Clinical trials: SARS-COV2 Infection
SARS-CoV Infection, Acute Respiratory Distress Syndrome
Glenzocimab in SARS-Cov-2 Acute Respiratory DistrEss syNdrome Related to COVID-19
A randomized, double blind, multicenter, placebo-controlled, parallel group, fixed dose, phase II study to evaluate the efficacy and safety of glenzocimab in ARDS.
- Conditions
- SARS-CoV Infection, Acute Respiratory Distress Syndrome, COVID-19, ARDS
- Trial name
- GARDEN (NCT04659109)
- Testing
- glenzocimab
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Acticor Biotech
Covid-19
Clinical Outcome of Patients With COVID-19 Pneumonia Treated With Corticosteroids and Colchicine
Cross sectional study of 301 adult patients with Covid-19 Pneumonia treated with corticosteroid and/or colchicine
- Trial name
- NCT04654416
- Testing
- Corticosteroid with or without colchicine
- Where
- Colombia
- Volunteers
- 301 people
- Sponsor
- Clínica Medellín - Grupo Quirónsalud
Influenza,Human, COVID-19
A Study to Learn About Flu and COVID-19 Vaccine Responses in Healthy People
This study is to learn about flu and COVID vaccines, either alone or when mixed together. Healthy people aged 18 or older can join. Participants will get one shot in each arm, either a flu or COVID vaccine, alone or mixed.
- Trial name
- NCT06683352
- Testing
- Investigational Influenza Vaccine, COVID-19 Vaccine, Investigational Influenza/COVID-19 Vaccine
- Where
- 22 sites in United States
- Volunteers
- 1,353 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
COVID-19
Trial to Evaluate Nitazoxanide for Treatment of Mild or Moderate COVID-19 in Subjects at High Risk of Severe Illness
The purpose of this study is to determine whether nitazoxanide (NTZ) is safe and effective in treating mild or moderate COVID-19 illness in adults and adolescents at highest risk for severe outcomes.
- Trial name
- NCT05157243
- Testing
- Nitazoxanide, Vitamin Super-B Complex, Standard of Care
- Sponsor
- Romark Laboratories L.C.
Immunosuppression, Cancer
Clinical Trial for Assessment of Anti-SARS-CoV-2 Serum for Early Treatment of COVID-19 Cases
Phase I/II Randomized Clinical Trial to evaluate the safety, pharmacokinetic and efficacy of Anti-SARS-CoV-2 hyperimmune serum. The study will include patients at early stage of COVID-19 with increased risk for severe disease due…
- Conditions
- Immunosuppression, Cancer, COVID-19, Other Complication of Kidney Transplant
- Trial name
- SOROCOV (NCT04834089)
- Testing
- AntiSARS-CoV-2 Serum
- Where
- 2 sites in Brazil
- Volunteers
- 618 people, healthy volunteers welcome
- Sponsor
- Butantan Institute
Covid19, Corona Virus Infection
Inhaled Aviptadil for the Treatment of COVID-19 in Patients at High Risk for ARDS
The world is currently experiencing a coronavirus (CoV-2) pandemic. A new (SARS)-CoV infection epidemic began in Wuhan, Hubei, China, in late 2019; originally called 2019- nCoV the virus is now known as SARSCoV- 2 and the disease…
- Conditions
- Covid19, Corona Virus Infection, ARDS, Aviptadil
- Trial name
- NCT04536350
- Testing
- Aviptadil 67μg
- Where
- 2 sites in Switzerland
- Volunteers
- 83 people
- Sponsor
- Prof. Dr. Jörg Leuppi
COVID-19 Pneumonia
A Clinical Study on Safety and Effectiveness of Mesenchymal Stem Cell Exosomes for the Treatment of COVID-19.
This clinical study aims to investigate the safety and efficacy of nebulized inhalation of extracellular vesicles derived from mesenchymal stem cells combined with standard therapy for COVID-19-infected individuals.
- Trial name
- NCT05787288
- Testing
- Extracellular Vesicles from Mesenchymal Stem Cells
- Where
- China
- Volunteers
- 240 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
COVID-19
Study of SHEN26 Capsule in Patients With Mild to Moderate COVID-19
This is a multicenter, randomized, double-blind, placebo-parallel-controlled phase II clinical trial. It is designed to evaluate the efficacy, safety, tolerability, and pharmacokinetic (PK) profile of SHEN26 capsules in Chinese…
- Trial name
- NCT05676073
- Testing
- SHEN26 dose 1, SHEN26 dose 2
- Where
- 4 sites in China
- Volunteers
- 91 people
- Sponsor
- Shenzhen Kexing Pharmaceutical Co., Ltd.
COVID-19, Lymphocytopenia
InterLeukin-7 to Improve Clinical Outcomes in Lymphopenic pAtients With COVID-19 Infection (Brazil Cohort)
Comparison of the effects of CYT107 vs Placebo administered by intra-muscular route (IM) at 10μg/kg twice a week for three weeks on immune reconstitution of lymphopenic COVID-19 patients
- Trial name
- ILIAD-7-BRA (NCT04927169)
- Testing
- Interleukin-7
- Where
- 6 sites in Brazil
- Volunteers
- 4 people
- Sponsor
- Revimmune
Neuroimaging, COVID-19
Neuroimaging Findings in Patients With COVID-19
This study aimed to discuss the neuroimaging findings and indications, epidemiological data, laboratory values, and the relationship of these variables with mortality in patients with COVID-19.
- Trial name
- NCT04734223
- Testing
- Neuroimaging Findings in Patients With COVID-19
- Where
- Turkey (Türkiye)
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Covid19, Appendicitis
the Impact of COVID-19 Pandemic on the Incidence and Outcome of Complicated Appendicitis
During the COVID-19 pandemic, we noticed a rise in complicated appendicitis cases presenting to our medical center. We collected objective data on all patients admitted to the surgical department with appendicitis during February…
- Trial name
- NCT04786041
- Testing
- laparoscopic appendectomy
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Long COVID, Long COVID Syndrome
Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19
At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue.
- Trial name
- NCT06864156
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Rehabilitacion
Acute Respiratory Distress Syndrome Due to SARS-CoV-2 Infection (Severe COVID19)
A Study of the C3 Inhibitor AMY-101 in Patients With ARDS Due to COVID-19 (SAVE)
The study is a prospective, randomized, placebo-controlled, single-blind phase 2 clinical study of the efficacy and safety of AMY-101, a potent C3 inhibitor, for the management of patients with ARDS caused by SARS-CoV-2…
- Trial name
- SAVE (NCT04395456)
- Testing
- AMY-101, WFI 5% glucose
- Volunteers
- 144 people
- Sponsor
- Amyndas Pharmaceuticals S.A.
Covid-19, SARS-CoV 2
Baricitinib Compared to Standard Therapy in Patients With COVID-19
There is urgent need of an effective therapy for Covid-19. To date, the best treatment of SARS-CoV-2 infection is unknown. Baricitinib has been identified as potential treatment for 2019-nCoV acute respiratory disease, because of…
- Conditions
- Covid-19, SARS-CoV 2, SARS Pneumonia
- Trial name
- BARICIVID-19 (NCT04393051)
- Testing
- Baricitinib Oral Tablet
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
COVID-19, Surgery
Impact of COVID-19 Pandemic on Hepatopancreatobiliary Surgical Services in Singapore
This paper is intended to report our observational study in evaluating the impact of the COVID-19 pandemic on Tan Tock Seng Hospital hepatopancreatobiliary unit's surgical workload from January to June across 2019 to 2022…
- Trial name
- NCT05572866
- Testing
- COVID-19 pandemic
- Where
- Singapore
- Volunteers
- 1,089 people
- Sponsor
- Tan Tock Seng Hospital
COVID-19 Pneumonia
Study to Evaluate the Efficacy and Safety of EG-009A Compared to DEX in Patients With COVID-19 Pneumonia
To study signals of efficacy and safety of a currently available dosage form (IM) of EG-009A in reducing the severity of respiratory disease in patients hospitalized with SARS-CoV-2 virus.
- Trial name
- NCT04561180
- Testing
- EG-009A, Standard of Care, Dexamethasone
- Sponsor
- Evergreen Therapeutics, Inc.
COVID-19, SARS-CoV-2 Infection
COVID-19: SARS-CoV-2-CZ-PREVAL-II Study
The aim of the SARS-CoV-2-CZ-PREVAL-II Study is to quantify the prevalence of participants with antibodies against SARS-CoV-2 and/or cell immunity against SARS-CoV-2 in specific subjects cohorts.
- Trial name
- NCT05096962
- Testing
- Quantitative analysis of SARS-CoV-2 antibodies, Cellular immunity
- Where
- Czechia
- Volunteers
- 7,268 people, healthy volunteers welcome
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Covid19, SARS-CoV2 Infection
Monitoring the Effectiveness and Safety of COVID-19 Vaccines at National University of Colombia
There are relevant questions that need to be answered about the effectiveness and safety of COVID-19 vaccines. The objective of this observational study is to follow up the clinical outcomes after vaccination in all the…
- Trial name
- NCT04887246
- Testing
- COVID-19 vaccines
- Where
- Colombia
- Volunteers
- 4,078 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Sars-CoV2
Rapid Detection of COVID-19 by Portable and Connected Biosensor
The objective of study is to estimate the sensitivity and specificity of the COR-DIAL based on nasopharyngeal samples taken at the patient's admission in relation to the final diagnosis of COVID-19 made by the medical team.
- Trial name
- COR-DIAL-1 (NCT04367142)
- Testing
- COVID-19 RT-PCR, Biosensor
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Lille
Oncology
Remote COVID-19 Symptom Tracking for Cancer Patients at Home During the Pandemic
This project will evaluate the benefit of an automated home symptom monitoring system, Symptom Care at Home, to track COVID-19 symptoms, provide instructions to reduce COVID-19 exposure, and reduce cancer symptom severity during…
- Trial name
- NCT04464486
- Testing
- SCH Intervention
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- University of Utah
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