Clinical trials: ST-elevation Myocardial Infarction (STEMI)
STEMI - ST Elevation Myocardial Infarction, Inferior Wall Myocardial Infarction
A Study to Evaluate Safety and Feasibility of PiCSO Therapy in Patients With ST Elevation Inferior Wall Myocardial Infarction.
The objective of this study is to assess safety and feasibility of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) therapy in patients with extensive ST elevation inferior wall myocardial infarction presenting…
- Trial name
- PiCSO-AMI-V (NCT04958421)
- Testing
- PiCSO Impulse System
- Where
- 11 sites in Denmark, France and 3 more
- Volunteers
- 25 people
- Sponsor
- Miracor Medical SA
STEMI, Anterior MI
Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction
The objective of this study is to assess efficacy and safety of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) therapy started post flow restoration but prior to stenting during percutaneous coronary…
- Trial name
- PiCSO-AMI-I (NCT03625869)
- Testing
- PiCSO
- Where
- 17 sites in Denmark, France and 4 more
- Volunteers
- 145 people
- Sponsor
- Miracor Medical SA
ST-segment Elevation Myocardial Infarction (STEMI)
PRasugrEl Monotherapy Following prImary percUtaneous Coronary Intervention for ST-elevation Myocardial Infarction
The aim of this study is to evaluate the safety of prasugrel monotherapy without aspirin versus 12-month dual antiplatelet therapy (DAPT) in patients with STEMI using platinum-chrome everolimus-eluting stent (PtCr-EES: SYNERGYTM).
- Trial name
- PREMIUM (NCT05709626)
- Testing
- No aspirin (Prasugurel monotherapy), 12-month DAPT
- Where
- Japan
- Volunteers
- 2,258 people
- Sponsor
- Kindai University
STEMI
Effect of rhBNP on CMD in Patients With STEMI After PPCI
The target population of this interventional study was STEMI patients. Primary discussion: Early rhBNP reduces microcirculation obstruction in STEMI patients undergoing primary PCI
- Trial name
- NCT05723315
- Testing
- recombinant human B-type natriuretic peptide
- Volunteers
- 160 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
STEMI - ST Elevation Myocardial Infarction
The Relationship Between MPV,PDW,PFT and ST Segment Resolution in STEMI Patients Treated With Thrombolytic or Primary PCI
The relationship between admission MPV, PDW, platelet function test and ST-segment resolution in STEMI patients treated with either thrombolytic therapy or primary percutaneous coronary intervention The relationship between…
- Trial name
- NCT03267199
- Testing
- Thrombolytic, Primary PCI, Complete blood count
- Sponsor
- Assiut University
STEMI
Intravascular Ultrasound Versus Angiography Guided Drug-coated Balloon Treatment for STEMI Patients：a Prospective, Multicenter, Randomized Controlled Trial
Objectives: The present study aimed to investigate the difference in late luminal loss (LLL) at 9-month after drug-coated balloon (DCB) treatment with intravascular ultrasound (IVUS) versus angiography for ST-segment elevated…
- Trial name
- NCT04475978
- Testing
- IVUS-guide DCB PTCA, Angio-guide DCB PTCA
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Xiamen Cardiovascular Hospital, Xiamen University
STEMI
Metabolic Characteristics of Type 2 Diabetes Mellitus Combined With Acute Myocardial Infarction: A Untargeted Metabolomics Study
This study is a retrospective case-control study. In this study, through untargeted metabolomics, investigators identified several specific changed serum metabolites in T2DM patients with or without AMI and their…
- Trial name
- NCT05601310
- Testing
- liquid chromatography-mass spectrometry (LC/MS) analysis
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Beijing Friendship Hospital
STEMI, Dyslipidemias
The Safety and Long-Term Clinical Benefit of PCSK9i in STEMI Patients
Patients with acute coronary syndromes (ACS) have an increased risk of recurrent ischemic events, particularly during the first year following the index event, which is mainly due to unattended risk factors and/ or poor…
- Trial name
- NCT05579418
- Testing
- Evolocumab
- Volunteers
- 350 people
- Sponsor
- Hamad Medical Corporation
STEMI
A Pilot Randomized Controlled Trial of Intravenous N-acetyl Cysteine in STEMI
The PANACEA trial is an investigator-initiated prospective, single-center, two-arm, non-blinded pilot randomized controlled trial of high-dose IV N-Acetylcysteine therapy used as an adjunct to pharmaco-invasive reperfusion in…
- Trial name
- PANACEA (NCT04023266)
- Testing
- Intravenous N-Acetylcysteine
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Alberta
STEMI - ST Elevation Myocardial Infarction
Laser Atherectomy for ST Elevation Myocardial Infarction
The objectives of this study are to observe and examine prospectively whether excimer laser coronary angioplasty (ELCA) and percutaneous coronary intervention with biodegradable-polymer platinum chromium everolimus-eluting stent…
- Trial name
- NCT03950310
- Testing
- Excimer laser catheter
- Where
- Japan
- Volunteers
- 142 people
- Sponsor
- Tokai University
Coronary Artery Disease, Myocardial Infarction
Compressive Elastic Dressing Versus TR Band
Radial approach is widely established in cardiac diagnostic and therapeutic treatments. It has been shown to decrease bleeding, vascular problems, and mortality rates when compared to the femoral approach.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Angina, Unstable, Angina, Stable
- Trial name
- Band Vs Gauze (NCT05409716)
- Testing
- Compressive Elastic dressing for hemostasis in cardiac procedure using radial approach, Wristband TR band for hemostasis in cardiac procedure using radial approach
- Where
- 2 sites in Palestinian Territories
- Volunteers
- 400 people
- Sponsor
- An-Najah National University
STEMI - ST Elevation Myocardial Infarction
Semi Occlusion of the Coronary Sinus as an Adjunct to PCI in STEMI Patients, FIH Clinical Study
The present study is planned to evaluate the safety and feasibility of the Booster Balloon catheter when applied to STEMI patients.
- Trial name
- NCT05557019
- Testing
- Booster Balloon Catheter
- Where
- 2 sites in Georgia, Israel
- Volunteers
- 20 people
- Sponsor
- Intratech Medical Ltd.
ST-segment Elevation Myocardial Infarction (STEMI)
The Efficacy and Safety of Ketotifen in Primary PCI Patients With STEMI
The purpose of this study was to evaluate the efficacy and safety of ketotifen (MC stabilizer) on the basis of standard treatment after primary PCI in STEMI patients.
- Trial name
- NCT05511831
- Testing
- Ketotifen Fumarate, standard treatment
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
STEMI
Prognostic Value of Lactate Levels in Patients With STEMI Undergoing Primary PCI
To assess the prognostic value of systemic arterial lactate levels in patients with ST segment elevation myocardial infarction undergoing primary PCI and correlate with the results of primary PCI and 30 days MACE follow up.
- Trial name
- NCT05503329
- Testing
- arterial lactate level
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ahmed Maher Teaching Hospital
STEMI - ST Elevation Myocardial Infarction, Microvascular Coronary Artery Disease
Impact of TMAO Serum Levels on Hyperemic IMR in STEMI Patients
Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods.
- Trial name
- TAMIR (NCT05406297)
- Testing
- pressure-temperature sensor guidewire-based measurement
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- Lithuanian University of Health Sciences
Acute Coronary Syndrome, STEMI
Platelet Inhibition With Ticagrelor 60 mg Versus Ticagrelor 90 mg in Elderly Patients With ACS
Elderly individuals are increasingly represented among patients with acute coronary syndrome (ACS). Dual antiplatelet therapy (DAPT) with aspirin and an oral P2Y12 receptor inhibitor has an established role in the prevention of…
- Conditions
- Acute Coronary Syndrome, STEMI, NSTEMI, Coronary Artery Disease
- Trial name
- PlinytheElder (NCT04739384)
- Testing
- Ticagrelor 90mg, Ticagrelor 60 mg
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Federico II University
ST-segment Elevation Myocardial Infarction (STEMI)
Evaluate Early Invasive Strategy for Patients With STEMI Presenting 24-48 Hours From Symptom Onset
The primary objective of the trial is to evaluate the efficacy of early invasive strategy for STEMI patients within 24-48h of symptom onset.
- Trial name
- NCT04962178
- Testing
- Primary PCI, Optimal medical therapy with primary PCI not performed
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Shanghai Zhongshan Hospital
STEMI
CMR or Angiography for FFR-guided Revascularisation
Around 50% of patients that present with ST Elevation Myocardial Infarction (STEMI) have residual disease in the non-culprit lesions.
- Trial name
- CRAFT-MI (NCT03408912)
- Testing
- FFR
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Coronary Heart Disease, Acute Myocardial Infarction
reGional Network for Acute Myocardial Infarction
Incidence of ST-segment Elevation Myocardial Infarction (STEMI) is rising and the existing emergency medical aid system for STEMI was not enough for timely perfusion treatment.
- Conditions
- Coronary Heart Disease, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
- Trial name
- GAMI (NCT03928119)
- Testing
- public education and network construction
- Where
- 8 sites in China
- Volunteers
- 7,102 people
- Sponsor
- Guangdong Provincial People's Hospital
STEMI - ST Elevation Myocardial Infarction
Thrombolysis in STEMI Patients Compared With pPCI on Recanalization Time in the Context of the COVID-19 Outbreak.
During the outbreak of COVID-19, for patients with acute ST-segment elevation myocardial infarction with unclear infection, the time of primary PCI is uncertain, and it is often expected to exceed 90 minutes or even 120 minutes.
- Trial name
- RESCUE-STEMI (NCT05354128)
- Testing
- Thrombolytic, percutaneous coronary stenting
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Ya-Wei Xu