Clinical trials: SNS
Urinary Incontinence, Urge
CAN-Stim Compared to SNS in Treatment of Urinary Urgency Incontinence With Wireless Neuromodulation Technology
This is a prospective, randomized, controlled, multi-center, study in which 150 evaluable subjects will be randomized 1:1 to receive either a Protect CAN-Stim or SNS InterStim® system.
- Trial name
- PROTECT (NCT02577302)
- Testing
- CAN-Stim - Protect CAN-Stim System, SNS - InterStim® System
- Where
- 15 sites in United States
- Volunteers
- 200 people
- Sponsor
- Uro Medical Corporation
Dysautonomia, ACCUVEIN
Screening for Alterations in the Autonomic Nervous System
Dysautonomia is an alteration of the autonomic nervous system that manifests itself in different forms, some of which are very disabling. Dysautonomia accompanies many pathologies.
- Conditions
- Dysautonomia, ACCUVEIN, Superficial Veins, Sympathetic Nervous System
- Trial name
- SYMPA-VEIN (NCT07029191)
- Testing
- Progressive standing test
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Hypertension
Effect of Exercise and Diet on Inflammation in Hypertensive Individuals
In addition to high blood pressure, hypertension is characterized by inflammation, which is the body's response to injury or infection. Inflammation has been found to cause plaque formation on artery walls.
- Trial name
- NCT00338572
- Testing
- Exercise Program, Combined Exercise and Diet Program
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- University of California, San Diego
Metabolic Syndrome, Type 2 Diabetes Mellitus
Effects of Sodium-glucose Co-transporter-2( SGLT-2 ) Inhibition on Sympathetic Nervous System Activity in Humans
This study is designed to investigate whether the sodium-glucose co-transporter-2 (SGLT-2) inhibitor Empagliflozin reduces sympathetic nervous system (SNS) activity in humans.
- Conditions
- Metabolic Syndrome, Type 2 Diabetes Mellitus, Obesity
- Trial name
- EMPA-SNS (NCT03912909)
- Testing
- Empagliflozin Oral Tablet [Jardiance]
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Royal Perth Hospital
Catecholamine; Overproduction, Catecholamine; Secretion
Sympathetic Activity and Cardiometabolic Complications
Recent studies on catecholamine physiology have shown a direct correlation with arterial hypertension, overcoming the exclusive role in the diagnosis and follow-up of chromaffin tumors.
- Conditions
- Catecholamine; Overproduction, Catecholamine; Secretion, Metabolic Syndrome, Hypertensive Heart Disease
- Trial name
- SYMPACT (NCT04495231)
- Where
- Italy
- Volunteers
- 1,380 people
- Sponsor
- University of Turin, Italy
Stress, Psychological, Inflammation
Does Propranolol Attenuate Inflammatory Responses to a Psychological Stressor?
This randomized, double-blind, placebo-controlled study of propranolol will shed important light on how sympathetic nervous system (SNS) activation influences psychological and inflammatory responses to acute stress.
- Conditions
- Stress, Psychological, Inflammation, Cortisol, Sympathetic Nervous System
- Trial name
- NCT02972554
- Testing
- Propanolol hydrochloride
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Obesity, Hypertension
Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease.
- Trial name
- NCT06482853
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Milton S. Hershey Medical Center
Vasoconstriction, Healthy
Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction
The purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.
- Conditions
- Vasoconstriction, Healthy, Insulin Resistance
- Trial name
- NCT05244694
- Testing
- Insulin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Plasma Exchange, Autonomic Failure
Plasma Exchange for Autoimmune Autonomic Failure
This study will explore whether an antibody is influencing the autonomic nervous system, and if its removal will eliminate signs and symptoms of failure in that system.
- Trial name
- NCT00359346
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Metabolic Syndrome
Effects of Pioglitazone Treatment on Sympathetic Nervous System Function in Metabolic Syndrome Obesity
An abdominal distribution of fat is associated with the greatest heart disease risk, because commonly, several risk factors of metabolic origin cluster in these individuals.
- Trial name
- NCT00408850
- Testing
- Pioglitazone, sugar pill
- Where
- Australia
- Volunteers
- 44 people
- Sponsor
- Baker Heart Research Institute
Heart Failure
Clinical Assessment of the Treatment With Cardiac Sympathetic Blockade on Chronic Heart Failure
The purpose of this study is to evaluate the effect of Cardiac Sympathetic Blockade on Mortality, re-hospitalization rate, symptoms, quality of life, exercise tolerance, cardiac structure, systolic function, electrical activities…
- Trial name
- CSB-CHF (NCT02391142)
- Testing
- Lidocaine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Diabetes Mellitus, Type 2
Evaluation of the Integrated Radio Frequency Denervation System to Improve Glycemic Control in Type 2 Diabetic Subjects
The objective of this early feasibility study is to evaluate the safety and performance of intravascular hepatic denervation using the Metavention Integrated Radio Frequency Denervation System (iRF System) to improve glycemic…
- Trial name
- DeLIVER (NCT04285554)
- Testing
- iRF System Hepatic Denervation
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Metavention
Cardiovascular Diseases
Loneliness and Social Connection in Cardiovascular Disease
The study evaluates the impact of vulnerable self-disclosure and perceived responsiveness in individuals across levels of loneliness. Participants will be randomized to a high disclosure or a low disclosure condition.
- Trial name
- NCT04195620
- Testing
- High self-disclosure, Low self-disclosure
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Morehead State University
Diabetic Nephropathies
Sympathetic Nervous System Inhibition for the Treatment of Diabetic Kidney Disease
The purpose of this study is to determine whether moxonidine is effective in reducing urine albumin levels in patients with diabetic kidney disease.
- Trial name
- NCT01094769
- Testing
- Moxonidine
- Where
- Australia
- Volunteers
- 48 people
- Sponsor
- Baker Heart and Diabetes Institute
Obesity, Abdominal
The Impact Of An Intermittent Energy Restricted Diet On Insulin Sensitivity In Men and Women With Central Obesity
An intermittent energy restricted (IER) diet may modify cardio-metabolic disease risk factors compared to an energy-matched continuous energy restricted (CER) diet.
- Trial name
- Met-IER (NCT02679989)
- Testing
- Intermittent Energy Restriction, Continuous Energy Restriction
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- King's College London
Social Network Strategy, HIV Self Testing
SNS to Increase HIV Testing Uptake and Linkage to Double Cascade Services Among Adolescent MSM and TGW in Thailand
UNAIDS aims to end AIDS by 2030 using "90-90-90" diagnosis-treatment-viral suppression targets. Thailand has achieved elimination of HIV mother-to-child transmission, but continues to see new infections among adolescent men who…
- Conditions
- Social Network Strategy, HIV Self Testing, Men Who Have Sex With Men
- Trial name
- NCT04953858
- Testing
- Social network strategy (SNS)
- Where
- Thailand
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Insulin Resistance, Autonomic Dysfunction
Role of Endothelin-1 Modulating Insulin-stimulated Blood Flow and Sympathetic Nervous System Activity in Obesity
The aim of this project is to determine role for ET-1 in individuals with obesity.
- Conditions
- Insulin Resistance, Autonomic Dysfunction, Obesity
- Trial name
- NCT05518422
- Testing
- Hyperinsulinemic, euglycemic infusion
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hypertension, Cardiovascular Diseases
Sympathetic Activity in Post-injury Outcomes: Impact on Sleep and caRdiovascular Health InvesTigation
The goal of this observational study is to learn about the long-term health of United States military service members who were injured during combat.
- Conditions
- Hypertension, Cardiovascular Diseases, Sleep Disorder, Arrythmia
- Trial name
- SPIRIT (NCT05971433)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Uniformed Services University of the Health Sciences
Health Care Acceptor
Comparative Effects of the Neurodynamic Slider and Tensioner Mobilisation Techniques on Sympathetic Nervous System Function: A Randomised Controlled Trial
In accordance with an independently matched group design methodology, 90 healthy volunteers (aged 18 to 40) were enlisted and randomly assigned to one of three experimental groups (sliding, tension, or control groups).
- Trial name
- NCT06098131
- Testing
- Neurodynamic
- Where
- Cyprus
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- European University Cyprus
Down Syndrome, Autonomic Dysfunction
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS).
- Trial name
- DIVE (NCT07238465)
- Testing
- Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver