Clinical trials: SPECT
Pulmonary Hypertension
Right Ventricular Hypertrophy and Pulmonary Hypertension: A Correlation Analysis
The study hypothesis is that a quantitative index can be derived from Tc-99m myocardial perfusion scans that accurately identifies the presence of left ventricular hypertrophy and pulmonary hypertension.
- Trial name
- NCT00875940
- Testing
- Diagnostic imaging procedures.
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cincinnati
Parkinson Disease, Alzheimer Disease
Evaluation of [123I]CLINDE and SPECT as a Marker of Inflammation in Subjects With PD or AD and in Healthy Subjects
To assess the dynamic uptake and washout of 123-I CLINDE, a potential imaging biomarker for inflammatory changes in brain, using single photon emission computed tomography (SPECT) in similarly aged healthy controls and subjects…
- Conditions
- Parkinson Disease, Alzheimer Disease, Healthy Controls, Multiple Sclerosis
- Trial name
- CLINDE (NCT00612872)
- Testing
- [123I]CLINDE
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinsonian Syndrome
A Study of Brain Imaging With Nuclear Medicine Technology in Individuals With and at Risk for Parkinson's Disease
This study involves study participants who have been clinically diagnosed with parkinsonian syndrome or who are at-risk for parkinsonian syndrome, have a family history of parkinsonian syndrome or exposure to environmental toxins…
- Trial name
- NCT00117819
- Testing
- [123I]ß CIT and SPECT imaging
- Where
- United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Compulsive and Infrequent Tanners
Gauging Of Light Dependent Experiences Through Neuroimaging (GOLDEN)
In the proposed study, the investigators will assess the brain's dopamine response to UVR light in individuals who use tanning beds both frequently and infrequently.
- Trial name
- GOLDEN (NCT01761032)
- Testing
- Tanning
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Coronary Artery Diseases, Chest Pain
Cardiac SPECT With Rotating Slant Hole Collimator
The goal is to conduct a clinical pilot study to evaluate the use of a rotating multi-segment slant-hole collimator in the detection of myocardial defects.
- Trial name
- NCT00328315
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pancreatic Cancer, Breast Cancer
The Clinical Application Value of SPECT Imaging Targeting LRRC15 in Malignant Tumors
Here's a polished version of the text: "This project involves patients with high-expression LRRC15 malignant tumors who are either clinically suspected of or diagnosed with pancreatic cancer, breast cancer, lung cancer, ovarian…
- Conditions
- Pancreatic Cancer, Breast Cancer, Lung Cancer, Sarcoma
- Trial name
- NCT07651020
- Testing
- Specific SPECT imaging agents targeting LRRC15
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Breast Neoplasms, Carcinoma, Ductal
Spect Analysis of Cardiac Perfusion Changes After Whole Breast/Chest Wall Radiation Therapy With ABC
Cardiac perfusion changes have been seen after whole breast / chest wall irradiation for breast cancer. The Active Breathing Coordinator (ABC) device theoretically decreases radiation exposure to the heart during radiation for…
- Conditions
- Breast Neoplasms, Carcinoma, Ductal, Adenocarcinoma
- Trial name
- NCT00321048
- Testing
- Active Breathing Coordinator
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Breast Cancer
99mTc Labelled Affibody SPECT/CT Imaging for Breast Cancer HER2 Characterization
This is an open-label single photon emission tomography/computed tomography (SPECT/CT) study to investigate the diagnostic performance and evaluation efficacy of 99mTc-ABH2 in breast cancer patients.
- Trial name
- NCT03546478
- Testing
- 99mTc-ABH2
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Major Depressive Disorder
The Serotonin Transporter Availability for Prognosing Major Depressive Disorder (MDD) Treatment and Detecting MDD
Objectives: 1. To evaluate the relationship between improvement of Hamilton Depression Rating Scale (HAMD) score and basal SERT availability (binding potential) for the prognosis of MDD subjects being treated with Sertraline HCl…
- Trial name
- STAPMDDTDM (NCT02473783)
- Testing
- Sertraline HCl, I-123-ADAM SPECT
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Nicotine Dependence
Nicotine Vaccination and Nicotinic Receptor Occupancy
This is a molecular imaging research study designed to examine how much nicotine gets into the brain before and after vaccination with NicVAX, a nicotine vaccine developed by Nabi Biopharmaceuticals.
- Trial name
- NCT00996034
- Testing
- NicVAX, [123I]5-IA-85380, Nicotine bitartrate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Yale University
Peripheral Artery Disease, Diabetes Mellitus
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical…
- Conditions
- Peripheral Artery Disease, Diabetes Mellitus, Chronic Limb-Threatening Ischemia
- Trial name
- NCT03622359
- Testing
- SPECT/CT perfusion imaging, PET/CT perfusion imaging
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Parkinsonian Syndrome, Parkinson Disease(PD)
A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients
This is a multicenter, open-label, non-controlled, non-randomized, phase 3 clinical study to compare the SPECT findings after a single IV administration of DaTSCAN™ ioflupane (123I) injection for patients with a clinical…
- Conditions
- Parkinsonian Syndrome, Parkinson Disease(PD), Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP)
- Trial name
- NCT04193527
- Testing
- DaTSCAN™ Ioflupane (123I) Injection
- Where
- 10 sites in China
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Parkinson Disease
Assessment of the Biodistribution and Safety of 123-I MZINT in Healthy Subjects and Parkinson Disease Patients
The overall plan of this project is to evaluate [123I] mZINT as a tool to assess SERT density in humans. This protocol will be completed in three parts.
- Trial name
- NCT00427674
- Testing
- [123I] mZINT injection and serial dynamic SPECT imaging
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Breast Cancer
Integrin α6-targeted SPECT Imaging of Breast Cancer
A novel radiotracer 99mTc-RWY targeting Integrin α6 was developed, and the pilot first-in-human study for SPECT imaging of breast cancer was performed in seven healthy volunteers and two breast cancer patients to assess the…
- Trial name
- NCT04289532
- Testing
- 99mTc-RWY
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Peking University
Healthy
Use of a Functional Neuroimaging Battery for the Evaluation of a Meditation Retreat
Over 2 decades scientists have been studying the effect on brain function from meditation practices. The purpose of this study is to measure the effect of a meditation retreat program on serotonin and dopamine transporter binding…
- Trial name
- FETZER (NCT02443766)
- Testing
- Meditation Retreat
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Healthy, Mood Disorder
Neuroimaging of St. John's Wort-Induced Changes of Serotonin Metabolism in Normal Subjects
St. John's Wort is a popular dietary supplement that many people take to elevate mood or relieve stress. This study will test in normal volunteers whether this preparation may alter mood and if so, by what means.
- Trial name
- NCT00001919
- Testing
- Hypericum (LI-160)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Heart Failure, Coronary Artery Disease
123I-mIBG SPECT Imaging
This study is being done with a radioisotope, 123I-mIBG (Adreview), to develop a nuclear diagnostic imaging test for patients with decreased heart function which can be used to predict the progression of the heart disease and…
- Trial name
- NCT02043522
- Testing
- Radioisotope
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Early-stage Breast Cancer
Sentinel Lymph Node Identification in Patients With Breast Cancer Using SPECT/CT
Role of SPECT/CT in detection of sentinel lymph node in patients with breast cancer that is in early stage with small mass with no nodal or distant metastasis using radioactive material nannocolloid that can change surgical…
- Trial name
- NCT03468374
- Testing
- lymphoscintigraphy, Single Photon Emission Tomography
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Assiut University
Alzheimer Disease
Evaluation of [123I] AV51 and SPECT as a Marker of Beta-amyloid Protein Deposition in Subjects With Alzheimer Disease in Comparison to Healthy Subjects
The main objectives of this proposal are as follows: To assess the dynamic uptake and washout of 123-I AV51, a potential imaging biomarker for β-amyloid burden in brain, using single photon emission computed tomography (SPECT) in…
- Trial name
- NCT00556660
- Testing
- [123I] AV-151
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Alzheimer Disease
Brain Imaging in Alzheimer's Disease
The purpose of this study is to use brain imaging technology to examine the role of certain brain chemicals in individuals with Alzheimer's disease (AD) and in healthy volunteers.
- Trial name
- NCT00039702
- Testing
- [123] 5-I-A-85380
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)