Clinical trials: Safety Issues
Sedentary Lifestyle, Occupational Exposure
Active Workplace Study
Exposure to sedentary work is an occupational hazard with significant health and safety consequences. Sedentary behavior is an independent predictor of heart disease, diabetes, early mortality, and accounts for the majority of…
- Conditions
- Sedentary Lifestyle, Occupational Exposure, Health Behavior, Safety Issues
- Trial name
- NCT03556670
- Testing
- Total Worker Health, Control
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Safety Issues, Feasibility
A Pilot Study of Deep Cervical Lymphatic-venous Anastomosis in the Treatment of Alzheimer's Disease
Alzheimer's disease (AD) is the most prevalent form of dementia, affecting 3-4% of the population over a lifetime. It's characterized by abnormal Amyloid-beta (Aβ) and tau protein expression and accumulation in the central…
- Conditions
- Safety Issues, Feasibility, Therapeutic Value
- Trial name
- NCT06448442
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Safety Issues
Effect of Lean Leadership Training Program on Head Nurses' Lean Performance and Staff Nurses' Workplace Safety at Mansoura Children Hospital
Effect of Lean Leadership Training Program on Head Nurses' Lean Performance and Staff Nurses' Workplace Safety at Mansoura Children Hospital
- Trial name
- leadership (NCT06989294)
- Testing
- Lean Leadership
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Safety Issues, Tolerance
First-in-human Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of C106 in Healthy Subjects
This is a FIH, double-blind, placebo-controlled, within-group randomised, trial designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of single and multiple ascending oral doses of compound 106 (C106) in…
- Conditions
- Safety Issues, Tolerance, Idiopathic Pulmonary Fibrosis, Pulmonary Hypertension
- Trial name
- NCT05427253
- Testing
- C106 solution
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vicore Pharma AB
Occupational Stress, Health Behavior
Corrections Work's Adverse Effects and a Total Worker Health Program to Enhance Well-being
Conduct a quasi-experimental pre-post study of a mindfulness-enhanced, web/app-enabled, scalable Total Worker Health (TWH) program among higher stress Corrections Professionals.
- Conditions
- Occupational Stress, Health Behavior, Safety Issues, Mental Health Wellness 1
- Trial name
- NCT05608889
- Testing
- Total Worker Health Mindfulness Enhanced Program
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kerry Kuehl
Toxicity, Safety Issues
Safety Assessment of P2Et Extract in Healthy Voluntary Subjects in Colombia
Caesalpinia spinosa extract is rich in gallotannins and other well characterized polyphenols and has a major antioxidant activity.
- Trial name
- NCT03663881
- Testing
- P2Et extract
- Where
- Colombia
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario San Ignacio
Safety Issues, Tolerability
SB17170 Phase1 Trial in Healthy Volunteer
This clinical trial aims to learn about the safety, tolerability, and pharmacokinetic properties of SB17170 and its active metabolite SB1703 in single and multiple oral administration in healthy adults.
- Conditions
- Safety Issues, Tolerability, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT05795192
- Testing
- SB17170
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- SPARK Biopharma
Morbid Obesity, Sleeve Gastrectomy
Safety of an Early Discharge Protocol After Sleeve Gastrectomy
Evaluate the safety and efficacy of an early discharge protocol (23 hours, overnight stay) after scheduled sleeve gastrectomy.
- Conditions
- Morbid Obesity, Sleeve Gastrectomy, Early Discharge, Safety Issues
- Trial name
- NCT03070457
- Testing
- Early discharge, Conventional protocol
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Microbial Colonization, Tolerance
SEPSIS: L. Plantarum Trial
Sepsis is a life-threatening clinical syndrome and a leading cause of neonatal deaths worldwide. The burden of neonatal sepsis and severe infection (SI) is particularly high in areas of South Asia and other resource-limited…
- Conditions
- Microbial Colonization, Tolerance, Safety Issues, Infant ALL
- Trial name
- NCT05180201
- Testing
- Synbiotic, Probiotic
- Where
- 2 sites in Bangladesh
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Anesthesia, Airway Morbidity
Preoxygenation Using High Flow Oxygen : Efficacy and Tolerance in Healthy Volunteers
High flow nasal cannula oxygen has been proposed to perform preoxygenation in patients with acute respiratory failure requiring orotracheal intubation in intensive care units.
- Conditions
- Anesthesia, Airway Morbidity, Safety Issues
- Trial name
- PreOx-OHD (NCT03399695)
- Testing
- preoxygenation
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Safety Issues, Pharmacokinetics
Effect of Clarithromycin on PK of Linaprazan, Linaprazan on PK of Clarithromycin and Linaprazan on PK of Midazolam
This is a phase I, open-label, fixed sequence design, drug-drug-interaction (DDI) study divided in 2 parts. Part I is designed to evaluate whether concomitant treatment with linaprazan glurate and clarithromycin, a strong…
- Conditions
- Safety Issues, Pharmacokinetics, Drug Interaction, Tolerability
- Trial name
- NCT05633147
- Testing
- Linaprazan glurate, Drug drug interaction (DDI) - Clarithromycin (Part I), Drug drug interaction (DDI) - Midazolam (Part 2)
- Where
- Sweden
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
Safety Issues, Tolerability
Single Ascending Dose and Multiple Ascending Dose Study of AVR-48
This is a Phase 1 (healthy adult volunteers), 2-part, double-blind, randomized, placebo controlled trial to evaluate the safety and pharmacokinetic (PK) profiles of escalating single doses of AVR-48 versus placebo (SAD) and…
- Conditions
- Safety Issues, Tolerability, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT06847698
- Testing
- AVR-48
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AyuVis Research, Inc.
Safety Issues
Safety Evaluation of Porous Silica in Men
The aim of the present study was to determine whether oral dosing, up to 9 grams/day, of porous silica administered as a food additive can be used safely in normal weight and obese male humans, without significant side effects on…
- Trial name
- NCT03667430
- Testing
- Porous silica
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Spray, Pain
Safety of Gebauer's Pain Ease and Gebauer's Ethyl Chloride
This study aims to determine if Gebauer's Pain Ease or Gebauer's Ethyl Chloride topical anesthetic sprays are safe for use as numbing agents prior to placing epidurals and arterial lines, based on whether they introduce increased…
- Conditions
- Spray, Pain, Safety Issues
- Trial name
- NCT04207710
- Testing
- Gebauer's Pain Ease Top Aerosol Mist Spray, Gebauer's Ethyl Chloride
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Reproducibility of Results, Safety Issues
Non-Invasive Blood Test Cross-Validation Study
The study considers a cross-validation approach to determine the effectiveness of a non-invasive comprehensive metabolic panel (NICMP), relative to the venipuncture method.
- Trial name
- NCT03991637
- Testing
- Non-Invasive Comprehensive Metabolic Panel
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Joseph Allen Jr.
Healthy, Safety Issues
Assessing the Effects of a Cannabidiol Derived From Hemp Supplement in Healthy Adults
The purpose of this prospective, randomized, double-blind, placebo-controlled trial is to assess the physiological, biochemical, and psychometric impacts of a brand-specific hemp-derived cannabidiol product in a sample of healthy…
- Trial name
- NCT05212402
- Testing
- Cannabinol
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Bioequivalency, Safety Issues
Bioequivalence Study of Iron Sucrose Injection in Healthy Participants
The goal of this clinical trial is to compare the pharmacokinetic profile of the single intravenous injection of the test product and reference product in healthy subjects and to evaluate the bio-equivalence and safety of these…
- Trial name
- NCT06674486
- Testing
- Iron Sucrose injection (Test product, manufactured by Sichuan Huiyu Pharmaceutical Co., Ltd) and Iron Sucrose injection (Reference product, Venofer), Iron Sucrose injection (Reference product, Venofer) and Iron Sucrose injection (Test product, manufactured by Sichuan Huiyu Pharmaceutical Co., Ltd)
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sichuan Huiyu Pharmaceutical Co., Ltd
Safety Issues, Pharmacokinetics
Safety and Pharmacokinetics of an Extract of Naringenin
This study evaluates the safety of administering single ascending doses (150, 300, 600, and 900 mg) of a citrus extract of the flavonoid narigenin, and assesses the blood concentrations of naringenin following oral administration…
- Trial name
- Citrus (NCT03582553)
- Testing
- Naringenin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Mental Health Issue, Anxiety Disorders
Delivering ICBT to Address Mental Health Challenges in Correctional Officers and Other Public Safety Personnel
Public safety personnel (PSP) have regular and often intense exposure to potentially traumatic events at work and are at higher risk for developing mental health problems such as posttraumatic stress disorder (PTSD).
- Conditions
- Mental Health Issue, Anxiety Disorders, Depressive Disorder, Post-Traumatic Stress Disorder
- Trial name
- NCT04666974
- Testing
- iCBT, In-Person CBT
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Dr. Nazanin Alavi
Drink Too Much, Drinking, Binge
Group-based Intervention for Club Patrons
The purpose of this study is to develop and test a group-based strategy for encouraging groups of young adults who are engaged in party behaviors at nightclubs to intervene with each other to reduce harms associated with overuse…
- Conditions
- Drink Too Much, Drinking, Binge, Drunk, Drug Use
- Trial name
- NCT03652688
- Testing
- Nightlife Safety Plans (NSP), Fire Safety
- Where
- 2 sites in United States
- Volunteers
- 959 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation