Clinical trials: ST Segment Elevation Myocardial Infarction (STEMI)
Myocardial Infarction
CIPAMI-Study: Clopidogrel Administered Prehospital to Improve Primary PCI in Patients With Acute Myocardial Infarction
Acute myocardial infarction is generally caused by a thrombotic occlusion of coronary arteries. Primary aim of early therapy is a fast and complete reperfusion of the infarcted myocardium, which can be achieved by either…
- Trial name
- NCT00372216
- Testing
- Clopidogrel (Iscover/Plavix)
- Where
- 25 sites in Austria, Germany
- Volunteers
- 337 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Heart Disease, Ischemic Heart Disease
Time to Thrombocytic Inhibition After Supine and Upright Ingestion of Efient
The purpose of the study is to clarify wether body posture during ingestion of 60mg Efient, a thrombocytic inhibitor, has influence on the time to thrombocytic inhibition.
- Conditions
- Heart Disease, Ischemic Heart Disease, ST-elevation Myocardial Infarction
- Trial name
- NCT01365741
- Testing
- Upright position
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiogenic Shock, Acute Myocardial Infarction
National Cardiogenic Shock Initiative
This study evaluates the use of early mechanical circulatory support in patients presenting with acute myocardial infarction and cardiogenic shock.
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCSI (NCT03677180)
- Where
- 75 sites in United States
- Volunteers
- 406 people
- Sponsor
- Henry Ford Health System
Acute ST-segment Elevation Myocardial Infarction (Patients Undergoing Emergency PCI)
Efficacy and Safety of Ultrasound Modulation of Stellate Ganglion for the Prevention of Ventricular Arrhythmia in Patients With ST-segment Elevation Myocardial Infarction
The goal of this multicenter, double-blind, randomized controlled trial is to evaluate the efficacy and safety of low-intensity focused ultrasound (LIFU) stellate ganglion modulation for preventing ventricular arrhythmias after…
- Trial name
- US-PRAY (NCT07587294)
- Testing
- Ultrasound modulation of the left stellate ganglion
- Where
- 7 sites in China
- Volunteers
- 100 people
- Sponsor
- Renmin Hospital of Wuhan University
Myocardial Infarction
Which Therapy for Acute Heart Attacks? (The WEST Study)
In the setting of acute myocardial infarction (heart attacks), the principle objective of the WEST Study is to compare the impact on clinical outcomes of 3 different treatment strategies.
- Trial name
- NCT00121446
- Testing
- tenecteplase, enoxaparin, clopidogrel
- Where
- 16 sites in Canada
- Volunteers
- 300 people
- Sponsor
- University of Alberta
ST Segment Elevation Myocardial Infarction, Left Ventricular Thrombus
Treatment of Post-STEMI Left Ventricular Thrombus With Optimized Anticoagulant
Left ventricular thrombus is a common complication subsequent to ST-segment elevation myocardial infarction (STEMI) that related to increased embolic events.
- Trial name
- EARLYmyo-LVT (NCT03764241)
- Testing
- Rivaroxaban, Vitamin K Antagonist
- Where
- China
- Volunteers
- 280 people
- Sponsor
- RenJi Hospital
ST Elevation Myocardial Infarction, Cardiogenic Shock
Clinical Characteristics and Outcomes Among STEMI Patients With Cardiogenic Shock at Abu Dhabi City
A retrospective study on the clinical characteristics and treatment outcomes of patients admitted with ST-elevation Myocardial Infarction (STEMI) complicated with cardiogenic shock (CS) during admission or CS development during…
- Trial name
- NCT06535503
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 400 people
- Sponsor
- Abu Dhabi Health Services Company
Contrast-induced Acute Kidney Injury, ST Elevation Myocardial Infarction
A Randomized Trial of Rosuvastatin Loading Combined With Early hydrAtion Versus Standard-of-care Medications for the Prevention of CIAKI in Patient With AMI Undergoing Emergency PCI
The CIAKI,as the third complication of PCI, was associated with adverse cardiac events after procedure. Moreover, because the rate of periprocedure hydration is inadequate in STEMI patients before primary PCI, the incidence of…
- Conditions
- Contrast-induced Acute Kidney Injury, ST Elevation Myocardial Infarction, Primary PCI, Rosuvastatin
- Trial name
- TRACK-AMI (NCT03526367)
- Testing
- hydration plus rosuvastatin therapy, Standard therapy
- Where
- China
- Sponsor
- Shenyang Northern Hospital
ST Elevation Myocardial Infarction
Optimal Reperfusion Strategy for STEMI Patients With Anticipated PPCI Delay
The OPTIMAL-REPERFUSION trial will help determine whether reduced-dose facilitated PCI strategy improves clinical outcomes in patients with STEMI and anticipated PPCI delay
- Trial name
- NCT04752345
- Testing
- Pharmacoinvasive strategy, Reduced-dose facilitated PCI strategy
- Volunteers
- 632 people
- Sponsor
- West China Hospital
ST Segment Elevation Myocardial Infarction
Efficacy of Intracoronary Infusion of Different Medicine in STEMI Patients Undergoing Primary PCI
The study intends to evaluate the efficacy of different medicine delivering by targed perfusion catheter incoronary administration on epicardial, myocardial perfusion and clinical outcomes in STEMI patients undergoing primary PCI.
- Trial name
- NCT03252665
- Testing
- Alprostadil, Nicorandil, Nitroglycerin
- Where
- China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Acute Myocardial Infarction, Ischemia-reperfusion Injury
The Effect of Melatonin on Ischemia-reperfusion Injury Following Acute Myocardial Infarction
In Denmark, 12.000 people a year, is struck by acute myocardial infarction. A third of these cannot be saved before treatment is possible.
- Trial name
- NCT01172171
- Testing
- Melatonin, N-acetyl-5-methoxytryptamine, Isotonic saline, Natrium chloride
- Where
- 2 sites in Denmark
- Volunteers
- 41 people
- Sponsor
- Herlev Hospital
Myocardial Infarction
Feedback Intervention and Treatment Times in ST- Elevation Myocardial Infarction
Part I (Pilot Phase): The purpose of this study is to examine if formalized data assessment and systematic feedback improves treatment times (i.e.
- Trial name
- FITT-STEMI (NCT00794001)
- Testing
- Data analysis and Feedback
- Where
- Germany
- Volunteers
- 50,000 people
- Sponsor
- Karl Heinrich Scholz
Myocardial Reperfusion, STEMI - ST Elevation Myocardial Infarction
Impact of Injection Pressure on Myocardial Reperfusion During Primary PCI
Percutaneous coronary intervention for myocardial infarction with ST elevation could be complicated with thrombus embolisation to the more distal segments of the culprit artery.
- Trial name
- ImPress (NCT03445364)
- Testing
- Use of different injection pressure during primary PCI
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University Hospital Sestre Milosrdnice
Acute Myocardial Infarction
Study to Assess the Safety and Cardiovascular Effects of Autologous Adipose-Derived Stromal Cells Implantation In Patients During the Acute Recovery Phase of ST-Elevation Myocardial Infarction
The intent of this clinical study is to answer the questions: 1) Is the proposed treatment safe? and 2) Is treatment effective in improving cardiac function and clinical outcomes?
- Trial name
- Acute MI (NCT01974128)
- Testing
- ASC isolation and implantation
- Where
- United States
- Sponsor
- Ageless Regenerative Institute
Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction
Safety and Efficacy of FAP iCDC in Acute Myocardial Infarction With Cardiogenic Shock
To study the safety and efficacy of fibroblast activation protein (FAP)-targeted allogeneic immunosuppressive chimeric antigen receptor-dendritic cell (CAR-DC) in the treatment of acute myocardial infarction with cardiogenic…
- Conditions
- Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT07380659
- Testing
- FAP allogeneic immunosuppressive CAR-DC
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Myocardial Infarction (AMI), Coronary Occlusion
AngelMed for Early Recognition and Treatment of STEMI
A prospective, randomized multicenter study of subjects with a high-risk of having a myocardial infarction (MI) due to acute coronary syndrome or bypass surgery.
- Conditions
- Acute Myocardial Infarction (AMI), Coronary Occlusion, Acute Coronary Syndrome
- Trial name
- ALERTS (NCT00781118)
- Testing
- Guardian System
- Where
- 95 sites in United States
- Volunteers
- 1,020 people
- Sponsor
- Angel Medical Systems
Acute Myocardial Infarction
Comparison Between Thrombolysis and Primary Percutaneous Coronary Intervention (PCI) to Treat ST-Segment Elevation Myocardial Infarction
The main objective is to compare a fibrinolytic strategy with an interventional strategy initiated as early as possible, preferably in the pre-hospital phase, with respect to resolution of ST-segment elevation at 120 minutes…
- Trial name
- SWEDES (NCT00806403)
- Testing
- reteplase 10+10 U, primary PCI
- Where
- 5 sites in Sweden
- Volunteers
- 205 people
- Sponsor
- Sahlgrenska University Hospital
Type 2 Diabetes, Acute Myocardial Infarction
Glucose Monitoring After Acute Myocardial Infarct in People With Diabetes
Glucose monitoring after Acute Myocardial infarct in people with diabetes is a Dexcom funded study that is investigating whether the use of continuous glucose monitors (Dexcom ONE model) in people with type 2 diabetes facilitates…
- Conditions
- Type 2 Diabetes, Acute Myocardial Infarction, Acute Myocardial Infarction With ST Elevation, Diabetes Complications
- Trial name
- GLAM (NCT05431296)
- Testing
- Dexcom ONE Continuous Glucose Monitoring System
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Imperial College London
Ischemic Mitral Regurgitation
Effect of Significant Ischemic Mitral Regurgitation on the Outcome of ST Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention
The goal of the study is to correlate the effect of ischemic mitral regurgitation on the outcome of STEMI patients treated with successful primary PCI using clinical data and echocardiography on presentation and during short term…
- Trial name
- NCT04106648
- Volunteers
- 134 people
- Sponsor
- Assiut University
ST Elevation Myocardial Infarction, Fibrinolysis
Ticagrelor vs High Dose Clopidogrel in Patients With ST Elevation Myocardial Infarction Post Fibrinolysis
This is a two-center, prospective, randomized, single-blind, investigator initiated, pharmacodynamic study of parallel design, carried out in 2 PCI-capable cardiology centers (Patras University Hospital and Konstantopoulio…
- Conditions
- ST Elevation Myocardial Infarction, Fibrinolysis, P2Y12 Inhibitor
- Trial name
- NCT01950416
- Testing
- Ticagrelor 180mg loading dose and 90mg bid maintenance dose, Clopidogrel 600mg loading dose and 150mg maintenance dose
- Where
- 2 sites in Greece
- Volunteers
- 56 people
- Sponsor
- University of Patras
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