Clinical trials: SNS
Healthy, Obesity
Effect of Ghrelin on Sympathetic Nervous System
Ghrelin is a newly discovered peptide that is secreted by the stomach. Its main role is to stimulate food intake but recent studies indicate that it also acts on the cardiovascular system to confer beneficial effects.
- Trial name
- NCT00912587
- Testing
- ghrelin
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Baker Heart and Diabetes Institute
Physical Activity, Sympathetic Nervous System
Neuropeptide Y and Sympathovagal Balance
Neuropeptide Y (NPY) activates the sympathetic and vagal nervous systems through the Y1 and Y2 receptors. This double-blind placebo-controlled crossover study investigated the sympathovagal balance during three exercises on a…
- Conditions
- Physical Activity, Sympathetic Nervous System, Secretion; Catecholamine
- Trial name
- NPY (NCT03933787)
- Testing
- Saxagliptin 5mg, ergometric test in healthy volunteers
- Where
- Switzerland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Eric Grouzmann
Heart Failure
Interval Versus Continuous Training in Heart Failure
BACKGROUND: The physiopathology of the heart failure involves compensatory mechanisms as exacerbated neurohormonal activity, endothelial dysfunction and consequently the muscle disability and exercise intolerance.
- Trial name
- NCT02448147
- Testing
- Interval training, Continuous training
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Autonomic Nervous System Diseases
PET Scan in Patients With Neurocardiologic Disorders
This study is designed to use PET scans in order to measure activity of the sympathetic nervous system. The sympathetic nervous system is the portion of the nervous system that maintains a normal supply of blood and fuel to…
- Trial name
- NCT00001418
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cardiac Disease, Risk Factor, Cardiovascular
Virtual Reality Based-therapy Applied to Physical Therapy in Cardiology.
The aim of this study is to investigate engagement, motivation, and the barriers to adherence of virtual reality based therapy (VRBT) in patients with cardiac diseases and risk factors to the development of cardiac diseases.
- Trial name
- NCT03377582
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 68 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Women, Sympathetic Nervous System
Early Neurovascular Adaptations in Aging Women
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
- Conditions
- Women, Sympathetic Nervous System, Aging, Blood Flow
- Trial name
- NCT06520982
- Testing
- Norepinephrine, Isoproterenol, Acetylcholine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Healthy Young Adults, Physical Activity Levels
Differences in Autonomic Recovery Between Physically Active and Inactive Women Following an Automated Massage Chair Intervention
The goal of this study is to investigate whether an automated massage chair can improve the body's recovery system in healthy young women (aged 19-26 years) who are either physically active or inactive.
- Conditions
- Healthy Young Adults, Physical Activity Levels, Inactive People
- Trial name
- NCT07529678
- Testing
- Massage chair
- Where
- Malaysia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Major Depressive Disorder
Stress and the Sympathetic Nervous System in Adults With Depression
To test our hypotheses, we will enroll healthy adults having no history of mood disorders and adults with major depressive disorder (MDD) having a broad range of depressive symptom severity.
- Trial name
- NCT04838262
- Testing
- Acute Stressors
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Spinal Cord Injury
Improving 24-hour Blood Pressure Stability in Spinal Cord Injury With Low Oxygen Therapy
This study examines the effects of low oxygen therapy (LOT) on the stability of 24-hour blood pressure in persons with chronic cervical spinal cord injury.
- Trial name
- NCT06691165
- Testing
- Low oxygen therapy (LOT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Glen Foster
Schizophrenia
Alleviating the Metabolic Side Effects of Antipsychotic Medications
The use of antipsychotic medications has increased over the past decade. While more recently developed medications are improved with regards to extrapyramidal side effects, the use of atypical antipsychotics has been associated…
- Trial name
- NCT01567124
- Testing
- Moxonidine
- Where
- 4 sites in Australia
- Sponsor
- Baker Heart and Diabetes Institute
Spinal Cord Injuries (SCI), Spinal Cord Injury
Transcutaneous Spinal Electrical Stimulation to Improve Exercise Function After Spinal Cord Injury.
