Clinical trials: SARCOIDOSIS
Pancreas Neoplasms, Lymphatic Metastasis
Comparing of Modified Wet Suction Technique and Dry Suction Technique for EUS-FNA of Solid Occupying Lesions
The purpose of this study is to compare the diagnosis accuracy of modified wet suction technique and 5ml dry suction technique on solid occupying lesions.
- Conditions
- Pancreas Neoplasms, Lymphatic Metastasis, Neoplasm Metastases, Unknown Primary Neoplasm Metastasis
- Trial name
- NCT02789371
- Testing
- the first pass is made with 5ml suction technique, the first pass is made with modified wet suction technique
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Bin Cheng
Cardiac Sarcoidosis, Sarcoidosis of the Heart
Exosome-based Omic Signatures of Disease Activity in Cardiac Sarcoidosis (EXODACS)
The purpose of this study is to develop a prospective cohort of patients with and without cardiac sarcoidosis as well as active and inactive disease to develop a prospective biobank from which exosome analysis of peripheral blood…
- Conditions
- Cardiac Sarcoidosis, Sarcoidosis of the Heart, Sarcoidosis With Myocarditis, Sarcoidosis, Cardiac
- Trial name
- EXODACS (NCT07604220)
- Testing
- Exosome Analysis
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Mayo Clinic
Sarcoidosis, Pulmonary
A Study to Estimate the Effect Sizes of HRCT Endpoints in Response to Glucocorticoid Induction Therapy in Subjects With Pulmonary Sarcoidosis
This is a multicenter, single-arm, unblinded/open-label study of the effect size of HRCT endpoints in response to glucocorticoid induction therapy in subjects with a diagnosis of pulmonary sarcoidosis who have not received…
- Trial name
- NCT03324503
- Testing
- Glucocorticoid (prednisone or prednisolone)
- Where
- 20 sites in United States, Netherlands and 1 more
- Volunteers
- 8 people
- Sponsor
- Celgene
Sarcoidosis
Muscle Strength and Exercise Capacity in Sarcoidosis Patients
The aim of this study is to examine exercise capacity, muscle strength and fatigue in sarcoidosis. In this longitudinal study the changes in prevalence of exercise intolerance, reduced muscle strength and fatigue will be…
- Trial name
- NCT00854672
- Where
- Netherlands
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cancer, Infection
Comparison of "Wet Suction" Technique to Contemporary "Dry Suction" Technique Using a 22 Gauge Needle for EUS FNA
ROLE OF SUCTION IN EUS-FNA: Current suction technique involves suctioning the aspirate into the needle that has an air column. The needle is not flushed with any liquid prior to passing into the desired solid lesion.
- Conditions
- Cancer, Infection, Inflammation, Tumor
- Trial name
- NCT01720745
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- University of Minnesota
Pulmonary Sarcoidosis
A Clinical Trial of Tulisokibart (MK-7240) in Participants With Pulmonary Sarcoidosis (MK-7240-016)
Researchers are looking for new ways to treat active pulmonary sarcoidosis (PS). This trial will help researchers learn if a trial medicine called tulisokibart can treat symptoms of active PS.
- Trial name
- NCT07867938
- Testing
- Tulisokibart, Background prednisone therapy
- Volunteers
- 158 people
- Sponsor
- Merck Sharp & Dohme LLC
Sarcoidosis
A Phase 2 Study With CC-220 in Skin Sarcoidosis
This study will evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of oral CC-220 in adult subjects with chronic cutaneous sarcoidosis.
- Trial name
- NCT02192489
- Testing
- CC-220 0.3 mg Daily, CC-220 0.6mg Daily
- Sponsor
- Celgene
Sarcoidosis
Janus Kinase Inhibition in Sarcoidosis
The purpose of this study is to investigate the role of the oral JAK1 inhibitor, abrocitinib 200 mg once daily, for the treatment of patients with moderate to severe cutaneous sarcoidosis.
- Trial name
- NCT05696795
- Testing
- Abrocitinib 200 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Sarcoidosis With Myocarditis, Sarcoidosis
Cell Free DNA in Cardiac Sarcoidosis
Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing…
- Conditions
- Sarcoidosis With Myocarditis, Sarcoidosis, Healthy, ST Elevation Myocardial Infarction
- Trial name
- cfDNA in CS (NCT03858777)
- Testing
- cell free DNA
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nabeel Hamzeh
Sarcoidosis
Trial of Antimycobacterial Therapy in Sarcoidosis
Growing research from independent laboratories provide an association between mycobacteria and sarcoidosis. More recent immunologic and molecular studies demonstrate immune responses to mycobacteria virulence factors.
- Trial name
- CLEAR (NCT01074554)
- Testing
- Antibiotic Regimen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University
Alpha 1 Antitrypsin Deficiency, AATD
Genomic Research in Alpha-1 Antitrypsin Deficiency
This project is designed to examine the interaction between the microflora in the lower airway and the concentration of a serum protein called alpha-1 antitrypsin.
- Trial name
- GRADS Alpha-1 (NCT01832220)
- Where
- 9 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Pittsburgh
Sarcoidosis, Pulmonary, Telerehabilitation
Feasibility & Effect of a Tele-rehabilitation Program in Pulmonary Sarcoidosis Pulmonary Sarcoidosis
Pulmonary sarcoidosis (PS) is defined as a multisystem granulomatous disorder of unknown cause affecting different vital organs, especially the lungs. PS manifest in reduction of pulmonary function.
- Trial name
- TeleSarco (NCT03914027)
- Testing
- Telerehabilitation
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Aarhus University Hospital
Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis
University of Virginia Natural History Study
Data and specimens will be collected longitudinally from patients seen in the UVA Interstitial Lung Disease (ILD) clinic in order to describe the phenotypic expression of various interstitial lung diseases.
- Conditions
- Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Sarcoidosis, Connective Tissue Diseases
- Trial name
- NCT04896138
- Testing
- Interstitial Lung Disease
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Interstitial Lung Disease, Pulmonary Sarcoidosis
CASPA: CArdiac Sarcoidosis in PApworth
Sarcoidosis is a disease of unknown cause which affects adults of all ethnic backgrounds. Clumps of tissue called granulomas develop primarily in the lungs, but can damage other organs, especially the heart.
- Conditions
- Interstitial Lung Disease, Pulmonary Sarcoidosis, Cardiac Sarcoidosis
- Trial name
- CASPA (NCT03599414)
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Sarcoidosis, Obstructive Sleep Apnea
Obstructive Sleep Apnoea in Sarcoidosis
Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Fatigue is a common problem in sarcoidosis affecting between 50% and 80% of patients, and thus represents a major impairment of their quality of life.
- Conditions
- Sarcoidosis, Obstructive Sleep Apnea, Fatigue, Sleepiness
- Trial name
- OSASA (NCT04156789)
- Testing
- Home sleep apnea testing
- Where
- Switzerland
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Malcolm Kohler
Ocular Sarcoidosis, Panuveitis
Ocular Sarcoidosis Open Label Trial of ACTHAR Gel
Treatment with ACTHAR Gel will result in a reduction of ocular inflammation in patients with active ocular sarcoidosis that requires systemic immunosuppressant therapy (hypothesis)
- Conditions
- Ocular Sarcoidosis, Panuveitis, Anterior Uveitis
- Trial name
- NCT02725177
- Testing
- Repository Corticotropin Injection, Repository Corticotropin Injection -Treatment Extension
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The Cleveland Clinic
Sarcoidosis-associated Pulmonary Hypertension
A Study in Participants With Sarcoidosis-associated Pulmonary Hypertension (SAPH) to Assess the Efficacy and Safety of Oral Selexipag
Oral selexipag is commercially available in several countries for the treatment of a particular group of pulmonary hypertension (PH) called pulmonary arterial hypertension (PAH).
- Trial name
- SPHINX (NCT03942211)
- Testing
- Selexipag
- Where
- 38 sites in United States, Belgium and 8 more
- Volunteers
- 10 people
- Sponsor
- Actelion
Sarcoidosis, Tuberculosis
The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
- Trial name
- uveitis (NCT02627209)
- Testing
- spectrophotometric assay, radial immunodiffusion
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ozlem Sahin
Sarcoidosis
ACTHAR Therapy for Central Nervous System Sarcoidosis
There is a need for a more reliable, expeditious therapy that can be used as an alternative to glucocorticoids in severe Central Nervous System (CNS) sarcoidosis.
- Trial name
- NCT02920710
- Testing
- Repository Corticotropin Injection
- Where
- United States
- Sponsor
- The Cleveland Clinic
Sarcoidosis
Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82
In this this investigation, 15 subjects with a high probability of cardiac sarcoidosis based on clinical criteria and abnormal cardiac FDG uptake on initial, clinically indicted FDG PET study will be considered for this study.
- Trial name
- NCT03048097
- Testing
- Fluorodeoxyglucose, Rubidium, FDG-PET/CT with Rb82 Myocardial Perfusion Imaging
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University