Clinical trials: STEMI
Myocardial Infarction
Role of Tirofiban and the Paclitaxel Eluting Stent in Postfibrinolysis Angioplasty
The conceptual hypothesis of this study is that, in patients with acute myocardial infarction and ST-segment elevation, the strategy of performing coronary angioplasty of the culprit artery with paclitaxel eluting stent…
- Trial name
- GRACIA3 (NCT00306228)
- Testing
- Postfibrinolysis percutaneous coronary intervention
- Where
- Spain
- Volunteers
- 436 people
- Sponsor
- GRACIA Group
Coronary Disease, Coronary Artery Ectasia
Outcomes After PCI of the Aneurysmatic Right Coronary Artery
This study aims to evaluate procedural and clinical outcomes of acute coronay syndrome (ACS) patients with aneurysmatic culprit right coronary artery (RCA).
- Conditions
- Coronary Disease, Coronary Artery Ectasia, Right Coronary Artery Occlusion, Right Coronary Artery Stenosis
- Trial name
- RIGHT-MARE (NCT05713201)
- Testing
- Percutaneous Coronary Intervention
- Where
- 8 sites in Italy, Spain
- Volunteers
- 90 people
- Sponsor
- San Luigi Gonzaga Hospital
STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
HELicobacter Pylori Screening in Patients With Acute Myocardial Infarction Pilot Study
The aim of this study is to determine the prevalence of Helicobacter pylori (Hp) infection in patients with myocardial infarction (MI).
- Trial name
- HELPpilot (NCT04289012)
- Testing
- Helicobacter Pylori screening by UBT
- Where
- 2 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Karolinska Institutet
Primary Angioplasty
Evaluation of Feasibility of Radial Access for Primary Angioplasty and to Assess it in High Risk Subgroups
Primary percutaneous coronary intervention is the preferred treatment for patients with ST-segment acute coronary syndrome. The radial access is an established approach, associated with a reduction in vascular access related…
- Trial name
- NCT03488407
- Volunteers
- 315 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
ST Elevation Myocardial Infarction (STEMI)
Effect of Long Term Trimetazidine Treatment on Final Myocardial Fibrosis for ST Eleviation Myocardial Infarction
Trimetazidine is a agent promoting glucose utilization by limiting fatty-acid oxidation.Trimetazidine could improve cardiac function in patients with ischemic heart disease.
- Trial name
- Easy (NCT07325955)
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Chinese PLA General Hospital
Myocardial Infarction
Myocardial Infarction With ST-Elevation
Mechanical recanalization of the culprit artery in acute myocardial infarction using stents provides in 2003, TIMI 3 flow restoration in more than 90% of patients.
- Trial name
- MISTRAL (NCT00638638)
- Testing
- Abciximab
- Where
- France
- Volunteers
- 292 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
ST Segment Elevation Myocardial Infarction
Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Non Culprit Lesions in Patients With ST-segment Elevation Myocardial Infarction
Functional assessment of non-culprit lesions during percutaneous coronary intervention (PCI) in patients with acute coronary syndrome could improve risk stratification and shorten the duration of hospital stay by decreasing the…
- Trial name
- WAVE (NCT02869906)
- Testing
- FFR and iFR
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliera San Camillo Forlanini
Optical Coherence Tomography, Dual Antiplatelet Therapy
OCT or Angiography Guided De-escalation of DAPT
Optical coherence tomography (OCT) offers a high-resolution intravascular imaging modality to accurately assess vessel and lumen geometry and identify the hallmark of a culprit lesion including plaque disruption and thrombus.
- Conditions
- Optical Coherence Tomography, Dual Antiplatelet Therapy, Antiplatelet De-escalation, Neointimal Coverage
- Trial name
- NCT06339021
- Testing
- OCT-guided PCI, Conventional angiography-based PCI, DAPT de-escalation
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shenyang Northern Hospital
ST Elevation Myocardial Infarction
SONOthrombolysis in Patients With an ST-segment Elevation Myocardial Infarction With fibrinoLYSIS (SONOSTEMI-LYSIS) Trial
This study will assess the safety and feasibility of sonothrombolysis in the acute management of STEMI undergoing reperfusion therapy with systemic fibrinolysis as part of a pharmacoinvasive approach
- Trial name
- SONOSTEMILYSIS (NCT04217304)
- Testing
- Definity® with High Mechanical Index Ultrasound
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- University of Alberta
Ischemic Heart Disease, ST-segment Elevation Myocardial Infarction
Late Reperfusion With Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction
Although recommended therapy for patients with ST-segment elevation myocardial infarction is primary PCI, it remains unestablished whether patients with a symptom duration of more 12 hours benefit from acute revascularisation.
- Trial name
- LATE-MI (NCT02445885)
- Testing
- PCI
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Thomas Engstrom
Acute Coronary Syndrome
Telemedical vs. Conventional Prehospital Care in Acute Coronary Syndromes
Telemedically supported paramedic care of acute coronary syndromes was compared to a historical control period of solely conventional on-scene physician care.
- Trial name
- NCT03132935
- Testing
- Telemedical support
- Where
- Germany
- Volunteers
- 221 people
- Sponsor
- RWTH Aachen University
STEMI (STE-ACS), Primary PCI for STEMI
The Effect of Atorvastatin 80 mg on Hs-CRP/Albumin Ratio in Reducing Thrombus Burden in PCI-STEMI Patients
40 STEMI patients who underwent primary PCI were subsequently allocated into two groups via a double-blind randomization method: An Atorvastatin 80 mg group and the control group.
- Trial name
- PCI-STEMI (NCT06871358)
- Testing
- Atorvastatin 80mg
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Sebelas Maret
Anterior Myocardial Infarction, Heart Failure
Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients
The main purpose of this study is to compare the myocardial protection effect of intravenous metoprolol combined with remote ischemic conditioning (RIC) and single treatment before reperfusion in Chinese patients with anterior…
- Trial name
- NCT03579914
- Testing
- Metoprolol Injectable Product, Romote Ischemic Conditioning (RIC), Metoprolol & RIC
- Where
- 16 sites in China
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Harbin Medical University
ST Elevation Myocardial Infarction
Trial Comparing Radial and Femoral Approach in Primary Percutaneous Coronary Intervention (PCI)
Percutaneous coronary interventions (PCIs) from the femoral approach have more bleeding complications related to access site in comparison to the radial approach in patients with acute coronary syndrome (ACS).
- Trial name
- STEMI-RADIAL (NCT01136187)
- Testing
- Access site in primary PCI
- Where
- 4 sites in Czechia
- Volunteers
- 707 people
- Sponsor
- Charles University, Czech Republic
STEMI, Elevated IMR (>32)
A Study of Low-dose Intracoronary Thrombolytic Therapy in STEMI (Heart Attack) Patients.
Heart attacks are caused by a blood clot blocking the blood vessels of the heart, preventing blood getting to the heart muscle. Opening up the artery with a balloon (angioplasty) and a small mesh tube (stent) although life saving…
- Trial name
- RESTORE-MI (NCT03998319)
- Testing
- Tenecteplase (1/3 systemic weight based dose), Sterile water for injection (WFI)
- Where
- 22 sites in Australia, New Zealand
- Volunteers
- 445 people
- Sponsor
- University of Sydney
ST-Segment Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
The FAVOR V AMI Trial
The FAVOR V AMI study is a prospective, multicenter, blinded, randomized, sham-controlled trial comparing the long-term clinical outcomes of the "Functional and Angiography-derived Strain inTegration (FAST)" technique…
- Conditions
- ST-Segment Elevation Myocardial Infarction, Multivessel Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT05669222
- Testing
- FAST Technique, Angiography
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Myocardial Infarction
Remote Ischemic Preconditioning in Primary PCI
Primary percutaneous coronary intervention (pPCI) is the preferred treatment in ST elevation myocardial infarction (STEMI). The infarct-related artery (IRA) can be opened in more than 90% of the patients.
- Trial name
- NCT00435266
- Testing
- Remote ischemic preconditioning
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- University of Aarhus
ST-Segment Elevation Myocardial Infarction (STEMI), No-Reflow Phenomenon
Adenosine Pre-Medication in Primary Percutaneous Coronary Intervention
Primary objective of the study is to evaluate the impact of adenosine pre-medication on incidence of slow flow/no-reflow after primary percutaneous coronary intervention.
- Conditions
- ST-Segment Elevation Myocardial Infarction (STEMI), No-Reflow Phenomenon, Coronary Slow Flow, Acute Myocardial Infarction
- Trial name
- AMPACT (NCT07536802)
- Testing
- Adenosine pre-medication, Standard care
- Where
- 2 sites in Pakistan
- Volunteers
- 1,148 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Myocardial Infarction, Reperfusion Injury
Pilot Study of Edaravone to Treat Acute Myocardial Infarction
Early reperfusion therapy has improved the clinical outcomes of patients with acute myocardial infarction (AMI), but these benefits are limited in some patients by reperfusion injuries.
- Trial name
- NCT00265239
- Testing
- edaravone
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Kumamoto University