Clinical trials: SARCOIDOSIS
Cardiac Sarcoidosis, Infective Endocarditis
A Prospective Diagnostic Trial of Al[¹⁸F]F-NOTA-folate PET in Patients With Suspected Cardiac Sarcoidosis and Infective Endocarditis
The goal of this prospective diagnostic study is to evaluate the imaging characteristics, diagnostic performance, radiation dosimetry, and safety of Al[¹⁸F]F-NOTA-folate PET imaging in patients with suspected cardiac sarcoidosis…
- Trial name
- FOL-CARD (NCT07814222)
- Testing
- Al[¹⁸F]F-NOTA-folate PET imaging, [15O]water PET imaging, Echocardiography
- Where
- Finland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Mediastinal Lymph Node Enlargement, Sarcoidosis
Bronchoscopic Sampling Techniques in Sarcoidosis
The development of endobronchial ultrasound (EBUS) and EBUS-guided transbronchial needle aspiration (EBUS-TBNA) has improved the safety and diagnostic accuracy of the mediastinal lymph node (MLN) sampling.
- Conditions
- Mediastinal Lymph Node Enlargement, Sarcoidosis, Tuberculosis, Lymphomas
- Trial name
- NCT01836822
- Testing
- EBUS guided transbronchial forceps biopsy (EBUS-TBFB), EBUS guided transbronchial needle aspiration (EBUS-TBNA), large bore (19G) histologic needle biopsy of the mediastinal lymph nodes
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Medical University of Warsaw
Lung Cancer, Lymphoma
Improving Genomic Profiling and Reducing Time to Cancer Treatment Via Targeted Use of Endoscopic Ultrasound
Aim: To investigate whether the novel 3rd generation FNB needle provides a better diagnostic accuracy than a standard FNA needle in EUS-B guided diagnosis of common deep seated thoracic malignancies (lung cancer and lymphoma).
- Conditions
- Lung Cancer, Lymphoma, Sarcoidosis
- Trial name
- IMPROVED (NCT06848738)
- Testing
- FNB, FNA
- Where
- 3 sites in Denmark
- Volunteers
- 362 people
- Sponsor
- Zealand University Hospital
Sarcoidosis
Validity, Reliability and Responsiveness of King's Sarcoidosis Questionnaire in a Danish Population
The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health status in patients with sarcoidosis. The KSQ was previously validated in English German and Dutch.
- Trial name
- NCT04388085
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Aarhus
Cardiac Sarcoidosis
Diagnostic Criteria in Cardiac Sarcoidosis
The purpose of the study is to evaluate the accuracy of the current diagnostic criteria of cardiac sarcoidosis.
- Trial name
- ELDORADO (NCT04737317)
- Testing
- ECG, Echo, laboratory tests, CMR, PET-CT, Biopsy
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heart Center Leipzig - University Hospital
Sarcoidosis
Exercise Training in Sarcoidosis (EXTRAS Study)
Exercise intolerance and reduced health status have been found in patients with sarcoidosis and has been related to skeletal muscle weakness.
- Trial name
- NCT00099424
- Testing
- High-intensity exercise training
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Gasthuisberg
Sarcoidosis, Cutaneous Sarcoidosis
Sirolimus in Cutaneous Sarcoidosis
Sarcoidosis is a multisystemic disease of unknown etiology characterized by the presence of epithelioid granulomas without caseous necrosis in the organs involved. Sarcoidosis cutaneous lesions can be severe.
- Trial name
- SIRIUS (NCT05458492)
- Testing
- Sirolimus
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Sarcoidosis
Somatostatin Receptor Imaging in Cardiac Sarcoidosis
The purpose of the trial is to determine the accuracy of Cu-64 labelled DOTATATE for diagnosing cardiac sarcoidosis using PET/CT or PET/MRI.
- Trial name
- NCT02812849
- Testing
- Cu-64 DOTATATE
- Where
- Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Muscular Sarcoidosis
Effect of Fermented Oyster Extract on Musculoskeletal Biomarkers in Relative Sarcopenia Adults
The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the fermented oyster extract on muscle strength, muscle mass, and muscle function in healthy adults for 12 weeks.
- Trial name
- NCT04109911
- Testing
- Fermented oyster extract
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Sarcoidosis, Pulmonary
Investigation of the Efficacy of Metformin Therapy on Pulmonary Sarcoidosis
This is a double blinded, randomized, placebo controlled clinical trial of 40 participants with pulmonary sarcoidosis. Primary Objective: To assess the steroid-sparing efficacy and safety of oral metformin therapy in participants…
- Trial name
- MetforminTOP (NCT05910554)
- Testing
- Metformin, Cellulose
- Sponsor
- University of Maryland, Baltimore
Cardiac Sarcoidosis, Sarcoidosis
Cardiac Sarcoidosis Response To Steroids Trial
There are no published clinical consensus guidelines on the treatment of cardiac sarcoidosis. Corticosteroid therapy is advocated by some experts, but is based on small observational studies, with varied clinical response.
