Clinical trials: ST-segment Elevation Myocardial Infarction (STEMI)
ST-segment Elevation Myocardial Infarction (STEMI)
The Effect of Morning vs Evening Aerobic Exercise Training on Cardiac Remodeling and Function Improvement in Patients After ST Elevation Myocardial Infarction
The aim of the study was to intervene in the Aerobic exercise time of patients with STEMI and to explore the optimal exercise time for STEMI patients
- Trial name
- NCT06385834
- Testing
- Morning aerobic exercise, Evening aerobic exercise
- Where
- China
- Volunteers
- 201 people
- Sponsor
- RenJi Hospital
ST-segment Elevation Myocardial Infarction (STEMI)
A Randomized Controlled Trial on the Efficacy and Safety of Butylphthalide in Reducing Myocardial Infarction Size and Improving Outcomes in STEMI Patients After Primary PCI
This study is a prospective, randomized, placebo-double-blind, multicenter clinical trial. The purpose of this study is to investigate whether "butylphthalide +PCI" combined treatment mode on the basis of traditional drug therapy…
- Trial name
- RISE (NCT06704685)
- Testing
- Butylphthalide
- Volunteers
- 40 people
- Sponsor
- Xiangya Hospital of Central South University
ST Segment Elevation Myocardial Infarction (STEMI), Coenzyme Q10
Effect Supplementation of COenzyme Q10 in Acute STEMI Underwent PPCI
Left ventricular remodeling can still occur after primary percutaneous coronary intervention (PCI). Global longitudinal strain (GLS) assessment has been used as a predictor of left ventricular remodeling.
- Trial name
- ESCOMI (NCT06661018)
- Testing
- Coenzyme Q 10
- Where
- 2 sites in Indonesia
- Volunteers
- 46 people
- Sponsor
- Universitas Diponegoro
ST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention
Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction
This is a double-blind, multicenter, randomized, placebo-controlled clinical trial. It is planned to enroll patients admitted with anterior ST-segment elevation myocardial infarction (STEMI) within 6h of symptom onset and undergo…
- Conditions
- ST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention, Cardioprotection
- Trial name
- COOPERATION (NCT04912518)
- Testing
- Dexmedetomidine (DEX)
- Where
- 9 sites in China
- Volunteers
- 250 people
- Sponsor
- Harbin Medical University
Coronary Artery Disease, Angina, Unstable
Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease
The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors…
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT04163484
- Testing
- Iodinated contrast
- Where
- Russia
- Volunteers
- 156 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
ST-segment Elevation Myocardial Infarction (STEMI)
Prolonged Clinical Follow-up of OPTIMA-5
The OPTIMA-5 trial is a prospective, multi-center, randomized, patient blinded, controlled trial comparing a single bolus of half-dose recombinant staphylokinase (r-SAK) with normal saline (NS) in patients with ST-segment…
- Trial name
- NCT05649696
- Testing
- Recombinant Staphylokinase, Normal Saline
- Where
- 8 sites in China
- Volunteers
- 210 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
ST-segment Elevation Myocardial Infarction (STEMI)
The Prognostic Value of Anion Gap in Predicting Major Adverse Cardiovascular Events Among Patients With ST-Segment Elevation Myocardial Infarction
This study aims to evaluate the prognostic value of the anion gap in predicting major adverse cardiovascular events among patients with ST-segment elevation myocardial infarction.
- Trial name
- ANGIO-STEMI (NCT06586424)
- Testing
- Anion gap
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Diponegoro
Acute Coronary Syndrome, ST-segment Elevation Myocardial Infarction (STEMI)
Predictive Value of NT-proBNP on MACEs After Acute Coronary Syndrome
The role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as a cardiac biomarker in predicting short-term major adverse cardiovascular events (MACEs) in patients with Acute coronary syndrome (ACS) has been insufficiently…
- Conditions
- Acute Coronary Syndrome, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), Major Adverse Cardiac Events
- Trial name
- MACEstdy (NCT06569511)
- Testing
- N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitive cardiac troponin T (hs-cTnT)
- Where
- Turkey (Türkiye)
- Volunteers
- 241 people
- Sponsor
- Haseki Training and Research Hospital
Coronary Artery Disease, Coronary Stenosis
ILUMIEN IV: OPTIMAL Percutaneous Coronary Intervention (PCI)
The objective of this prospective, single-blind clinical investigation is to demonstrate the superiority of an Optical Coherence Tomography (OCT)-guided stent implantation strategy as compared to an angiography-guided stent…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Atherosclerosis, STEMI
- Trial name
- NCT03507777
- Testing
- Coronary PCI guided by OCT, Coronary PCI guided by Angiography
- Where
- 90 sites in United States, Australia and 18 more
- Volunteers
- 2,487 people
- Sponsor
- Abbott Medical Devices
Acute Coronary Syndrome, Myocardial Infarction
What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI?
The optimal antithrombotic management in patients with coronary artery disease (CAD) and concomitant atrial fibrillation (AF) is unknown.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Atrial Fibrillation, Atrial Flutter
- Trial name
- WOEST-3 (NCT04436978)
- Testing
- 30-day DAPT, Guideline-directed therapy
- Where
- 20 sites in Belgium, Netherlands
- Volunteers
- 2,000 people
- Sponsor
- St. Antonius Hospital
ST-segment Elevation Myocardial Infarction (STEMI), Diabetes Mellitus
Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI
The aim of the prospective observational DISTEMI-Study in people with and without Diabetes mellitus (DI) after new onset of ST-Segment Elevation Myocardial Infarction (STEMI) aged 18-80 years at inclusion into the study is to…
- Conditions
- ST-segment Elevation Myocardial Infarction (STEMI), Diabetes Mellitus, Insulin Resistance, Non-Alcoholic Fatty Liver Disease
- Trial name
- DISTEMI (NCT05046483)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Coronary Artery Disease, Angina, Unstable
Distal vs. Forearm Radial Artery Access
The Distal Radial Access (DRA) to the coronaries has emerged recently. It's done via the distal radial artery in the radial fossa, which is known as the snuff-box.
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable, Non STEMI
- Trial name
- DRAvsFRA (NCT04125992)
- Testing
- distal radial artery access in coronary angiography and angioplasty, Forearm radial artery access in coronary angiography and angioplasty
- Where
- Palestinian Territories
- Volunteers
- 212 people
- Sponsor
- An-Najah National University
Acute Coronary Syndrome, Depression
MBCT Delivered Via Group Videoconferencing for ACS Syndrome Patients With Depressive Symptoms
Brief Summary: The aim of this study is to explore the initial feasibility and acceptability of (a) Mindfulness-Based Cognitive Therapy (MBCT) adapted for ACS patients; (b) the group videoconferencing delivery medium; and (c)…
- Conditions
- Acute Coronary Syndrome, Depression, Myocardial Infarction, Unstable Angina
- Trial name
- NCT04231097
- Testing
- MBCT intervention for ACS patients
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
ST-segment Elevation Myocardial Infarction (STEMI)
PRasugrEl Monotherapy Following prImary percUtaneous Coronary Intervention for ST-elevation Myocardial Infarction
The aim of this study is to evaluate the safety of prasugrel monotherapy without aspirin versus 12-month dual antiplatelet therapy (DAPT) in patients with STEMI using platinum-chrome everolimus-eluting stent (PtCr-EES: SYNERGYTM).
- Trial name
- PREMIUM (NCT05709626)
- Testing
- No aspirin (Prasugurel monotherapy), 12-month DAPT
- Where
- Japan
- Volunteers
- 2,258 people
- Sponsor
- Kindai University
ST-segment Elevation Myocardial Infarction (STEMI)
The Efficacy and Safety of Ketotifen in Primary PCI Patients With STEMI
The purpose of this study was to evaluate the efficacy and safety of ketotifen (MC stabilizer) on the basis of standard treatment after primary PCI in STEMI patients.
- Trial name
- NCT05511831
- Testing
- Ketotifen Fumarate, standard treatment
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
ST-segment Elevation Myocardial Infarction (STEMI)
Evaluate Early Invasive Strategy for Patients With STEMI Presenting 24-48 Hours From Symptom Onset
The primary objective of the trial is to evaluate the efficacy of early invasive strategy for STEMI patients within 24-48h of symptom onset.
- Trial name
- NCT04962178
- Testing
- Primary PCI, Optimal medical therapy with primary PCI not performed
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Shanghai Zhongshan Hospital
Angina, Stable, Angina, Unstable
Atherosclerotic Lesion Proteomics by Harvesting Angioplasty Balloons (ALPHA).
The purpose of the study is to identify proteins, metabolites and signal pathways related directly to symptomatic atherosclerosis and to disease progression.
- Conditions
- Angina, Stable, Angina, Unstable, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), ST-segment Elevation Myocardial Infarction (STEMI)
- Trial name
- NCT05319366
- Where
- 2 sites in Denmark
- Volunteers
- 225 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myocardial Infarction, Acute Coronary Syndrome
HeartHome: A Nurse-Driven, Home-Based Cardiac Rehabilitation Program
The purpose of this implementation trial is to execute a nurse-led, home-based cardiac rehabilitation (HBCR) program, evaluate the program's impact on patient outcomes over 6 months; and compare outcomes of HeartHome (HH)…
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- NCT04131816
- Testing
- HeartHome
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Coronary Syndrome, STEMI - ST-segment Elevation Myocardial Infarction
Kitasato PCI Registry
The Kitasato PCI Registry is a single-center, observational, prospective study. This study aims to investigate the impact of characteristics in clinical manifestation, patients' background, procedure of percutaneous coronary…
- Conditions
- Acute Coronary Syndrome, STEMI - ST-segment Elevation Myocardial Infarction, NSTEMI - Non-ST-Segment Elevation Myocardial Infarction, Atherosclerosis
- Trial name
- NCT05308329
- Testing
- Intra-coronary imaging device, PCI procedural characteristics
- Where
- Japan
- Volunteers
- 4,500 people
- Sponsor
- Kitasato University
STEMI - ST Elevation Myocardial Infarction, Multi Vessel Coronary Artery Disease
Impact of Residual Syntax Score and Syntax Revascularization Index on Outcomes of ACS Patients With Multi-Vessel Disease
The investigators want to assess the use of the residual SYNTAX score and the SYNTAX Revascularization Index as predictors for in-hospital outcomes and mid-term (6 months to 1 year) outcomes in patients with multi-vessel disease…
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Multi Vessel Coronary Artery Disease, NSTEMI - Non-ST Segment Elevation MI, ACS - Acute Coronary Syndrome
- Trial name
- NCT03138473
- Testing
- Residual SYNTAX Score, SYNTAX Revascularization Index
- Where
- Egypt
- Volunteers
- 149 people
- Sponsor
- Assiut University