Clinical trials: SAH
Vasospasm Intracranial
Therapeutic Hypercapnia After Aneurysmal Subarachnoid Hemorrhage - Optimum Duration of Hypercapnia
Temporary hypercapnia leads to a reproducible increase of cerebral blood flow (CBF) and brain tissue oxygenation (StiO2) as shown in a previous study (Trial-Identification: NCT01799525).
- Trial name
- NCT04687605
- Testing
- Temporary hypercapnia
- Volunteers
- 12 people
- Sponsor
- University of Wuerzburg
Hypertension, Intracranial Hemorrhage
The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy
This study is a single-arm, open label protocol evaluating the use of Cleviprex to rapidly control hypertension in patients who present with intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH), and that require ICP…
- Conditions
- Hypertension, Intracranial Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NCT01042574
- Testing
- Clevidipine butyrate
- Where
- United States
- Sponsor
- Methodist Healthcare - Memphis
Aneurysmal Subarachnoid Hemorrhage
Prevention of Ischemia in Aneurysmal Subarachnoid Hemorrhage Through Remote Ischemic Preconditioning
Aneurysmal subarachnoid hemorrhage (SAH) is a severe form of stroke caused by bleeding around the brain. Despite early treatment of the initial hemorrhage, many patients develop delayed cerebral ischemia several days later, which…
- Trial name
- HMA (NCT07761520)
- Testing
- Remote Ischemic Preconditioning
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Safety and Efficacy of Nicardipine for the Control of Blood Pressure After SAH
The purpose of this research is to explore ways to improve and simplify control of blood pressure in patients with SAH or ICH. This research will be done by comparing tow different medications that are routinely used to help…
- Trial name
- NCT00490464
- Testing
- Nicardipine and Nipride
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Illinois Chicago
SAH (Subarachnoid Hemorrhage)
Cerebrolysin in SAH (Subarachnoidal Haemorrhage) - Observational Study
Subarachnoid haemorrhage often affects people in middle age and is associated with high mortality or neurological damage. In recent years, advances in surgical techniques have im-proved the mortality rate.
- Trial name
- NCT06429943
- Where
- Poland
- Volunteers
- 47 people
- Sponsor
- Pomeranian Medical University Szczecin
Headaches Associated With Subarachnoid Hemorrhage (SAH)
Randomized Trial for Pain Management in Low-grade Subarachnoid Hemorrhage
Headaches associated with subarachnoid hemorrhage (SAH) cause severe pain. Headache management is complex, requiring a balance between pain control and preservation of neurological assessment.
- Trial name
- NCT01851720
- Testing
- Low dose fentanyl PCA, Standard IV fentanyl bolus
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Cerebral Vasospasm, Delayed Cerebral Ischemia
Bilateral Bispectral Index (BIS) Study
The purpose of this study is to assess real time changes in raw and processed EEG in relation to the clinical and radiological evidence of cerebral vasospasm.
- Conditions
- Cerebral Vasospasm, Delayed Cerebral Ischemia, Subarachnoid Hemorrhage
- Trial name
- BIS (NCT01187420)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Subarachnoid Hemorrhage, Aneurysmal, Headache
BLOCK-SAH - PPF-Block for Post-SAH Headache
BLOCK-SAH is a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial with a sequential parallel comparison design (SPCD) of bilateral pterygopalatine fossa (PPF) injections with 20mg ropivacaine +…
- Trial name
- BLOCK-SAH (NCT06008795)
- Testing
- Pterygopalatine Fossa Nerve Block with Ropivacaine and Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 195 people
- Sponsor
- University of Florida
Subarachnoid Aneurysm Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Nimodipine Variability in SAH
Aneurysmal subarachnoid hemorrhage (SAH) is a life-threatening neurological illness: it is bleeding in the brain after a bulging blood vessel (a brain aneurysm) ruptures.
- Trial name
- ASH-II (NCT07065903)
- Where
- 3 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- University of Alberta
Spontaneous Subarachnoid Hemorrhage
Baricitinib for the Lung Injury Following Spontaneous SAH
The present study is a randomized, parallel control, and double-blind trial designed to assess the efficacy of baricitinib in reducing the occurrence of pulmonary complications in patients with spontaneous subarachnoid hemorrhage…
- Trial name
- BLISS (NCT06439615)
- Testing
- Baricitinib 4 MG, Standard treatment
- Volunteers
- 100 people
- Sponsor
- Tang-Du Hospital
Aneurysmal Subarachnoid Hemorrhage
Hypercapnia to Prevent Secondary Ischemia in SAH
Delayed cerebral vasospasm and secondary ischemic infarction are feared complications after aneurysmal subarachnoid hemorrhage (aSAH). To date, there is no effective therapy to prevent these ischemic complications.
- Trial name
- SAHCO2 (NCT01799525)
- Testing
- Hypercapnia by reduction of respiratory volume
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Wuerzburg University Hospital
Subarachnoid Hemorrhage (SAH)
ICP Versus Intracranial Compliance Guided Management in SAH
The purpose of this study is to determine whether treatment guided also by ICP mean wave amplitude improves outcome compared to international standard care in patients with SAH.
- Trial name
- NCT00248690
- Testing
- ICP mean wave amplitude
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Brain Ischemia
TicAgreLor Versus Placebo to Prevent Cerebral ISCHemia in anEuRysmal Low Grade SAH A Double Blinded Randomised Controlled Study
Among aneurysmal subarachnoid hemorrhage (aSAH) survivors, ischemic injuries such as peri procedural thromboembolic events (TEE) and delayed cerebral ischemia (DCI) represent the most important disabling complications.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Ischemia, Endovascular Procedure
- Trial name
- TALISCHER-SAH (NCT07821008)
- Testing
- Experimental group: ticagrelor
- Where
- 7 sites in France
- Volunteers
- 274 people
- Sponsor
- University Hospital, Toulouse
Subarachnoid Hemorrhage
Ventriculostomies in SAH: ICP Open or Not?
The purpose of this study is explore how cerebrospinal fluid (CSF) drainage impacts outcomes for patients diagnosed with subarachnoid hemorrhage (SAH).
- Trial name
- VISION (NCT00787020)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Duke University
Subarachnoid Hemorrhage, Aneurysmal
Complement Inhibition: Attacking the Overshooting Inflammation @Fter Subarachnoid Hemorrhage (CIAO@SAH)
Aneurysmal subarachnoid hemorrhage (SAH) can lead to devastating outcomes for patients, like cognitive decline. This is caused by early brain injury (EBI) followed by delayed cerebral ischemia (DCI).
- Trial name
- CIAO@SAH (NCT06359782)
- Testing
- C1 Esterase Inhibitor Injection [Cinryze]
- Where
- Netherlands
- Volunteers
- 128 people
- Sponsor
- Haaglanden Medical Centre
Traumatic Brain Injury (TBI), Subarachnoid Hemorrhage (SAH)
Non-invasive Brain Pressure Monitoring After Trauma or Hemorrhage
Introduction: Increased intracranial pressure (ICP) is considered to be the most important intracranial mechanism causing secondary injury in patients admitted after acute traumatic brain injury (TBI) and intracranial haemorrhage…
- Trial name
- NCT02172703
- Testing
- Non-invasive ICP measurement device
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- Javier Fandino, MD
Coma
Multimodal Resonance Imaging for Outcome Prediction on Coma Patients
Stroke, traumatic head injury, subarachnoid hemorrhage and cerebral anoxia are main causes of a coma condition implying severe brain damage and thus, poor prognosis.
- Trial name
- MRI-Coma (NCT00577954)
- Testing
- Multimodal MRI
- Where
- France
- Volunteers
- 417 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Circadian Rhythm Disorders
Effects of Blocking Blue Light at Night Post CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH
Purpose The purpose of this study is to determine whether filtering out blue light at nighttime reduces post-surgical inflammation and/or moderates cognitive decline and mood and sleep alterations in patients undergoing elective…
- Trial name
- NCT04578249
- Testing
- Blue light-blocking goggles, Clear goggles
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- West Virginia University
Subarachnoid Hemorrhage
HyperHAES Versus Placebo - Effect on Intracranial Pressure in SAH Patients
The purpose of this study is to determine whether 7.2% NaCl in 6% hydroxyethyl starch will lower intracranial pressure (ICP) in SAH-patients with normal or moderately elevated ICP in a placebo controlled study, and to describe…
- Trial name
- NCT00199706
- Testing
- 7.2% NaCl in 6% hydroxyethyl starch solution
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus
Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH)
In all the Western populations, the annual incidence of subarachnoid hemorrhage (SAH) increase with age. In patients older than 70 years, the occurrence of SAH exposes them to high risk of morbidity and a poor quality of life.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus, Cerebral Vasospasm
- Trial name
- FASHE (NCT00692744)
- Where
- 2 sites in France
- Volunteers
- 353 people
- Sponsor
- University Hospital, Rouen