Clinical trials: Safety and Tolerability in Healthy Subjects
Healthy Volunteers, Safety
Safety, Tolerability, and Pharmacokinetics of RCS-21 in Healthy Volunteers.
The goal of this clinical trial is to evaluate the safety and tolerability of RCS-21 in healthy volunteers. Participants will be asked to inhale a single dose or multiple doses of RCS-21 and their health status will be constantly…
- Conditions
- Healthy Volunteers, Safety, Tolerability, Pharmacokinetics
- Trial name
- AMIR-21 (NCT06752122)
- Testing
- RCS-21 (SAD), RCS-21 (MD)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- RNATICS GmbH
Safety and Tolerability in Healthy Volunteers
Safety and Tolerability Evaluation of IgG Binding Protein LT
This study evaluates the safety and tolerability of the food ingredient IgG Binding Protein LT (BP-LT) when added to a daily diet.
- Trial name
- NCT07824011
- Testing
- IgG Binding Protein LT
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bactolife A/S
Safety and Tolerability in Healthy Volunteers
Safety and Tolerability Evaluation of BP-LT
This study evaluates the safety and tolerability of the food ingredient BP-LT when added to a daily diet. BP-LT is a stable protein ingredient being functional in the gastrointestinal tract and without systemic absorption.
- Trial name
- NCT07819695
- Testing
- BP-LT
- Where
- Bangladesh
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bactolife A/S
Safety and Tolerability in Healthy Volunteers
Safety and User Experience of BP-CBB
This study is the first-in human study for the food ingredient BP-CBB and aims aims to build on the excellent safety and tolerability observed in the extensive food safety assessment performed for BP-CBB, as well as the consumer…
- Trial name
- NCT07628608
- Testing
- BP-CBB
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bactolife A/S
Healthy, Safety Evaluation of Escalating Doses
A Study to Test the Effects of Nezavist at Different Doses in Healthy Adults
The goal of this clinical trial is to determine the safety, tolerability and effects of Nezavist in healthy adults. The main questions it aims to answer are: What is the safety and maximum tolerated dose (MTD) of orally…
- Conditions
- Healthy, Safety Evaluation of Escalating Doses, Tolerability
- Trial name
- NCT06633562
- Testing
- Nezavist SDD
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Lohocla Research Corporation
Safety and Tolerability in Healthy Volunteers
Safety and Tolerability of an Ultra Absorbency Menstrual Tampon Compared to a Commercially Marketed Tampon
A Randomized, Open-Label, Evaluator-Blinded, Cross-Over Clinical Study to Confirm the Safety and Tolerability of an Ultra Absorbency Menstrual Tampon Compared to a Commercially Marketed Tampon
- Trial name
- NCT07807891
- Testing
- Tampon
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lyv Life Inc. (dba: Cora)
Safety and Tolerability in Healthy Volunteers
Phase 1 Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TRT-448 in Healthy Adult Subjects
Phase 1, Randomized, Double-blind, Placebo-controlled, Single Ascending and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TRT-448 in Healthy Adult Subjects
- Trial name
- TRT-448-101 (NCT07745751)
- Testing
- TRT-448
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Trotana, Inc.
Safety and Tolerability in Healthy Subjects
Phase 1 Study of Oral MG001
This research study is the first time the new medication MG001 is being tested in people. MG001 is a formulation of mitragynine, a compound that comes from a plant called Mitragyna speciosa (sometimes known as kratom), which some…
- Trial name
- NCT07204171
- Testing
- mitragynine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Evaluate the Safety and Tolerability of ZKLJ02 Injection in Healthy Chinese Research Participants
A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ZKLJ02 Injection in Healthy Chinese Research Participants
A randomized, double-blind, placebo-controlled, dose-escalation Phase I clinical study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single intravenous administration of ZKLJ02 injection in…
- Trial name
- ZKLJ02-I (NCT07638098)
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yunnan Zhongke Longjin Biotechnology Co.,Ltd.
Healthy, Safety and Tolerability
Evaluating the Safety, Tolerability, and Pharmacokinetics of DF-003 in Healthy Subjects
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics (PK; drug metabolism) of DF-003 after oral administration of single and multiple ascending doses in healthy subjects.
- Trial name
- NCT05997641
- Testing
- DF-003
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shanghai Yao Yuan Biotechnology Ltd. (also known as Drug Farm)
Evaluate the Safety and Tolerability, Healthy and Overweight or Obese Participants
Phase 1 Study of Ascending Doses of CMS-D008 in Healthy and Overweight/Obese Adults
This study is a first-in-human clinical trial of CMS-D008 conducted in Chinese healthy and overweight or obese adult participants, consisting of three parts: Part-1 Single Ascending Dose (SAD) study (hereinafter referred to as…
- Trial name
- NCT07518589
- Testing
- CMS-D008
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Shenzhen Kangzhe Biotechnology Co., Ltd.
Safety and Tolerability, Healthy Volunteers
Phase 1 Study to Evaluate Safety, Tolerability and Pharmacokinetics/-Dynamics of AK1967 (Procizumab)
Dipeptidyl peptidase 3 (DPP3) is a protease involved in the degradation of several cardiovascular mediators. During cardiogenic shock, upregulation of the vasoconstrictive molecule angiotensin II is a physiologic and potentially…
- Trial name
- NCT06331884
- Testing
- AK1967 (Procizumab)
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- 4TEEN4 Pharmaceuticals GmbH
Evaluate PK Profile, Evaluate PD Profile
A Study Testing the Effects of Different THC Doses on Psychological and Biological Function
The goal of this clinical trial is to learn how a investigational medicinal product (THC) affects psychological and physical responses in healthy adults with prior cannabis use experience.
- Conditions
- Evaluate PK Profile, Evaluate PD Profile, Healthy Adults, Safety and Tolerability in Healthy Volunteers
- Trial name
- DRATT (NCT07346690)
- Testing
- AVCN319301b (6mg), AVCN319301b (9mg), AVCN319301b (15mg)
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Safety and Tolerability in Healthy Subjects
BACK4 Safety Evaluation
To characterize the safety of combined RF and EMS therapies with the BACK4 device in healthy volunteers. Subjects will receive 3 treatments of increasing intensity over a one week period.
- Trial name
- NCT07153900
- Testing
- Treatment with BACK4 System
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- SWIMS America Corp.
Safety, Tolerability
A Phase 1 Study of Y-3 in US Healthy Volunteers.
The goal of this clinical trial is to assess the safety, tolerability, and pharmacokinetic profiles of Y-3 in healthy adult volunteers in the United States.
- Conditions
- Safety, Tolerability, Pharmacokinetic Study in Healthy Volunteers
- Trial name
- NCT06770491
- Testing
- Y-3 for injection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Neurodawn Pharmaceutical Co., Ltd.
Exercise, Blood Pressure
Effects of Lentil Protein Hydrolysate on Blood Pressure Control, Vascular Function and Exercise Performance
Examining the safety and tolerability of Lentil Protein Hydrolysate in healthy males and females whilst exploring the effects of a dose range on blood pressure control and vascular function and exercise performance
- Conditions
- Exercise, Blood Pressure, Vasodilation, Vascular Function in Healthy Volunteers
- Trial name
- NCT06894875
- Testing
- Lentil protein hydrolysate
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nuritas Ltd
Safety and Tolerability in Healthy Volunteers
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of SSS39 Injection in Healthy Chinese Subjects
To evaluate the safety, tolerability, and pharmacokinetics of SSS39 injection in healthy Chinese subjects
- Trial name
- NCT07057726
- Testing
- SSS39
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Safety and Tolerability in Healthy Volunteers
Evaluation of the Safety and Tolerability of Three Doses of Diamine Oxidase (DAO) in Healthy Volunteers
The main aim of this study is to evaluate the safety and tolerability of the product administered, of 3 different doses. Safety will be evaluated by recording and assessing adverse events, vital signs, laboratory tests and ECG.
- Trial name
- DAO-MAX2024 (NCT06715163)
- Testing
- Dose 1 (42mg) of DAO, Dose 2 (84mg) of DAO, Dose 3 (210mg) of DAO
- Where
- Spain
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- AB Biotek
Safety, Tolerability
A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD7503 in Healthy Participants
This study will evaluate safety, tolerability and pharmacokinetics (PK) of AZD7503, following subcutaneous (SC) administration of single ascending doses of AZD7503 in healthy participants.
- Conditions
- Safety, Tolerability, Pharmacokinetics, Healthy Participants
- Trial name
- NCT05143905
- Testing
- AZD7503
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Adult Subjects, Pharmacokinetics
A Phase I Pharmacokinetics Study for KT07 Capsule
This is a phase 1 single-center study to assess the pharmacokinetics (PK), safety and tolerability of KT07 capsules in healthy adult subjects. This study consists of 2 parts: Part 1 and Part 2.
- Conditions
- Healthy Adult Subjects, Pharmacokinetics, Safety and Tolerability
- Trial name
- NCT05223660
- Testing
- Low dose KT07, High dose KT07
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Yiling Pharmaceutical Inc.