Clinical trials: ST Segment Elevation Myocardial Infarction (STEMI)
Non-ST Elevation Myocardial Infarction, Frail Elderly Syndrome
the Invasive and Conservative Strategies in Elderly Frail Patients With Non-STEMI
The role of a routine invasive strategy in frail patients with non-ST-segment elevation acute myocardial infarction is currently uncertain. We hypothesize that a routine invasive strategy will improve outcomes.
- Trial name
- MOSCA-FRAIL (NCT03208153)
- Testing
- Invasive, Conservative
- Where
- Spain
- Volunteers
- 167 people
- Sponsor
- University of Valencia
Acute STEMI, PPCI
On vs Off-hour PPCI in STEMI Patients
ST-elevation myocardial infarction (STEMI) remains a leading cause of morbidity and mortality globally, and timely reperfusion with primary percutaneous coronary intervention (PPCI) is the gold-standard treatment1.
- Conditions
- Acute STEMI, PPCI, Observational Study, Coronary Artery Disease (CAD)
- Trial name
- On vs Off PPCI (NCT07860086)
- Where
- Egypt
- Volunteers
- 450 people
- Sponsor
- Assiut University
ST Elevation Myocardial Infarction (STEMI)
IMPROVE-STEMI: pPCI Plus Low-dose r-SK in STEMI
This is a multicenter, prospective, pragmatic, randomized controlled trial (IMPROVE-STEMI) aiming to evaluate the efficacy and safety of intracoronary low-dose recombinant streptokinase combined with primary percutaneous coronary…
- Trial name
- IMPROVE-STEMI (NCT07875179)
- Testing
- Recombinant Streptokinase
- Where
- China
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Coronary Artery Disease, Myocardial Infarction
Delayed Plaque Morphology in Patients With STEMI After Thrombus Aspiration During Primary PCI
The purpose of this study is to characterize the plaque morphology in patients with acute STEMI by OCT after aspiration thrombectomy.
- Trial name
- STEMI-OCT (NCT02384824)
- Testing
- Primary Percutaneous Intervention
- Volunteers
- 100 people
- Sponsor
- Jian'an Wang,MD,PhD
Acute Myocardial Infarction
Investigating Temporal Improvements in Survival Following ST-elevation Myocardial Infarction.
The aim of the study was to use data from the Myocardial Ischaemia National Audit Project (MINAP) to investigate whether temporal improvements in survival were associated with changes in patients' baseline clinical risk or use of…
- Trial name
- NCT03749694
- Volunteers
- 232,353 people
- Sponsor
- University of Leeds
Coronary Artery Disease, Acute Coronary Syndrome
A Comparison of an Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent With a Durable Polymer Everolimus-Eluting Stent for Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
PCI is considered as the reperfusion strategy of choice for patients with acute STEMI. Data from RCTs and meta-analyses demonstrate a consistent and strong signal towards a significant reduction in MACE among patients with STEMI…
- Trial name
- BIOSTEMI (NCT02579031)
- Testing
- Orsiro, Xience
- Where
- 10 sites in Switzerland
- Volunteers
- 1,300 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease
Evaluation of Effectiveness and Safety of the GENOUS STENT (IRIS-GENOUS STEMI)
The objective of this study is to evaluate effectiveness and safety of GENOUS EPC-coated stent in patients with STEMI with other drug-eluting stents (DESs).
- Trial name
- NCT01348373
- Where
- 16 sites in South Korea
- Volunteers
- 464 people
- Sponsor
- Seung-Jung Park
CONUT Score, ST Elevation (STEMI) Myocardial Infarction
Association of Prognostic Nutritional Index and Controlling Nutritional Status Score With ST Elevation Myocardial Infarction
It is well known that malnutrition is a prognostic risk factor in chronic heart failure (CHF). Weight loss and the development of cardiac cachexia are associated with poor prognosis in CHF.
- Conditions
- CONUT Score, ST Elevation (STEMI) Myocardial Infarction, Mortality
- Trial name
- NCT07369037
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Muğla Sıtkı Koçman University
Neutrophils.Hypersegmented | Bld-Ser-Plas, STEMI - ST Elevation Myocardial Infarction
CLEAR SYNERGY Neutrophil Substudy
CLEAR SYNERGY is an international multi center 2x2 randomized placebo controlled trial of colchicine and spironolactone in patients with STEMI.
- Trial name
- NCT03874338
- Testing
- Colchicine Pill
- Where
- United States
- Volunteers
- 322 people
- Sponsor
- NYU Langone Health
Acute Myocardial Infarction
Evaluation of Neointimal Coverage of EES and BMS After Implantation in STEMI Patients by Optical Coherence Tomography
Primary percutaneous coronary intervention (PCI) represents the preferred reperfusion strategy for patients with ST-segment elevation myocardial infarction (STEMI), since it is more effective than thrombolytic regimens in…
- Trial name
- NeoCover (NCT01875835)
- Testing
- Xience™ V stent (Abbott Vascular, Santa Clara, California, USA), Multilink-Vision stent(Abbott Vascular, Santa Clara, California, USA)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Harbin Medical University
ST Elevation Myocardial Infarction
SNPs in the DNase 1 Gene Impair Its Activity and Are Increased in a STE-ACS Patient Cohort Compared to Healthy Controls
Neutrophil extracellular traps (NETs) and deoxyribonuclease (DNase) activity determine outcome in ST elevation acute coronary syndrome (STE-ACS). DNase single nucleotide polymorphisms (SNPs) were increased in a japanese cohort.
- Trial name
- NCT02615015
- Testing
- Blood draw
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Myocardial Infarction
CMR for Prognosis Assessment in NSTEMI
The prognostic significance of cardiac magnetic resonance (CMR) derived parameters of myocardial and microvascular injury has not been fully elucidated yet in non-ST-Elevation myocardial infarction (NSTEMI) patients.
- Trial name
- NCT03516578
- Testing
- Cardiac magnetic resonance imaging
- Volunteers
- 314 people
- Sponsor
- Heart Center Leipzig - University Hospital
High Bolus Dose of Tirofiban
Effect of Upstream High Bolus Dose of Tirofiban in Primary PCI for the Patients With STEMI on Short Term Outcome
The goal of the study to investigate the impact of upstream HBD of Tirofiban on short outcome of STEMI patient.
- Trial name
- TISP (NCT04111289)
- Testing
- -Administration of tirofiban (25 ug/kg bolus and 0.15 ug/kg/min maintenance infusion)
- Volunteers
- 150 people
- Sponsor
- Assiut University
Acute Coronary Syndrome:, Non ST Elevation Myocardial Infarction
Assessment of Coronary Flow Reserve by Doppler Flow Wire in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Differences Between the Loading Dose of Ticagrelor and Clopidogrel
The administration of these drugs is realized according to the European Society of Cardiology guidelines. All patients will be pretreated with aspirin 300 mg orally, heparin iv to maintain an activated clotting time of >250 sec…
- Conditions
- Acute Coronary Syndrome:, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- NCT02032290
- Testing
- Assessment of Coronary Flow Reserve, Percutaneous coronary intervention, ticagrelor loading
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Azienda Policlinico Umberto I
Acute ST-segment Elevation Myocardial Infarction
Effect of Low-dose Intracoronary Reteplase on Myocardial Infarct Size During Primary Percutaneous Coronary Intervention
OBJECTIVE: To determine whether a therapeutic strategy involving low-dose intracoronary fibrinolytic therapy with reteplase infused after coronary reperfusion will reduce the myocardial infarction size.
- Trial name
- RECOVERII (NCT04571580)
- Testing
- Normal Saline, Reteplase Injection 9mg, Reteplase Injection 18mg
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Ge Junbo
Acute ST-elevation Myocardial Infarction
Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction.
Heart imaging with magnetic resonance imaging (MRI) provides detailed insights into heart function and injury. The nature and significance of heart injury after a heart attack is incompletely understood.
- Trial name
- BHF MR-MI (NCT02072850)
- Testing
- Coronary pressure wire, Magnetic resonance imaging of the heart
- Where
- United Kingdom
- Volunteers
- 324 people
- Sponsor
- NHS National Waiting Times Centre Board
ST Segment Elevation Myocardial Infarction
Efficacy of Intracoronary Infusion of Different Medicine in STEMI Patients Undergoing Primary PCI
The study intends to evaluate the efficacy of different medicine delivering by targed perfusion catheter incoronary administration on epicardial, myocardial perfusion and clinical outcomes in STEMI patients undergoing primary PCI.
- Trial name
- NCT03252665
- Testing
- Alprostadil, Nicorandil, Nitroglycerin
- Where
- China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
ST Elevated Myocardial Infarction
Rituximab in Patients With ST-elevation Myocardial Infarction
The main objective is to compare the effect of a single injection of two doses of rituximab versus placebo on 6 months left ventricular systolic function, using CMR, in patients who have had an acute anterior STEMI.
- Trial name
- RITA-MI2 (NCT05211401)
- Testing
- Active arm 1000 mg
- Where
- France
- Volunteers
- 372 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ST Elevation Myocardial Infarction
The Predictive Value of eGFR for Adverse Cardiovascular Events in Patients With STEMI
Estimated glomerular filtration rate(eGFR) is significantly reduced in patients with ST-segment elevation myocardial infarction (STEMI).
- Trial name
- NCT03984071
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Dongying Zhang
ST-Elevation Myocardial Infarction
Myocardial Salvage Assessed by Cardiovascular Magnetic Resonance - Impact on Outcome
In acute myocardial infarction cardiovascular magnetic resonance imaging can retrospectively detect the myocardium at risk and the irreversible injury.
- Trial name
- NCT00952224
- Testing
- magnetic resonance imaging
- Where
- Germany
- Volunteers
- 267 people
- Sponsor
- University of Leipzig
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