Clinical trials: Sadness
Healthy Volunteers
Single and Multiple Ascending Dosing Administration of MF-300 in Healthy Participants
The study will consist of 2 parts, Study Parts 1 (1a: single ascending dose [SAD] Phase; and 1b: Food Effect Phase) and Part 2 (multiple ascending dose [MAD] Phase).
- Trial name
- NCT07613684
- Testing
- MF-300 SAD, MF-300 Food Effect, MF-300 MAD
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Epirium Bio Inc.
Postpartum Depression (PPD), Postpartum Anxiety
Investigation of TVNS Administration on Postpartum Mental Health
The aim of the study is to explore whether transcutaneous vagus nerve stimulation (tVNS) may be effective in preventing mood swings and depressive symptoms in the postpartum phase, as well as serving as a supplementary…
- Conditions
- Postpartum Depression (PPD), Postpartum Anxiety, Postpartum Sadness, Postpartum Blues
- Trial name
- NCT06682689
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Seasonal Affective Disorder, Mood Disorders
Clinical Trials of Three Non-Drug Treatments for Winter Depression (SAD)
We are offering non-pharmacologic therapy for alleviation of symptoms associated with depressed mood that recurs annually in fall or winter.
- Conditions
- Seasonal Affective Disorder, Mood Disorders, Depression
- Trial name
- NCT00006517
- Testing
- bright light box, dawn simulator, high-output negative ion generator
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York State Psychiatric Institute
Depression
Assessment of Music Experiences in Navigating Depression Part 2
This study is again looking at the use of music and music therapy experiences in navigating depression. The researchers will provide 11 sessions of music therapy and half will be followed by recitals at the Third Street School…
- Trial name
- AMEND (NCT07218055)
- Testing
- Music therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Social Anxiety Disorder
Open-label Safety Trial of PH94B in Social Anxiety Disorder (SAD)
This study evaluates the safety and tolerability of PH94B with repeated dosing over a period of up to 12 months. Participating subjects will use PH94B up to 4 times a day when they encounter anxiety-provoking situations in daily…
- Trial name
- NCT05030350
- Testing
- PH94B
- Where
- 3 sites in United States
- Volunteers
- 481 people
- Sponsor
- VistaGen Therapeutics, Inc.
Social Anxiety Disorder, Social Phobia
Therapeutic Processes in iCBT for SAD
The current study examines therapeutic processes during internet-based cognitive-behavioral therapy for social anxiety disorder. Participants will be randomized to either treatment or wait-list conditions.
- Trial name
- NCT03709615
- Testing
- Internet delivered CBT for social anxiety disorder
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- University of Haifa
Seasonal Affective Disorder
Bright Light Therapy in Seasonal Affective Disorder (SAD)
Bright light therapy (BLT) is widely accepted as first-line treatment of seasonal affective disorder (SAD). However, the mechanism of action of BLT is still widely unknown.
- Trial name
- NCT01293409
- Testing
- Transcranial Brain-Targeted Bright Light Treatment
- Where
- Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Anxiety Disorders, Depression
Early Intervention Coping Kids (TIM) Follow up Study
The project objectives are to investigate if a preventive intervention targeting anxious and sad children aged 8 to 12 years has haf the anticipated long-term effects, 5 years after receiving the intervention.
- Trial name
- FOPPT4 (NCT05766072)
- Testing
- EMOTION Kids coping with anxiety and depression (Mestrende barn in Norwegian)
- Where
- Norway
- Volunteers
- 217 people
- Sponsor
- University of Oslo
Schizophrenia, Schizoaffective Disorder
Does The Addition Of Divalproex Sodium ER To An Atypical Antipsychotic Drug (APD) Improve Cognition And Psychopathology In Outpatients With Schizophrenia (SCH) Or Schizoaffective Disorder (SAD)?
The major objective of this proposal is to test the hypothesis that the addition of divalproex sodium to an atypical antipsychotic drug other than clozapine will significantly improve: a) cognition; and b) psychopathology…
- Trial name
- NCT00306475
- Testing
- Divalproex Sodium Extended-Release Tablets
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Postpartum Sadness
The Importance of Discharge Education for Mommy Blues
The study will be conducted with participants who will give birth at Farabi Training and Research Hospital in Darıca District, Kocaeli Province.
- Trial name
- NCT06293274
- Testing
- Discharge training
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Alzheimer s Disease
SAD Study of CGB3002 in Healthy Participants
This is a randomized, double-blind, placebo-controlled phase I clinical study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of single ascending IV doses of CGB3002 in healthy participants.
- Trial name
- NCT07660341
- Testing
- CGB3002 0.08 mg/kg, CGB3002 0.4 mg/kg, CGB3002 1.2 mg/kg
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- ChainGen Biopharma Ltd
Sadness
Psychophysiological Effects of Birdsongs VS Music
The main goal of this study is to learn the psychophysiological effects of birdsongs on sadness. The main questions it aims to answer are: 1. Can birdsongs alleviate sadness in a short term? 2.
- Trial name
- NCT06581445
- Testing
- Birdsongs, Music
- Where
- China
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Social Anxiety Disorder
CvC-SAD (Clinician vs Coach)Self-help Versions in a RCT
Background: Social Anxiety Disorder (SAD) is a common mental problem, where people experience severe and disabling anxiety about social situations and interactions.
- Trial name
- NCT05292612
- Testing
- iCBT(C&W) for SAD
- Where
- Hong Kong
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cystic Fibrosis
SAD and MAD of Inhaled AR-501 in Health Adults and P. Aeruginosa Infected Cystic Fibrosis Subjects
This is a Phase 1/2a randomized, double-blind, two-part, dose-ascending, multicenter study of AR-501 (gallium citrate) solution, administered via inhalation, in healthy adult and P.
- Trial name
- NCT03669614
- Testing
- Inhaled AR-501
- Where
- 25 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Aridis Pharmaceuticals, Inc.
Social Anxiety Disorder
12-Week Study of Pristiq (Desvenlafaxine) Social Anxiety Disorder
This study is designed to evaluate the efficacy and safety of Pristiq® in treatment of the symptoms of Generalized Social Anxiety Disorder (SAD).
- Trial name
- NCT01316302
- Testing
- Pristiq
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- The Medical Research Network
Acute Agitation
Safety and Tolerability of INP105 (Olanzapine by I231 POD® Device) Nasal Spray in Healthy Volunteers - SNAP 101
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of INP105, which is an investigational drug-device combination product comprised of the drug component OLZ administered by a…
- Trial name
- SNAP101 (NCT03624322)
- Testing
- Zyprexa IM, Zydis, INP105
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Impel Pharmaceuticals
Small Airway Disease, Asthma
Small Airways Disease (SAD) in Severe Asthma as a Novel Endpoint and Distinct Target for Biological Therapy.
Severe asthma is now widely accepted to be a heterogeneous syndrome consisting of multiple phenotypes identified by specific biomarkers and targeted by tailored biological therapies.
- Trial name
- SASAB (NCT05792592)
- Testing
- IOS (Impulse Oscillometry)
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Major Depressive Disorder, Dysthymia
Safety and Efficacy Study of Citalopram and Lithium for the Treatment of Depressive Mood Disorder Symptoms
The investigators hypothesize that patients receiving citalopram in combination with lithium will have a greater reduction in depressive symptoms than patients receiving citalopram in combination with placebo.
- Conditions
- Major Depressive Disorder, Dysthymia, Depression Not Otherwise Specified, Borderline Personality Disorder
- Trial name
- NCT01189812
- Testing
- Lithium Carbonate, Citalopram
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Columbia Northwest Pharmaceuticals
Emotional Dysregulation, Anxiety
Comparing the Effectiveness of Reappraisal Strategies in Adult Participants
The goal of this clinical trial is to learn which reappraisal strategy works better to reduce sadness and anxiety in emerging adults.
- Conditions
- Emotional Dysregulation, Anxiety, Sadness, Anxiety Disorders and Symptoms
- Trial name
- NCT07008209
- Testing
- Reconstrual Strategy Training, Repurposing Strategy Training, Active Control
- Where
- Turkey (Türkiye)
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Ibn Haldun University
Mother Infant Contact
The Effect of Mother-Infant Contact Barrier on Maternal Sadness and Adaptation
This study was conducted to investigate the effect of mother-infant contact deprivation on maternal sadness and maternal adaptation. The research is a randomized controlled experimental study.
- Trial name
- NCT06688604
- Testing
- skin contact
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University