Clinical trials: SCI
Spinal Cord Injury
Transcutaneous Electrical Spinal Cord Stimulation for Lower Limbs
This study is to determine if non-invasive electrical stimulation of the spinal cord can be used to: 1) assess spared function following a spinal cord injury; and 2) be use for rehabilitation.
- Trial name
- NCT01949285
- Testing
- Transcutaneous Electrical Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NeuroEnabling Technologies, Inc.
Spinal Cord Injuries
Umbilical Cord Blood Cell (MC001) Transplant Into Injured Spinal Cord Followed by the Locomotor Training
Umbilical cord blood mononuclear stem cells (UCBMSCs) transplant followed by the intensive locomotor training for up to 5±1 hours a day, 5±1 days a week, and for 3-6 months for treatment in patients with chronic, stable and…
- Trial name
- NCT03979742
- Testing
- Umbilical Cord Blood Mononuclear Cell, Locomotor Training
- Where
- 2 sites in Taiwan
- Volunteers
- 6 people
- Sponsor
- StemCyte, Inc.
Spinal Cord Injury (SCI)
Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI
This is a safety study of human spinal cord-derived neural stem cell (HSSC) transplantation for the treatment of chronic spinal cord injury.
- Trial name
- SCI (NCT01772810)
- Testing
- Human spinal cord stem cells.
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Neuralstem Inc.
Tetraplegia/Tetraparesis, Quadriplegia
GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
The GB-PRIME Study is an early feasibility study designed to assess the clinical safety and functionality of the Neuralink N1 Implant and R1 Robot.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Quadriplegia/Tetraplegia, Cervical Spinal Cord Injury
- Trial name
- GB-PRIME (NCT07127172)
- Testing
- N1 Implant, R1 Robot
- Where
- 2 sites in United Kingdom
- Volunteers
- 7 people
- Sponsor
- Neuralink Corp
Neuropathic Pain, Spinal Cord Injuries
Clinical Trial to Evaluate Safety, Tolerability and Efficacy of NFX88 in SCI
In summary, this small-scale study is designed to demonstrate that the NFX88 is safe and well tolerated, as well as preliminary evidence of improvement in the score of VAS, PD-Q, and PGIC scales.
- Trial name
- NCT04148573
- Testing
- NFX88 - 1, NFX88 - 2, NFX88 - 3
- Where
- 7 sites in Spain
- Volunteers
- 44 people
- Sponsor
- Neurofix S.L.
Hepatitis B
Safety and Immunogenicity of Recombinant Hepatitis B Vaccine Sci-B-Vac® Compared to Engerix-B®
This study was a comparative, randomized, double-blind clinical study of the efficacy and safety of Sci-B-Vac® (10 μg dose) and the Engerix-B® (20 μg dose) vaccines in two parallel groups of hepatitis B-naive healthy adult…
- Trial name
- NCT04209400
- Testing
- Sci-B-Vac®, Engerix-B®
- Where
- Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VBI Vaccines Inc.
SCI - Spinal Cord Injury
Phoenix Exoskeleton for SCI Users
This study will evaluate the Phoenix device for safety and effectiveness at allowing persons with SCI who are non-ambulatory or poorly ambulatory to stand up and walk under a variety of conditions.
- Trial name
- NCT03175055
- Testing
- Phoenix
- Where
- 4 sites in United States, Hong Kong
- Volunteers
- 40 people
- Sponsor
- US Bionics
Hepatitis B
A Bridging Study: Comparing Two Lots of Sci-B-Vac™ and Engerix-B in Healthy Adults
This was a single-blind, 3-arm, comparative, controlled, randomized, study conducted at one site in Vietnam whose primary objective was to demonstrate clinical equivalence of the two production lots of Sci-B-Vac vaccine produced…
- Trial name
- NCT04531098
- Testing
- Sci-B-Vac-Lot B, Sci-B-Vac-Lot A, Engerix-B
- Where
- Vietnam
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- VBI Vaccines Inc.
Spinal Cord Injury, Acquired Brain Injury
Safety and Usability of the STELO Exoskeleton in People With Acquired Brain Injury and Spinal Cord Injury
Gait impairment in people with acquired brain injury (ABI) and spinal cord injury (SCI) can be very heterogeneous. For this reason, STELO has been developed: a new concept of exoskeleton based on modular technology for gait…
- Trial name
- NCT05265377
- Testing
- Stelo
- Where
- 3 sites in Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- MarsiBionics
Spinal Cord Injury
Cethrin in Acute Cervical Spinal Cord Injury
This is a multicenter, randomized, double-blind, placebo-controlled Phase IIb/III study designed to evaluate the efficacy and safety of Cethrin as a treatment for acute cervical spinal cord injury.
- Trial name
- NCT02053883
- Testing
- Cethrin (BA-210)
- Sponsor
- BioAxone BioSciences, Inc.
Spinal Cord Injuries, Paraplegia
ExoAtlet II For SCI Patients
This study will evaluate the ExoAtlet II exoskeleton for safety and effectiveness of providing persons with a spinal cord injury (SCI) who are non-ambulatory or have limited ambulatory function, to stand up and ambulate under a…
- Trial name
- EXOATLET2SCI (NCT04215081)
- Testing
- Gait training using ExoAtlet exoskeleton
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- COSMO ROBOTICS CO., Ltd
ALS (Amyotrophic Lateral Sclerosis), TBI Traumatic Brain Injury
Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro
The goal of this study is refine the usability of a BCI capable communication platform. The study will take place in the United States area and will enroll up to 10 participants with late stage ALS, traumatic brain injury (TBI)…
- Conditions
- ALS (Amyotrophic Lateral Sclerosis), TBI Traumatic Brain Injury, SCI - Spinal Cord Injury, Stroke
- Trial name
- NCT07209943
- Testing
- Cognixion + Apple Vision Pro
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cognixion
Spinal Cord Injury, Acute, Spinal Cord Injury at C4 Level With Complete Lesion
Safety and Exploratory Efficacy of Transplantation Therapy Using PSA-NCAM(+) NPC in AIS-A Level of Sub-acute SCI
This study intends to evaluate the safety and exploratory efficacy of transplantation therapy using neural precursor cells (PSA-NCAM(+) NPC) derived from the human embryonic stem cell line for the treatment of paralysis and other…
- Conditions
- Spinal Cord Injury, Acute, Spinal Cord Injury at C4 Level With Complete Lesion, Spinal Cord Injury at C5-C7 Level With Complete Lesion
- Trial name
- SB-SCI-001 (NCT04812431)
- Testing
- Neural precursor cells derived from human embryonic stem cell line
- Where
- 2 sites in South Korea
- Volunteers
- 5 people
- Sponsor
- S.Biomedics Co., Ltd.
Acute Spinal Cord Injury (SCI)
Additional Phase 3 Study of KP-100IT in Subjects With Acute Spinal Cord Injury
This is a Phase 3, multicenter, open-label, single-arm additional study to evaluate the efficacy of intrathecal KP-100IT in patients with acute spinal cord injury.
- Trial name
- NCT07722962
- Testing
- KP-100IT
- Where
- 3 sites in Japan
- Volunteers
- 10 people
- Sponsor
- Kringle Pharma, Inc.
Injuries, Spinal Cord
The WISE Trial - Walking Improvement for SCI With Exoskeleton
A randomized, controlled trial comparing exoskeleton gait training with standard gait training or no gait training in community-dwelling participants with chronic incomplete spinal cord injury
- Trial name
- WISE (NCT02943915)
- Testing
- Ekso GT Rehabilitation Therapy, Body Weight Supported (BWS) Treadmill Training
- Where
- 10 sites in United States
- Volunteers
- 45 people
- Sponsor
- Ekso Bionics
Spinal Cord Injuries (SCI), Respiratory Insufficiency
Abdominal Stimulation to Improve Cough After Spinal Cord Injury
The goal of this clinical trial is to learn if abdominal functional electrical stimulation (FES) using the VentFree Respiratory Muscle Stimulator improves cough strength in adults with a new spinal cord injury (SCI).
- Trial name
- COUFES (NCT07626931)
- Testing
- Respiratory Muscle Stimulator, Supervised Cough Training
- Volunteers
- 150 people
- Sponsor
- Liberate Medical
Acute Spinal Cord Injury (SCI), Spinal Cord Diseases
NG004 in Spinal Cord Injury Patients
This is the FIH, multicenter, open-label, sequential, multiple ascending dose trial of NG004 in patients with acute incomplete cervical SCI.
- Conditions
- Acute Spinal Cord Injury (SCI), Spinal Cord Diseases, Central Nervous System Diseases, Nervous System Diseases
- Trial name
- SPROUT (NCT06817577)
- Testing
- NG004
- Where
- 6 sites in Germany, Switzerland
- Volunteers
- 20 people
- Sponsor
- NovaGo Therapeutics AG
Acute Spinal Cord Injury (SCI)
Expanded Access to Elezanumab
This is an expanded access program (EAP) for eligible participants. This program is designed to provide access to Elezanumab prior to approval by the local regulatory agency. Availability will depend on territory eligibility.
- Trial name
- NCT04278235
- Testing
- Elezanumab
- Sponsor
- AbbVie
Spinal Cord Injury (SCI), Chronic Urinary Retention
Tissue Bonding Cystostomy(TBC)
Spinal Cord Injured [SCI] patients typically cannot "pee". Injury to the spinal cord disrupts the in-coming and out-going brain signals that coordinate bladder sensation and the emptying of bladder.
- Conditions
- Spinal Cord Injury (SCI), Chronic Urinary Retention, Urinary Incontinence
- Trial name
- TBC (NCT01771159)
- Testing
- TBC
- Volunteers
- 10 people
- Sponsor
- Uro-Research, LLC
Iliofemoral; Thrombosis
Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT
This is a study of a medical procedure that utilizes a commercially available catheter (the Bullfrog® Micro-Infusion Device) to locally deliver a commercially available anti-inflammatory drug (dexamethasone sodium phosphate…
- Trial name
- DEXTERITY-SCI (NCT04858776)
- Testing
- Perivascular dexamethasone
- Where
- 15 sites in United States, Ireland and 1 more
- Volunteers
- 60 people
- Sponsor
- Mercator MedSystems, Inc.