Clinical trials: ST-segment Elevation Myocardial Infarction, open to volunteers
ST-Elevation Myocardial Infarction (STEMI)
Reducing Slow/No-Reflow With Prophylactic High-Dose Intracoronary Adenosine Protocol in ST-Elevation Myocardial Infarction The REFLOW AMI Trial
The REFLOW AMI Trial aims to determine whether prophylactic high-dose intracoronary adenosine reduces slow-flow or no-reflow (SNR) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous…
- Trial name
- REFLOW AMI (NCT07898696)
- Testing
- Adenosine, Standard Treatment only
- Where
- 2 sites in Pakistan
- Volunteers
- 660 people
- Sponsor
- Prof Muzaffar Ali Zahidi
ST Elevation Myocardial Infarction, C-Reactive Protein
CRP Apheresis in STEMI
Background: In patients with acute ST-elevation myocardial infarction (STEMI), the amount of infarcted myocardium (infarct size) is known to be a major predictor for adverse remodeling and recurrent adverse cardiovascular events.
- Conditions
- ST Elevation Myocardial Infarction, C-Reactive Protein, Apheresis, Myocardial Injury
- Trial name
- NCT04939805
- Testing
- Selective CRP apheresis using the PentraSorb®-CRP system
- Where
- 5 sites in Austria, Germany
- Volunteers
- 202 people
- Sponsor
- Medical University Innsbruck
No Reflow Phenomenon, Reperfusion Injuries, Myocardial
Evaluating SGLT2 Inhibitors for the Reduction of No-Reflow Phenomenon in Patients Undergoing PCI
Study Background \& Purpose: The no-reflow phenomenon is a significant complication occurring in patients with acute myocardial infarction who undergo percutaneous coronary intervention (PCI).
- Conditions
- No Reflow Phenomenon, Reperfusion Injuries, Myocardial, Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT07898709
- Testing
- Empagliflozin (SGLT2i), dapagliflozin, Standard medical treatment
- Where
- 4 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
STEMI - ST Elevation Myocardial Infarction
Correlation Between Triglyceride Glucose Index and Residual SYNTAX Score in STEMI Patients Undergoing PPCI
The goal of this study To check correlation between triglyceride glucose (TyG) index and residual SYNTAX score (RSS) in STEMI patients undergoing PPCI. 2.
- Trial name
- NCT06642259
- Testing
- Echocardiography
- Volunteers
- 185 people
- Sponsor
- Assiut University
Myocardial Infarction, Myocardial Ischemia
OPTIMISER Registry - A Prospective Cohort Study to Describe the OPTIMal Management and Outcomes of PatIents PreSEnting With Acute MyocaRdial Infarction
The purpose of the OPTIMISER Registry is to prospectively and retrospectively collect baseline, clinical and procedural data in patients who present with AMI and are treated with PCI as well as prospectively collect the clinical…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, STEMI, NSTEMI
- Trial name
- OPTIMISER (NCT04988672)
- Where
- Switzerland
- Volunteers
- 4,000 people
- Sponsor
- Luzerner Kantonsspital
Acute Coronary Syndromes, ST Elevation Myocardial Infarction
Smartphone AI Assistance for Prehospital ECG Interpretation
Prehospital providers interpret 12-lead electrocardiograms (ECGs) under time pressure and without immediate expert support. Missed acute coronary occlusion - occlusion myocardial infarction (OMI) - delays reperfusion, while false…
- Conditions
- Acute Coronary Syndromes, ST Elevation Myocardial Infarction, Non-ST Elevated Myocardial Infarction, Myocardial Infarction (MI)
- Trial name
- ECG-IA (NCT07810686)
- Testing
- Smartphone large language model assistance (GPT-4o, version-locked)
- Where
- Switzerland
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- École Supérieure de Soins Ambulanciers - College of Higher Education in Prehospital Care
ST Elevation Myocardial Infarction
Efficacy and Safety of a Half-dose Bolus of r-SAK Prior to Primary PCI in ST-elevation Myocardial Infarction
As an effective treatment for acute ST-segment elevation myocardial infarction (STEMI), early reperfusion may reduce the infarct size and improve the prognosis of patients.
- Trial name
- OPTIMA-6 (NCT05410925)
- Testing
- Recombinant staphylokinase
- Where
- 61 sites in China
- Volunteers
- 2,260 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
STEMI, Diabete Mellitus
Inflammatory and Hematological Indices in Diabetic STEMI Patients Undergoing Primary PCI
ST-segment Elevation Myocardial Infarction (STEMI) remains a major cause of mortality despite the adoption of Primary Percutaneous Coronary Intervention (PPCI) as the standard treatment.
- Trial name
- NCT07155395
- Volunteers
- 1,000 people
- Sponsor
- Assiut University
ST Elevation Myocardial Infarction (STEMI)
Drug-Eluting Balloon or Drug-Eluting Stent in Acute Myocardial Infarction: A Randomized Controlled Trial
The objective of the study is to compare drug-coated balloon (DCB) with the gold standard drug-eluting stent (DES) in percutaneous coronary intervention (PCI) for patients presenting with ST-elevation myocardial infarction…
- Trial name
- BOOST-AMI (NCT06746233)
- Testing
- Drug (paclitaxel) coated balloon (DCB), Second-generation Drug Eluting Stent (DES)
- Where
- 5 sites in Bosnia and Herzegovina, Serbia
- Volunteers
- 598 people
- Sponsor
- Institute of Cardiovascular Diseases, Vojvodina
Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome
Cardiac MRI Prior to Invasive Coronary Angiography in Patients With Suspected Non-ST-Elevation Myocardial Infarction
Patients with a suspected myocardial infarction are subdivided into ST-elevation and non-ST-elevation myocardial infarctions (STEMI and NSTEMI, respectively) using ECG.
- Trial name
- KaPSICA-CMR (NCT06566625)
- Testing
- Cardiac MRI (CMR) examination
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis
Timing of FFR-guided PCI for Non-IRA in NSTEMI and MVD (OPTION-NSTEMI)
Many patients with non-ST-segment elevation myocardial infarction (NSTEMI) have multivessel coronary artery disease (MVD), which is associated with poor clinical outcomes.
- Conditions
- Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis, Multi Vessel Coronary Artery Disease
- Trial name
- NCT04968808
- Testing
- Staged in-hospital complete revascularization, Immediate complete revascularization
- Where
- South Korea
- Volunteers
- 1,014 people
- Sponsor
- Chonnam National University Hospital
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS)
Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death.
- Conditions
- Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS), Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
- Trial name
- SurvSCA (NCT07112547)
- Where
- 10 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Myocardial Infarction, STEMI
Breisgau PHENO-HEART MI
Coronary heart disease and its acute complication, myocardial infarction (MI), represent the leading causes of death in Europe and the United States.
- Conditions
- Myocardial Infarction, STEMI, NSTEMI
- Trial name
- NCT06166407
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Freiburg
Acute Myocardial Infarction
Intervention of Suxiao Jiuxin Pill on Instability of Vulnerable Plaque in Acute Myocardial Infarction
The incidence of cardiovascular disease is still high in China under the condition of non-standard treatment of Western medicine.
- Trial name
- NCT05466968
- Testing
- Suxiao Jiuxin Pills
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Xiaolu Li
Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction
Hong Kong Cardiogenic Shock Initiative
Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) is a severe condition with high mortality. Early revascularization and Impella device (Abiomed) support improve outcomes.
- Conditions
- Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction, Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction
- Trial name
- HK CSI (NCT07323238)
- Where
- Hong Kong
- Volunteers
- 320 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
ST-segment Elevation Myocardial Infarction (STEMI)
A Randomized Controlled Trial on the Efficacy and Safety of Butylphthalide in Reducing Myocardial Infarction Size and Improving Outcomes in STEMI Patients After Primary PCI
This study is a prospective, randomized, placebo-double-blind, multicenter clinical trial. The purpose of this study is to investigate whether "butylphthalide +PCI" combined treatment mode on the basis of traditional drug therapy…
- Trial name
- RISE (NCT06704685)
- Testing
- Butylphthalide
- Volunteers
- 40 people
- Sponsor
- Xiangya Hospital of Central South University
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall, Cardiovascular Diseases
Impact, Cost, and Sustainability of a Customized, Low-Cost Intervention to Reduce Cardiovascular Disease Burden in India: A Cluster Randomized Trial
The ICRAG-2 project aims to assess the impact, cost-effectiveness, and sustainability of a low-cost, multipronged intervention package to reduce cardiovascular disease (CVD) burden in India.
- Trial name
- ENABLE (NCT06836661)
- Testing
- FDC and TLC and medication adherance, Patients will Enhanced Usual Care (EUC)
- Where
- India
- Volunteers
- 1,560 people
- Sponsor
- St. John's Research Institute
Acute Cardiovascular Disease, ST-segment Elevation Myocardial Infarction (STEMI)
MAchine Learning to Boost the Early Diagnosis of Acute Cardiovascular Conditions
The research project aims to develop clinical decision support tools integrating established diagnostic variables and machine learning (ML) models for rapid diagnosis of acute life-threatening cardiovascular conditions in…
- Conditions
- Acute Cardiovascular Disease, ST-segment Elevation Myocardial Infarction (STEMI), NSTEMI - Non-ST Segment Elevation MI
- Trial name
- MALBEC (NCT06927791)
- Testing
- Machine learning based development of a diagnostic tool for acute cardiovascular disease
- Where
- Switzerland
- Volunteers
- 200,000 people
- Sponsor
- University Hospital, Basel, Switzerland
ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
Intensive Lipid-lowering in Patients With STEMI and NSTEMI (Germany on Target)
Intensive Lipid-Lowering Therapy guided by a cloud-based Software System (CLIMEDO GmbH) improves (European Society of Cardiolofgy/European Atherosclerosis Society) ESC/EAS-guideline recommended LDL-cholesterol target attainment…
- Conditions
- ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction, LDL-cholesterol
- Trial name
- GoT (NCT05587621)
- Testing
- statins, ezetimibe, bempedoic acid, evolocumab, alirocumab, inclisiran
- Where
- 10 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Jena University Hospital
ST Segment Elevation Myocardial Infarction
Ischemic Postconditioning in STEMI Patients Treated With Primary PCI
In a prospective, randomized clinical trial the iPOST2 trial will determine whether ischemic postconditioning reduces reperfusion injury and this will translate into improved clinical outcome of heart failure and death for STEMI…
- Trial name
- iPOST2 (NCT03787745)
- Testing
- Ischemic postconditioning, Conventional
- Where
- Denmark
- Volunteers
- 1,800 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet