Clinical trials: Safety Study
Healthy Volunteers, Safety
Safety, Tolerability, and Pharmacokinetics of RCS-21 in Healthy Volunteers.
The goal of this clinical trial is to evaluate the safety and tolerability of RCS-21 in healthy volunteers. Participants will be asked to inhale a single dose or multiple doses of RCS-21 and their health status will be constantly…
- Conditions
- Healthy Volunteers, Safety, Tolerability, Pharmacokinetics
- Trial name
- AMIR-21 (NCT06752122)
- Testing
- RCS-21 (SAD), RCS-21 (MD)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- RNATICS GmbH
Firearm Safety, Firearm Safety Storage
Firearm Secure Storage Device Distribution RCT
This study aims to learn how to best promote safe firearm storage in the community. Firearm injuries are a major public health concern, and securely storing firearms can help prevent accidental injuries, suicide, and unauthorized…
- Trial name
- NCT07886983
- Testing
- Cable locks, Lock box, Lock box and cable locks
- Volunteers
- 1,858 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Gut Health, Gastrointestinal Symptoms
IgG Binding Protein LT in Support of a Healthy Gut on the Go
PS52 is a randomized, double-blind, placebo-controlled, fully decentralized study sponsored by Bactolife A/S and conducted by People Science, Inc.
- Conditions
- Gut Health, Gastrointestinal Symptoms, Safety in Healthy Adults
- Trial name
- NCT07873957
- Testing
- IgG Binding Protein LT
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Bactolife A/S
Safety and Tolerability in Healthy Volunteers
Safety and Tolerability Evaluation of IgG Binding Protein LT
This study evaluates the safety and tolerability of the food ingredient IgG Binding Protein LT (BP-LT) when added to a daily diet.
- Trial name
- NCT07824011
- Testing
- IgG Binding Protein LT
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bactolife A/S
Safety, Tolerability
A First-in-Human SAD and MAD Study in HV to Evaluate Oral YR011 Tablet
This is a Phase I clinical trial (protocol number: YR-011-B07) sponsored by Hangzhou Yirui Pharmaceutical Technology Co., Ltd., focusing on the novel oral small-molecule drug YR011 (active ingredient: PA032, a Kv1.3 channel…
- Conditions
- Safety, Tolerability, Pharmacokinetic
- Trial name
- NCT07878481
- Testing
- Kv1.3 potassium channel blocker (PA032, investigational oral small-molecule drug)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hangzhou Yirui Pharmaceutical Technology Co., Ltd
Safety Issues
A Phase 1 Study to Evaluate the Safety/Tolerability, PK/PD of RG002C0106 Injection in Healthy Adults
This is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability and PK/PD profiles of RG002C0106 injection in healthy adult subjects.
- Trial name
- NCT06494527
- Testing
- RG002C0106
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rigerna Therapeutics Co., Ltd.; Rigerna Therapeutics (Beijing) Co., Ltd.
Patient Handoff, Healthcare Team
Handoffs and Transitions in Critical Care - Understanding Scalability
The investigators will leverage implementation science and engineering to adapt, implement, and rigorously evaluate tailored postoperative handoff protocols and implementation strategies.
- Conditions
- Patient Handoff, Healthcare Team, Communication, Patient Safety
- Trial name
- HATRICC-US (NCT04571749)
- Testing
- Customized handoff
- Where
- 5 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Birth Outcomes, Safety
Simultaneous mRNA COVID-19 and IIV Vaccination in Pregnancy Study
This study is a prospective, randomized clinical trial. During this study, pregnant women will be randomly assigned to receive IIV and mRNA COVID-19 vaccine either simultaneously or sequentially (7-14 days apart).
- Conditions
- Birth Outcomes, Safety, Adverse Event Following Immunization
- Trial name
- NCT06503900
- Testing
- mRNA COVID-19 vaccine, IIV4 (quadrivalent inactivated influenza vaccine)
- Where
- 6 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Duke University
Patient Safety, Patient Safety Education
Patient Safety Competency-Building Program for Healthcare Professionals in Pediatric Cardiac Critical Care in Ethiopia
This study aims to develop and evaluate a patient safety competency-building program for healthcare professionals involved in pediatric cardiac critical care in Ethiopia.
- Trial name
- NCT07844369
- Testing
- Patient Safety Competency-Building Program
- Where
- Ethiopia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Woong-Han Kim
To Evaluate the Efficacy and Safety of Selected TCM Elbow Manipulation in Treating, Lateral Epicondylitis
Efficacy and Safety of Selected Traditional Chinese Medicine Elbow Manipulation Versus Mill's Manipulation as Control for Lateral Epicondylitis
Background: Lateral epicondylitis (LE), also referred to as lateral elbow tendinopathy and tennis elbow, is commonly seen clinically as an orthopedic disease.
