Clinical trials: ST-Segment Elevation Myocardial Infarction (STEMI)
ST Segment Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI
In STEMI patients undergoing PPCI there is a delayed onset of action of oral P2Y12 receptor inhibitors, including prasugrel and ticagrelor.
- Trial name
- CANTIC (NCT03247738)
- Testing
- Cangrelor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
STEMI - ST Elevation Myocardial Infarction, Myocardial Dysfunction
Percutaneous Revascularization in Infarction With Late Presentation and Absence of Viability: Effects on Left Ventricular Remodeling and Contractility
The purpose of this study is to evaluate whether late recanalization in patients with ST elevation myocardial infarction (STEMI) without Viability on Cardiovascular Magnetic Resonance Image (MRI) can reduce the reverse remodeling…
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Myocardial Dysfunction, Percutaneous Coronary Intervention
- Trial name
- NCT05160311
- Testing
- Optimized Medical Treatment (OMT), Drug Eluting Stent (DES) Coronary Angioplasty
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
ST Elevation Myocardial Infarction
Cardiovascular Patient Outcomes and Research Team Primary PCI Registry
The proposed study is a registry of patients treated with primary angioplasty for acute myocardial infarction. The aim of this registry is to define the outcomes of patients treated for acute, ST-segment myocardial infarction…
- Trial name
- CPORT (NCT02201264)
- Where
- 14 sites in United States
- Volunteers
- 6,726 people
- Sponsor
- Johns Hopkins University
STEMI
Follow up of Clinical Outcome of Deferred vs Immediate Stenting in High Thrombus Stemi Patients
To compare the effect of immediate stenting versus deferred stenting - with use of glycoproteinIIbIIIa inhibitor \& low molecular weight heparin - on the clinical outcome -3 and 6 months after stenting \& also infarct size using…
- Trial name
- NCT05793671
- Testing
- PPCI in heavy thrombus burden STEMI patients
- Volunteers
- 440 people
- Sponsor
- Assiut University
Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction
Hong Kong Cardiogenic Shock Initiative
Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) is a severe condition with high mortality. Early revascularization and Impella device (Abiomed) support improve outcomes.
- Conditions
- Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction, Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction
- Trial name
- HK CSI (NCT07323238)
- Where
- Hong Kong
- Volunteers
- 320 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Acute Myocardial Infarction
To Investigate the Role of Upstream High Dose Statin in STEMI
This is a double-blinded randomized placebo controlled trial investigating the role of upstream 80mg Atorvastastin-calcium in patients undergoing percutaneous intervention for acute STEMI.
- Trial name
- IMPRES (NCT01050348)
- Testing
- Atorvastatin calcium
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- The Western Pennsylvania Hospital
Acute Coronary Syndrome (ACS)
Lp(a) Lowering Study of Pelacarsen (TQJ230) in Patients in the US With Elevated Lp(a) and Recent ACS (STEMI/NSTEMI) - Lp(a)FRONTIERS PEARL
CTQJ230A1US13 is a randomized, double-blind, placebo-controlled, multicenter phase IIIb study designed to evaluate the efficacy, safety, tolerability, and coronary plaque effects of early pelacarsen (TQJ230) initiation in…
- Trial name
- NCT07625306
- Testing
- Pelacarsen
- Sponsor
- Novartis Pharmaceuticals
ST Elevation Myocardial Infarction
MGuard™ Prime Stent System Clinical Trial in Patients With Acute ST Elevation Myocardial Infarction
To evaluate the safety and efficacy of the MGuard™ Prime stent in the treatment of blocked arteries in coronary arteries in patients undergoing a stenting procedure due to having a heart attack.
- Trial name
- MASTER-II (NCT01869738)
- Testing
- MGuard Prime, (BMS/DES)
- Where
- 56 sites in United States, Belgium and 10 more
- Volunteers
- 310 people
- Sponsor
- InspireMD
CaIMR, Prognosis
The Usefulness of CaIMR in Patients With STEMI
The coronary artery system is composed of three different types of blood vessels, namely epicardial arteries, arterioles and capillaries.
- Conditions
- CaIMR, Prognosis, ST-segment Elevation Myocardial Infarction
- Trial name
- NCT04984915
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Zhongnan Hospital
Acute Myocardial Infarction, Coronary Artery Disease
Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease
COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment…
- Trial name
- COMPLETE-2 (NCT05701358)
- Testing
- Physiology-guided NCL PCI, Angiography-guided NCL PCI
- Where
- 138 sites in United States, Australia and 18 more
- Volunteers
- 5,100 people
- Sponsor
- Population Health Research Institute
Acute Myocardial Infarction
POST-dilatation to Improve Outcomes in Acute STEMI Patients Undergoing Primary With OCT Assessment
To evaluate the effective and safety of post-dilatation in patients with acute ST segment elevated myocardial infarction undergoing primary percutaneous intervention after thrombus aspiration assessed by optical coherence…
- Trial name
- POST-STEMI (NCT02121223)
- Testing
- post-dilatation with a Quantum Maverick balloon, manual thrombus aspiration + Promus Element stent implant
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stable Angina, Unstable Angina
International Collaboration of Comprehensive Physiologic Assessment
The current study evaluated prognostic implication of comprehensive physiologic assessment using fractional flow reserve, coronary flow reserve (CFR) and index of microcirculatory resistance (IMR).
- Conditions
- Stable Angina, Unstable Angina, Non-ST Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction
- Trial name
- NCT03690713
- Testing
- Fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance
- Where
- 4 sites in Japan, South Korea and 1 more
- Volunteers
- 1,397 people
- Sponsor
- Seoul National University Hospital
ST Elevation Myocardial Infarction
Impact of Glycemic State on Patients ST Elevation Myocardial Infarction With Primary Percutaneous Coronary Angioplasty
ST-elevation myocardial infarction is a major cause of morbidity and mortality worldwide. ST-elevation myocardial infarction damages the regional myocardium that undergoes ischemia and necrosis, resulting in impairment of both…
- Trial name
- NCT03266978
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Myocardial Reperfusion Injury
Role of Endothelin in Microvascular Dysfunction Following PCI for NSTEMI
Percutaneous coronary intervention (PCI) for acute coronary syndromes frequently fails to restore myocardial perfusion despite establishing epicardial vessel patency.
- Trial name
- BQ-123 (NCT00586820)
- Testing
- BQ-123
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mayo Clinic
ST Elevation Myocardial Infarction
Efficacy and Safety of a Half-dose Bolus of r-SAK Prior to Primary PCI in ST-elevation Myocardial Infarction
As an effective treatment for acute ST-segment elevation myocardial infarction (STEMI), early reperfusion may reduce the infarct size and improve the prognosis of patients.
- Trial name
- OPTIMA-6 (NCT05410925)
- Testing
- Recombinant staphylokinase
- Where
- 61 sites in China
- Volunteers
- 2,260 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
STEMI - ST Elevation Myocardial Infarction
Century Clot-Guided Prophylactic Rivaroxaban for Post STEMI Complicating Left Ventricular Thrombus
To manage the ST-segment elevation myocardial infarction (STEMI) caused by plaque rupture, triggers platelet activation/aggregation and thrombin generation, requires dual (platelet and coagulation) pathway inhibition.
- Trial name
- NCT06013020
- Testing
- NOAC+DAPT, DAPT
- Where
- China
- Volunteers
- 374 people
- Sponsor
- Zunyi Medical College
Coronary Artery Disease
Drug Elution and Distal Protection During Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction
The purpose of this study is to evaluate the clinical, echocardiographic and angiographic outcome of distal protection in the infarct related coronary artery and implantation of drug eluting versus bare metal stents in patients…
- Trial name
- NCT00192868
- Testing
- Distal protection and drug eluting stent
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiogenic Shock, Acute Myocardial Infarction
National Cardiogenic Shock Initiative
This study evaluates the use of early mechanical circulatory support in patients presenting with acute myocardial infarction and cardiogenic shock.
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCSI (NCT03677180)
- Where
- 75 sites in United States
- Volunteers
- 406 people
- Sponsor
- Henry Ford Health System
Coronary Artery Disease, ST-segment Elevation Myocardial Infarction
Post-Marketing Safety Study in ST-Segment Elevation Myocardial Infarction (STEMI) Participants Undergoing Primary Percutaneous Coronary Intervention (PCI) Procedure With VISIPAQUE® as the Contrast Medium
The purpose of this study is to prospectively observe the incidence rate of acute kidney injury (AKI), major adverse renal and cardiovascular events (MARCE) in participants who were diagnosed with ST-segment elevation myocardial…
- Trial name
- NCT03671603
- Testing
- Iodixanol
- Where
- 36 sites in China, South Korea
- Volunteers
- 2,755 people
- Sponsor
- GE Healthcare
Coronary Artery Disease, Percutaneous Coronary Intervention
Thrombus Aspiration in Heavy Thrombus Burden Acute ST-elevation Myocardial Infarction
Recent guidelines for the management of ST-elevation myocardial infarction (STEMI) recommend against the routine use of thrombus aspiration (TA) during primary percutaneous coronary intervention (PPCI) (Class III indication).
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, ST Elevation Myocardial Infarction
- Trial name
- TSUNAMI (NCT04912570)
- Testing
- Manual Thrombus Aspiration, Standard PCI
- Where
- 4 sites in Egypt
- Volunteers
- 124 people
- Sponsor
- The Young Investigator Group of Cardiovascular Research
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