Clinical trials: SARS-CoV-2 Infections
Mental Health, Quality of Life
Impact of COVID-19 on Mental Health of Health Care Workers
The impact of the current Covid-19 pandemic on healthcare workers is enormous. This longitudinal study investigates the prevalence of mental health problems and the quality of life of healthcare workers during and after the…
- Trial name
- COVID-Impact (NCT04382196)
- Testing
- Online survey
- Where
- Belgium
- Volunteers
- 524 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Covid19
Evaluation of the INDICAID™ COVID-19 Rapid Antigen Test
The INDICAID™ Rapid Antigen Test was used in real-world outbreak testing. The antigen test was used together with PCR testing. This study was designed to evaluate whether the addition of a rapid antigen test decreased time to…
- Trial name
- NCT04904510
- Testing
- INDICAID™ COVID-19 Rapid Antigen Test
- Where
- United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Covid-19
Famotidine vs Placebo for the Treatment of Non-Hospitalized Adults With COVID-19
The overall objective of this study is to evaluate the clinical efficacy of oral famotidine in symptomatic non-hospitalized patients with confirmed COVID-19.
- Trial name
- NCT04724720
- Testing
- Famotidine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Northwell Health
ARDS Due to Disease Caused by SARS Co-V-2
Clinical Effects of Sivelestat Sodium on Improving ARDS in Patients With COVID-19
The goal of this retrospective multicentre cohort study is to examine the association between receipt of sivelestat and improvement in oxygenation among patients with acute respiratory distress syndrome (ARDS) induced by…
- Trial name
- NCT06218862
- Testing
- Sivelestat sodium, Control
- Where
- China
- Volunteers
- 387 people
- Sponsor
- The First Hospital of Jilin University
Olfactory Disorder
Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19)
The study will be a randomized controlled trial, involving patients with hyposmia/anosmia of onset immediately after an upper respiratory viral illness, assigned to three distinct study arms.
- Trial name
- NCT04374474
- Testing
- Olfactory retraining, corticosteroid nasal irrigation, smell household Items
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
SARS-CoV 2, SARS
Clinical Trial of Sarilumab in Adults With COVID-19
Early administration of sarilumab in hospitalized patients infected with COVID-19 who have pulmonary infiltrates and are at high risk of unfavorable evolution could decrease/prevent progression to acute respiratory distress…
- Trial name
- SARICOR (NCT04357860)
- Testing
- Sarilumab 200 MG/1.14 ML Subcutaneous Solution [KEVZARA], Sarilumab 400 MG/2.28 ML Subcutaneous Solution [KEVZARA], Best available treatment
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
COVID-19
Non-comparative Trial of the Combination of HCQ and AZI in the Treatment of ICU Patients
This research is designed as an open-label,non-comparative prospective trial.
- Trial name
- NCT04458948
- Testing
- Hydroxychloroquine, Azithromycin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of New Mexico
Fibromyalgia, Covid-19 Fear
The Effects of Covid-19 Pandemic on The Patients With Fibromyalgia
The investigators planned to analyze the effect of Covid-19 fear and anxiety on the daily life, sleep quality and depression-anxiety levels of fibromyalgia patients.
- Conditions
- Fibromyalgia, Covid-19 Fear, Covid-19 Anxiety, Daily Life
- Trial name
- NCT04686578
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Covid19, Stress, Psychological
Psychological Impact of COVID-19 Pandemic in Healthcare Workers
Background. The current coronavirus disease (COVID-19) has a great impact worldwide. Healthcare workers play an essential role and are one of the most exposed groups.Information about the psychosocial impact on healthcare workers…
- Conditions
- Covid19, Stress, Psychological, Work Related Stress, Epidemic Disease
- Trial name
- PSIMCOV (NCT04506515)
- Testing
- Psychological stress and adaptation at work score (PSAS)
- Where
- Spain
- Volunteers
- 3,000 people
- Sponsor
- Hospital General Universitario de Valencia
COVID-19
LY3819253 (LY-CoV555) for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
This study looks at the safety and effectiveness of LY3819253 in treating COVID-19 in people who have been hospitalized with the infection.
- Trial name
- NCT05780268
- Testing
- LY3819253, Remdesivir
- Where
- 57 sites in United States, Denmark and 2 more
- Volunteers
- 314 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID, Diabetes Mellitus, Type 2
Impact of Tele-interventions During the COVID-19 Pandemic in Patients With Diabetes Mellitus
INTRODUCTION In critical situations, such as the current COVID 19 pandemic, themes of fear, uncertainty and stigmatization are common and constitute barriers to appropriate medical and mental health interventions.
