Clinical trials: ST-elevation Myocardial Infarction (STEMI)
STEMI
ExosoMe as Integrative Tool for pRognostic Stratification of Adverse Cardiac remodeLing in stEmi Patients: the MIRACLE Study
This is a multicenter observational prospective study aimed to assess whether plasma exosomes can help identify, at an early stage, patients at high risk of adverse remodeling after STEMI (ST-elevation myocardial infarction) …
- Trial name
- MIRACLE (NCT06070974)
- Testing
- CMR and blood collection
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Centro Cardiologico Monzino
Acute Coronary Syndrome, STEMI
The Effect of Colchicine on Inflammation in ACS Patients
This study will evaluate whether the anti-inflammatory effect of colchicine is beneficial in ACS patients
- Trial name
- NCT06054100
- Testing
- Colchicine Tablets
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
STEMI, Large Thrombus Burden
Upfront Premedication For Reduction of Microvascular Obstruction and No-reflow in Treating ST-segment Elevation Myocardial Infarction
Angiographic no-reflow during primary PCI procedures occurs at relatively high rate (25%) and is associated with worsening of long term morbidity and mortality.
- Conditions
- STEMI, Large Thrombus Burden, No-Reflow Phenomenon
- Trial name
- UPFRONT-STEMI (NCT05393557)
- Testing
- Upfront preparation of microcirculation to minimize risks of no-reflow and reperfusion injury
- Volunteers
- 626 people
- Sponsor
- Cairo University
STEMI
Short Course Low Dose Oral Colchicine After ST Elevation Myocardial Infarction(STEMI)
To Study Efficacy and safety oral colchicine 0.6 mg post ST Elevation myocardial infraction (STEMI)
- Trial name
- NCT06020300
- Testing
- Oral Colchicine 0.6 mg, Oral Pyridoxine 10 mg
- Where
- Malaysia
- Volunteers
- 64 people
- Sponsor
- National University of Malaysia
ST Elevation (STEMI) Myocardial Infarction of Other Sites
PREdisposition Genetical in Cardiac Insufficiency = Genetic Predisposition to Heart Failure
Our main goal is to create a prospective cohort of 1500 patients with a first large myocardial infarction allowing us, in a second step, to identify susceptibility genes for the progression of patients towards chronic heart…
- Trial name
- PREGICA (NCT01113268)
- Testing
- Cohort
- Where
- France
- Volunteers
- 658 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ST-segment Elevation Myocardial Infarction (STEMI), Diabetes Mellitus
Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI
The aim of the prospective observational DISTEMI-Study in people with and without Diabetes mellitus (DI) after new onset of ST-Segment Elevation Myocardial Infarction (STEMI) aged 18-80 years at inclusion into the study is to…
- Conditions
- ST-segment Elevation Myocardial Infarction (STEMI), Diabetes Mellitus, Insulin Resistance, Non-Alcoholic Fatty Liver Disease
- Trial name
- DISTEMI (NCT05046483)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Coronary Artery Disease, Aortic Valve Disease
Deploying Novel Imaging Modalities Towards a Three-dimensional (3D) CARDIOvascular PATHology
The goal of the 3D-CARDIOPATH study is to investigate the potential added value of emerging 3D imaging modalities by imaging ex vivo cardiac specimens (diseased coronary arteries, calcific aortic valves, and thrombotic materials)…
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Aortic Valve Calcification, STEMI
- Trial name
- 3D-CARDIOPATH (NCT05975567)
- Testing
- Three-dimensional imaging of the collected cardiac specimens
- Volunteers
- 70 people
- Sponsor
- Aristotle University Of Thessaloniki
STEMI, Intravascular Imaging
Intravascular ULTRAsound-Guided PCI in Patients With ST-Elevation Myocardial Infarction
The main goal of the ULTRA-STEMI trial is to investigate the prognostic impact of IVUS-guided PCI in patients with STEMI and correlate IVUS measurements with clinical, procedural, imaging and follow-up outcomes of interest.
- Conditions
- STEMI, Intravascular Imaging, IVUS
- Trial name
- ULTRA-STEMI (NCT05974930)
- Testing
- IVUS imaging for primary PCI guidance
- Volunteers
- 80 people
- Sponsor
- Aristotle University Of Thessaloniki
Heart Attack, Cardiac Event
Mobile Advanced Multi-Parameter Reporting in Patients Wearing a Novel Device: Utilization During Cardiac Rehabilitation
Advanced remote multi-parameter reporting during cardiac rehabilitation (MAPS-III). The primary purpose of this observational study is to collect baseline information of cardiac rehabilitation usage in the US for post-myocardial…
- Conditions
- Heart Attack, Cardiac Event, Cardiac Disease, Cardiac Infarct
- Trial name
- MAPS-III (NCT05957172)
- Testing
- ZOLL Arrhythmia Management System
- Sponsor
- Zoll Medical Corporation
STEMI - ST Elevation Myocardial Infarction
Clinical Characteristics and Prognosis of STEMI Patients Undergoing Primary Percutaneous Coronary Angioplasty and Angiographic Data
Gensini score (GS) provides valuable information on severity and prognosis of coronary artery disease (CAD). We aim to evaluate the relationship between the severity of CAD determined by the GS and short and long term of…
- Trial name
- NCT05679843
- Volunteers
- 3,000 people
- Sponsor
- Central Hospital, Nancy, France
Coronary Artery Disease, Angina, Unstable
Distal vs. Forearm Radial Artery Access
The Distal Radial Access (DRA) to the coronaries has emerged recently. It's done via the distal radial artery in the radial fossa, which is known as the snuff-box.
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable, Non STEMI
- Trial name
- DRAvsFRA (NCT04125992)
- Testing
- distal radial artery access in coronary angiography and angioplasty, Forearm radial artery access in coronary angiography and angioplasty
- Where
- Palestinian Territories
- Volunteers
- 212 people
- Sponsor
- An-Najah National University
STEMI - ST Elevation Myocardial Infarction
Comparison of Anticoagulation Prolongation vs. no Anticoagulation in STEMI Patients After Primary PCI
The RIGHT study is a large randomized study dedicated to post-PPCI anticoagulation in STEMI patients. The investigators propose to evaluate the clinical efficacy and safety of anticoagulation prolonged for at least 48 hours after…
- Trial name
- RIGHT (NCT03664180)
- Testing
- Bivalirudin, Enoxaparin, Unfractionated heparin
- Where
- China
- Volunteers
- 2,989 people
- Sponsor
- Beijing Anzhen Hospital
Acute Coronary Syndrome, Depression
MBCT Delivered Via Group Videoconferencing for ACS Syndrome Patients With Depressive Symptoms
Brief Summary: The aim of this study is to explore the initial feasibility and acceptability of (a) Mindfulness-Based Cognitive Therapy (MBCT) adapted for ACS patients; (b) the group videoconferencing delivery medium; and (c)…
- Conditions
- Acute Coronary Syndrome, Depression, Myocardial Infarction, Unstable Angina
- Trial name
- NCT04231097
- Testing
- MBCT intervention for ACS patients
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
STEMI - ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
In-hospital Versus After-discharge Complete Revascularization
Patients with STEMI and multivessel disease in whom the culprit lesion has been successfully revascularized during prmimary PCI, will be randomized to in-hospital or after-discharge complete revascularization.
- Trial name
- REVIVA-ST (NCT04743154)
- Testing
- In-hospital nonculprit-lesions percutaneous coronary intervention (PCI), After-discharge nonculprit-lesions percutaneous coronary intervention (PCI)
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Hospital General Universitario de Valencia
STEMI, NSTEMI
Evaluation of Safety and Efficacy of Two Ticagrelor-based De-escalation Antiplatelet Strategies in Acute Coronary Syndrome
The ELECTRA-SIRIO 2 study is a randomized, multicenter, double-blind, investigator-initiated clinical trial aimed to evaluate safety and efficacy of two ticagrelor-based de-escalation antiplatelet strategies in patients with…
- Conditions
- STEMI, NSTEMI, Unstable Angina
- Trial name
- ELECTRA-SIRIO (NCT04718025)
- Testing
- Ticagrelor 90mg, Ticagrelor 60mg, Aspirin
- Where
- Poland
- Volunteers
- 4,500 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Coronary Disease, Coronary Artery Ectasia
Outcomes After PCI of the Aneurysmatic Right Coronary Artery
This study aims to evaluate procedural and clinical outcomes of acute coronay syndrome (ACS) patients with aneurysmatic culprit right coronary artery (RCA).
- Conditions
- Coronary Disease, Coronary Artery Ectasia, Right Coronary Artery Occlusion, Right Coronary Artery Stenosis
- Trial name
- RIGHT-MARE (NCT05713201)
- Testing
- Percutaneous Coronary Intervention
- Where
- 8 sites in Italy, Spain
- Volunteers
- 90 people
- Sponsor
- San Luigi Gonzaga Hospital
STEMI
Follow up of Clinical Outcome of Deferred vs Immediate Stenting in High Thrombus Stemi Patients
To compare the effect of immediate stenting versus deferred stenting - with use of glycoproteinIIbIIIa inhibitor \& low molecular weight heparin - on the clinical outcome -3 and 6 months after stenting \& also infarct size using…
- Trial name
- NCT05793671
- Testing
- PPCI in heavy thrombus burden STEMI patients
- Volunteers
- 440 people
- Sponsor
- Assiut University
STEMI - ST Elevation Myocardial Infarction, Anterior Wall Myocardial Infarction
A Study to Evaluate the Safety and Efficacy of PiCSO in Anterior STEMI Patients
The objective of this study is to assess the safety and efficacy of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) as adjunct to percutaneous coronary intervention (PCI) compared to PCI in the setting of acute…
- Trial name
- PiCSO-AMI-II (NCT05497011)
- Testing
- PiCSO Impulse System
- Sponsor
- Miracor Medical SA
STEMI - ST Elevation Myocardial Infarction
Predictors of Failed Thrombolysis in Acute Myocardial Infarction
The purpose of this observational study is to assess why thrombolytic treatment with tissue-plasminogen activator (t-PA) fails in patients with acute ST-segment elevation myocardial infarction (STEMI).
- Trial name
- TROFAMI (NCT05347732)
- Testing
- Successfull thrombolysis
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
STEMI - ST Elevation Myocardial Infarction, Anterior MI
Observational Registry to Evaluate Real World Usage of PiCSO Impulse System in STEMI Patients as Part of Post-marketing Surveillance
A prospective, multicenter, single-arm, open label registry of commercially treated patients with PiCSO Impulse System.
- Trial name
- PiCSO-AMI-IV (NCT04566289)
- Testing
- PiCSO
- Where
- Germany
- Sponsor
- Miracor Medical SA