Clinical trials: ST-elevation Myocardial Infarction (STEMI)
ST-Segment Elevation Myocardial Infarction
Ticagrelor and Intracoronary Morphine in Patients Undergoing Primary Percutaneous Coronary Intervention
A 2 by 2 factorial, multicenter, prospective, randomized, open-label, blinded endpoint trial. Patients undergoing primary PCI for STEMI will be eligible.
- Trial name
- NCT01738100
- Testing
- Ticagrelor, Clopidogrel, Morphine Sulfate
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Hyeon-Cheol Gwon
STEMI (ST Elevation MI)
Inhibition of Late Sodium Current (INa) to Prevent Coronary MICROvascular Dysfunction in Patients Presenting With ST-Elevation Myocardial Infarction and Multivessel Disease: INaMICRON Study
This is a Phase IIb, multicentric, prospective, randomized (1:1 ratio), open label, and no profit study, with the aim of evaluating the efficacy of late INa current inhibition to improve coronary microcirculation in patients…
- Trial name
- INaMICRON (NCT07380919)
- Testing
- Ranolazine
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Acute ST Segment Elevation Myocardial Infarction, Prognosis
Predictive Value of Combining AccuIMR and AccuFFR in Patients With STEMI
Patients with acute myocardial infarction were enrolled retrospectively. The fractional flow reserve (AccuFFR) and microcirculatory resistance index (AccuIMR) based on coronary angiography were analyzed, and the relationship…
- Trial name
- NCT06435728
- Testing
- AccuIMR and AccuFFR
- Where
- China
- Volunteers
- 1,297 people
- Sponsor
- Peking University Third Hospital
Coronary Artery Disease
Local Thrombolytics Before Thrombectomy in STEMI
Background Prompt reperfusion with percutaneous coronary intervention (PCI) in the setting of ST-elevation myocardial infarction (STEMI) improves clinical outcomes through salvage of myocardial tissue.
- Trial name
- DISSOLUTION (NCT01568931)
- Testing
- Urokinase, Saline
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
ST Elevation Myocardial Infarction
3 Months Versus 12 Months Dual Antiplatelet Therapy After Drug-eluting Stent Implantation in STEMI
To compare the clinical outcomes of dual antiplatelet therapy with aspirin and P2Y12 receptor inhibitor vs. ticagrelor monotherapy at 3 months after PCI in patients with ST-elevation myocardial infarction.
- Trial name
- BULK-STEMI (NCT04570345)
- Testing
- ticagrelor monotherapy, Aspirin with P2Y12 receptor inhibitor
- Where
- South Korea
- Volunteers
- 1,002 people
- Sponsor
- Dong-A University
STEMI, Multi Vessel Coronary Artery Disease
STaged Interventional Strategies for Acute ST-seGment Elevation Myocardial Infarction Patient With Multi-vessel Disease（STAGED）
An investigator-initiated, randomized, multicenter, two-arm, open-label study of consecutive patients presenting with STEMI and MVD Objectives: The present study aimed to investigate the difference in major adverse cardiac event…
- Conditions
- STEMI, Multi Vessel Coronary Artery Disease, Percutaneous Coronary Intervention, AMI Patients With Multivessel Disease, Staged PCI
- Trial name
- SAGED (NCT04918030)
- Testing
- Early staged PCI, Late staged PCI
- Where
- China
- Volunteers
- 1,586 people
- Sponsor
- Xiamen Cardiovascular Hospital, Xiamen University
Non-ST Elevation Myocardial Infarction (NSTEMI), Angina, Unstable
Coronary Angioplasty in Octogenarians With Emergent Coronary Syndromes
A multicenter, randomized clinical trial in elderly patients (over 80 years old) with unstable angina pectoris or Non-ST elevation myocardial infarction (NSTEMI).
- Trial name
- 80+ (NCT02126202)
- Testing
- Coronary angiography and revascularization if feasible
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Sahlgrenska University Hospital
Coronary Artery Stenoses, Stable Angina
e-BioMatrix 6 Month DAPT France
Prospective, multi-center observational study to be conducted in up to 30 French interventional cardiology centers. The purpose of this observational study is to capture, in French Centers, clinical data of the BioMatrix Flex™…
- Conditions
- Coronary Artery Stenoses, Stable Angina, Ischemia, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCT03461484
- Volunteers
- 2,098 people
- Sponsor
- Biosensors Europe SA
ST Elevation Acute Myocardial Infarction
Does Cyclosporine ImpRove Clinical oUtcome in ST Elevation Myocardial Infarction Patients at 3 Years of Follow-up. CIRCUS II Study
Infarct size is a major determinant of vital prognosis after AMI. We recently reported that cyclosporine A, when administered immediately prior to PCI reperfusion, can significantly reduce infarct size in STEMI patients.
- Trial name
- CIRCUS II (NCT02934217)
- Testing
- Injection of Cyclosporin, Echocardiography
- Where
- France
- Volunteers
- 868 people
- Sponsor
- Hospices Civils de Lyon
Non ST Elevation Myocardial Infarction
Non-invasive and Invasive Plaque Characterisation
The accuracy of coronary plaque characterization with Multi-slice computed tomography as compared to intravascular ultrasound and optical coherence tomography will be investigated in patients presenting with acute coronary…
- Trial name
- NCT01833338
- Testing
- Imaging
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
ST-segment Elevation Myocardial Infarction (STEMI)
Bivalirudin with Prolonged Infusion During PCI Versus Heparin After Fibrinolytic Therapy
This multicenter, randomized controlled trial in China aims to enroll 2,400 patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) within 24 hours post-fibrinolysis.
- Trial name
- BRIGHT-FIT (NCT06861374)
- Testing
- Bivalirudin, Unfractionated heparin
- Volunteers
- 2,400 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Coronary Artery Disease
ST Segment Detection Study
The purpose of ST Detect study is to evaluate whether naturally occurring spontaneous coronary events and exercise induced cardiac ischemia, give rise to detectable changes on intracardiac electrogram (EGM) signals in patients…
- Trial name
- ST Detect (NCT00930969)
- Testing
- ICD
- Where
- 25 sites in United States, Austria and 5 more
- Volunteers
- 175 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
ST Elevation Myocardial Infarction
Long-term Clinical Outcomes of intraVascular Ultrasound-guided vs Angiography-guided Primary pErcutaneous Intervention in Patients With Acute ST Segment Elevated Myocardial Infarction
To examine the impact of IVUS guidance on clinical outcomes in the patient with Acute ST Segment Elevated Myocardial Infarction.
- Trial name
- LOVEinSTEMI (NCT04063345)
- Testing
- IVUS-guided PCI, Angiography-guided PCI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
ST-Elevation Myocardial Infarction
Endothelin Receptor Blockade in Acute ST-elevation Myocardial Infarction
Background and Objective: Acute coronary syndrome is characterized by compromised blood flow at the epicardial and microvascular levels.
- Trial name
- NCT00502528
- Testing
- BQ-123
- Where
- Austria
- Volunteers
- 57 people
- Sponsor
- Medical University of Vienna
STEMI - ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Non Culprit Functional Evaluation With 3D Angio QFR in STEMI PCI Procedure
Reliability of 3D angio QFR functional evaluation of all non culprit lesions >50% in STEMI patients during first acute procedure
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Disease
- Trial name
- NCT02998853
- Testing
- QFR measurement by dedicated workstation on xrays angio selected runs
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera Sant'Anna e San Sebastiano
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI)
Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction
To determine whether long-term treatment with oral betablocker therapy after myocardial infarction in patient with no heart failure reduces the composite outcome of recurrent MI, all-cause mortality, revascularisation with…
- Conditions
- Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction (nSTEMI), ST Elevation Myocardial Infarction
- Trial name
- DANBLOCK (NCT03778554)
- Testing
- Metoprolol Succinate, Bisoprolol, Carvedilol
- Where
- Denmark
- Volunteers
- 2,760 people
- Sponsor
- Bispebjerg Hospital
Survival Myocardial Area After Acute Myocardial Death, Left Ventricular Ejection Fraction
Clinical Study of Cardiomyopeptidin on Postoperative Ischemia-reperfusion Injury in Patients With Primary PCI
In this study, advanced techniques of myocardial nuclear magnetic perfusion scanning were used to quantitatively assess infarct size after acute myocardial infarction, saved viable myocardium, and microcirculatory obstruction…
- Trial name
- NCT03958422
- Testing
- cardiomyopeptidin
- Volunteers
- 160 people
- Sponsor
- Dalian Zhen-Ao Bio-Tech Co., Ltd.
ACS - Acute Coronary Syndrome, NSTEMI - Non-ST Segment Elevation MI
MCG Discovery Study in Emergency Departments
This prospective discovery study is designed to demonstrate the feasibility of using an unshielded, mobile MCG device in an Emergency Department (ED) setting.
- Trial name
- NCT06095557
- Testing
- Sponsor MCG device
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- SB Technology, Inc.
ST-segment Elevation Myocardial Infarction (STEMI)
Compare Early With Deferred Invasive Strategy for STEMI Presenting 24-48 Hours From Symptom Onset
The primary objective of the trial is to compare the efficacy of early with deferred invasive strategy for patients with ST-segment elevation myocardial infarction (STEMI) within 24-48h of symptom onset.
- Trial name
- NCT04575012
- Testing
- Deferred invasive strategy, Early invasive strategy
- Volunteers
- 1,200 people
- Sponsor
- Shanghai Zhongshan Hospital
Myocardial Infarction
Assessment of the Effects of Atorvastatin Therapy on Myocardial Deformation Characteristics, in Patients With STEMI
The primary goal To assess the effect of atorvastatin in patients treated since the first 24-96 hours of the disease on the parameters of global and regional myocardial deformation in the infarcted area and the structural and…
- Trial name
- CONTRAST (NCT02590653)
- Testing
- Atorvastatin
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Penza State University
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