Clinical trials: SARCOIDOSIS
Sarcoidosis, Pulmonary
Risk Indicators of Sarcoidosis Evolution-Unified Protocol
The purpose of this study is to develop prediction models that can prognosticate patients with sarcoidosis using clinical data and blood markers that can be obtained during a clinic visit.
- Trial name
- RISE-UP (NCT05567133)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Francisco
Sarcoidosis, Osteoporosis Risk
Bone Mineral Density in Patients With Sarcoidosis
To assess the frequency and risk factors of decreased bone mineral density (BMD) and vertebral fractures in Danish patients with sarcoidosis.
- Trial name
- NCT06238037
- Where
- Denmark
- Volunteers
- 144 people
- Sponsor
- University of Aarhus
Sarcoidosis
Use of Immunosuppressive Therapy for Sarcoidosis
Retrospective review of the outcome of use of immunosuppressive drugs in treatment of sarcoidosis
- Trial name
- NCT02356445
- Testing
- Cytotoxic drug
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of Cincinnati
Sarcoidosis
A Clinical Study of Tranilast in the Treatment of Sarcoidosis
56 patients with sarcoidosis will be selected to receive treatment of tranilast.The investigators can analyse the changes in the thickness and area of skin lesions before and after treatment as well as other involved organs…
- Trial name
- NCT03528070
- Testing
- Tranilast
- Volunteers
- 56 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cardiac Sarcoidosis, Infective Endocarditis
A Prospective Diagnostic Trial of Al[¹⁸F]F-NOTA-folate PET in Patients With Suspected Cardiac Sarcoidosis and Infective Endocarditis
The goal of this prospective diagnostic study is to evaluate the imaging characteristics, diagnostic performance, radiation dosimetry, and safety of Al[¹⁸F]F-NOTA-folate PET imaging in patients with suspected cardiac sarcoidosis…
- Trial name
- FOL-CARD (NCT07814222)
- Testing
- Al[¹⁸F]F-NOTA-folate PET imaging, [15O]water PET imaging, Echocardiography
- Where
- Finland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cervical Cancer, Fallopian Tube Cancer
Immunotoxin Therapy in Treating Patients With Advanced Solid Tumors
RATIONALE: Immunotoxins can locate tumor cells and kill them without harming normal cells. Immunotoxin therapy may be effective in treating advanced solid tumors.
- Conditions
- Cervical Cancer, Fallopian Tube Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00066651
- Testing
- SS1(dsFv)-PE38 immunotoxin
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Sarcoidosis, Chronic Beryllium Disease
Study Comparing Chronic Beryllium Disease to Pulmonary Sarcoidosis
Inhalation of beryllium can induce specific sensitization and diffuse pulmonary granulomatosis called chronic beryllium disease (CBD).
- Trial name
- BERYSARC (NCT06113991)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sarcoidosis, Lymph Node Disease
Radiographic Characteristics of Mediastinal and Hilar Lymph Nodes in Sarcoidosis
Background: This study aimed to investigate the diagnostic value of thoracic computerized tomography (CT) which is a noninvasive method making the diagnosis of sarcoidosis.
- Trial name
- NCT04735302
- Testing
- Radiographic Feature
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Karadeniz Technical University
Cardiac Sarcoidosis
Macrophage PET/CT Imaging Using 64Cu-DOTATATE for the Diagnosis of Cardiac Sarcoidosis
The purpose of the CuDOSIS study is to examine the diagnostic value of activated macrophage imaging in patients with or under evaluation for cardiac sarcoidosis.
- Trial name
- CuDOSIS (NCT06131112)
- Testing
- 64Cu-DOTATATE PET/CT scan
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sarcoidosis
Effect of the Number of Needle Revolutions Inside the Node on the Diagnostic Yield of EBUS-TBNA in Sarcoidosis
The investigators plan to evaluate the effect of the number of needle revolutions inside the node on the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with…
- Trial name
- NCT02875756
- Testing
- 10 revolutions, 20 revolutions
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Infective Endocarditis, Cardiac Sarcoidosis
Evaluation of the Impact of a Patient Education Protocol on the Quality of 18F-FDG PET Imaging Indicated for Investigation of Cardiac Inflammation
The aim of this study is to assess the impact of implementing a patient education and preparation protocol for FDG PET (18F-FDG PET) imaging on the quality of imaging results.
- Trial name
- CARTEP (NCT07029295)
- Testing
- Sending a link to the video, Compliance questionnaire, Determination of beta-hydroxybutyrate (BHB) in capillary blood
- Where
- 2 sites in France
- Volunteers
- 138 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Sarcoidosis, Lung Function
Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis
Sarcoidosis is a granulomatous disease for which the molecular and immunologic association with mycobacteria continues to strengthen.
- Trial name
- CLEAR Lung (NCT01169038)
- Testing
- levaquin; ethambutol; rifampin and azithromycin.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University
Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
Heart scarring, also known as fibrosis, plays a major role in a lot of heart muscle abnormalities. These abnormalities of the heart muscle can lead to major issues such as symptoms of heart failure, dangerous heart rhythm…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy, Cardiac Sarcoidosis, Hypertensive Heart Disease
- Trial name
- CHIEFTain (NCT06409585)
- Testing
- 68Ga-FAPI or 18F-AlF-FAPI cardiac PET-MR, Echocardiogram, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cardiac Transplant, Cardiac Sarcoid
DEtection of Cellular Inflammation With FERumoxytol in the HEART
To non-invasively image myocardial accumulation of ultrasmall superparamagnetic particles of iron oxide (USPIOs) by an increase in R2* values (compared to controls) within the myocardium of patients with: i.
- Conditions
- Cardiac Transplant, Cardiac Sarcoid, Myocarditis, Healthy Volunteers
- Trial name
- DECIFER (NCT02319278)
- Testing
- Ferumoxytol
- Where
- 3 sites in United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Pulmonary Sarcoidosis
Study of Multiple-Ascending-Dose Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis With or Without Extrapulmonary Manifestations
Study of Multiple-Ascending-Dose Study of XTMAB-16 in Patients with Pulmonary Sarcoidosis with or Without Extrapulmonary Manifestations
- Trial name
- NCT05890729
- Where
- 33 sites in United States, Czechia and 4 more
- Volunteers
- 32 people
- Sponsor
- Xentria, Inc.
Sarcoidosis
A Trial of EBUS-TBNA Versus Conventional TBNA in Diagnosis of Sarcoidosis
The investigators hypothesize that conventional or EBUS-TBNA will have equal efficiency in diagnosing sarcoidosis when performed in conjunction with endobronchial and transbronchial lung biopsy.
- Trial name
- NCT01908868
- Testing
- EBUS-TBNA, Conventional TBNA, Endobronchial and transbronchial biopsy
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Cutaneous Sarcoidosis
A Study of Brepocitinib in Adults With Cutaneous Sarcoidosis
This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with cutaneous sarcoidosis.
- Trial name
- BEACON (NCT06978725)
- Testing
- Oral Brepocitinib
- Where
- 44 sites in United States, Australia and 1 more
- Volunteers
- 168 people
- Sponsor
- Priovant Therapeutics, Inc.
Sarcoidosis
Pathogen Specific Immunity in Patients With Sarcoidosis
The purpose of this study is to assess the lung cells of healthy volunteers and patients with stage II and III pulmonary sarcoidosis for pathogen specific memory immunity and gene expression patterns.
- Trial name
- NCT00217789
- Testing
- Bronchoalveolar Lavage and Venipuncture
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Sarcoidosis, Pulmonary Fibrosis
The Influence of Personality on Pulmonary Fibrosis and Sarcoidosis
A number of studies have shown that the quality of life of two common interstitial lung diseases (ild), sarcoidosis and pulmonary fibrosis patients, is impaired and that fatigue is a substantial problem for those patients.
- Trial name
- NCT00504621
- Volunteers
- 450 people
- Sponsor
- Maastricht University Medical Center
Sarcoidosis
Development of a Novel Human In Vitro Sarcoidosis Model
There is currently no experimental model that accurately represents sarcoidosis. The lack of a useful research model significantly slows progress towards developing new treatments for sarcoidosis.
- Trial name
- NCT01857401
- Testing
- No intervention, observational study only
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Elliott Crouser MD