Clinical trials: SARS-CoV Infection
Covid19, SARS-CoV Infection
COVID-19 in Polish Ice Swimmers.
Ice swimming is an increasingly common phenomenon in Poland. It has been confirmed that it has a beneficial effect on health by increasing the natural non-specific immunity to infections.
- Conditions
- Covid19, SARS-CoV Infection, Resistance, Disease, Hypothermia
- Trial name
- ICE (NCT04817280)
- Testing
- Ice Swimming
- Where
- 3 sites in Poland
- Volunteers
- 2,534 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Covid19, SARS-CoV Infection
Reactogenicity, Safety and Immunogenicity of QazCoVac-P COVID-19 Vaccine
Randomized, Blind, Placebo-controlled Phase- I Study and Randomized, Open Phase Phase-II Study of QazCoVac-P - COVID-19 Subunit Vaccine in Healthy Adult Volunteers From 18 Years Old and Elder
- Conditions
- Covid19, SARS-CoV Infection, Vaccine Adverse Reaction
- Trial name
- NCT04930003
- Testing
- QazCoVac-P -COVID-19 Subunit Vaccine
- Where
- Kazakhstan
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Research Institute for Biological Safety Problems
COVID-19, SARS CoV 2 Infection
Evaluation of Point-of-Care (EPOC) for COVID-19
EPOC is designed to examine the feasibility of conducting two point-of-care (POC) tests the LumiraDx SARS-CoV-2 Antibody Test and the RightSign COVID-19 IgG/IgM Rapid Test for SARS-CoV-2 antibodies and compare the reproducibility…
- Trial name
- (EPOC) (NCT05227404)
- Testing
- LumiraDX, RightSign, Case Control
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of Minnesota
COVID-19, Coronavirus Infection
Hydroxychloroquine and Lopinavir/ Ritonavir to Improve the Health of People With COVID-19: "The Hope Coalition - 1"
The COVID-19 pandemic has been characterized by high morbidity and mortality, especially in certain subgroups of patients. To date, no treatment has been shown to be effective in controlling this disease in hospitalized patients…
- Conditions
- COVID-19, Coronavirus Infection, Virus Disease, Acute Respiratory Infection
- Trial name
- NCT04403100
- Testing
- Hydroxychloroquine Sulfate Tablets, Lopinavir/ Ritonavir Oral Tablet, Hydroxychloroquine Sulfate Tablets plus Lopinavir/ Ritonavir Oral Tablets
- Where
- 4 sites in Brazil
- Volunteers
- 1,968 people
- Sponsor
- Cardresearch
Covid19, SARS-CoV Infection
COVID-19 Prophylaxis South Africa (COVER HCW)
This is a randomised, multi-center, open label, adaptive, exploratory trial to assess the efficacy of two different drug regimens in terms of preventing symptomatic COVID-19 disease in healthcare workers at high risk of exposure…
- Trial name
- COVER (NCT04561063)
- Testing
- Nitazoxanide, Sofosbuvir/Daclatasvir
- Where
- 2 sites in South Africa
- Volunteers
- 1,950 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Covid19, SARS-CoV Infection
Camostat With Bicalutamide for COVID-19
This will be a randomized, open-label study to determine if camostat+ bicalutamide decreases the proportion of people with COVID-19 who require hospitalization, compared to historical controls.
- Conditions
- Covid19, SARS-CoV Infection, Coronavirus Infection
- Trial name
- COMBO (NCT04652765)
- Testing
- Camostat Mesilate, Bicalutamide 150 mg
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Covid19, SARS-CoV Infection
Impact of Auricular Vagus Nerve Neuromodulation on COVID-19 Positive Inpatients Outcome
The COVID-19 pandemic has already overwhelmed the sanitary capacity. Additional therapeutic arsenals, albeit untested in the given context but previously proven to be efficacious in a related clinical context, that could reduce…
- Trial name
- SOS-COVID19 (NCT04341415)
- Testing
- Auricular neuromodulation, Control
- Where
- 2 sites in France
- Volunteers
- 31 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
rt PCR, COVID
SARS-CoV 2 in Personal Protective Equipment
SARS-CoV-2 transmission is frequently occurring in hospital settings, with numerous reported cases of nosocomial transmission highlighting the vulnerability of healthcare workers.
- Conditions
- rt PCR, COVID, Personal Protective Equipment PPE, SARS-CoV 2
- Trial name
- NCT04398043
- Volunteers
- 16 people
- Sponsor
- Hospital de Clinicas José de San Martín
Covid19, SARS-CoV Infection
An Efficacy and Safety Clinical Trial of an Investigational COVID-19 Vaccine (BBV152) in Adult Volunteers
The BBV152 vaccine is being developed to prevent COVID-19, the disease resulting from Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) infection.
- Trial name
- NCT04641481
- Testing
- BBV152
- Where
- India
- Volunteers
- 25,800 people, healthy volunteers welcome
- Sponsor
- Bharat Biotech International Limited
SARS CoV 2 Infection, COVID-19 Breakthrough
SARS-CoV-2 Specific Antibody Responses and Impact for COVID-19 Disease in Ethiopia
In this study we aim to characterize SARS CoV-2 strain specific immune response (SARS-CoV-2 Spike IgG) in health care workers and general populations at the Jimma Medical Center and the St.
- Conditions
- SARS CoV 2 Infection, COVID-19 Breakthrough, COVID-19 Recurrent
- Trial name
- CoVICIS (NCT06435403)
- Where
- 2 sites in Ethiopia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Michael Hoelscher
SARS-CoV 2, COVID
Precision Immunology to Determine the Immune Response in Patients With COVID-19
To better understand the immune response to SARS-CoV-2 infection, we devised a precision immunology approach to systematically study the immune function of different patient cohorts
- Trial name
- NCT04360733
- Testing
- Blood draw
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Infections, Respiratory, Virus Diseases
A Trial Investigating the Safety and Effects of Four BNT162 Vaccines Against COVID-19 in Healthy and Immunocompromised Adults
Originally, the study was planned to include two parts, i.e., Part A and Part B, however Part B was cancelled due to changes in the overall clinical development plan.
- Conditions
- Infections, Respiratory, Virus Diseases, Infection Viral, Vaccine Adverse Reaction
- Trial name
- NCT04380701
- Testing
- BNT162a1, BNT162b1, BNT162b2
- Where
- 5 sites in Germany
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
SARS-CoV-2 Infection, COVID-19
Evaluation of Concordance Between Exhaled Air Test (eBAM-CoV) and RT-PCR to Detect SARS-CoV-2
During the COVID-19 pandemic, testing primarily relied on the use of nasopharyngeal swabs to detect the SARS-CoV-2 virus, responsible for the disease.
- Conditions
- SARS-CoV-2 Infection, COVID-19, Coronavirus
- Trial name
- eBAM_CoV (NCT06099795)
- Testing
- eBAM Cov Testing
- Where
- 2 sites in France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
SARS-CoV, SARS-CoV-2
Study of VXCO-100, a SARS-CoV Candidate Vaccine in Healthy Adults in the United States
The purpose of this study is to evaluate the safety and immunogenicity of ascending dose levels of VXCO-100 in healthy adults.
- Trial name
- NCT05870839
- Testing
- VXCO-100
- Where
- 3 sites in United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Vaccine Company, Inc, a wholly owned subsidiary of Eli Lilly and Company
SARS-CoV Infection, SARS (Severe Acute Respiratory Syndrome)
High Flow Nasal Cannula HFNC In Covid-19 Patients
Many non-invasive ventilatory choices are available for COVID-19 patient who are having mild to moderate respiratory distress and their use will decrease the chance of ICU admission, intubation and mechanical ventilation in…
- Trial name
- HFNC19LGH (NCT04560257)
- Testing
- High flow nasal cannula HFNC
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Lahore General Hospital
Respiratory Symptoms, Autonomic Nervous System Dysfunction
CoVID-19 Evaluation of Neurological and Autonomic Nervous System Troubles in Intensive Care Unit Patients
Since the spread of the COVID-19 disease, several studies have reported the presence of neurological symptoms in patients infected with SARS-CoV-2 such as dysgeusia, hypo or anosmia, hypopsia, the presence of headaches or…
- Trial name
- COVENANT-ICU (NCT06060795)
- Testing
- Electro-conductance measurement
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier St Anne
COVID-19, Venous Thromboembolism
Prevalence and Severity of Venous Thromboembolism in a General Population During the COVID-19 Pandemic
The purpose of this study is to investigate the prevalence of venous thromboembolism in a regional health care system (Region Östergötland, Sweden) before and during the SARS-COV-2 pandemic.
- Conditions
- COVID-19, Venous Thromboembolism, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- NCT04400877
- Testing
- Diagnostic examination for venous thromboembolism
- Where
- Sweden
- Volunteers
- 7,795 people
- Sponsor
- University Hospital, Linkoeping
Influenza, Novel Respiratory Virus-1 Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV)
Respiratory Virus Hospitalization Study (FLU 003 Plus)
Following the sudden and unexpected emergence of influenza A(H1N1)pdm09 (2009 H1N1) virus, this observational study was initiated to estimate rates of morbidity and mortality and to examine predictors of severity among…
- Conditions
- Influenza, Novel Respiratory Virus-1 Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), Novel Respiratory Virus-2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)
- Trial name
- NCT01056185
- Where
- 63 sites in United States, Argentina and 10 more
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
SARS-CoV 2
Current and Past SARS-CoV-2 Infection and COVID-19 in Healthcare
The SARS-CoV-2 pandemic and resulting COVID-19 disease causes a substantial burden on healthcare systems. Little is known about how the infection spreads within healthcare.
- Trial name
- NCT04411576
- Testing
- Throat swab sample for measuring current infection with SARS-CoV-2, Blood sample for serology to measure past infection with SARS-CoV-2
- Where
- Sweden
- Volunteers
- 26,326 people
- Sponsor
- Karolinska University Hospital
SARS CoV 2 Infection
A Safety and Tolerability Study of Sotrovimab (VIR-7831) Prophylaxis Against COVID-19 in Immunocompromised Individuals
This is an open-label study examining the safety and tolerability of sotrovimab, administered in two sequential doses as prophylaxis in immunocompromised patients with impaired humoral immunity against SARS-CoV-2.
- Trial name
- NCT05210101
- Testing
- Sotrovimab
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Sophia Koo, M.D.