Our overall objective is to decrease the prevalence of multiple sedentary-related diseases that are secondary consequences of spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Spinal Injury
- Trial name
- NCT07692191
- Testing
- Transcutaneous spinal electrical stimulation (TSES)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Stress, Sympathetic Nervous System
Glucose Levels as a Biomarker for Stress in Firefighters
Stress is known to cause physical structures in the brain to dysregulate, resulting in health problems like cancer, cardiac disease, metabolic disorders (obesity), and depression.
- Conditions
- Stress, Sympathetic Nervous System, Hypothalamic Pituitary Adrenal
- Trial name
- NCT06899373
- Testing
- Continuous glucometer
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Utah
Renal Failure
Assessment of the Sympathetic Nervous System Blockade of the Upper Limb After a Brachial Plexus Block in Patients With End Stage Renal Failure
The purpose of this study is to investigate what effect a local anesthetic nerve block of the arm in patients with end stage renal failure has upon blood flow in the skin of the arm.
- Trial name
- NCT01135979
- Where
- United Kingdom
- Sponsor
- University of Nottingham
Healthy, Pain
Selective Nerve Stimulation (SNS) Pilot Study
The purpose of this study is to examine if a new device, the SNS (Selective Nerve Stimulator), is effective in changing the way nerves work as pain killing drugs sometimes do.
- Trial name
- SNS (NCT01259271)
- Testing
- Selective Nerve Stimulation (SNS) stimulator device
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Codman & Shurtleff
Prediabetes, Obese
Inflammation Inhibition in Prediabetic Humans
Prediabetes, characterized by elevated fasting blood sugar or exaggerated blood sugar response to sugar ingestion, effects over 79 million adult Americans and is a precursor to the development of Type 2 diabetes.
- Trial name
- INCITE (NCT01977417)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Syncope
Evaluation of Chronic Orthostatic Intolerance
This study will conduct tests with patients with primary chronic orthostatic intolerance (COI) to learn more about this disorder of the autonomic nervous system.
- Trial name
- NCT00069693
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
Brain Receptors in Sympathetic Nervous System Regulation
The purpose of this study is to investigate the role of brain receptors called alpha2-adrenoreceptors in regulating the sympathetic nervous system, which maintains the supply of blood and fuel to the body's organs in times of…
- Trial name
- NCT00029627
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Weight Loss
A Social-networking-site(SNS) Based Weight Loss Behavior Intervention- the Effect of Social Network and Multi-level Factors on Weight Loss
In this project, investigators plan to conduct a randomized control trial of a weight loss intervention that is remotely delivered via SNS among the obese adult patients (20-64 years old, BMI ≥ 27 kg/m2) recruited from weight…
- Trial name
- NCT06237933
- Testing
- Enhanced intervention via social networking site (SNS), Standard intervention
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- National Taiwan University Hospital
Healthy
Effects of Manual vs Instrument-assisted Manipulation on Electromyographic Activity and Sympathetic Nervous System
This study evaluates the effects of manual and instrument-assisted cervical manipulation on electromyographic activity and sympathetic nervous system.
- Trial name
- NCT03736148
- Testing
- Manual Manipulation, Instrument-assisted Manipulation
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Hypertension, Renal Denervation
The Predictive Role of Proteomics in Blood Pressure Response of Hypertensive Patients Undergoing Renal Denervation.
Renal sympathetic nervous activity plays a crucial role in the development and maintenance of hypertension (HTN). Renal denervation (RDN) is a minimally invasive catheter-based treatment using mainly radiofrequency or ultrasound…
- Conditions
- Hypertension, Renal Denervation, Proteomics
- Trial name
- PREDICT-RDN (NCT06208501)
- Testing
- Urine sample for proteomic analysis, ABPM, OBPM
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Hippocration General Hospital