Clinical trials: SCI
SCI - Spinal Cord Injury
TPAD for Recovery of Standing After Severe SCI
The purpose of this study is to investigate how standing and sitting balance control is altered after spinal cord injury (SCI) and how a new type of robotic assistive device may be used to improve muscle function.
- Trial name
- NCT06643312
- Testing
- The Tethered Pelvic Assist Device (TPAD)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Neuropathic Pain
BreEStim Pre-trial
The overall goal is to evaluate the effectiveness of different stimulation protocol of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) in managing neuropathic pain after spinal cord injury (SCI).
- Trial name
- NCT07878429
- Testing
- Single-pulse BreEStim Treatment, Multiple-pulse BreEStim Treatment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injury, Acquired Brain Injury
Safety and Usability of the STELO Exoskeleton in People With Acquired Brain Injury and Spinal Cord Injury
Gait impairment in people with acquired brain injury (ABI) and spinal cord injury (SCI) can be very heterogeneous. For this reason, STELO has been developed: a new concept of exoskeleton based on modular technology for gait…
- Trial name
- NCT05265377
- Testing
- Stelo
- Where
- 3 sites in Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- MarsiBionics
Spinal Cord Injuries, Obesity
Effects of Intermittent Hypoxia (IH) on Metabolism and Dysglycemia, in Overweight/Obese Persons SCI
The purpose of this research is to examine changes in blood glucose control and metabolism in individuals with SCI and non injured controls at rest and during exercise after five days of exposure to IH.
- Conditions
- Spinal Cord Injuries, Obesity, Insulin Resistance
- Trial name
- NCT02973438
- Testing
- Intermittent Hypoxia (IH)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injury, Sleep Disordered Breathing
Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI
The purpose of this study is to look at the effect of exciting using drugs to target a specific pathway in the body, that relies on a natural chemical the body produces called 'serotonin', in patients with spinal cord injury…
- Trial name
- REST-SCI (NCT02458469)
- Testing
- Buspirone, Trazodone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Acute Spinal Cord Injury, Spinal Cord Injuries
Spasticity and Functional Recovery After SCI
Spasticity is one of the most common symptoms manifested in humans with spinal cord injury (SCI). However, the neural mechanisms underlying the development of spasticity over time after an acute SCI are not yet understood.
- Trial name
- NCT06030531
- Testing
- Measures of spasticity, connectivity and analysis of single nucleotide polymorphisms and biomarkers of inflammation, Analysis of biomarkers
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Demyelinating Disorders, MCI
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
The overall objective is to obtain an assessment of the pharmacokinetics of [18F]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple…
- Conditions
- Demyelinating Disorders, MCI, Alzheimer's Disease (AD), MS (Multiple Sclerosis)
- Trial name
- NCT06999434
- Testing
- [ 18F]3F4AP, [18F]MK6240, [11C]PIB
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yale University
Spinal Cord Injuries
CNS Changes Following SCI
The objective of this study is to better understand the structural and functional changes that the central nervous system (CNS) undergoes following spinal cord injury and how these changes relate to clinical measures.
- Trial name
- NCT03772548
- Testing
- MRI
- Where
- Switzerland
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Zurich
SCI - Spinal Cord Injury
Gut-Brain Neural Coupling in Spinal Cord Injury
The purpose of this research is to determine the effects of food on brain and stomach activity in persons with and without spinal cord injury (SCI).
- Trial name
- NCT07052344
- Testing
- Preload condition, Ad-libitum control condition
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injuries
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
NeuroSuitUp is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University…
- Trial name
- NeuroSuitUp (NCT05465486)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
SCI
AIH for Spinal Cord Repair
Contusive cervical spinal cord injury (cSCI) impairs upper limb function (reach-and-grasp) which limits daily-life activities and thus decreases the quality of life.
- Trial name
- NCT03780829
- Testing
- hypoxia, D-cycloserine, exercise training
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Neuroplasticity After Spinal Cord Injury
The long-term goal is to acquire scientific knowledge that can be used to develop mechanistic-driven intervention strategies aiming at restoring upper and lower-limb motor function in individuals with cervical or thoracic spinal…
- Trial name
- NCT02446210
- Testing
- Magstim 200, Digitimer electrical stimulator
- Where
- United States
- Volunteers
- 514 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Enhancing Indoor, Community, and Advanced Wheelchair Skills in Spinal Cord Injury (SCI)
We propose to test an evidence-based wheelchair skills training program to optimize wheelchair safety and performance in veterans with SCI.
- Trial name
- NCT00434018
- Testing
- Wheelchair Skills Training, Basic Health Education
- Where
- 3 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injuries
Lower Extremity Outcome Measures in SCI
Lower extremity (LE) function of patients with a spinal cord injury (SCI) will be assessed in an observational project with a cross-sectional and a longitudinal study design.
- Trial name
- NCT04032314
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injuries
Protein Supplementation and Neuromuscular Electrical Stimulation in Persons With SCI
The aim of this pilot study is to explore how body composition, circulating markers of metabolic health and skin integrity in persons with a spinal cord injury (SCI) are affected by 12 weeks of quadriceps neuromuscular electrical…
- Trial name
- NCT05249985
- Testing
- NMES, Protein
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
SCI
Intranasal Administration of a Prokinetic for Bowel Evacuation in Persons With SCI
DWE (difficulty with evacuation) is a common and an important quality of life issue after spinal cord injury. Not only is the management DWE time-consuming and unpleasant, but the results are often suboptimal in terms of…
- Trial name
- IN NEO (NCT00855283)
- Testing
- IN NEO, IN NEO + IN Glycopyrrolate, IV Visit
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injuries
Workout on Wheels Internet Intervention (WOWii)
Project WOWii examines how useful and effective an online format is for helping people with SCI get more exercise over 4 months.
- Trial name
- NCT03189095
- Testing
- WOWii (Workout on Wheels Internet Intervention)
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Cervical Spinal Cord Injury
Rebuilding Inter-limb Transfer in Cervical SCI
The purpose of this study in people living with cervical Spinal Cord Injury (SCI) is to examine the effects of paired neurostimulation (i.e., PCMS) combined with contralateral motor training on inter-limb transfer of ballistic…
- Trial name
- NCT06440538
- Testing
- PCMS + Contralateral Motor Training, PCMS + Rest
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Spinal Cord Injury, Insulin Resistance
IR and Microvascular Blood Flow in SCI
Persons with spinal cord injury (SCI) are at an increased risk for metabolic disorders, including that of insulin resistance. As a result of neurological injury, they often have impaired mechanisms that regulate blood vessel…
- Trial name
- NCT02034331
- Testing
- Insulin iontophoresis, Acetylcholine Iontophoresis, Heat application
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
Spinal Stimulation + FES-Assisted Cough Training in SCI
The overall objective of this proposal is to determine if transcutaneous spinal cord stimulation (tSCS) delivered concurrently with functional electrical stimulation (FES)-assisted cough training (FES-Cough) is an effective…
- Trial name
- NCT07683780
- Testing
- tSCS combined with FES-Cough
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Milap Sandhu