Clinical trials: SCI
Motor Complete Spinal Cord Injury
The Effects of Passive Gait Training in Complete Motor Spinal Cord Injury (SCI)
The purpose of this study is to determine whether a three times per week, 2 month robotic assisted treadmill gait training program, will beneficially affect the fitness, physical and psychological well-being, and the vascular and…
- Trial name
- NCT01349478
- Testing
- LOKOMAT
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Dr. Gabriel Zeilig
Spinal Cord Injuries (SCI), Spinal Cord Injury
Transcutaneous Spinal Electrical Stimulation to Improve Exercise Function After Spinal Cord Injury.
Our overall objective is to decrease the prevalence of multiple sedentary-related diseases that are secondary consequences of spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Spinal Injury
- Trial name
- NCT07692191
- Testing
- Transcutaneous spinal electrical stimulation (TSES)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Neuropathic Pain, Spinal Cord Injuries
Clinical Trial to Evaluate Safety, Tolerability and Efficacy of NFX88 in SCI
In summary, this small-scale study is designed to demonstrate that the NFX88 is safe and well tolerated, as well as preliminary evidence of improvement in the score of VAS, PD-Q, and PGIC scales.
- Trial name
- NCT04148573
- Testing
- NFX88 - 1, NFX88 - 2, NFX88 - 3
- Where
- 7 sites in Spain
- Volunteers
- 44 people
- Sponsor
- Neurofix S.L.
Spinal Cord Injuries, Hand Weakness
Cognitive-based Prosthetics to Improve Grasp and Reaching After SCI
Rehabilitation of functional movements after spinal cord injury (SCI) requires commitment and engagement to the processes of physical therapy.
- Trial name
- NCT04577573
- Testing
- Cognition glove, Sensory brace
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Physical Disability
Physical Fitness, Exercise Self-efficacy, Physical Activity Level in People With Spinal Cord Injury (SCI)
This is a single blind randomized controlled trial study which will conducted on people with paraplegia wheelchair users. The objectives of this study is to investigates the effects of 16 weeks of 'Graded Exercise Integrated…
- Trial name
- NCT03420170
- Testing
- Graded Exercise Integrated Education, Conventional Physical Therapy
- Volunteers
- 40 people
- Sponsor
- Universiti Teknologi Mara
Spinal Cord Injuries, Aging
Exercise and Nutrition Education for Older Adults With Spinal Cord Injury: A Pilot Randomized Controlled Trial
Older adults living with a spinal cord injury (SCI) experience an increased burden of secondary health conditions than, coupled with age-related complications, may negatively affect physical and mental health, as well as…
- Trial name
- NCT07845851
- Testing
- Individualized Exercise Training, Nutrition Education, Behavioral Support
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Spinal Cord Injuries, Muscle Pareses
A Novel Combined Neuromodulation Therapy to Enhance Balance and Neuroplasticity
Many people with partial damages in their spinal cord (iSCI) have physical impairments such as muscle paralysis in legs which make standing balance difficult.
- Conditions
- Spinal Cord Injuries, Muscle Pareses, Fall
- Trial name
- NCT05940636
- Testing
- Activity-based rehabilitation+electrical stimulation
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Spinal Cord Injuries
Non-invasive Spinal Stimulation as an Adjuvant Therapy for Trunk Control After Pediatric SCI
The overall purpose of this study is to test the efficacy of multi-modal training combining activity-based locomotor training and transcutaneous spinal stimulation (ABLT+scTS) to improve sitting posture and trunk control in…
- Trial name
- NCT05091463
- Testing
- Biostim-5/Neostim transcutaneous spinal stimulator
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Louisville
Hepatitis B
Safety and Immunogenicity of Recombinant Hepatitis B Vaccine Sci-B-Vac® Compared to Engerix-B®
This study was a comparative, randomized, double-blind clinical study of the efficacy and safety of Sci-B-Vac® (10 μg dose) and the Engerix-B® (20 μg dose) vaccines in two parallel groups of hepatitis B-naive healthy adult…
- Trial name
- NCT04209400
- Testing
- Sci-B-Vac®, Engerix-B®
- Where
- Russia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VBI Vaccines Inc.
Tetraplegia
Feasibility of Home Based Transcutaneous Spinal Cord Stimulation for Persons With SCI
The proposed study will focus on the feasibility of and effectiveness to a home-based program for persons with chronic SCI focused on upper limb training augmented with a transcutaneous neurostimulator supported via a video…
- Trial name
- NCT06140706
- Testing
- transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Palo Alto Health Care System
Spinal Cord Injury
Improve Dynamic Lateral Balance of Humans With SCI
This study is to test whether pelvis perturbation training paired with transcutaneous spinal direct current stimulation (tsDCS) will be effective in improving dynamic balance and locomotor function in humans with SCI.
