Clinical trials: SARS-COV-2 Infections
SARS-CoV-2
Post-Marketing Non-Acute Safety Study in Japan After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA-1273 COVID-19 Vaccine in Persons at High Risk of Severe COVID-19
The goal of this study is to assess serious adverse events associated with hospitalizations in the non-acute phase after vaccination with the mRNA-1273 vaccine in persons with underlying diseases who are considered to have a high…
- Trial name
- NCT05894590
- Where
- Japan
- Volunteers
- 13,680 people
- Sponsor
- ModernaTX, Inc.
COVID -19, Respiratory Failure
Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, Effects on Oxygenation in Hypoxic COVID-19 Patients. Prospective Cohort Study.
To determine whether the use of oxygen hoods as compared to conventional high-flow oxygen delivery systems, and the effects on oxygenation, mechanical ventilation and mortality rates in hypoxic patients with COVID-19.
- Conditions
- COVID -19, Respiratory Failure, Hypoxia
- Trial name
- NCT04407260
- Testing
- Oxygen Hood
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Northwell Health
Covid19, Corona Virus Infection
A Study of Baricitinib (LY3009104) in Children With COVID-19
The purpose for this study is to determine if the study drug baricitinib is effective and safe in hospitalized pediatric participants with Coronavirus disease 2019 (COVID -19) and to confirm the dose.
- Trial name
- COV-BARRIER (NCT05074420)
- Testing
- Baricitinib
- Where
- 14 sites in United States, Brazil and 2 more
- Volunteers
- 6 people
- Sponsor
- Eli Lilly and Company
Coronavirus Disease, SARS-CoV-2 Infection
ImmuneSense™ COVID-19 Cross-Reactivity Study
Adaptive Biotechnologies has developed a clinical test called T-Detect COVID Test that can identify a T-cell response to the SARS-CoV-2 virus, indicating recent or prior infection This study aims to evaluate the potential…
- Trial name
- NCT05112874
- Where
- United States
- Sponsor
- Adaptive Biotechnologies
Hypertension, Covid19
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR)
The COVID-19 pandemic is the biggest medical challenge in decades. Individuals with pre-existing cardiovascular diseases have a higher risk of severe disease and death from COVID-19.
- Trial name
- LOCHINVAR (NCT05087290)
- Testing
- Cases, Controls
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Glasgow
Diabetes, COVID-19
RADx-UP- Impact of Community Health Worker Deployment
The proposed project will implement and evaluate a brief Community Health Worker (CHW) intervention through the Albany Area Primary Health Care, a rural Federally Qualified Health Center (FQHC).
- Conditions
- Diabetes, COVID-19, Community Health Workers, Health Behavior
- Trial name
- NCT05863884
- Testing
- Impact of Community Health Worker Home Deployment on COVID-19 Vaccine Confidence and Uptake
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Morehouse School of Medicine
COVID-19, Uremia
Paxlovid in the Treatment of COVID-19 Patients With Uremia
This study is a single-center, open-label, randomized controlled clinical study to evaluate the effect of Paxlovid on the virus-negative time and disease progression in uremic patients infected with SARS-CoV-2 (omicron variants).
- Trial name
- NCT05386433
- Testing
- Paxlovid, standard-of-care
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
COVID-19
A Study to Learn About Bivalent COVID-19 RNA Vaccine Candidate(s) in Healthy Infants and Children
The purpose of this clinical trial is to learn about the safety and immune responses of the study vaccine (called a bivalent BNT162b2 Omicron containing vaccine) in healthy infants and children.
- Trial name
- NCT05630352
- Testing
- Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 3 microgram dose, Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 6 microgram dose, Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 10 microgram dose
- Volunteers
- healthy volunteers welcome
- Sponsor
- BioNTech SE
COVID, Hypertension
COVID-19 Blood Pressure Endothelium Interaction Study (OBELIX)
The current COVID-19 pandemic (caused by the SARS-CoV-2 virus) represents the biggest medical challenge in decades. Whilst COVID-19 mainly affects the lungs it also affects multiple organ systems, including the cardiovascular…
- Trial name
- OBELIX (NCT04409847)
- Testing
- ABPM, ECG, FMD
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- NHS Greater Glasgow and Clyde
SARS-CoV-2
GLS-5310 Vaccine for the Prevention of SARS-CoV-2 (COVID-19)
This clinical trial will evaluate the safety, tolerability and immunogenicity of GLS-5310 DNA vaccine against SARS-CoV-2(COVID-19) in healthy volunteers.
- Trial name
- NCT04673149
- Testing
- GLS-5310
- Where
- South Korea
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- GeneOne Life Science, Inc.
COVID 19 Vaccine
Effects of COVID 19 Vaccine on Egyptian Population
The aim of this study is to identify adverse events following vaccination by the COVID-19 vaccine by evaluating adverse side effects, hematological values; immunogenicity in the Egyptian candidates in response to COVID-19…
- Trial name
- NCT04809948
- Testing
- viral vector vaccine
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Assiut University
COVID-19 Pneumonia
Clinical Presentations and Outcomes of Patients With Covid-19 Pneumonia
This study aims at determining clinical presentations and outcomes of patients with covid-19 pneumonia and also follow up of patients for up to 6 months to detect possibility of post covid fibrosis
- Trial name
- NCT05092555
- Testing
- Nasopharyngeal swap for Reverse transcription polymerase chain reaction
- Volunteers
- 200 people
- Sponsor
- Sohag University
Telerehabilitation
Telerehabilitation in Rheumatic Diseases
Telerehabilitation (TR) became more popular during COVID-19 pandemic due to social isolation and curfew. Exercise is one of treatments for patients with rheumatic diseases that are known to have low levels of physical activity.
- Trial name
- NCT05493384
- Testing
- Telerehabilitation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Leukemia, Acute, Covid19
Clinical Characteristics of Patients With Leukemia and COVID-19
The purpose of this study is to describe the main clinical characteristics of patients with de novo acute lymphoblastic leukemia treated inside the third level hospitals converted to Coronavirus disease 2019 (COVID-19) attention…
- Conditions
- Leukemia, Acute, Covid19, Leukemia, Lymphoblastic
- Trial name
- NCT04745416
- Where
- 2 sites in Mexico
- Volunteers
- 30 people
- Sponsor
- Hospital General de Mexico
COVID-19
An Open Non-comparative Study of the Efficacy and Safety of Aprotinin in Patients Hospitalized With COVID-19
The observational study will be carried out in two stages. At the first stage, the efficacy and safety of Aprotinin intravenous infusion as add-on therapy to the standard of care will be studied.
- Trial name
- NCT04527133
- Testing
- Aprotinin
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Aviron LLC
Vaccine Response Impaired, Vaccine Adverse Reaction
Vaccine Observation to Include All Communities for Equitable Science
VOICES is a longitudinal, prospective, observational study that will enroll up to 10,000 subjects of diverse racial backgrounds being administered an emergency use authorized COVID-19 vaccine, for collection and analysis of stool…
- Trial name
- VOICES (NCT04770649)
- Testing
- COVID-19 vaccine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Persephone Biosciences
Long Covid19, Long COVID
Intermittent Fasting and a No-Sugar Diet for Long COVID Symptoms
This cross-over study will assess a no added sugar diet, a restricted daily eating window, and one or two full day water fasts to determine if there is an effect on self-reported symptoms of Long Covid (PASC).
- Trial name
- NCT06214455
- Testing
- Low sugar diet and 10-12 hour eating window, Low sugar diet, 8 hour eating window and fasting
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- Pacific Northwest University of Health Sciences
Pulse Steroid and Immunoglobulins Drugs in Covid 19 Patients
Combined Use of Immunoglobulin and Pulse Steroid Therapies in Severe Covid-19 Patients
In December 2019, SARS-COV-2 was isolated from patients for the first time . It then rapidly turned into a pandemic affecting the whole world.While most Covid patients survive the disease with mild symptoms, some may develop…
- Trial name
- NCT06223984
- Testing
- pulse steroid and nanogam
- Where
- Turkey (Türkiye)
- Volunteers
- 178 people
- Sponsor
- Konya City Hospital
COVID-19
A Phase III of COVID-19 Vaccine EuCorVac-19 in Healthy Adults Aged 18 Years and Older
A phase III, randomized, observer-blind, active-controlled, parallel-group, multi-center study to evaluate immunogenicity and safety of a preventive COVID-19 vaccine EuCorVac-19 in healthy adults aged 18 years and older
- Trial name
- NCT05603052
- Testing
- EuCorVac-19, ChAdOx1 nCoV-19
- Where
- Democratic Republic of the Congo
- Volunteers
- 2,852 people, healthy volunteers welcome
- Sponsor
- EuBiologics Co.,Ltd
Covid19, Morbidity
BCG to Reduce Absenteeism Among Health Care Workers During the COVID-19 Pandemic
The COVID-19 pandemic challenges available hospital capacity. Strategies to protect health care workers (HCW) are desperately needed.
- Conditions
- Covid19, Morbidity, Absenteeism
- Trial name
- EDCTP (NCT04641858)
- Testing
- BCG-Denmark, Saline
- Where
- 2 sites in Guinea-Bissau, Mozambique
- Volunteers
- 668 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
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