- Conditions
- COVID, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT04344210
- Testing
- Tele-interventions related to diabetes management and mental well-being
- Where
- Brazil
- Volunteers
- 149 people
- Sponsor
- Federal University of Rio Grande do Sul
Pulmonary Infection, Covid-19
Triiodothyronine for the Treatment of Critically Ill Patients With COVID-19 Infection
This study is a phase II, parallel, prospective, randomized, double-blind, placebo controlled trial. The present study will aim to address the efficacy and safety of acute administration of triiodothyronine on ICU patients…
- Trial name
- Thy-Support (NCT04348513)
- Testing
- T3 solution for injection
- Where
- Greece
- Volunteers
- 5 people
- Sponsor
- Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.
COVID-19 Vaccine
A Study to Evaluate Immunogenicity and Safety of MVC-COV1901 Vaccine Compared With AZD1222
The primary objective of the study is to measure the anti-SARS-CoV-2 neutralizing antibody titres in adult participants, in particular elderly, so as to demonstrate immunogenic superiority of MVC-COV1901 to the active control…
- Trial name
- NCT05426343
- Testing
- MVC-COV1901, AZD1222
- Where
- Paraguay
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medigen Vaccine Biologics Corp.
COVID-19, Respiratory Distress Syndrome
Comparison of Two Respiratory Physiotherapy Treatments in Postcovid-19 Patients.
To test the effectiveness of a respiratory physiotherapy treatment plan in patients who have passed COVID-19, comparing two randomized groups, for the performance of different respiratory musculature training protocols.
- Trial name
- NCT05435443
- Testing
- PowerBreathe and PEP Therosold tools
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Universidad Católica de Ávila
Covid19, Sars-CoV-2 Infection
Post Acute Sequelae of COVID-19
COVID-19, a novel coronavirus, has caused widespread mortality and morbidity since it emerged in 2019. There is ongoing research and growing literature describing severe acute respiratory syndrome (SARS-COV-2).
- Conditions
- Covid19, Sars-CoV-2 Infection, Dyspnea Caused by 2019-nCoV, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- PASC (NCT04964115)
- Testing
- Cohort study
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Coronavirus, N95
Medical Masks vs N95 Respirators for COVID-19
A randomized controlled trial in which health care workers will be randomized to either medical masks or N95 respirators when providing care to patients with COVID-19.
- Conditions
- Coronavirus, N95, Medical Mask
- Trial name
- NCT04296643
- Testing
- Medical Mask, N95 respirator
- Where
- 15 sites in Canada, Egypt and 2 more
- Volunteers
- 1,009 people
- Sponsor
- McMaster University
Covid19, SARS-CoV Infection
Study of Oral Administration of Ribavirin and Nitazoxamide Versus Placebo in COVID-19
This is a single center, randomized, double-blind, 2-arm, parallel-group study of DuACT in participants with clinical symptoms of COVID-19 that have begun within the past 72 hours prior to testing.
- Trial name
- DuACT (NCT04563208)
- Testing
- DuACT
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- University of Witwatersrand, South Africa
COVID-19, Hospitalized COVID-19 Patients
LUSZ Treatment Efficacy in Hospitalized COVID-19 Patients
This study aims first to assess the efficacy, safety, and effectiveness of the LUSZ COVID-19 therapy consisting of a comparative study of three different treatment approaches: antiviral, antiretroviral, and immunosuppressive IL-6…
- Trial name
- LUSZ_AVIST (NCT05925140)
- Testing
- Lopinavir / Ritonavir, Remdesivir (RDV), Tocilizumab
- Where
- 2 sites in Lebanon
- Volunteers
- 1,000 people
- Sponsor
- Lebanese University
Covid19
Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 Infection
The current study was conducted at Qena Governorate, Egypt, during the period from May 2020, to July 2020. The study included 305 COVID-19 cases diagnosed by PCR, patients were randomly assigned to one of three study limps…
- Trial name
- NCT04622891
- Testing
- Clarithromycin 500mg, Azithromycin
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- South Valley University
Coronavirus Infection, COVID
Monovalent Recombinant COVID19 Vaccine
This is a study to test a new vaccine (Covax-19) against COVID-19. COVID-19 is a potentially deadly disease that is caused by a new strain of coronavirus called SARS-CoV-2.
- Trial name
- COVAX19 (NCT04453852)
- Testing
- COVID19 vaccine, Saline
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vaxine Pty Ltd