Tampere University Hospital
Depression, Anxiety
Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression
A Dual-Center, Randomized, Controlled, Blinded, Prospective Study on the Effects of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients with Mild-to-Severe Depression
- Conditions
- Depression, Anxiety, S-ketamine, Breast Cancer
- Trial name
- NCT07374198
- Testing
- Esketamine 0.3mg/kg, normal saline
- Volunteers
- 142 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Pain, Postoperative Cognitive Dysfunction
S-ketamine Prevents Postoperative Pain and Cognitive Dysfunction After Tibial Fracture
Purpose: To explore effects of S-ketamine on postoperative pain and cognitive dysfunction after tibial fracture and orthopedic surgery.
- Trial name
- NCT04643132
- Testing
- Normal saline, S-ketamine (low-dose), S-ketamine (high-dose)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University General Hospital
Depression, Anxiety, Cardiac Surgery
Effect of Esketamine on Perioperative Negative Mood in Patients Undergoing Cardiac Valve Surgery
A multicenter, randomized controlled, blinded prospective study to investigate the effects of esketamine on perioperative anxiety and depression in patients undergoing cardiac valve surgery.
- Conditions
- Depression, Anxiety, Cardiac Surgery, S-ketamine
- Trial name
- NCT06608030
- Testing
- Esketamine, normal saline
- Where
- 2 sites in China
- Volunteers
- 142 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Pain
Effect of S-ketamine in Cesarean Section Combined Anesthesia
To compare the anti-hyperalgesia effect between S-ketamine with placebo for Maternal receiving elective Cesarean Section under Combined spinal and epidural analgesia.
- Trial name
- NCT05414006
- Testing
- S-ketamine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Healthy
A Study to Investigate the Different Modes of (S) Ketamine Administration in Healthy Participants
The purpose of this study is to determine the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of different modes of (S) ketamine administration in healthy participants.
- Trial name
- NCT03808259
- Testing
- (S)-ketamine Oral Thin Film, (S)-ketamine IV Infusion
- Where
- Belgium
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Atelectasis
Effects of Small-dose S-ketamine on Anesthesia-induced Atelectasis in Anesthetized Patients Accessed by Pulmonary Ultrasound
Background: Atelectasis occurs in the majority of patients with general anesthesia, which can lead to postoperative pulmonary complications (PPCs) and affect the postoperative outcome.
- Trial name
- NCT04745286
- Testing
- S-ketamine, normal saline group
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital