Clinical trials: SIRS
Sepsis, Thrombocytopenia
rhTPO in Critical Patients With Thrombocytopenia
The primary objectives of this study are to assess the impact of rhTPO on mortality among severe sepsis patients with thrombocytopenia, as well as changes of platelet counts and platelet transfusion rates.
- Trial name
- NCT02094248
- Testing
- TPO, control
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Jinling Hospital, China
Sepsis, Sepsis and Septic Shock
Role of Transposable Elements in Septic Immune Aging
The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1.
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis With Multiple Organ Dysfunction (MOD), Sepsis With Acute Organ Dysfunction
- Trial name
- SITE (NCT06809868)
- Testing
- RNA and DNA Sequencing
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sepsis
Neutrophil Phenotypic Profiling and Organ Injury Assessment in Patients With Sepsis
In this research study we want to learn more about the character of neutrophils that are present in the blood of children with sepsis. Sepsis is a severe type of infection, affecting various parts of the body.
- Trial name
- NCT04103268
- Testing
- sepsis
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Boston Children's Hospital
Sepsis - to Reduce Mortality in the Intensive Care Unit
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis
Sepsis is a severe, life-threatening condition caused by an abnormal host response to infection, which includes systemic inflammation, oxidative stress, and increasing organ dysfunction.
- Trial name
- NCT07655791
- Testing
- Nicotinamide 1000 mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Septic Shock
The Effect of Rapid Fluid Challenge Under Pulmonary Artery Catheter Monitoring on Physiological Indexes of Patients With Septic Shock
Fluid challenge is often carried out in septic shock patients. Its responsiveness usually requires invasive monitoring. The pulmonary artery catheter(PAC) is the most effective means of monitoring.To use non-invasive methods is…
- Trial name
- NCT03661268
- Testing
- fluid chanllenge
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chengdu Fifth People's Hospital
Sepsis, Vitamin B6
Clinical Analysis of Vitamin B6 in Sepsis
Methodology Patients A total of 128 patients with sepsis and AKI who were admitted to several centers including Huzhou first people's Hospital combined with Wuxing People's Hospital, Linghu people's Hospital and Nanxun people's…
- Conditions
- Sepsis, Vitamin B6, Kidney Injury, Inflammatory Response
- Trial name
- NCT06008223
- Testing
- vitamin B6, 0.9% sodium chloride solution
- Where
- China
- Volunteers
- 128 people
- Sponsor
- The First People's Hospital of Huzhou
Sepsis
Methylene Blue in Sepsis: A Randomized Controlled Trial
The purpose of this study is to investigate whether the addition of Methylene Blue to the standard treatment of septic shock will reduce vasopressor requirements
- Trial name
- SMURF (NCT00486174)
- Testing
- methylene blue
- Sponsor
- Queen's University
Sepsis, Trauma
Longitudinal Gene Expression Profiling in Adults After Traumatic Injury
The purpose of this study is to examine the immune response to traumatic injury and subsequent infections in critically ill adults.
- Conditions
- Sepsis, Trauma, Infection
- Trial name
- NCT02656459
- Testing
- 11-gene set
- Where
- 3 sites in United States, Germany
- Volunteers
- 52 people
- Sponsor
- Stanford University
Sepsis
Differential Clinical Phenotypes Of Early CD4+ And CD8+ T-Cell Recovery And Association With 28-Day Mortality In Sepsis Patients
This is a retrospective non-interventional cohort study. Medical records of adult patients with sepsis admitted to the intensive care unit will be retrospectively reviewed.
- Trial name
- NCT07787780
- Testing
- CD4+/CD8+ T-cell dynamic recovery status
- Where
- China
- Volunteers
- 303 people
- Sponsor
- Sichuan Provincial People's Hospital
Systemic Inflammatory Response Syndrome, Sepsis
Vitamin D and Critically Ill Patients
The higher rate of vitamin D deficiency is spotted among patients being hospitalized or in critical condition. Especially, vitamin D level below normal prolongs hospital stay and increases incidence of adverse prognosis and…
- Trial name
- NCT01636232
- Where
- China
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Cardiac Surgery, Extracorporeal Circulation; Complications
Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children
Cardiac surgery requires the use of extracorporeal circulation (ECC). Age-related differences in inflammatory response, the greater susceptibility of immature organ systems to injury and the larger ratio of extracorporeal…
- Conditions
- Cardiac Surgery, Extracorporeal Circulation; Complications, Metabolism, Low Cardiac Output
- Trial name
- CardiOGlcNAc (NCT06754709)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital
Sepsis - to Reduce Mortality in the Intensive Care Unit, Trauma Coagulopathy
ROTEM in Sepsis Trauma Outcome in Intensive Care
This prospective observational study aims to investigate the ability of advanced ROTEM analysis using Principal Component Analysis (PCA) to detect early signs of disseminated intravascular coagulation (DIC) and trauma-induced…
- Trial name
- ROSTIC (NCT06891599)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Stockholm
Sepsis
Severe Sepsis and Septic Shock Registry
The aim of this study is to construct multi-center sepsis registry that can be used for data warehousing and clinical research.
- Trial name
- NCT02936232
- Where
- 3 sites in South Korea
- Volunteers
- 3,000 people
- Sponsor
- Seoul National University Hospital
Shock, Septic
Comparison of Vasopressin and Other Pressors in Septic Shock
The purpose of this study is to compare the classical tactics in the treatment of septic shock (dopamine, noradrenalin and dobutamine) to the use of vasopressin as first choice pressor.
- Trial name
- NCT00269685
- Testing
- vasopressin
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Inpatient Hospitalization, Intensive Care Unit Admission, Inpatient Mortality, Sepsis and Septic Shock
Linking Novel Diagnostics With Data-Driven Clinical Decision Support in the Emergency Department
The primary objective of this study is to validate the use of an electronic clinical decision support (CDS) tool, TriageGO with Monocyte Distribution Width (TriageGO-MDW), in the emergency department (ED).
- Trial name
- NCT05335135
- Testing
- TriageGO-MDW Clinical Decision Support, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Stocastic, LLC
Severe Sepsis
Symphony IL-6 Cutoff Establishment Study for Patients at Risk of Severe Sepsis Due to COVID-19
Symphony IL-6 is a device that quantitates human IL-6 by fluorescence enzyme immunoassay (FEIA) from whole-blood specimens. Use of Symphony IL- 6 removes the need for plasma separation before testing.
- Trial name
- NCT05060250
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Bluejay Diagnostics, Inc.
Shock, Septic, Sepsis
Balanced Salt Solution VS. Normal Saline Solution in Septic Shock
The Purpose of this study is to determine the impact of balanced salt solution versus chloride rich solution on clinical outcomes in paediatric severe sepsis or septic shock
- Trial name
- NCT02336620
- Testing
- Ringer acetate, Normal saline
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Ramathibodi Hospital
Sepsis
The Degree, Duration and Frequency of Insulin Resistance in Non-operated Patients With Sepsis
Surgery induces insulin resistance lasting for 2-3 weeks. We wanted to elucidate if stress-metabolic, medical conditions carry the same effect.
- Trial name
- NCT04969159
- Testing
- no intervention
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Jens Rikardt Andersen
Infection, Sepsis
Early Identification of SEPsis SIGNs in Emergency Department
Objective of SepSIGN project is to validate biomarkers able to predict the clinical worsening of patients freshly admitted at Emergency Department.
- Trial name
- SepSIGN (NCT04261621)
- Where
- 12 sites in United States, France and 1 more
- Volunteers
- 815 people
- Sponsor
- BioMérieux
Severe Sepsis and Septic Shock
Comparison of Sensitivity Between Presepsine and Lactate for the Diagnosis of Severe Sepsis.
Severe sepsis and sepsis shock are common in emergency department, with a high mortality rate. The potential severity of this disease impose a diagnosis as early as possible to start antibiotic therapy and hemodynamic support.
- Trial name
- PREDI (NCT02300415)
- Testing
- blood sample
- Sponsor
- Centre Hospitalier Universitaire de Nice