- Trial name
- CASTOR (NCT01210677)
- Testing
- Prednisone
- Where
- Canada
- Sponsor
- Ottawa Heart Institute Research Corporation
Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis
Investigation of Pectoralis Muscle Strength in Elderly With Interstitial Lung Disease
Interstitial lung disease (ILD) is a restrictive lung disease characterized by impaired lung function, exercise limitation and skeletal muscle dysfunction.
- Conditions
- Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Sarcoidosis, Pulmonary, Geriatric
- Trial name
- NCT04803617
- Testing
- Assessment of pulmonary function and pectoralis muscle strength
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Habibedurdu
Mediastinal Lymphadenopathy, Lung Cancer
Mediastinal EBUS Cryobiopsy Study In Sweden
This study is a prospective observational non-randomized clinical trial where all the participitants undergo the same procedure and every participitant's samples are compared to each other.
- Conditions
- Mediastinal Lymphadenopathy, Lung Cancer, Sarcoidosis, Lymphoma
- Trial name
- MECRIS (NCT06347939)
- Testing
- Mediastinal lymph nodes cryobiopsies
- Where
- 2 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Pulmonary Sarcoidosis
Study of Intravenous ATYR1923 (Efzofitimod) for Pulmonary Sarcoidosis
This randomized, double-blind, placebo matched to efzofitimod-controlled, study will evaluate the safety, tolerability, immunogenicity, pharmacokinetic (PK), and preliminary efficacy of multiple ascending doses of IV efzofitimod…
- Trial name
- NCT03824392
- Where
- 15 sites in United States
- Volunteers
- 37 people
- Sponsor
- aTyr Pharma, Inc.
Stage 2 Pulmonary Sarcoidosis, Stage 3 Pulmonary Sarcoidosis
Safety of Intravenous Infusion of Human Placenta-Derived Cells (PDA001) for the Treatment of Adults With Stage II or III Pulmonary Sarcoidosis
The primary objective of the study is to assess the safety and tolerability of a single dose of PDA001 (given twice) in subjects with Stage II or III Pulmonary Sarcoidosis (PS) who are refractory to one or more of the following…
- Trial name
- NCT01440192
- Testing
- PDA001 (cenplacel-L)
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- Celularity Incorporated
Interstitial Lung Disease
Effect of Respiratory Muscle Training in Interstitial Lung Patients
The aim of this study is to investigate the possible effects of inspiratory muscle training (IMT) on respiratory functions, functional capacity, balance and quality of life in patients with interstitial lung disease.
- Trial name
- NCT05106556
- Testing
- Conventional Chest Physiotherapy, Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Bezmialem Vakif University
Sarcoidosis
Impact of Chemokine Receptor 5 (CCR5) Inhibition on Sarcoidosis Immunophenotypes
The study hypothesizes that inhibition of the receptor CCR5 by maraviroc will diminish inflammation in patients with sarcoidosis.
- Trial name
- GRADS (NCT02134717)
- Testing
- all subjects will receive maraviroc 300mg orally twice a day for 6 weeks, Bronchoscopy with bronchoalveolar lavage, venipunctures
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Kevin F. Gibson
Sarcoidosis
Use of Immunosuppressive Therapy for Sarcoidosis
Retrospective review of the outcome of use of immunosuppressive drugs in treatment of sarcoidosis
- Trial name
- NCT02356445
- Testing
- Cytotoxic drug
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of Cincinnati
Mesothelioma
SS1(dsFV)PE38 Plus Pemetrexed and Cisplatin to Treat Malignant Pleural Mesothelioma
Background: Standard therapy for mesothelioma is a combination of the drugs pemetrexed and cisplatin. However, the benefits of this treatment are limited, and in most treated patients the disease continues to worsen.
- Trial name
- NCT01445392
- Testing
- Multicycle SS1P, Pemetrexed, Cisplatin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes Mellitus, Sarcoidosis
Salivary Proteins in Disease and Health
This study will examine saliva samples from healthy volunteers and patients with various diseases to learn more about how disease affects the mouth and salivary glands.
- Conditions
- Diabetes Mellitus, Sarcoidosis, Dental Caries, Sjorgren's Syndrome
- Trial name
- NCT00100204
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)