- Trial name
- NCT02991248
- Testing
- robotic training, spinal cord electrical stimulation, treadmill
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Shirley Ryan AbilityLab
SCI - Spinal Cord Injury
Phoenix Exoskeleton for SCI Users
This study will evaluate the Phoenix device for safety and effectiveness at allowing persons with SCI who are non-ambulatory or poorly ambulatory to stand up and walk under a variety of conditions.
- Trial name
- NCT03175055
- Testing
- Phoenix
- Where
- 4 sites in United States, Hong Kong
- Volunteers
- 40 people
- Sponsor
- US Bionics
Spinal Cord Injuries, Neurogenic Detrusor Overactivity
TTNS in SCI Patients With Neurogenic Detrusor Overactivity
This is a prospective, single-arm, pilot study to assess effectiveness and tolerability of transcutaneous tibial nerve stimulation (TTNS) in managing neurogenic detrusor overactivity in spinal cord injury patients.
- Trial name
- NCT07785258
- Testing
- TTNS
- Where
- Singapore
- Volunteers
- 12 people
- Sponsor
- National University Hospital, Singapore
Psychological Well-Being, Spinal Cord Injuries
Self-Management Program for AIS D SCI
About 25-51% of adults with acquired spinal cord injury (SCI) have "AIS D" SCI, the lowest severity grade of neurologic injury. Veterans with AIS D SCI generally have better outcomes in mobility, community integration, and…
- Trial name
- SCISM-D (NCT05800717)
- Testing
- SCI Self-Management for AIS D
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries (SCI)
Epidural Spinal Cord Stimulation for Restoring Walking in Spinal Cord Injury
The goal of this clinical trial is to evaluate the safety and effectiveness of Epidural Electrical Stimulation (EES) combined with rehabilitation training for the reconstruction of walking in patients with chronic spinal cord…
- Trial name
- NCT07306052
- Testing
- Epidural spinal cord stimulation, Rehabilitation Therapy, positron emission tomography-computed tomography (PET-CT)
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Arterial Stiffness, Renin Angiotensin Aldosterone System
RAAS and Arterial Stiffness in SCI
The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.
- Conditions
- Arterial Stiffness, Renin Angiotensin Aldosterone System, Orthostatic Hypotension, Spinal Cord Injury
- Trial name
- NCT04510974
- Testing
- Spinal Cord Injury
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Hepatitis B
A Bridging Study: Comparing Two Lots of Sci-B-Vac™ and Engerix-B in Healthy Adults
This was a single-blind, 3-arm, comparative, controlled, randomized, study conducted at one site in Vietnam whose primary objective was to demonstrate clinical equivalence of the two production lots of Sci-B-Vac vaccine produced…
- Trial name
- NCT04531098
- Testing
- Sci-B-Vac-Lot B, Sci-B-Vac-Lot A, Engerix-B
- Where
- Vietnam
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- VBI Vaccines Inc.
Spinal Cord Injury, Acute, Paraplegia
Functional Electrical Stimulation Cycling in SCI
Spinal cord injury (SCI) is a devastating, life-altering injury; requiring tremendous changes in an individual's lifestyle. Cycling, provides an ideal way for individuals with SCI to exercise and address the long-term…
- Conditions
- Spinal Cord Injury, Acute, Paraplegia, Tetraplegia
- Trial name
- NCT04064385
- Testing
- FES Cycling
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Glasgow Caledonian University
Spinal Cord Injuries, Neurological Injury
Physiological Changes Induced Through MEP Conditioning in People With SCI
The study team is currently recruiting volunteers who are interested in participating in a brain-spinal cord-muscle response training study that aims to better understand the changes that take place in the nervous system as a…
- Conditions
- Spinal Cord Injuries, Neurological Injury, Paralysis, Spasticity, Muscle
- Trial name
- NCT04286191
- Testing
- Operant Conditioning, Control Group
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Spinal Cord Injuries
High Intensity Exercise in Incomplete SCI
The goal of this study is to identify the comparative efficacy of high-intensity walking training in individuals with chronic, motor incomplete spinal cord injury as compared to lower-intensity walking exercise.
- Trial name
- NCT03714997
- Testing
- Walking training
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Indiana University