- Trial name
- NCT07843771
- Testing
- Selected Traditional Chinese Medicine manipulation, Mill's Manipulation
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Sleep, Fatigue
Sleep, Mindfulness, and Shift-Level Safety Performance in Perianesthesia Nurses
Perianesthesia (preoperative and postanesthesia care unit, PACU) nurses work rotating, often extended shifts that can disrupt sleep and increase fatigue, both of which are recognized threats to patient safety in high-acuity…
- Conditions
- Sleep, Fatigue, Patient Safety
- Trial name
- NCT07832721
- Testing
- Sleep, Mindfulness, and Shift-Level Safety Observation Toolkit
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Volkan Gokmen
Missed Nursing Care, Patient Safety
Perioperative Nursing Workload, Missed Care, and Near-Miss Events
This prospective, single-center observational study examines the relationship between perioperative nursing workload and safety-critical perioperative nursing care in the operating rooms of Agri Training and Research Hospital.
- Conditions
- Missed Nursing Care, Patient Safety, Workload
- Trial name
- NCT07834580
- Testing
- Structured Direct Observation and Workload Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Volkan Gokmen
Pediatric Safety
Pediatric Acceptability Evaluation of a Cosmetic Product
The goal of this clinical trial is to evaluate the dermatological safety and acceptability of a cosmetic product in healthy pediatric participants.
- Trial name
- NCT07839104
- Testing
- moisturizing cream
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Safety Study
Hyperthermia Safety Study Uses Temperature Management System to Gently Raise Participant's Body Temperature to a Fever-range Level in a Controlled Setting.
The Abreu BTT 700 Temperature Management System (TMS) is a device that gently raises the body temperature of the participant to a fever-range level in a controlled setting. There will be one study treatment session.
- Trial name
- BTT (NCT07564440)
- Testing
- Hyperthermia
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Marc Abreu
Randomised Clinical Trial, Double Blind
Phase I Study of VLPDEN-02 Dengue Vaccine in Healthy Adults
This is a Phase 1, randomized, double-blind, placebo-controlled, dose escalation study. Forty-two flavivirus-naïve adults will be enrolled and will receive 3 administrations of VLPDEN-02 or control at days 0, 28, and 56.
- Conditions
- Randomised Clinical Trial, Double Blind, Dengue, Challenge Test
- Trial name
- NCT07831473
- Testing
- VLPDEN-02 1.0 µg (0.25 µg of each VLP) + ALFQ adjuvant, VLPDEN-02 10 µg (2.5 µg of each VLP) + ALFQ adjuvant, VLPDEN-02 100 µg (25 µg of each VLP) + ALFQ adjuvant
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VLP Therapeutics
Safety
Evaluation of Allergenicity by HRIPT and Phototest
This clinical study will evaluate the dermatological safety and allergenic potential of a cosmetic product. The study will use the Human Repeat Insult Patch Test (HRIPT) and phototest procedures to assess whether the product may…
- Trial name
- HRIPT + FOTO (NCT07797192)
- Testing
- Blancy Pro
- Where
- Brazil
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Safety and Tolerability in Healthy Volunteers
Safety and Tolerability Evaluation of BP-LT
This study evaluates the safety and tolerability of the food ingredient BP-LT when added to a daily diet. BP-LT is a stable protein ingredient being functional in the gastrointestinal tract and without systemic absorption.
- Trial name
- NCT07819695
- Testing
- BP-LT
- Where
- Bangladesh
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bactolife A/S
Patient Safety Education and Nursing Students' Attitudes Toward Medical Errors
Effects of Two Teaching Methods on Nursing Students' Attitudes Toward Medical Errors
The aim of this study is to compare the effects of patient safety education delivered through the Pecha Kucha method, scenario-based teaching, and traditional teaching on nursing students' attitudes toward medical errors.
- Trial name
- NCT07822438
- Testing
- Pecha Kucha-Based Patient Safety Education, Scenario-Based Patient Safety Education, Traditional Lecture-Based Patient Safety Education
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Patient Safety, Medical Errors
Specialist Review of Harm Ratings for Clinical Responses Acronym: NOHARM
The purpose of this study is to determine how closely potential-harm ratings assigned using the NOHARM rubric agree with independent ratings from specialty-matched physicians.
- Trial name
- NCT07823062
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stanford University
Safety and Tolerability in Healthy Volunteers
Safety and User Experience of BP-CBB
This study is the first-in human study for the food ingredient BP-CBB and aims aims to build on the excellent safety and tolerability observed in the extensive food safety assessment performed for BP-CBB, as well as the consumer…
- Trial name
- NCT07628608
- Testing
- BP-CBB
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bactolife A/S