Clinical trials: SRS
Brain Metastases
A Proof-of-principle Study of HBO-SRS for Brain Metastases
Patients with brain metastases who are candidates for treatment with stereotactic radiosurgery (SRS) are potential study participants.
- Trial name
- NCT01850563
- Testing
- Hyperbaric oxygen given at 2.4 ATA for 30 minutes immediately prior to SRS - HBOT for 30 minutes - SRS without prior HBO
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
NSCLC Stage IV, Brain Metastases
Camrelizumab Combined With Local Treatment in NSCLC Patients With BM
To evaluate the efficacy and safety of Camrelizumab Combined with Chemotherapy and Local Treatment in non-small cell lung cancer with brain metastases.
- Conditions
- NSCLC Stage IV, Brain Metastases, Immunotherapy
- Trial name
- NCT04291092
- Testing
- Immunotherapy, WBRT, Chemotherapy
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Zhejiang Cancer Hospital
NSCLC, EGFR Gene Mutation
A Study to Evaluate the Efficacy of Osimertinib With Early Intervention SRS Treatment Compared to the Continuation of Osimertinib Alone, in Patients With EGFR Mutated NSCLC and Asymptomatic Brain Metastases
This study involves patients with EGFR-mutated NSCLC and asymptomatic brain metastases. This is an open-label, randomized study, comparing the continuation of Osimertinib treatment alone to Osimertinib treatment combined with…
- Conditions
- NSCLC, EGFR Gene Mutation, EGF-R Positive Non-Small Cell Lung Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT05033691
- Testing
- Stereotactic surgery
- Where
- Israel
- Volunteers
- 162 people
- Sponsor
- Hadassah Medical Organization
Brain Neoplasms, Adult, Malignant
Stereotactic Radiosurgery (SRS) Dose-Escalation Study for Brain Metastasis
SRS dose escalation for brain metastases in radiation-naïve patients will establish true tolerable doses, which may exceed the current standard doses.
- Trial name
- SRS (NCT02645487)
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Texas Southwestern Medical Center
Brain Metastases, Non-small Cell Lung Cancer
SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI
Despite the impressive response rate to third-generation EGFR-TKIs, resistance inevitably develops in most patients. Stereotactic radiotherapy plays a growing role in the management of patients with brain metastasis.
- Trial name
- NCT06020066
- Testing
- EGFR-TK Inhibitor, Stereotactic radiotherapy
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Fudan University
Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma
Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases
This pilot trial studies the side effects of giving pembrolizumab together with stereotactic radiosurgery to treat patients with melanoma or non-small cell lung cancer that has spread to the brain.
- Conditions
- Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Mucosal Melanoma, Ocular Melanoma
- Trial name
- NCT02858869
- Testing
- Pembrolizumab, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Brain (Nervous System) Cancers, Brain Metastasases
Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / Metastases
When cancer spreads to the brain, doctors often use a precise type of radiation therapy called stereotactic radiosurgery (SRS) to treat these tumors.
- Conditions
- Brain (Nervous System) Cancers, Brain Metastasases, SRS
- Trial name
- GK-LIVE (NCT07162246)
- Testing
- Radiation Therapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Neoplasms, Arteriovenous Malformation of Central Nervous System
RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT
The RSSearch® Registry is an international multi-year database designed to track SRS/SBRT (Stereotactic Radiosurgery/Stereotactic Body Radiation Therapy) utilization, treatment practices and outcomes to help determine, over time…
- Conditions
- Neoplasms, Arteriovenous Malformation of Central Nervous System, Trigeminal Neuralgia
- Trial name
- NCT01885299
- Testing
- SRS/SBRT
- Where
- 13 sites in United States
- Volunteers
- 50,000 people
- Sponsor
- The Radiosurgery Society
Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain
Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases
This phase III trial studies stereotactic radiosurgery (SRS) before surgery to see how well it works compared with SRS after surgery in treating patients with cancer that has spread to the brain (brain metastases).
- Trial name
- NCT03741673
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- M.D. Anderson Cancer Center
Brain Metastases
Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases
Radiosurgery is the use of a focal high dose of radiation therapy to ablate or kill a tumor. This trial will enroll patients with brain metastases 4 cm or less in greatest diameter and will compare 0mm margin to a 2mm margin for…
- Trial name
- NCT06857006
- Testing
- brain metastases radiosurgery
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Alabama at Birmingham
Colorectal Cancer, Brain Metastases, Adult
Local Treatment Strategies for Brain Metastases of Colorectal Cancer
COLBRAIN trial is an international (2 countries) observational, multicenter (15 centers) retrospective cohort study designed to investigate local treatment strategies for brain metastases of colorectal cancer.
- Trial name
- COLBRAIN (NCT07448662)
- Testing
- Neurosurgical Resection (NRS): En-bloc (EBR), Total piecemeal (TPR), Subtotal (SPR) or Partial (PPR), Radiotherapy (RT): Stereotactic Radiosurgery/Radiotherapy (SRS/SRT), Whole-Brain Radiotherapy (WBRT), Combined Local Treatment Modalities
- Where
- 15 sites in Belarus, Russia
- Volunteers
- 700 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Brain Metastases
Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases
This is a single-arm, single-center pilot study in which 10 patients with one to four brain metastases diagnosed on brain magnetic resonance imaging (MRI) within the past 30 days will be evaluated for study eligibility and…
- Trial name
- NCT04545814
- Testing
- Stereotactic Radiosurgery, Surgical Resection, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical College of Wisconsin
Metastasis to Brain of Unknown Primary
18F ML-10 for Early Detection of Response of Brain Metastases to SRS
The purpose of this study is to evaluate the potential of [18F]-ML-10 to serve as a non-invasive imaging tool for the early detection of apoptosis in brain metastases in response to radiation therapy, in patients subjected to…
- Trial name
- NCT00696943
- Testing
- ([18F]-ML-10)
- Volunteers
- 1 people
- Sponsor
- Aposense Ltd.
Brain Metastases
Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases
This clinical study is a parallel, prospective observational single-centre trial in patients presenting with 5 to 30 brain metastases.
- Trial name
- NCT03775330
- Testing
- Stereotactic Radiosurgery (SRS), Whole brain radiation (WBRT)
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- Sunnybrook Health Sciences Centre
Brain Cancer, Brain Metastases
Single vs Multi-fraction SRS Patients on Immunotherapy
This study is meant to compare different surgical approaches to brain cancer.
- Trial name
- MIGRAINE (NCT04427228)
- Testing
- Radiosurgery Single Treatment, Radiosurgery Three Treatments
- Where
- United States
- Sponsor
- University of Chicago
Brain Metastases
Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial
This research study is studying two different types of radiation as treatment for brain metastases (tumors in the brain that spread from a cancer that originated elsewhere in the body)
- Trial name
- NCT03075072
- Testing
- Whole brain radiation, Stereotactic radiation (SRS)
- Where
- 2 sites in United States
- Volunteers
- 196 people
- Sponsor
- Brigham and Women's Hospital
Anterior Vaginal Wall Prolapse, Vaginal Apex/Uterine Prolapse
Demonstrate the Safety and Preformance of the SRS Device for the Treatment of Pelvic Organ Prolapse
A prospective, single arm, pre-market, multi-center clinical study to evaluate the safety and performance of the SRS (Lyra Medical) vaginal mesh in POP patients
- Trial name
- NCT02209337
- Testing
- SRS
- Where
- 3 sites in Hungary, Israel
- Volunteers
- 20 people
- Sponsor
- Lyra Medical Ltd.
Metastatic Cancer, Brain Metastases
Stereotactic Radiosurgery (SRS) for Multiple CNS Mets
This study is designed to determine outcome for patients with 5 or more central nervous system (CNS) metastatic lesions treated with stereotactic radiosurgery (SRS).
- Trial name
- NCT02567643
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Sponsor
- The Cooper Health System
Brain Metastases, Adult Solid Tumor
Cyberknife Radiosurgery for Patients With Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence
For patients with cerebral oligometastases who are in adequate clinical condition stereotactic radiosurgery (SRS) is the treatment of choice, being recommended by international guidelines for the treatment of one to four lesions.
- Trial name
- CYBER-SPACE (NCT03303365)
- Testing
- stereotactic radiosurgery (SRS)
- Where
- Germany
- Volunteers
- 203 people
- Sponsor
- Juergen Debus
Anterior Vaginal Wall Prolapse With/Without Apical/Uterine Descent
Multicenter, Prospective, Non-randomized, Single-arm, Interventional Study for the Evaluation of the Safety and Preformance of the SRS Device for the Treatment of Pelvic Organ Prolapse
A prospective, single arm, multi-center clinical study to evaluate the safety and performance of the SRS (Lyra Medical) vaginal mesh in POP patients
- Trial name
- NCT03195361
- Testing
- SRS - Self Retaining Support system
- Where
- 3 sites in Israel
- Volunteers
- 50 people
- Sponsor
- Lyra Medical Ltd.